Immunity

IL-2: Change Structure � Change Function.

Immunity

Bluestone JA, Crellin N, Trotta E

Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation.

Immunity

Binstadt BA, Brumbaugh KM, Dick CJ, Scharenberg AM, Williams BL, Colonna M, Lanier LL, Kinet JP, Abraham RT, Leibson PJ

Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit.

Immunity

Nadjsombati MS, McGinty JW, Lyons-Cohen MR, Jaffe JB, DiPeso L, Schneider C, Miller CN, Pollack JL, Nagana Gowda GA, Fontana MF, Erle DJ, Anderson MS, Locksley RM, Raftery D, von Moltke J

CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification.

Immunity

Fujimoto M, Fujimoto Y, Poe JC, Jansen PJ, Lowell CA, DeFranco AL, Tedder TF

NKG2D blockade prevents autoimmune diabetes in NOD mice.

Immunity

Ogasawara K, Hamerman JA, Ehrlich LR, Bour-Jordan H, Santamaria P, Bluestone JA, Lanier LL

The hyper IgE syndrome and mutations in TYK2.

Immunity

Woellner C, Schäffer AA, Puck JM, Renner ED, Knebel C, Holland SM, Plebani A, Grimbacher B

Different nuclear signals are activated by the B cell receptor during positive versus negative signaling.

Immunity

Healy JI, Dolmetsch RE, Timmerman LA, Cyster JG, Thomas ML, Crabtree GR, Lewis RS, Goodnow CC

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