Mission Bay

Kevin Shannon, MD

Professor

Pediatrics

Kevin Shannon, MD studies signaling mechanisms that regulate the growth and differentiation of normal and leukemic stem cells. He is particularly interested in the genetic and biochemical basis of inherited leukemia predispositions and the regulation of hematopoietic stem cell and progenitor cell growth by Ras signaling.

Dean Sheppard, MD

Professor

Medicine

Dean Sheppard, MD, PhD studies the role of integrins and signaling mechanisms in cell and tissue interactions in the lung, specifically in lung injury and fibrosis.

Deepak Srivastava, MD

Professor

M_PEDS-CARDIOLOGY

Our laboratory focuses on understanding the causes of heart disease and on using knowledge of cardiac developmental pathways to devise novel therapeutic approaches for human cardiac disorders. Specifically, we study the molecular events regulating early and late developmental decisions that instruct progenitor cells to adopt a cardiac cell fate and subsequently fashion a functioning heart. We focus on transcriptional and post-transcriptional steps, including those involving microRNAs. We have leveraged this knowledge to reprogram fibroblasts directly into cardiomyocyte-like cells for regenerative purposes. We also seek to identify the causes of human cardiovascular disease by applying modern genetic technologies for the study of complex traits such as congenital heart disease. By using a spectrum of approaches including mouse and human genetics, molecular and developmental biology, and biochemistry we hope to develop a broad understanding of the biology underlying cardiogenesis and cardiovascular disorders.

Hua Su, MD

Professor

Anesthesia

Hua Su, MD studies gene and cell based therapies for cerebral vascular diseases, including stroke.

Saul Villeda, PhD

Associate Professor

Anatomy

Saul Villeda, PhD studies how molecular immune-related changes in old blood impair stem cell function and cognitive processes in the brain during aging, and conversely how young blood can reverse these impairments.