
Professor
Neurology
+1 415 502-1694
William Weiss, MD, PhD is interested in developing and characterizing mouse models that faithfully recapitulate the biology and genetics of human tumors of the nervous system.
Publications
Synergistic RAS-MAPK and AKT Activation in MYC-Driven Tumors via Adjacent PVT1 Rearrangements.
bioRxiv : the preprint server for biology
EGFR and EGFRvIII coopt host defense pathways, promoting progression in glioblastoma.
Neuro-oncology
Author Correction: MYC phase separation selectively modulates the transcriptome.
Nature structural & molecular biology
3D genome topology distinguishes molecular subgroups of medulloblastoma.
American journal of human genetics
In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy responses in glioblastoma.
Genome biology
Editor's Note: Inhibition of Phosphatidylinositol 3-Kinase Destabilizes Mycn Protein and Blocks Malignant Progression in Neuroblastoma.
Cancer research
PRDM6 promotes medulloblastoma by repressing chromatin accessibility and altering gene expression.
Scientific reports
Aurora Kinase A inhibition enhances DNA damage and tumor cell death with 131I-MIBG therapy in high-risk neuroblastoma.
EJNMMI research
MYC phase separation selectively modulates the transcriptome.
Nature structural & molecular biology
Aurora Kinase A inhibition enhances DNA damage and tumor cell death with 131I-MIBG therapy in high-risk neuroblastoma.
Research square
Author Correction: Diagnostic yield of pediatric and prenatal exome sequencing in a diverse population.
NPJ genomic medicine
The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling.
Nature communications
PRDM6 promotes medulloblastoma by repressing chromatin accessibility and altering gene expression.
bioRxiv : the preprint server for biology
Hedgehog target genes regulate lipid metabolism to drive basal cell carcinoma and medulloblastoma.
Research square
Diagnostic yield of pediatric and prenatal exome sequencing in a diverse population.
NPJ genomic medicine
Loss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma by triggering MYC amplification and genomic instability.
Nature communications
Clinical significance and molecular annotation of cellular morphometric subtypes in lower-grade gliomas discovered by machine learning.
Neuro-oncology
N-myc-Mediated Translation Control Is a Therapeutic Vulnerability in Medulloblastoma.
Cancer research
Epigenetic Rewiring Underlies SMARCA4-Dependent Maintenance of Progenitor State in Pediatric H3K27M Diffuse Midline Glioma.
Cancer discovery
Author Correction: Failure of human rhombic lip differentiation underlies medulloblastoma formation.
Nature
Transposon Mutagenesis Reveals RBMS3 Silencing as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis.
Cancer research
Developing Bottom-Up Induced Pluripotent Stem Cell Derived Solid Tumor Models Using Precision Genome Editing Technologies.
The CRISPR journal
EGFR ligands dictate tumour suppression.
Nature cell biology
Generation of immunocompetent syngeneic allograft mouse models for pediatric diffuse midline glioma.
Neuro-oncology advances
All eyes on a phosphatase in glioma stem cells.
The Journal of experimental medicine
Subgroup and subtype-specific outcomes in adult medulloblastoma.
Acta neuropathologica
A SHHecret target of relapsed medulloblastoma: Astrocytes.
The Journal of experimental medicine
The synergy of BET inhibitors with aurora A kinase inhibitors in MYCN-amplified neuroblastoma is heightened with functional TP53.
Neoplasia (New York, N.Y.)
Deep immune profiling reveals targetable mechanisms of immune evasion in immune checkpoint inhibitor-refractory glioblastoma.
Journal for immunotherapy of cancer
Heterozygous ANKRD17 loss-of-function variants cause a syndrome with intellectual disability, speech delay, and dysmorphism.
American journal of human genetics
The transcriptional landscape of Shh medulloblastoma.
Nature communications
Integrated molecular and clinical analysis of low-grade gliomas in children with neurofibromatosis type 1 (NF1).
Acta neuropathologica
Drugging the "Undruggable" MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers.
Cancer research
Utility of Human-Derived Models for Glioblastoma.
Cancer discovery
Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma.
Cell reports. Medicine
Depatuxizumab Mafodotin (ABT-414)-induced Glioblastoma Cell Death Requires EGFR Overexpression, but not EGFRY1068 Phosphorylation.
Molecular cancer therapeutics
Betacellulin drives therapy resistance in glioblastoma.
Neuro-oncology
Conversations on mutism: risk stratification for cerebellar mutism based on medulloblastoma subtype.
Neuro-oncology
Translating Basic Science Discoveries into Improved Outcomes for Glioblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers.
Cell reports
In Vitro Assay to Study Tumor-macrophage Interaction.
Journal of visualized experiments : JoVE
Mechanisms of Resistance to EGFR Inhibition Reveal Metabolic Vulnerabilities in Human GBM.
Molecular cancer therapeutics
Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis.
Cell stem cell
Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma.
Nature communications
GateFinder: projection-based gating strategy optimization for flow and mass cytometry.
Bioinformatics (Oxford, England)
A CK1α Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
An oncolytic measles virus-sensitive Group 3 medulloblastoma model in immune-competent mice.
Neuro-oncology
Dual HDAC and PI3K Inhibition Abrogates NFκB- and FOXM1-Mediated DNA Damage Response to Radiosensitize Pediatric High-Grade Gliomas.
Cancer research
Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1-TGF-β-OTX2-SNAIL via PTEN inhibition.
Brain : a journal of neurology
A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment.
Cancer cell
Antisecretory Factor-Mediated Inhibition of Cell Volume Dynamics Produces Antitumor Activity in Glioblastoma.
Molecular cancer research : MCR
CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.
The Journal of clinical investigation
Cross-activating c-Met/β1 integrin complex drives metastasis and invasive resistance in cancer.
Proceedings of the National Academy of Sciences of the United States of America
Inhibiting 4EBP1 in Glioblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Glioblastoma cellular cross-talk converges on NF-κB to attenuate EGFR inhibitor sensitivity.
Genes & development
Targeting Alpha Toxin To Mitigate Its Lethal Toxicity in Ferret and Rabbit Models of Staphylococcus aureus Necrotizing Pneumonia.
Antimicrobial agents and chemotherapy
Breast density estimation from high spectral and spatial resolution MRI.
Journal of medical imaging (Bellingham, Wash.)
Combined BRAFV600E and MEK blockade for BRAFV600E-mutant gliomas.
Journal of neuro-oncology
Cholesterol: An Achilles' Heel for Glioblastoma?
Cancer cell
Neuroblastoma.
Nature reviews. Disease primers
Critical Role of Alpha-Toxin and Protective Effects of Its Neutralization by a Human Antibody in Acute Bacterial Skin and Skin Structure Infections.
Antimicrobial agents and chemotherapy
Inhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumors.
Oncotarget
BRAF Status in Personalizing Treatment Approaches for Pediatric Gliomas.
Clinical cancer research : an official journal of the American Association for Cancer Research
Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis.
The Lancet. Oncology
Erratum to: Survival advantage combining a BRAF inhibitor and radiation in BRAF V600E-mutant glioma.
Journal of neuro-oncology
Generating trunk neural crest from human pluripotent stem cells.
Scientific reports
Rational design of a monomeric and photostable far-red fluorescent protein for fluorescence imaging in vivo.
Protein science : a publication of the Protein Society
Survival advantage combining a BRAF inhibitor and radiation in BRAF V600E-mutant glioma.
Journal of neuro-oncology
EAG2 potassium channel with evolutionarily conserved function as a brain tumor target.
Nature neuroscience
Downregulation of MYCN through PI3K Inhibition in Mouse Models of Pediatric Neural Cancer.
Frontiers in oncology
Spinal Myxopapillary Ependymomas Demonstrate a Warburg Phenotype.
Clinical cancer research : an official journal of the American Association for Cancer Research
Preliminary assessment of dispersion versus absorption analysis of high spectral and spatial resolution magnetic resonance images in the diagnosis of breast cancer.
Journal of medical imaging (Bellingham, Wash.)
A new "angle" on kinase inhibitor design: Prioritizing amphosteric activity above kinase inhibition.
Molecular & cellular oncology
The genetics of splicing in neuroblastoma.
Cancer discovery
WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma.
Acta neuropathologica communications
Radiotherapy followed by aurora kinase inhibition targets tumor-propagating cells in human glioblastoma.
Molecular cancer therapeutics
An improved monomeric infrared fluorescent protein for neuronal and tumour brain imaging.
Nature communications
Assessment and prognostic significance of the epidermal growth factor receptor vIII mutation in glioblastoma patients treated with concurrent and adjuvant temozolomide radiochemotherapy.
International journal of cancer
The prenatal origins of cancer.
Nature reviews. Cancer
Cytogenetic prognostication within medulloblastoma subgroups.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Glial progenitors as targets for transformation in glioma.
Advances in cancer research
Residual analysis of the water resonance signal in breast lesions imaged with high spectral and spatial resolution (HiSS) MRI: a pilot study.
Medical physics
Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma.
Science (New York, N.Y.)
BET bromodomain inhibition of MYC-amplified medulloblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group.
Acta neuropathologica
TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma.
Acta neuropathologica
EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma.
Cancer cell
It takes two to tango: Dual inhibition of PI3K and MAPK in rhabdomyosarcoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Neuroblastoma and MYCN.
Cold Spring Harbor perspectives in medicine
Starvation favors glioma stem cells.
Nature neuroscience
Blockade of glioma proliferation through allosteric inhibition of JAK2.
Science signaling
Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
A robust method to derive functional neural crest cells from human pluripotent stem cells.
American journal of stem cells
What underlies the diversity of brain tumors?
Cancer metastasis reviews
G34, another connection between MYCN and a pediatric tumor.
Cancer discovery
Molecular imaging of neuroblastoma progression in TH-MYCN transgenic mice.
Molecular imaging and biology
Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy.
Proceedings of the National Academy of Sciences of the United States of America
Th-MYCN mice with caspase-8 deficiency develop advanced neuroblastoma with bone marrow metastasis.
Cancer research
Targeting MYCN in neuroblastoma by BET bromodomain inhibition.
Cancer discovery
Tumor dosimetry using [124I]m-iodobenzylguanidine microPET/CT for [131I]m-iodobenzylguanidine treatment of neuroblastoma in a murine xenograft model.
Molecular imaging and biology
Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma.
Acta neuropathologica
Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.
Genes & development
Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma.
Proceedings of the National Academy of Sciences of the United States of America
PTEN promoter methylation and activation of the PI3K/Akt/mTOR pathway in pediatric gliomas and influence on clinical outcome.
Neuro-oncology
Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC.
Cancer cell
Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy.
Proceedings of the National Academy of Sciences of the United States of America
Matching mice to malignancy: molecular subgroups and models of medulloblastoma.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
Kinetics of inhibitor cycling underlie therapeutic disparities between EGFR-driven lung and brain cancers.
Cancer discovery
Subgroup-specific alternative splicing in medulloblastoma.
Acta neuropathologica
Paracrine signaling through MYCN enhances tumor-vascular interactions in neuroblastoma.
Science translational medicine
Inhibition of PI3K-Akt-mTOR signaling in glioblastoma by mTORC1/2 inhibitors.
Methods in molecular biology (Clifton, N.J.)
Biological and clinical heterogeneity of MYCN-amplified medulloblastoma.
Acta neuropathologica
Targeted therapy for BRAFV600E malignant astrocytoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Genetically engineered murine models--contribution to our understanding of the genetics, molecular pathology and therapeutic targeting of neuroblastoma.
Seminars in cancer biology
Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma.
Cancer cell
Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct.
Acta neuropathologica
PCDH10 is a candidate tumour suppressor gene in medulloblastoma.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
Cooperation of the HDAC inhibitor vorinostat and radiation in metastatic neuroblastoma: efficacy and underlying mechanisms.
Cancer letters
Vorinostat increases expression of functional norepinephrine transporter in neuroblastoma in vitro and in vivo model systems.
Clinical cancer research : an official journal of the American Association for Cancer Research
Principles and current strategies for targeting autophagy for cancer treatment.
Clinical cancer research : an official journal of the American Association for Cancer Research
Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide.
Neuro-oncology
Non-stem cell origin for oligodendroglioma.
Cancer cell
Radiation dose estimation using preclinical imaging with 124I-metaiodobenzylguanidine (MIBG) PET.
Medical physics
Addiction to B-MYB.
Oncotarget
Pleiotropic role for MYCN in medulloblastoma.
Genes & development
Intratumoral therapy of glioblastoma multiforme using genetically engineered transferrin for drug delivery.
Cancer research
Myc proteins as therapeutic targets.
Oncogene
Targeting the RTK-PI3K-mTOR axis in malignant glioma: overcoming resistance.
Current topics in microbiology and immunology
A translational end-run for a rare, genetically enigmatic tumor.
Cancer biology & therapy
Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality.
Cancer research
Adenovirus-mediated hPNPase(old-35) gene transfer as a therapeutic strategy for neuroblastoma.
Journal of cellular physiology
The side story of stem-like glioma cells.
Cell stem cell
EGFR signals to mTOR through PKC and independently of Akt in glioma.
Science signaling
PI3K signaling in glioma--animal models and therapeutic challenges.
Brain pathology (Zurich, Switzerland)
Chemotherapy-induced apoptosis in a transgenic model of neuroblastoma proceeds through p53 induction.
Neoplasia (New York, N.Y.)
A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition.
The Biochemical journal
Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity.
EMBO reports
Characterization of structurally distinct, isoform-selective phosphoinositide 3'-kinase inhibitors in combination with radiation in the treatment of glioblastoma.
Molecular cancer therapeutics
BMPs oppose Math1 in cerebellar development and in medulloblastoma.
Genes & development
Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells.
Journal of cellular biochemistry
Recognizing and exploiting differences between RNAi and small-molecule inhibitors.
Nature chemical biology
Malignant progression and blockade of angiogenesis in a murine transgenic model of neuroblastoma.
Cancer research
A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma.
Cancer research
Cell lines from MYCN transgenic murine tumours reflect the molecular and biological characteristics of human neuroblastoma.
European journal of cancer (Oxford, England : 1990)
Structure-guided development of affinity probes for tyrosine kinases using chemical genetics.
Nature chemical biology
Brain tumors in S100beta-v-erbB transgenic rats.
Journal of neuropathology and experimental neurology
Childhood tumors of the nervous system as disorders of normal development.
Current opinion in pediatrics
Genotype-phenotype correlations in tuberous sclerosis: who and how to treat.
Annals of neurology
Isoform specific inhibitors of PI3 kinase in glioma.
Cell cycle (Georgetown, Tex.)
Inhibition of phosphatidylinositol 3-kinase destabilizes Mycn protein and blocks malignant progression in neuroblastoma.
Cancer research
Chemical genetic approaches to the development of cancer therapeutics.
Current opinion in genetics & development
Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3.
Nature genetics
Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8.
Cancer research
Mechanisms of embryonal tumor initiation: distinct roles for MycN expression and MYCN amplification.
Proceedings of the National Academy of Sciences of the United States of America
Can mouse models for brain tumors inform treatment in pediatric patients?
Seminars in cancer biology
Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach.
Cancer research
Effects of MYCN antisense oligonucleotide administration on tumorigenesis in a murine model of neuroblastoma.
Journal of the National Cancer Institute
Genome-wide array CGH analysis of murine neuroblastoma reveals distinct genomic aberrations which parallel those in human tumors.
Cancer research
Targeted therapy of brain tumors utilizing neural stem and progenitor cells.
Frontiers in bioscience : a journal and virtual library
Chemical genetic blockade of transformation reveals dependence on aberrant oncogenic signaling.
Current biology : CB
A head holder for magnetic resonance imaging that allows the stereotaxic alignment of spontaneously occurring intracranial mouse tumors.
Journal of neuroscience methods
Genetics of brain tumors.
Current opinion in pediatrics
Targeted expression of MYCN causes neuroblastoma in transgenic mice.
The EMBO journal