About the Broad Center

Innovative and collaborative research to understand and treat the world’s most devastating diseases

Dear Colleagues,

I am honored and excited to begin my tenure as the Director of the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research. As many of you know, I started my career here as an Assistant Professor in 2007, as a joint hire between the Dept of Surgery and the Broad Center; I am so grateful for the opportunities that this community has provided for my career. It has been a joy to form collaborations and friendships with so many of you over the years.

Our stem cell program has an incredible foundation, established by Arnold Kriegstein’s leadership and vision. We are fortunate to have a membership of brilliant investigators on multiple campuses at UCSF, including in our state-of-the-art Regeneration Medicine Building. We have experienced and committed staff members who have ensured seamless continuation of our program during a pandemic and this time of transition. This strong foundation will be important as we define our identity and set a vision for the next decade.

We are living in a transformative era in medicine: next-generation sequencing technologies are rapidly improving our ability to understand cell biology in health and disease, and our newfound ability to edit the genome offers an incredible potential to correct pathogenic mutations. Within UCSF, the recent growth of numerous scientific Centers and Institutes at multiple campuses, as well as the renewed focus on programmatic growth at Parnassus, offer multiple opportunities for productive collaborations. The growing commitment to issues of diversity, equity, and inclusion, both locally and globally, brings a new lens to our views about our faculty, staff, and learners, as well as the diseases that we study. Finally, the refunding of CIRM promises to bring significant funding for stem cell and gene therapy research, as well as support for educating the next generation.

In short, the stars are aligned for our collective success: we have the potential to improve our knowledge base in many key areas of stem cell biology, as well as develop life-saving therapies for many diseases in which our stem cell community has specific expertise. As a clinician-scientist, I am excited to promote excellence on both sides of the bridge and build systems that can enable appropriate programs to cross the “valley of death” into clinical translation. My vision is to transform the Broad Center by strengthening our research programs in strategic areas, forging intentional collaborations across campuses, and improving our capacity for clinical translation.

Since I took on this role, I have enjoyed meeting with many of you individually and in groups to discuss your opinions about the strengths, weaknesses, opportunities, and threats for our program. I have also put together a Steering Committee to focus on specific programmatic areas such as DEI, Education, Faculty Mentoring, Technology, and Translation. I look forward to working together to ensure the continued success of our stem cell program.

Sincerely,

Tippi C. Mackenzie, MD

Professor of Surgery

Benioff UCSF Professor in Children's Health

Director, The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research

Co-Director, Center for Maternal-Fetal Precision Medicine

John G. Bowes Distinguished Professor in Stem Cell and Tissue Biology

 

Our Mission

"To create an inclusive, collaborative community that catalyzes our strong basic science expertise while accelerating stem cell therapies for patients."