
Professor
Medicine
+1 415 514-4269
Dean Sheppard, MD, PhD studies the role of integrins and signaling mechanisms in cell and tissue interactions in the lung, specifically in lung injury and fibrosis.
Publications
Stromal heterogeneity in the adult lung delineated by single-cell genomics.
American journal of physiology. Cell physiology
Dual αVβ8 Integrin and PD-1 Blockade Overcomes TGFβ-Mediated B-Cell Suppression to Enhance Anti-Glioma Immunity.
Neuro-oncology
Radial glia integrin avb8 regulates cell autonomous microglial TGFβ1 signaling that is necessary for microglial identity.
Nature communications
ATF4 drives regulatory T cell functional specification in homeostasis and obesity.
Science immunology
Independent and interactive effects of viral species on risk for lower respiratory tract illnesses in early life.
medRxiv : the preprint server for health sciences
Monocytes and interstitial macrophages contribute to hypoxic pulmonary hypertension.
The Journal of clinical investigation
Impaired Myofibroblast Proliferation is a Central Feature of Pathologic Post-Natal Alveolar Simplification.
bioRxiv : the preprint server for biology
IL-13 and IL-17A activate ß1 integrin through an NF-kB/Rho kinase/PIP5K1? pathway to enhance force transmission in airway smooth muscle.
Proceedings of the National Academy of Sciences of the United States of America
Macrophage-fibroblast crosstalk drives Arg1-dependent lung fibrosis via ornithine loading.
bioRxiv : the preprint server for biology
IL-13 and IL-17A Activate β1 Integrin through an NF-kB/Rho kinase/PIP5K1γ pathway to Enhance Force Transmission in Airway Smooth Muscle.
bioRxiv : the preprint server for biology
The Puerto Rican Infant Metagenomic and Epidemiologic Study of Respiratory Outcomes (PRIMERO): Design and Baseline Characteristics for a Birth Cohort Study of Early-life Viral Respiratory Illnesses and Airway Dysfunction in Puerto Rican Children.
medRxiv : the preprint server for health sciences
Dynamic fibroblast-immune interactions shape wound healing after brain injury.
bioRxiv : the preprint server for biology
An in vivo screening platform identifies senolytic compounds that target p16INK4a+ fibroblasts in lung fibrosis.
The Journal of clinical investigation
Challenges and Opportunities for Commercializing Technologies in the Pulmonary Arena: An Official American Thoracic Society Report.
Annals of the American Thoracic Society
APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints.
Nature immunology
Radial glia promote microglial development through integrin αVβ8 -TGFβ1 signaling.
bioRxiv : the preprint server for biology
An immune-based tool platform for in vivo cell clearance.
Life science alliance
An integrated cell atlas of the lung in health and disease.
Nature medicine
Anti-Integrin αvβ6 Autoantibodies Are a Novel Biomarker That Antedate Ulcerative Colitis.
Gastroenterology
A stapled chromogranin A-derived peptide homes in on tumors that express αvβ6 or αvβ8 integrins.
International journal of biological sciences
Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung.
Science (New York, N.Y.)
Macrophage Cx43 Is Necessary for Fibroblast Cytosolic Calcium and Lung Fibrosis After Injury.
Frontiers in immunology
IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis.
American journal of physiology. Lung cellular and molecular physiology
Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation.
Nature communications
Integrin α2β1 regulates collagen I tethering to modulate hyperresponsiveness in reactive airway disease models.
The Journal of clinical investigation
Stuck in a Moment: Does Abnormal Persistence of Epithelial Progenitors Drive Pulmonary Fibrosis?
American journal of respiratory and critical care medicine
Induced hepatic stellate cell integrin, α8β1, enhances cellular contractility and TGFβ activity in liver fibrosis.
The Journal of pathology
Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung.
Nature cell biology
Dual antagonists of α5β1/αvβ1 integrin for airway hyperresponsiveness.
Bioorganic & medicinal chemistry letters
Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice.
Science translational medicine
Lack of Flvcr2 impairs brain angiogenesis without affecting the blood-brain barrier.
The Journal of clinical investigation
Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis.
Nature communications
Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking.
Science advances
A disease-associated mutation in fibrillin-1 differentially regulates integrin-mediated cell adhesion.
The Journal of biological chemistry
Impaired aV�8 and TGF� signaling lead to microglial dysmaturation and neuromotor dysfunction.
The Journal of experimental medicine
β6 -integrin serves as a novel serum tumor marker for colorectal carcinoma.
International journal of cancer
IL-17A Recruits Rab35 to IL-17R to Mediate PKCα-Dependent Stress Fiber Formation and Airway Smooth Muscle Contractility.
Journal of immunology (Baltimore, Md. : 1950)
Loss of Integrin αvβ8 in Murine Hepatocytes Accelerates Liver Regeneration.
The American journal of pathology
Arhgef12 drives IL17A-induced airway contractility and airway hyperresponsiveness in mice.
JCI insight
Cell division cycle 7 kinase is a negative regulator of cell-mediated collagen degradation.
American journal of physiology. Lung cellular and molecular physiology
TGF-β1 Signaling and Tissue Fibrosis.
Cold Spring Harbor perspectives in biology
Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8.
Proceedings of the National Academy of Sciences of the United States of America
Fra-2 negatively regulates postnatal alveolar septation by modulating myofibroblast function.
American journal of physiology. Lung cellular and molecular physiology
An Official American Thoracic Society Workshop Report: Use of Animal Models for the Preclinical Assessment of Potential Therapies for Pulmonary Fibrosis.
American journal of respiratory cell and molecular biology
Pharmacologic Blockade of αvβ1 Integrin Ameliorates Renal Failure and Fibrosis In Vivo.
Journal of the American Society of Nephrology : JASN
Targeting integrin α5β1 ameliorates severe airway hyperresponsiveness in experimental asthma.
The Journal of clinical investigation
Transforming growth factor-β plays divergent roles in modulating vascular remodeling, inflammation, and pulmonary fibrosis in a murine model of scleroderma.
American journal of physiology. Lung cellular and molecular physiology
Exploring N-Arylsulfonyl-l-proline Scaffold as a Platform for Potent and Selective αvβ1 Integrin Inhibitors.
ACS medicinal chemistry letters
An Epithelial Integrin Regulates the Amplitude of Protective Lung Interferon Responses against Multiple Respiratory Pathogens.
PLoS pathogens
Pulmonary Th17 Antifungal Immunity Is Regulated by the Gut Microbiome.
Journal of immunology (Baltimore, Md. : 1950)
IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches.
Science (New York, N.Y.)
α-Smooth muscle actin is an inconsistent marker of fibroblasts responsible for force-dependent TGFβ activation or collagen production across multiple models of organ fibrosis.
American journal of physiology. Lung cellular and molecular physiology
Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β.
Nature immunology
Critical Appraisal of the Utility and Limitations of Animal Models of Scleroderma.
Current rheumatology reports
Integrin αvβ6 critically regulates hepatic progenitor cell function and promotes ductular reaction, fibrosis, and tumorigenesis.
Hepatology (Baltimore, Md.)
Adaptive Immune Regulation of Mammary Postnatal Organogenesis.
Developmental cell
Unexpected Role for Adaptive αβTh17 Cells in Acute Respiratory Distress Syndrome.
Journal of immunology (Baltimore, Md. : 1950)
The αvβ1 integrin plays a critical in vivo role in tissue fibrosis.
Science translational medicine
Epithelial-mesenchymal interactions in fibrosis and repair. Transforming growth factor-β activation by epithelial cells and fibroblasts.
Annals of the American Thoracic Society
Innate antiviral host defense attenuates TGF-� function through IRF3-mediated suppression of Smad signaling.
Molecular cell
Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking aV�8-TGF� signaling in the brain.
Development (Cambridge, England)
IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction.
The Journal of clinical investigation
The cell biology of asthma.
The Journal of cell biology
Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress.
Proceedings of the National Academy of Sciences of the United States of America
Inhibition of the αvβ6 integrin leads to limited alteration of TGF-α-induced pulmonary fibrosis.
American journal of physiology. Lung cellular and molecular physiology
Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report.
American journal of respiratory and critical care medicine
TGF-β activation and function in immunity.
Annual review of immunology
Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs.
Nature medicine
Eosinophils secrete IL-4 to facilitate liver regeneration.
Proceedings of the National Academy of Sciences of the United States of America
The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases.
The Journal of clinical investigation
ROCKing pulmonary fibrosis.
The Journal of clinical investigation
Effective treatment of mouse sepsis with an inhibitory antibody targeting integrin αvβ5.
Critical care medicine
Therapy for fibrotic diseases: nearing the starting line.
Science translational medicine
Epistatic interactions between Tgfb1 and genetic loci, Tgfbm2 and Tgfbm3, determine susceptibility to an asthmatic stimulus.
Proceedings of the National Academy of Sciences of the United States of America
Integrin-mediated regulation of TGFβ in fibrosis.
Biochimica et biophysica acta
Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction.
Proceedings of the National Academy of Sciences of the United States of America
Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing.
The Journal of clinical investigation
Modulation of acute lung injury by integrins.
Proceedings of the American Thoracic Society
Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung.
The Journal of experimental medicine
IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia.
American journal of physiology. Lung cellular and molecular physiology
IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction.
Nature medicine
Alternaria induces STAT6-dependent acute airway eosinophilia and epithelial FIZZ1 expression that promotes airway fibrosis and epithelial thickness.
Journal of immunology (Baltimore, Md. : 1950)
Epithelial cells utilize cortical actin/myosin to activate latent TGF-β through integrin α(v)β(6)-dependent physical force.
Experimental cell research
The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells.
The Journal of clinical investigation
Absence of integrin αvβ3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation.
American journal of respiratory and critical care medicine
Cross talk among TGF-β signaling pathways, integrins, and the extracellular matrix.
Cold Spring Harbor perspectives in biology
Integrin αvβ5-mediated TGF-β activation by airway smooth muscle cells in asthma.
Journal of immunology (Baltimore, Md. : 1950)
Blocking TGFβ via Inhibition of the αvβ6 Integrin: A Possible Therapy for Systemic Sclerosis Interstitial Lung Disease.
International journal of rheumatology
Recommendations for the classification of diseases as CFTR-related disorders.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Aspen Lung Conference 2010: systems biology of lung diseases--progress in the omics era.
Proceedings of the American Thoracic Society
Short form of α9 promotes α9β1 integrin-dependent cell adhesion by modulating the function of the full-length α9 subunit.
Experimental cell research
Osteopontin undergoes polymerization in vivo and gains chemotactic activity for neutrophils mediated by integrin alpha9beta1.
The Journal of biological chemistry
Phosphorylation of Trask by Src kinases inhibits integrin clustering and functions in exclusion with focal adhesion signaling.
Molecular and cellular biology
Expression of av�8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice.
The Journal of clinical investigation
Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages.
The Journal of clinical investigation
beta6 Integrin subunit deficiency alleviates lung injury in a mouse model of bronchopulmonary dysplasia.
American journal of respiratory cell and molecular biology
Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis.
Developmental cell
Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein.
The Journal of biological chemistry
Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q).
The American journal of pathology
Loss of integrin alpha9beta1 results in defects in proliferation, causing poor re-epithelialization during cutaneous wound healing.
The Journal of investigative dermatology
The alpha9beta1 integrin enhances cell migration by polyamine-mediated modulation of an inward-rectifier potassium channel.
Proceedings of the National Academy of Sciences of the United States of America
Dust mites' dirty dealings with dendritic cells.
Nature medicine
Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production.
The American journal of pathology
Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms.
Circulation research
An essential role for fibronectin extra type III domain A in pulmonary fibrosis.
American journal of respiratory and critical care medicine
Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients.
The Journal of clinical investigation
Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation.
American journal of respiratory and critical care medicine
Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1.
American journal of respiratory cell and molecular biology
Essential role for MFG-E8 as ligand for alphavbeta5 integrin in diurnal retinal phagocytosis.
Proceedings of the National Academy of Sciences of the United States of America
Genomics and proteomics of lung disease: conference summary.
American journal of physiology. Lung cellular and molecular physiology
Integrin alpha9beta1 directly binds to vascular endothelial growth factor (VEGF)-A and contributes to VEGF-A-induced angiogenesis.
The Journal of biological chemistry
Roles of the innate immune system in mammary gland remodeling during involution.
Journal of mammary gland biology and neoplasia
Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse.
The American journal of pathology
Identification and molecular characterization of multiple phenotypes in integrin knockout mice.
Methods in enzymology
Pulmonary emphysema: when more is less.
Physiology (Bethesda, Md.)
Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function.
American journal of respiratory cell and molecular biology
Alpha9beta1: a novel osteoclast integrin that regulates osteoclast formation and function.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
ADAM33 is not essential for growth and development and does not modulate allergic asthma in mice.
Molecular and cellular biology
Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix.
Proceedings of the National Academy of Sciences of the United States of America
Transforming growth factor beta: a central modulator of pulmonary and airway inflammation and fibrosis.
Proceedings of the American Thoracic Society
Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury.
The Journal of clinical investigation
Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure.
American journal of respiratory cell and molecular biology
Mfge8 is critical for mammary gland remodeling during involution.
Molecular biology of the cell
Integrin-mediated activation of latent transforming growth factor beta.
Cancer metastasis reviews
Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmatics.
Genetic epidemiology
ADAM disintegrin-like domain recognition by the lymphocyte integrins alpha4beta1 and alpha4beta7.
The Biochemical journal
Characterization of integrin beta6 and thrombospondin-1 double-null mice.
Journal of cellular and molecular medicine
Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway.
The Journal of biological chemistry
Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma.
The Journal of clinical investigation
Loss of synchronized retinal phagocytosis and age-related blindness in mice lacking alphavbeta5 integrin.
The Journal of experimental medicine
The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1.
The Journal of biological chemistry
Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma.
American journal of respiratory and critical care medicine
Mice lacking the integrin beta5 subunit have accelerated osteoclast maturation and increased activity in the estrogen-deficient state.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Fishing in the bloodstream: insights into the mechanisms of pulmonary hypertension?
American journal of respiratory and critical care medicine
Spermidine/spermine N1-acetyltransferase specifically binds to the integrin alpha9 subunit cytoplasmic domain and enhances cell migration.
The Journal of cell biology
Roles of alphav integrins in vascular biology and pulmonary pathology.
Current opinion in cell biology
Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9.
Journal of virology
Function-blocking integrin alphavbeta6 monoclonal antibodies: distinct ligand-mimetic and nonligand-mimetic classes.
The Journal of biological chemistry
Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma.
American journal of respiratory and critical care medicine
Role of multiple beta1 integrins in cell adhesion to the disintegrin domains of ADAMs 2 and 3.
Experimental cell research
Transforming growth factor-beta-dependent and -independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) mice.
The American journal of pathology
Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation.
American journal of respiratory cell and molecular biology
ADAM33 is not associated with asthma in Puerto Rican or Mexican populations.
American journal of respiratory and critical care medicine
Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism.
The Journal of biological chemistry
Functions of pulmonary epithelial integrins: from development to disease.
Physiological reviews
The importance of race and ethnic background in biomedical research and clinical practice.
The New England journal of medicine
Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema.
Nature
Endothelial integrins and angiogenesis: not so simple anymore.
The Journal of clinical investigation
Enteric expression of the integrin alpha(v)beta(6) is essential for nematode-induced mucosal mast cell hyperplasia and expression of the granule chymase, mouse mast cell protease-1.
The American journal of pathology
Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group.
American journal of respiratory and critical care medicine
Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma.
Nature medicine
Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans.
Proceedings of the National Academy of Sciences of the United States of America
The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1.
The Journal of cell biology
Killed by leukocytes that don't know when to leave.
Nature immunology
Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling.
The Journal of cell biology
Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions.
The Journal of biological chemistry
The EIIIA segment of fibronectin is a ligand for integrins alpha 9beta 1 and alpha 4beta 1 providing a novel mechanism for regulating cell adhesion by alternative splicing.
The Journal of biological chemistry
Integrin alphavbeta1 is a receptor for foot-and-mouth disease virus.
Journal of virology
Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins.
Nature medicine
Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types.
American journal of respiratory cell and molecular biology
The cytoplasmic domain of the integrin alpha9 subunit requires the adaptor protein paxillin to inhibit cell spreading but promotes cell migration in a paxillin-independent manner.
Molecular biology of the cell
Expression of the alphavbeta6 integrin promotes migration and invasion in squamous carcinoma cells.
The Journal of investigative dermatology
Pulmonary fibrosis: a cellular overreaction or a failure of communication?
The Journal of clinical investigation
TGF-beta is a critical mediator of acute lung injury.
The Journal of clinical investigation
Role of the cytoplasmic domain of the beta-subunit of integrin alpha(v)beta6 in infection by foot-and-mouth disease virus.
Journal of virology
Expression of the beta6 integrin subunit is associated with sites of neutrophil influx in lung epithelium.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
RGD-independent binding of integrin alpha9beta1 to the ADAM-12 and -15 disintegrin domains mediates cell-cell interaction.
The Journal of biological chemistry
Inhibitory effects of MLDG-containing heterodimeric disintegrins reveal distinct structural requirements for interaction of the integrin alpha 9beta 1 with VCAM-1, tenascin-C, and osteopontin.
The Journal of biological chemistry
A primary culture model of differentiated murine tracheal epithelium.
American journal of physiology. Lung cellular and molecular physiology
Functional genomics and expression profiling: be there or be square.
American journal of respiratory cell and molecular biology
Tissue transglutaminase, coagulation factor XIII, and the pro-polypeptide of von Willebrand factor are all ligands for the integrins alpha 9beta 1 and alpha 4beta 1.
The Journal of biological chemistry
Fatal bilateral chylothorax in mice lacking the integrin alpha9beta1.
Molecular and cellular biology
In vivo functions of integrins: lessons from null mutations in mice.
Matrix biology : journal of the International Society for Matrix Biology
The epithelial integrin alphavbeta6 is a receptor for foot-and-mouth disease virus.
Journal of virology
Mapping of the cryptic integrin-binding site in osteopontin suggests a new mechanism by which thrombin can regulate inflammation and tissue repair.
Trends in cardiovascular medicine
Two mechanisms of genistein inhibition of cystic fibrosis transmembrane conductance regulator Cl- channels expressed in murine cell line.
The Journal of physiology
Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis.
Proceedings of the National Academy of Sciences of the United States of America
Normal development, wound healing, and adenovirus susceptibility in beta5-deficient mice.
Molecular and cellular biology
The integrin alpha(9)beta(1) binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin.
The Journal of biological chemistry
Analysis of gene expression in human bullous keratopathy corneas containing limiting amounts of RNA.
Investigative ophthalmology & visual science
Distinct roles for astrocyte alphavbeta5 and alphavbeta8 integrins in adhesion and migration.
Journal of cell science
Airway remodeling and repair.
American journal of respiratory and critical care medicine
Inhibition of heterologously expressed cystic fibrosis transmembrane conductance regulator Cl- channels by non-sulphonylurea hypoglycaemic agents.
British journal of pharmacology
Fibronectin and alpha5beta1 integrin mediate binding of Pseudomonas aeruginosa to repairing airway epithelium.
The European respiratory journal
The integrin alpha9beta1 mediates adhesion to activated endothelial cells and transendothelial neutrophil migration through interaction with vascular cell adhesion molecule-1.
The Journal of cell biology
Requirement for IL-13 independently of IL-4 in experimental asthma.
Science (New York, N.Y.)
Regulated expression of the integrin alpha9beta1 in the epithelium of the developing human gut and in intestinal cell lines: relation with cell proliferation.
Journal of cellular biochemistry
Expression of the human integrin beta6 subunit in alveolar type II cells and bronchiolar epithelial cells reverses lung inflammation in beta6 knockout mice.
American journal of respiratory cell and molecular biology
Airway epithelial integrins: why so many?
American journal of respiratory cell and molecular biology
The integrin alphavbeta6 is critical for keratinocyte migration on both its known ligand, fibronectin, and on vitronectin.
Journal of cell science
Identification of the ligand binding site for the integrin alpha9 beta1 in the third fibronectin type III repeat of tenascin-C.
The Journal of biological chemistry
Requirements for allergen-induced airway hyperreactivity in T and B cell-deficient mice.
Molecular medicine (Cambridge, Mass.)
Comparison of the gating behaviour of human and murine cystic fibrosis transmembrane conductance regulator Cl- channels expressed in mammalian cells.
The Journal of physiology
Expression of the alpha9beta1 integrin in human colonic epithelial cells: resurgence of the fetal phenotype in a subset of colon cancers and adenocarcinoma cell lines.
International journal of cancer
Epidermal integrin expression is upregulated rapidly in human fetal wound repair.
Journal of pediatric surgery
Integrin alpha v beta 6 enhances coxsackievirus B1 lytic infection of human colon cancer cells.
Virology
Stromal fibroblasts influence oral squamous-cell carcinoma cell interactions with tenascin-C.
International journal of cancer
Osteopontin N-terminal domain contains a cryptic adhesive sequence recognized by alpha9beta1 integrin.
The Journal of biological chemistry
Differential regulation of airway epithelial integrins by growth factors.
American journal of respiratory cell and molecular biology
Distinct structural requirements for interaction of the integrins alpha 5 beta 1, alpha v beta 5, and alpha v beta 6 with the central cell binding domain in fibronectin.
Cell adhesion and communication
Fibronectin and its alpha 5 beta 1-integrin receptor are involved in the wound-repair process of airway epithelium.
The American journal of physiology
Identification of a sequence within the integrin beta6 subunit cytoplasmic domain that is required to support the specific effect of alphavbeta6 on proliferation in three-dimensional culture.
The Journal of biological chemistry
Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains.
The Journal of biological chemistry
Epithelial integrins.
BioEssays : news and reviews in molecular, cellular and developmental biology
Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin.
The Journal of cell biology
Multiplicity of fibronectin-binding alpha V integrin receptors in colorectal cancer.
British journal of cancer
Differential modulation of integrin receptors and extracellular matrix laminin by transforming growth factor-beta 1 in rat alveolar epithelial cells.
Experimental cell research
Expression of the integrin subunit alpha 9 in the murine embryo.
Developmental dynamics : an official publication of the American Association of Anatomists
Vitronectin enhances internalization of crocidolite asbestos by rabbit pleural mesothelial cells via the integrin alpha v beta 5.
The Journal of clinical investigation
The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin.
The Journal of biological chemistry
A point mutation in the integrin beta 6 subunit abolishes both alpha v beta 6 binding to fibronectin and receptor localization to focal contacts.
American journal of respiratory cell and molecular biology
Distribution of integrins alpha v beta 6 and alpha 9 beta 1 and their known ligands, fibronectin and tenascin, in human airways.
American journal of respiratory cell and molecular biology
Localized distribution of alpha 9 integrin in the cornea and changes in expression during corneal epithelial cell differentiation.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells.
Journal of cell science
Localization of the alpha v subfamily of integrins and their putative ligands in synovial lining cell layer.
The Journal of rheumatology
Staphylococcus aureus stimulates neutrophil recruitment by stimulating interleukin-8 production in dog trachea.
The American journal of physiology
Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain.
The Journal of biological chemistry
The integrin alpha 9 beta 1 mediates cell attachment to a non-RGD site in the third fibronectin type III repeat of tenascin.
The Journal of biological chemistry
The alpha v beta 6 integrin promotes proliferation of colon carcinoma cells through a unique region of the beta 6 cytoplasmic domain.
The Journal of cell biology
Disruption of integrin function and induction of tyrosine phosphorylation by the autonomously expressed beta 1 integrin cytoplasmic domain.
The Journal of biological chemistry
Dominant negative mutants: tools for the study of protein function in vitro and in vivo.
American journal of respiratory cell and molecular biology
Effects of beta subunit cytoplasmic domain deletions on the recruitment of the integrin alpha v beta 6 to focal contacts.
Cell adhesion and communication
Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor.
The Journal of biological chemistry
Polymerase chain reaction cloning with degenerate primers: homology-based identification of adhesion molecules.
Methods in enzymology
Identification and characterization of novel airway epithelial integrins.
The American review of respiratory disease
Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle.
The Journal of cell biology
Restricted distribution of integrin beta 6 mRNA in primate epithelial tissues.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Transforming growth factor beta differentially regulates expression of integrin subunits in guinea pig airway epithelial cells.
The Journal of biological chemistry
Characterization of the integrin alpha v beta 6 as a fibronectin-binding protein.
The Journal of biological chemistry
Airway oedema and obstruction in guinea pigs exposed to inhaled endotoxin.
British journal of industrial medicine
Polarized regulation of fibronectin secretion and alternative splicing by transforming growth factor.
The Journal of biological chemistry
Novel integrin alpha and beta subunit cDNAs identified in airway epithelial cells and lung leukocytes using the polymerase chain reaction.
American journal of respiratory cell and molecular biology
The response of guinea pig airway epithelial cells and alveolar macrophages to environmental stress.
American journal of respiratory cell and molecular biology
Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes.
The Journal of biological chemistry
Lack of bronchoconstrictor response to sulfuric acid aerosols and fogs.
The American review of respiratory disease
The effects of sequential exposure to acidic fog and ozone on pulmonary function in exercising subjects.
The American review of respiratory disease
Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction.
The Journal of biological chemistry
Acid fog-induced bronchoconstriction. The role of hydroxymethanesulfonic acid.
The American review of respiratory disease
Potential bronchoconstrictor stimuli in acid fog.
Environmental health perspectives
Epithelium removal alters responsiveness of guinea pig trachea to substance P.
Journal of applied physiology (Bethesda, Md. : 1985)
Sulfur dioxide and asthma--a double-edged sword?
The Journal of allergy and clinical immunology
A tachykinin receptor antagonist inhibits and an inhibitor of tachykinin metabolism potentiates toluene diisocyanate-induced airway hyperresponsiveness in guinea pigs.
The American review of respiratory disease
Acidity potentiates bronchoconstriction induced by hypoosmolar aerosols.
The American review of respiratory disease
Arachidonic acid metabolites do not mediate toluene diisocyanate-induced airway hyperresponsiveness in guinea pigs.
Prostaglandins
Toluene diisocyanate increases airway responsiveness to substance P and decreases airway neutral endopeptidase.
The Journal of clinical investigation
Tumor necrosis factor inhibits a polymorphonuclear leukocyte-dependent airway edema in guinea pigs.
Journal of applied physiology (Bethesda, Md. : 1985)
Karyotypic analysis of the human monoblastic cell line U937.
Cancer genetics and cytogenetics
Phosphoramidon potentiates the increase in lung resistance mediated by tachykinins in guinea pigs.
The American review of respiratory disease
Mechanisms of acute increases in airway responsiveness caused by environmental chemicals.
The Journal of allergy and clinical immunology
Symptomatic bronchoconstriction after short-term inhalation of sulfur dioxide.
The American review of respiratory disease
The roles of pH and ionic species in sulfur dioxide- and sulfite-induced bronchoconstriction.
The American review of respiratory disease
What does exercise have to do with "exercise-induced" asthma?
The American review of respiratory disease
Tachykinins mediate the acute increase in airway responsiveness caused by toluene diisocyanate in guinea pigs.
The American review of respiratory disease
Apparent effect of catalase on airway edema in guinea pigs. Role of endotoxin contamination.
The American review of respiratory disease
The role of titratable acidity in acid aerosol-induced bronchoconstriction.
The American review of respiratory disease
Physiology of the parasympathetic nervous system of the lung.
Postgraduate medical journal
Hydroxyurea inhibits airway hyperresponsiveness in guinea pigs by a granulocyte-independent mechanism.
The American review of respiratory disease
Interaction of cromolyn and a muscarinic antagonist in inhibiting bronchial reactivity to sulfur dioxide and to eucapnic hyperpnea alone.
The American review of respiratory disease
Granulocyte-mediated airway edema in guinea pigs.
Journal of applied physiology (Bethesda, Md. : 1985)
The usefulness of induced sputum in the diagnosis of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome.
The American review of respiratory disease
Effects of esmolol on airway function in patients with asthma.
Journal of clinical pharmacology
Acute effects of routine firefighting on lung function.
American journal of industrial medicine
Airway hyperresponsiveness and inflammation induced by toluene diisocyanate in guinea pigs.
The American review of respiratory disease
Effect of eucapnic hypoxia on bronchomotor tone and on the bronchomotor response to dry air in asthmatic subjects.
The American review of respiratory disease
Aminophylline increases the toxicity but not the efficacy of an inhaled beta-adrenergic agonist in the treatment of acute exacerbations of asthma.
The American review of respiratory disease
Respiratory heat loss is not the sole stimulus for bronchoconstriction induced by isocapnic hyperpnea with dry air.
The American review of respiratory disease
Pharmacotherapy of asthma.
The Western journal of medicine
Effect of 0.25 ppm sulfur dioxide on airway resistance in freely breathing, heavily exercising, asthmatic subjects.
The American review of respiratory disease
Lack of bronchomotor response to up to 3 ppm formaldehyde in subjects with asthma.
Environmental research
Morphine sulfate inhibits bronchoconstriction in subjects with mild asthma whose responses are inhibited by atropine.
The American review of respiratory disease
Interaction of sulfur dioxide and dry cold air in causing bronchoconstriction in asthmatic subjects.
Journal of applied physiology: respiratory, environmental and exercise physiology
Magnitude of the interaction between the bronchomotor effects of sulfur dioxide and those of dry (cold) air.
The American review of respiratory disease
Respiratory water loss as a stimulus to exercise-induced bronchoconstriction.
The Journal of allergy and clinical immunology
Alteration in osmolarity of inhaled aerosols cause bronchoconstriction and cough, but absence of a permeant anion causes cough alone.
The American review of respiratory disease
Variable inhibition of histamine-induced bronchoconstriction by atropine in subjects with asthma.
The Journal of allergy and clinical immunology
Sulfur dioxide-induced bronchoconstriction in freely breathing, exercising, asthmatic subjects.
The American review of respiratory disease
Antihistaminic versus anticholinergic effects of atropine on canine trachealis muscle.
The American review of respiratory disease
Effect of exercise rate and route of inhalation on sulfur-dioxide-induced bronchoconstriction in asthmatic subjects.
The American review of respiratory disease
Purification of uroporphyrinogen decarboxylase from human erythrocytes. Immunochemical evidence for a single protein with decarboxylase activity in human erythrocytes and liver.
The Biochemical journal
Chest pain and hypoxemia from inhalation of a trichloroethane aerosol product.
Journal of toxicology. Clinical toxicology
Mechanism of cough and bronchoconstriction induced by distilled water aerosol.
The American review of respiratory disease
Tolerance to sulfur dioxide-induced bronchoconstriction in subjects with asthma.
Environmental research
Effect of route of atropine delivery on bronchospasm from cold air and methacholine.
Journal of applied physiology: respiratory, environmental and exercise physiology
Intravenous versus inhaled atropine for inhibiting bronchoconstrictor responses in dogs.
Journal of applied physiology: respiratory, environmental and exercise physiology
Occupational asthma.
The Western journal of medicine
Effect of the oronasal breathing route on sulfur dioxide-induced bronchoconstriction in exercising asthmatic subjects.
The American review of respiratory disease
Inhibition of sulfur dioxide-induced bronchoconstriction by disodium cromoglycate in asthmatic subjects.
The American review of respiratory disease
Exercise increases sulfur dioxide-induced bronchoconstriction in asthmatic subjects.
The American review of respiratory disease
Lower threshold and greater bronchomotor responsiveness of asthmatic subjects to sulfur dioxide.
The American review of respiratory disease