Cancer research | Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF

Editor's Note: Inhibition of Phosphatidylinositol 3-Kinase Destabilizes Mycn Protein and Blocks Malignant Progression in Neuroblastoma.

Cancer research

Chesler L, Schlieve C, Goldenberg DD, Kenney A, Kim G, McMillan A, Matthay KK, Rowitch D, Weiss WA

p53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells.

Cancer research

Hirose Y, Berger MS, Pieper RO

Targeting a Plk1-Controlled Polarity Checkpoint in Therapy-Resistant Glioblastoma-Propagating Cells.

Cancer research

Lerner RG, Grossauer S, Kadkhodaei B, Meyers I, Sidorov M, Koeck K, Hashizume R, Ozawa T, Phillips JJ, Berger MS, Nicolaides T, James CD, Petritsch CK

Multiple mechanisms of N-(phosphonoacetyl)-L-aspartate drug resistance in SV40-infected precrisis human fibroblasts.

Cancer research

Schaefer DI, Livanos EM, White AE, Tlsty TD

A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma.

Cancer research

Fan QW, Cheng CK, Nicolaides TP, Hackett CS, Knight ZA, Shokat KM, Weiss WA

Abstract 2281: The interrelationship between maternal periconception folate nutritional intake and child’s genetic liability in the etiology of childhood acute lymphoblastic leukemia.

Cancer research

Yijin Xiang, Catherine Metayer, Scott Kogan, Xiaomei Ma, Joseph Wiemels

Mouse intestinal goblet cells expressing SV40 T antigen directed by the MUC2 mucin gene promoter undergo apoptosis upon migration to the villi.

Cancer research

Gum JR, Hicks JW, Gillespie AM, Rius JL, Treseler PA, Kogan SC, Carlson EJ, Epstein CJ, Kim YS

STAT3 Establishes an Immunosuppressive Microenvironment during the Early Stages of Breast Carcinogenesis to Promote Tumor Growth and Metastasis.

Cancer research

Jones LM, Broz ML, Ranger JJ, Ozcelik J, Ahn R, Zuo D, Ursini-Siegel J, Hallett MT, Krummel M, Muller WJ

Topoisomerase II inhibition and altered kinetics of formation and repair of nitrosourea and cisplatin-induced DNA interstrand cross-links and cytotoxicity in human glioblastoma cells.

Cancer research

Ali-Osman F, Berger MS, Rajagopal S, Spence A, Livingston RB

Heat shock protein 90alpha recruits FLIPS to the death-inducing signaling complex and contributes to TRAIL resistance in human glioma.

Cancer research

Panner A, Murray JC, Berger MS, Pieper RO

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