
Professor
Neurological Surgery
+1 415 476-9473
Scott Baraban, PhD studies pediatric malformation-associated epilepsies in genetic mouse models to explore how seizures develop. He also researches the potential of embryonic progenitor cells to inhibit epilepsy following transplantation.
Publications
Zebrafish models of human-duplicated SRGAP2 reveal novel functions in microglia and visual system development.
bioRxiv : the preprint server for biology
Testing of putative antiseizure medications in a preclinical Dravet syndrome zebrafish model.
Brain communications
Host brain environmental influences on transplanted medial ganglionic eminence progenitors.
Scientific reports
Testing of putative antiseizure drugs in a preclinical Dravet syndrome zebrafish model.
bioRxiv : the preprint server for biology
Cell therapy for neurological disorders: Progress towards an embryonic medial ganglionic eminence progenitor-based treatment.
Frontiers in neuroscience
Clemizole and trazodone are effective antiseizure treatments in a zebrafish model of STXBP1 disorder.
Epilepsia open
Xenotransplantation of porcine progenitor cells in an epileptic California sea lion (Zalophus californianus): illustrative case.
Journal of neurosurgery. Case lessons
A zebrafish-centric approach to antiepileptic drug development.
Disease models & mechanisms
Phenotypic analysis of catastrophic childhood epilepsy genes.
Communications biology
Interneuron Origins in the Embryonic Porcine Medial Ganglionic Eminence.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Enhancing glucose metabolism via gluconeogenesis is therapeutic in a zebrafish model of Dravet syndrome.
Brain communications
Phenotype-Based Screening of Synthetic Cannabinoids in a Dravet Syndrome Zebrafish Model.
Frontiers in pharmacology
Imaging epilepsy in larval zebrafish.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
Interneuron deficits in neurodevelopmental disorders: Implications for disease pathology and interneuron-based therapies.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
Zebrafish studies identify serotonin receptors mediating antiepileptic activity in Dravet syndrome.
Brain communications
Network Properties Revealed during Multi-Scale Calcium Imaging of Seizure Activity in Zebrafish.
eNeuro
Dlx1 and Dlx2 Promote Interneuron GABA Synthesis, Synaptogenesis, and Dendritogenesis.
Cerebral cortex (New York, N.Y. : 1991)
Preclinical Animal Models for Dravet Syndrome: Seizure Phenotypes, Comorbidities and Drug Screening.
Frontiers in pharmacology
Publisher Correction: PAFAH1B1 haploinsufficiency disrupts GABA neurons and synaptic E/I balance in the dentate gyrus.
Scientific reports
Persistent seizure control in epileptic mice transplanted with gamma-aminobutyric acid progenitors.
Annals of neurology
Mutations of conserved non-coding elements of PITX2 in patients with ocular dysgenesis and developmental glaucoma.
Human molecular genetics
PAFAH1B1 haploinsufficiency disrupts GABA neurons and synaptic E/I balance in the dentate gyrus.
Scientific reports
Behavioral Comorbidities and Drug Treatments in a Zebrafish scn1lab Model of Dravet Syndrome.
eNeuro
Catastrophic Epilepsies of Childhood.
Annual review of neuroscience
Viral tracing of presynaptic inputs to newly born dentate granule cells in a rodent model of mesial temporal lobe epilepsy.
Annals of neurology
Clemizole and modulators of serotonin signalling suppress seizures in Dravet syndrome.
Brain : a journal of neurology
A Novel Long-term, Multi-Channel and Non-invasive Electrophysiology Platform for Zebrafish.
Scientific reports
Synaptic integration of transplanted interneuron progenitor cells into native cortical networks.
Journal of neurophysiology
Advancing epilepsy treatment through personalized genetic zebrafish models.
Progress in brain research
Interneuron Transplantation as a Treatment for Epilepsy.
Cold Spring Harbor perspectives in medicine
Large-Scale Phenotype-Based Antiepileptic Drug Screening in a Zebrafish Model of Dravet Syndrome
eNeuro
Animal models in epilepsy research: legacies and new directions.
Nature neuroscience
14-3-3e and ? regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience
GABAB receptors in maintenance of neocortical circuit function.
Experimental neurology
Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position.
Neuron
What new modeling approaches will help us identify promising drug treatments?
Advances in experimental medicine and biology
Bidirectional homeostatic plasticity induced by interneuron cell death and transplantation in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Neocortical integration of transplanted GABA progenitor cells from wild type and GABA(B) receptor knockout mouse donors.
Neuroscience letters
GABA progenitors grafted into the adult epileptic brain control seizures and abnormal behavior.
Nature neuroscience
Forebrain Electrophysiological Recording in Larval Zebrafish.
Journal of Visualized Experiments
Forebrain electrophysiological recording in larval zebrafish.
Journal of visualized experiments : JoVE
Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment.
Nature communications
The devil is in the details: stem cells for the treatment of epilepsy.
Epilepsy currents
ALLN rescues an in vitro excitatory synaptic transmission deficit in Lis1 mutant mice.
Journal of neurophysiology
LIS1 deficiency promotes dysfunctional synaptic integration of granule cells generated in the developing and adult dentate gyrus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Familial cortical myoclonus with a mutation in NOL3.
Annals of neurology
Cell Therapy Using GABAergic Neural Progenitors.
Jasper\u0027s Basic Mechanisms of the Epilepsies
A novel zebrafish model of hyperthermia-induced seizures reveals a role for TRPV4 channels and NMDA-type glutamate receptors.
Experimental neurology
Expression and function of KCNQ channels in larval zebrafish.
Developmental neurobiology
Impaired neural development in a zebrafish model for Lowe syndrome.
Human molecular genetics
Aberrant expression of genes necessary for neuronal development and Notch signaling in an epileptic mind bomb zebrafish.
Developmental dynamics : an official publication of the American Association of Anatomists
Deletion of Dlx1 results in reduced glutamatergic input to hippocampal interneurons.
Journal of neurophysiology
Chapter 50 Animal Models of Epilepsy.
Youmans Neurological Surgery
The promise of an interneuron-based cell therapy for epilepsy.
Developmental neurobiology
Spontaneous seizures and altered gene expression in GABA signaling pathways in a mind bomb mutant zebrafish.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Robust tonic GABA currents can inhibit cell firing in mouse newborn neocortical pyramidal cells.
The European journal of neuroscience
Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zebrafish as a model for studying genetic aspects of epilepsy.
Disease models & mechanisms
Seizures, enhanced excitation, and increased vesicle number in Lis1 mutant mice.
Annals of neurology
Basic mechanisms of MCD in animal models.
Epileptic disorders : international epilepsy journal with videotape
Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1.1 mutant mice.
Proceedings of the National Academy of Sciences of the United States of America
Inhibitory inputs to hippocampal interneurons are reorganized in Lis1 mutant mice.
Journal of neurophysiology
PEDIATRIC EPILEPSY | Mechanisms of Epileptogenesis in Models of Pediatric Epilepsy Syndromes Associated with Brain Malformation.
Encyclopedia of Basic Epilepsy Research
Zebrafish as a Simple Vertebrate Organism for Epilepsy Research.
Animal Models of Epilepsy
Developing cell transplantation for temporal lobe epilepsy.
Neurosurgical focus
Characterization of inhibitory circuits in the malformed hippocampus of Lis1 mutant mice.
Journal of neurophysiology
Emerging epilepsy models: insights from mice, flies, worms and fish.
Current opinion in neurology
Neocortical hyperexcitability in a human case of tuberous sclerosis complex and mice lacking neuronal expression of TSC1.
Annals of neurology
Granule cell dispersion and aberrant neurogenesis in the adult hippocampus of an LIS1 mutant mouse.
Developmental neuroscience
Preface.
Developmental neuroscience
Stromal-derived factor-1 (CXCL12) regulates laminar position of Cajal-Retzius cells in normal and dysplastic brains.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience
A role for the mTOR pathway in surface expression of AMPA receptors.
Neuroscience letters
Embryonic and early postnatal abnormalities contributing to the development of hippocampal malformations in a rodent model of dysplasia.
The Journal of comparative neurology
CHAPTER 15 Modeling Epilepsy and Seizures in Developing Zebrafish Larvae.
Models of Seizures and Epilepsy
Contributing Authors.
Models of Seizures and Epilepsy
Dysfunction of synaptic inhibition in epilepsy associated with focal cortical dysplasia.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy.
Nature neuroscience
Prolonged NMDA-mediated responses, altered ifenprodil sensitivity, and epileptiform-like events in the malformed hippocampus of methylazoxymethanol exposed rats.
Journal of neurophysiology
Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression.
Neuroscience
Abnormal cortical cells and astrocytomas in the Eker rat model of tuberous sclerosis complex.
Epilepsia
Pain without gain (of function): sodium channel dysfunction in epilepsy.
Epilepsy currents
Interneuron Diversity series: Interneuronal neuropeptides--endogenous regulators of neuronal excitability.
Trends in neurosciences
A potential role for astrocytes in mediating the antiepileptic actions of furosemide in vitro.
Neuroscience
Target-specific neuropeptide Y-ergic synaptic inhibition and its network consequences within the mammalian thalamus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Neuropeptide Y modulates a G protein-coupled inwardly rectifying potassium current in the mouse hippocampus.
Neuroscience letters
NPY sensitivity and postsynaptic properties of heterotopic neurons in the MAM model of malformation-associated epilepsy.
Journal of neurophysiology
Heterotopic neurons with altered inhibitory synaptic function in an animal model of malformation-associated epilepsy.
The Journal of neuroscience : the official journal of the Society for Neuroscience
A review of gene expression patterns in the malformed brain.
Molecular neurobiology
Effects of antiepileptic drugs on induced epileptiform activity in a rat model of dysplasia.
Epilepsy research
Epilepsy Research Takes Flight.
Epilepsy currents
Epilepsy Research Takes Flight.
Epilepsy currents
Epilepsy Research Takes Flight.
Epilepsy currents
Conditions sufficient for nonsynaptic epileptogenesis in the CA1 region of hippocampal slices.
Journal of neurophysiology
Hippocampal heterotopia with molecular and electrophysiological properties of neocortical neurons.
Neuroscience
Y5 receptors mediate neuropeptide Y actions at excitatory synapses in area CA3 of the mouse hippocampus.
Journal of neurophysiology
Epileptogenesis in the Dysplastic Brain: A Revival of Familiar Themes.
Epilepsy currents
Hippocampal heterotopia lack functional Kv4.2 potassium channels in the methylazoxymethanol model of cortical malformations and epilepsy.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Properties of a calcium-activated K(+) current on interneurons in the developing rat hippocampus.
Journal of neurophysiology
Characterization of heterotopic cell clusters in the hippocampus of rats exposed to methylazoxymethanol in utero.
Epilepsy research
Hippocampal dysplasia in rats exposed to cocaine in utero.
Brain research. Developmental brain research
Role of the Y5 neuropeptide Y receptor in limbic seizures.
Proceedings of the National Academy of Sciences of the United States of America
Modulation of burst frequency, duration, and amplitude in the zero-Ca(2+) model of epileptiform activity.
Journal of neurophysiology
Osmolarity, ionic flux, and changes in brain excitability.
Epilepsy research
Effects of hyposmolar solutions on membrane currents of hippocampal interneurons and mossy cells in vitro.
Journal of neurophysiology
Life without neuropeptide Y.
Recent progress in hormone research
Neuropeptide Y and limbic seizures.
Reviews in the neurosciences
Knock-out mice reveal a critical antiepileptic role for neuropeptide Y.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Evidence for increased seizure susceptibility in rats exposed to cocaine in utero.
Brain research. Developmental brain research
Osmolarity modulates K+ channel function on rat hippocampal interneurons but not CA1 pyramidal neurons.
The Journal of physiology
Effects of prenatal cocaine exposure on the developing hippocampus: intrinsic and synaptic physiology.
Journal of neurophysiology
Flurothyl seizure susceptibility in rats following prenatal methylazoxymethanol treatment.
Epilepsy research
Role of medulla oblongata in generation of sympathetic and vagal outflows.
Progress in brain research
Dissociation of synchronization and excitability in furosemide blockade of epileptiform activity.
Science (New York, N.Y.)
Electrophysiology of CA1 pyramidal neurons in an animal model of neuronal migration disorders: prenatal methylazoxymethanol treatment.
Epilepsy research
Kappa opioid receptor-mediated suppression of voltage-activated potassium current in a catecholaminergic neuronal cell line.
The Journal of pharmacology and experimental therapeutics
Effects of morphine and morphine withdrawal on adrenergic neurons of the rat rostral ventrolateral medulla.
Brain research
Voltage-activated potassium currents in acutely dissociated hippocampal dentate gyrus neurons from neonatal rats.
Brain research. Developmental brain research
Respiratory Control of Sympathetic Nerve Activity During Naxolone-Precipitated Morphine Withdrawal in Rats.
Survey of Anesthesiology
Respiratory control of sympathetic nerve activity during naloxone-precipitated morphine withdrawal in rats.
The Journal of pharmacology and experimental therapeutics