
Professor
HDCCC
Rosemary Akhurst, PhD studies the role of signaling molecules and genetic modifiers in vasculogenesis, the formation of the vascular network during development.
Publications
Abstract A055: Dissecting mechanisms of tumor anti-PD1 resistance due to host genetic variation within ADAM17.
Cancer immunology research
Stem-cell states converge in multistage cutaneous squamous cell carcinoma development.
Science (New York, N.Y.)
From shape-shifting embryonic cells to oncology: The fascinating history of epithelial mesenchymal transition.
Seminars in cancer biology
Gene networks reveal stem-cell state convergence during preneoplasia and progression to malignancy in multistage skin carcinogenesis.
bioRxiv : the preprint server for biology
Genetic polymorphism in Methylenetetrahydrofolate Reductase chloride transport protein 6 (MTHFR CLCN6) gene is associated with keratinocyte skin cancer in a cohort of renal transplant recipients.
Skin health and disease
TGF�: Signaling Blockade for Cancer Immunotherapy.
Annual review of cancer biology
TGF� biology in cancer progression and immunotherapy.
Nature reviews. Clinical oncology
α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas.
Journal for immunotherapy of cancer
Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition.
Science signaling
Targeting TGF-β Signaling for Therapeutic Gain.
Cold Spring Harbor perspectives in biology
Matters of context guide future research in TGF� superfamily signaling.
Science signaling
Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking aV�8-TGF� signaling in the brain.
Development (Cambridge, England)
Genetic variants of Adam17 differentially regulate TGF� signaling to modify vascular pathology in mice and humans.
Proceedings of the National Academy of Sciences of the United States of America
BMP-9 balances endothelial cell fate.
Proceedings of the National Academy of Sciences of the United States of America
Multiple self-healing squamous epithelioma (MSSE): rare variants in an adjacent region of chromosome 9q22.3 to known TGFBR1 mutations suggest a digenic or multilocus etiology.
The Journal of investigative dermatology
Erratum: Targeting the TGFß signalling pathway in disease.
Nature Reviews Drug Discovery
Epistatic interactions between Tgfb1 and genetic loci, Tgfbm2 and Tgfbm3, determine susceptibility to an asthmatic stimulus.
Proceedings of the National Academy of Sciences of the United States of America
Targeting the TGF� signalling pathway in disease.
Nature reviews. Drug discovery
The paradoxical TGF-� vasculopathies.
Nature genetics
Complexities of TGF-� targeted cancer therapy.
International journal of biological sciences
TGF- -induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion.
Development
TGF-�-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion.
Journal of cell science
Defective retinal vascular endothelial cell development as a consequence of impaired integrin aV�8-mediated activation of transforming growth factor-�.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Mouse and human strategies identify PTPN14 as a modifier of angiogenesis and hereditary haemorrhagic telangiectasia.
Nature communications
Erratum: Mouse and human strategies identify PTPN14 as a modifier of angiogenesis and hereditary haemorrhagic telangiectasia.
Nature communications
The complexities of TGF-� action during mammary and squamous cell carcinogenesis.
Current pharmaceutical biotechnology
TGF�1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research
Outgrowth of drug-resistant carcinomas expressing markers of tumor aggression after long-term T�RI/II kinase inhibition with LY2109761.
Cancer research
Taking thalidomide out of rehab.
Nature medicine
Elevated cutaneous Smad activation associates with enhanced skin tumor susceptibility in organ transplant recipients.
Clinical cancer research : an official journal of the American Association for Cancer Research
Transforming growth factor-beta in breast cancer: too much, too late.
Breast cancer research : BCR
The type I TGF-beta receptor is covalently modified and regulated by sumoylation.
Nature cell biology
Reversal of EMT by Small-Molecule Inhibitors of TGF-ß Type I and II Receptors: Implications for Carcinoma Treatment.
Transforming Growth Factor-ß in Cancer Therapy, Volume II
Differentiation plasticity regulated by TGF-beta family proteins in development and disease.
Nature cell biology
TGF beta inhibition for cancer therapy.
Current cancer drug targets
Large- and small-molecule inhibitors of transforming growth factor-beta signaling.
Current opinion in investigational drugs (London, England : 2000)
Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility.
Proceedings of the National Academy of Sciences of the United States of America
A sweet link between TGFbeta and vascular disease?
Nature genetics
TGFbeta inhibition of yolk-sac-like differentiation of human embryonic stem-cell-derived embryoid bodies illustrates differences between early mouse and human development.
Journal of cell science
Mutations of TGFbeta signaling molecules in human disease.
Annals of medicine
TGF beta signaling in health and disease.
Nature genetics
Cancer: dangerous liaisons.
Nature
Mouse strain-dependent heterogeneity of resting limbal vasculature.
Investigative ophthalmology & visual science
Genetic modifiers interact with maternal determinants in vascular development of Tgfb1(-/-) mice.
Human molecular genetics
Metastasis is driven by sequential elevation of H-ras and Smad2 levels.
Nature cell biology
Latent transforming growth factor-beta activation in mammary gland: regulation by ovarian hormones affects ductal and alveolar proliferation.
The American journal of pathology
TGF-beta antagonists: why suppress a tumor suppressor?
The Journal of clinical investigation
TGF-beta signaling in cancer--a double-edged sword.
Trends in cell biology
TGF-ß signaling in cancer — a double-edged sword.
Trends in cell biology
TGF-beta signaling in tumor suppression and cancer progression.
Nature genetics
Isolation, identification, and molecular characterization of strains of Photorhabdus luminescens from infected humans in Australia.
Journal of clinical microbiology
Genetic events and the role of TGF beta in epithelial tumour progression.
The Journal of pathology
Epithelial carcinogenesis in the mouse: correlating the genetics and the biology.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Transforming growth factor beta is essential for spindle cell conversion of mouse skin carcinoma in vivo: implications for tumor invasion.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
Mapping of a major genetic modifier of embryonic lethality in TGF beta 1 knockout mice.
Nature genetics
Altered epidermal cell growth control in vivo by inducible expression of transforming growth factor beta 1 in the skin of transgenic mice.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
The role of transforming growth factor ß during cardiovascular development.
Molecular Physiology of Growth
Transforming growth factor ßS: Biochemistry and biological activities in vitro and in vivo.
Growth Factors
Liposome-medicated gene transfer and expression via the skin.
Human molecular genetics
Circulating human factor IX produced in keratin-promoter transgenic mice: a feasibility study for gene therapy of haemophilia B.
Human molecular genetics
Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice.
Development (Cambridge, England)
Concerted action of TGF-beta 1 and its type II receptor in control of epidermal homeostasis in transgenic mice.
Genes & development
Analysis of homozygous TGF beta 1 null mouse embryos demonstrates defects in yolk sac vasculogenesis and hematopoiesis.
Annals of the New York Academy of Sciences
Localization of transforming growth factor-alpha RNA and protein in the skin of psoriatic patients receiving therapy.
The British journal of dermatology
Physical methods of gene delivery using keratinocytes as a target for somatic cell gene therapy.
Gene therapy
RNA and protein localisations of TGF beta 2 in the early mouse embryo suggest an involvement in cardiac development.
Development (Cambridge, England)
Positive and negative growth control in multistage skin carcinogenesis.
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
Rapid induction and clearance of TGF beta 1 is an early response to wounding in the mouse embryo.
Developmental genetics
Transforming growth factor ßs and cardiac development.
Growth Factors and the Cardiovascular System
The role of TGF-beta s in mammalian development and neoplasia.
Molecular reproduction and development
Palatal expression of TGF-ß isoforms in normal and retinoic acid-treated mouse embryos.
Retinoids in Normal Development and Teratogenesis
Discordant transforming growth factor beta 1 RNA and protein localization during chemical carcinogenesis of the skin.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
Embryonic gene expression patterns of TGF beta 1, beta 2 and beta 3 suggest different developmental functions in vivo.
Development (Cambridge, England)
Functional loss of tumour suppressor genes in multistage chemical carcinogenesis.
Princess Takamatsu symposia
Expression of TGF-beta isoforms during first trimester human embryogenesis.
Development (Cambridge, England)
Localization of elevated transforming growth factor-alpha in psoriatic epidermis.
The Journal of investigative dermatology
Differential expression of TGF beta isoforms in murine palatogenesis.
Development (Cambridge, England)
TGF beta in murine morphogenetic processes: the early embryo and cardiogenesis.
Development (Cambridge, England)
The role of TGF beta in mouse development.
Annals of the New York Academy of Sciences
Transforming growth factor betas in mammalian embryogenesis.
Progress in growth factor research
The role of transforming growth factor-ß in mouse development and carcinogenesis.
Biochemical Society Transactions
Chemical induction of oncogene mutations and growth factor activity in mouse skin carcinogenesis.
Environmental health perspectives
Intracellular localisation and expression of mammalian CDC2 protein during myogenic differentiation.
Differentiation; research in biological diversity
Prospects for Gene Therapy Now and in the Future.
Studies in Inherited Metabolic Disease
Prospects for gene therapy now and in the future.
Journal of inherited metabolic disease
The action of oncogenes and growth factors in tumour initiation and promotion.
Carcinogenesis; a comprehensive survey
Molecular analysis of chemical carcinogenesis in the skin.
The British journal of cancer. Supplement
Chorionic gonadotrophin-beta mRNA, a trophoblast marker, is expressed in human 8-cell embryos derived from tripronucleate zygotes.
Human reproduction (Oxford, England)
Embryonic expression pattern of TGF beta type-1 RNA suggests both paracrine and autocrine mechanisms of action.
Development (Cambridge, England)
Isolation and Characterization of a Variant Myoblast Cell Line That is Temperature Sensitive for Differentiation.
Molecular and cellular biology
Isolation and characterization of a variant myoblast cell line that is temperature sensitive for differentiation.
Molecular and cellular biology
Isolation and characterization of a variant myoblast cell line that is temperature sensitive for differentiation.
Molecular and cellular biology
Sea urchin actin gene linkages determined by genetic segregation.
Developmental biology
Structure and organization of the CyIII actin gene subfamily of the sea urchin, Strongylocentrotus purpuratus.
Journal of molecular biology
The use of gene probes in studying human reproduction and embryology.
Human reproduction (Oxford, England)
Sea urchin actin gene subtypes. Gene number, linkage and evolution.
Journal of molecular biology
Dev. Biol
Differential expression of the actin gene family of Strongylocentrotus purpuratus
Regulation of the relative abundances of mRNAs in hepatoma and liver.
Advances in experimental medicine and biology
Post-transcriptional control of messenger abundance.
Molecular biology reports