
Professor
Pharmaceutical Chemistry
+1 415 514-9962
Zev Gartner, PhD is working to organize the body’s building blocks into defined structures spanning the subcellular to tissue length scales.
Publications
Revealing a coherent cell state landscape across single cell datasets with CONCORD.
bioRxiv : the preprint server for biology
Reducing batch effects in single cell chromatin accessibility measurements by pooled transposition with MULTI-ATAC.
bioRxiv : the preprint server for biology
Swirling motion of breast cancer cells radially aligns collagen fibers to enable collective invasion.
bioRxiv : the preprint server for biology
Four-Dimensional Bioprinting: Harnessing Active Mechanics to Build with Living Inks.
Cold Spring Harbor perspectives in biology
MAGIC matrices: freeform bioprinting materials to support complex and reproducible organoid morphogenesis.
bioRxiv : the preprint server for biology
Selection promotes age-dependent degeneration of the mitochondrial genome.
bioRxiv : the preprint server for biology
Single-cell analysis of breast cancer metastasis reveals epithelial-mesenchymal plasticity signatures associated with poor outcomes.
The Journal of clinical investigation
D-SPIN constructs gene regulatory network models from multiplexed scRNA-seq data revealing organizing principles of cellular perturbation response.
bioRxiv : the preprint server for biology
Coordinated immune dysregulation in juvenile dermatomyositis revealed by single-cell genomics.
JCI insight
Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains.
Nature cell biology
deMULTIplex2: robust sample demultiplexing for scRNA-seq.
Genome biology
Coordinated immune dysregulation in Juvenile Dermatomyositis revealed by single-cell genomics.
bioRxiv : the preprint server for biology
Epithelial TNF controls cell differentiation and CFTR activity to maintain intestinal mucin homeostasis.
The Journal of clinical investigation
Loss of PPARγ activity characterizes early protumorigenic stromal reprogramming and dictates the therapeutic window of opportunity.
Proceedings of the National Academy of Sciences of the United States of America
Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains.
bioRxiv : the preprint server for biology
Patterning and folding of intestinal villi by active mesenchymal dewetting.
bioRxiv : the preprint server for biology
Configurational entropy is an intrinsic driver of tissue structural heterogeneity.
bioRxiv : the preprint server for biology
Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation.
Cell systems
deMULTIplex2: robust sample demultiplexing for scRNA-seq.
bioRxiv : the preprint server for biology
Microfluidics-free single-cell genomics with templated emulsification.
Nature biotechnology
Programming the Self-Organization of Endothelial Cells into Perfusable Microvasculature.
Tissue engineering. Part A
Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling.
Nature cell biology
Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation.
Science translational medicine
A reductionist approach to determine the effect of cell-cell contact on human epidermal stem cell differentiation.
Acta biomaterialia
Mapping hormone-regulated cell-cell interaction networks in the human breast at single-cell resolution.
Cell systems
Systematically quantifying morphological features reveals constraints on organoid phenotypes.
Cell systems
Single cell enhancer activity distinguishes GABAergic and cholinergic lineages in embryonic mouse basal ganglia.
Proceedings of the National Academy of Sciences of the United States of America
Bisphenol A replacement chemicals, BPF and BPS, induce protumorigenic changes in human mammary gland organoid morphology and proteome.
Proceedings of the National Academy of Sciences of the United States of America
Setting boundaries for tissue patterning.
Science (New York, N.Y.)
Single-Cell Protein Profiling by Microdroplet Barcoding and Next-Generation Sequencing.
Methods in molecular biology (Clifton, N.J.)
Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids.
Cell stem cell
AMULET: a novel read count-based method for effective multiplet detection from single nucleus ATAC-seq data.
Genome biology
EPH/EPHRIN regulates cellular organization by actomyosin contractility effects on cell contacts.
The Journal of cell biology
Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids.
Cell stem cell
Roadmap for the multiscale coupling of biochemical and mechanical signals during development.
Physical biology
T cell circuits that sense antigen density with an ultrasensitive threshold.
Science (New York, N.Y.)
Simple, Affordable, and Modular Patterning of Cells using DNA.
Journal of visualized experiments : JoVE
Simple, Affordable, and Modular Patterning of Cells using DNA.
Journal of Visualized Experiments
High diversity droplet microfluidic libraries generated with a commercial liquid spotter.
Scientific reports
Expanding the boundaries of synthetic development.
Developmental biology
Identifying Enthalpic Barriers to Entropically-Driven Structural Disruption in Breast Cancers.
Biophysical journal
Guiding tissue-scale self-organization.
Nature materials
Abstract 351: Alterations in immune cell signatures during breast cancer metastasis at single cell resolution.
Cancer research
Organoid models for mammary gland dynamics and breast cancer.
Current opinion in cell biology
High Throughput Yeast Strain Phenotyping with Droplet-Based RNA Sequencing.
Journal of Visualized Experiments
High Throughput Yeast Strain Phenotyping with Droplet-Based RNA Sequencing.
Journal of visualized experiments : JoVE
Balancing Act: Cell Polarity and Shape Compete to Ensure Robust Development.
Developmental cell
Antibody-Drug Conjugates Targeting the Urokinase Receptor (uPAR) as a Possible Treatment of Aggressive Breast Cancer.
Antibodies (Basel, Switzerland)
MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices.
Nature methods
Human organoids: a new dimension in cell biology.
Molecular biology of the cell
DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors.
Cell systems
Paracrine costimulation of IFN-? signaling by integrins modulates CD8 T cell differentiation.
Proceedings of the National Academy of Sciences of the United States of America
Cell-Specific Chemical Delivery Using a Selective Nitroreductase-Nitroaryl Pair.
ACS chemical biology
An Oil-Free Picodrop Bioassay Platform for Synthetic Biology.
Scientific reports
Characterizing cellular mechanical phenotypes with mechano-node-pore sensing.
Microsystems & nanoengineering
Engineered Tissue Folding by Mechanical Compaction of the Mesenchyme.
Developmental cell
Opportunities for organoids as new models of aging.
The Journal of cell biology
Printed droplet microfluidics for on demand dispensing of picoliter droplets and cells.
Proceedings of the National Academy of Sciences of the United States of America
Unraveling cell-to-cell signaling networks with chemical biology.
Nature chemical biology
Dissecting the stem cell niche with organoid models: an engineering-based approach.
Development (Cambridge, England)
Non-autonomous cell proliferation in the mammary gland and cancer.
Current opinion in cell biology
Abseq: Ultrahigh-throughput single cell protein profiling with droplet microfluidic barcoding.
Scientific reports
192 Diagnosis and therapy of aggressive breast cancers by targeting urokinase receptor.
European Journal of Cancer
Effects of cell type and configuration on anabolic and catabolic activity in 3D co-culture of mesenchymal stem cells and nucleus pulposus cells.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Rapid Organoid Reconstitution by Chemical Micromolding.
ACS biomaterials science & engineering
Fabrication of 3-D Reconstituted Organoid Arrays by DNA-Programmed Assembly of Cells (DPAC).
Current protocols in chemical biology
Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers.
Journal of visualized experiments : JoVE
Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers.
Journal of Visualized Experiments
Mysteries in a Minimal Genome.
ACS central science
Interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communities.
Nature communications
Coupling between apical tension and basal adhesion allow epithelia to collectively sense and respond to substrate topography over long distances.
Integrative biology : quantitative biosciences from nano to macro
Programmed synthesis of three-dimensional tissues.
Nature methods
A strategy for tissue self-organization that is robust to cellular heterogeneity and plasticity.
Proceedings of the National Academy of Sciences of the United States of America
Formation of spatially and geometrically controlled three-dimensional tissues in soft gels by sacrificial micromolding.
Tissue engineering. Part C, Methods
Efficient targeting of fatty-acid modified oligonucleotides to live cell membranes through stepwise assembly.
Biomacromolecules
Production and Targeting of Monovalent Quantum Dots.
Journal of Visualized Experiments
Production and targeting of monovalent quantum dots.
Journal of visualized experiments : JoVE
A modular approach for assembling aldehyde-tagged proteins on DNA scaffolds.
Journal of the American Chemical Society
Cells: Shaping tissues and organs.
Molecular biology of the cell
Regulating Spatiotemporal Dynamics of Notch Signaling in Live Cells via Magnetoplasmonic Nanoprobes.
Biophysical journal
Mycobacterium tuberculosis Rv3406 is a type II alkyl sulfatase capable of sulfate scavenging.
PloS one
Directing the assembly of spatially organized multicomponent tissues from the bottom up.
Trends in cell biology
Cellular microfabrication: observing intercellular interactions using lithographically-defined DNA capture sequences.
Langmuir : the ACS journal of surfaces and colloids
Chemically programmed cell adhesion with membrane-anchored oligonucleotides.
Journal of the American Chemical Society
Direct cell surface modification with DNA for the capture of primary cells and the investigation of myotube formation on defined patterns.
Langmuir : the ACS journal of surfaces and colloids
Programmed assembly of 3-dimensional microtissues with defined cellular connectivity.
Proceedings of the National Academy of Sciences of the United States of America
Boron nitride nanotubes are noncytotoxic and can be functionalized for interaction with proteins and cells.
Journal of the American Chemical Society
Evolutionary approaches for the discovery of functional synthetic small molecules.
Pure and Applied Chemistry
DNA-templated organic synthesis and selection of a library of macrocycles.
Science (New York, N.Y.)
Directed evolution of ligand dependence: small-molecule-activated protein splicing.
Proceedings of the National Academy of Sciences of the United States of America
Translation of DNA into synthetic N-acyloxazolidines.
Journal of the American Chemical Society
Two Enabling Architectures for DNA-Templated Organic Synthesis.
Angewandte Chemie
Two enabling architectures for DNA-templated organic synthesis.
Angewandte Chemie (International ed. in English)
Directing Otherwise Incompatible Reactions in a Single Solution by Using DNA-Templated Organic Synthesis.
Angewandte Chemie
Directing otherwise incompatible reactions in a single solution by using DNA-templated organic synthesis.
Angewandte Chemie (International ed. in English)
Multistep small-molecule synthesis programmed by DNA templates.
Journal of the American Chemical Society
Expanding the Reaction Scope of DNA-Templated Synthesis .
Angewandte Chemie
Expanding the reaction scope of DNA-templated synthesis.
Angewandte Chemie (International ed. in English)
The generality of DNA-templated synthesis as a basis for evolving non-natural small molecules.
Journal of the American Chemical Society