Professor
      
            M_Physiology
      
            
      
            +1 415 476-8747
      Yuh Nung Jan, PhD identifies genes involved in maintaining adult neural stem cells in mice with the intent of defining their precise functions. With this knowledge, he hopes to develop therapies for neurological disorders, such as Parkinson’s disease.
Publications
Atypical developmental remodeling of dopamine neurons involves AKT-GSK3β signaling and glia-mediated axon degeneration.
bioRxiv : the preprint server for biology
      
            
      
      A cell-based scrambling assay reveals phospholipid headgroup preference of TMEM16F on the plasma membrane.
bioRxiv : the preprint server for biology
      
            
      
      Experimental tools and emerging principles of organellar mechanotransduction.
Trends in cell biology
      
            
      
      Wide-ranging cellular functions of ion channels and lipid scramblases in the structurally related TMC, TMEM16 and TMEM63 families.
Nature structural & molecular biology
      
            
      
      SLAPSHOT reveals rapid dynamics of extracellularly exposed proteome in response to calcium-activated plasma membrane phospholipid scrambling.
Communications biology
      
            
      
      TMEM16F exacerbates tau pathology and mediates phosphatidylserine exposure in phospho-tau-burdened neurons.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Nonlinear compliance of NompC gating spring and its implication in mechanotransduction.
bioRxiv : the preprint server for biology
      
            
      
      Molecular recording of calcium signals via calcium-dependent proximity labeling.
Nature chemical biology
      
            
      
      A personal perspective of the voltage-gated potassium channel studies.
Nature structural & molecular biology
      
            
      
      Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels.
Nature cell biology
      
            
      
      Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase.
Nature communications
      
            
      
      A new cell in an old tactile sensory organ.
Nature cell biology
      
            
      
      SLAPSHOT reveals rapid dynamics of extracellularly exposed proteome in response to calcium-activated plasma membrane phospholipid scrambling.
bioRxiv : the preprint server for biology
      
            
      
      The GARP complex prevents sterol accumulation at the trans-Golgi network during dendrite remodeling.
The Journal of cell biology
      
            
      
      A photo-switchable assay system for dendrite degeneration and repair in Drosophila melanogaster.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Kv1.1 preserves the neural stem cell pool and facilitates neuron maturation during adult hippocampal neurogenesis.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly.
Science (New York, N.Y.)
      
            
      
      TMEM16C is involved in thermoregulation and protects rodent pups from febrile seizures.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Interorganelle communication, aging, and neurodegeneration.
Genes & development
      
            
      
      TMEM16K is an interorganelle regulator of endosomal sorting.
Nature communications
      
            
      
      Mechanisms of neurite repair.
Current opinion in neurobiology
      
            
      
      Mechanosensitive Ion Channels: Structural Features Relevant to Mechanotransduction Mechanisms.
Annual review of neuroscience
      
            
      
      The microtubule regulator ringer functions downstream from the RNA repair/splicing pathway to promote axon regeneration.
Genes & development
      
            
      
      Paralytic, the Drosophila voltage-gated sodium channel, regulates proliferation of neural progenitors.
Genes & development
      
            
      
      Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.
Cell reports
      
            
      
      Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity.
eLife
      
            
      
      TMEM16B Calcium-Activated Chloride Channels Regulate Action Potential Firing in Lateral Septum and Aggression in Male Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
      
            
      
      Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.
Cell reports
      
            
      
      TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      JNK signaling coordinates with ecdysone signaling to promote pruning of Drosophila sensory neuron dendrites.
Development (Cambridge, England)
      
            
      
      Glial ensheathment of the somatodendritic compartment regulates sensory neuron structure and activity.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Chemically induced vesiculation as a platform for studying TMEM16F activity.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Coiled-coil structure-dependent interactions between polyQ proteins and Foxo lead to dendrite pathology and behavioral defects.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Influences: Cold Spring Harbor summer courses and Drosophila melanogaster neurogenetics.
The Journal of general physiology
      
            
      
      Dendrite regeneration of adult Drosophila sensory neurons diminishes with aging and is inhibited by epidermal-derived matrix metalloproteinase 2.
Genes & development
      
            
      
      Phosphatidylinositol-(4, 5)-bisphosphate regulates calcium gating of small-conductance cation channel TMEM16F.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Cytoplasmic Cl- couples membrane remodeling to epithelial morphogenesis.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Cellular Phenotypes in Human iPSC-Derived Neurons from a Genetic Model of Autism Spectrum Disorder.
Cell reports
      
            
      
      Phospholipid Homeostasis Regulates Dendrite Morphogenesis in Drosophila Sensory Neurons.
Cell reports
      
            
      
      Composition and Control of a Deg/ENaC Channel during Presynaptic Homeostatic Plasticity.
Cell reports
      
            
      
      A Defensive Kicking Behavior in Response to Mechanical Stimuli Mediated by Drosophila Wing Margin Bristles.
The Journal of neuroscience : the official journal of the Society for Neuroscience
      
            
      
      N-linked glycosylation of Kv1.2 voltage-gated potassium channel facilitates cell surface expression and enhances the stability of internalized channels.
The Journal of physiology
      
            
      
      In vivo dendrite regeneration after injury is different from dendrite development.
Genes & development
      
            
      
      Transmembrane channel-like (tmc) gene regulates Drosophila larval locomotion.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Rational design of a monomeric and photostable far-red fluorescent protein for fluorescence imaging in vivo.
Protein science : a publication of the Protein Society
      
            
      
      Spindle-F Is the Central Mediator of Ik2 Kinase-Dependent Dendrite Pruning in Drosophila Sensory Neurons.
PLoS genetics
      
            
      
      EAG2 potassium channel with evolutionarily conserved function as a brain tumor target.
Nature neuroscience
      
            
      
      Regulation of axon regeneration by the RNA repair and splicing pathway.
Nature neuroscience
      
            
      
      Four basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Rationally designed fluorogenic protease reporter visualizes spatiotemporal dynamics of apoptosis in vivo.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Double-bromo and extraterminal (BET) domain proteins regulate dendrite morphology and mechanosensory function.
Genes & development
      
            
      
      An improved monomeric infrared fluorescent protein for neuronal and tumour brain imaging.
Nature communications
      
            
      
      Drosophila Valosin-Containing Protein is required for dendrite pruning through a regulatory role in mRNA metabolism.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Female contact modulates male aggression via a sexually dimorphic GABAergic circuit in Drosophila.
Nature neuroscience
      
            
      
      Sound response mediated by the TRP channels NOMPC, NANCHUNG, and INACTIVE in chordotonal organs of Drosophila larvae.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing.
Nature neuroscience
      
            
      
      Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC).
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Increased neuronal activity fragments the Golgi complex.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.
Genes & development
      
            
      
      Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam.
Genes & development
      
            
      
      Contribution of visual and circadian neural circuits to memory for prolonged mating induced by rivals.
Nature neuroscience
      
            
      
      Voltage-gated potassium channels and the diversity of electrical signalling.
The Journal of physiology
      
            
      
      Kv1.1-dependent control of hippocampal neuron number as revealed by mosaic analysis with double markers.
The Journal of physiology
      
            
      
      Yoshiki Hotta's influence.
Journal of neurogenetics
      
            
      
      Activity of the mitochondrial calcium uniporter varies greatly between tissues.
Nature communications
      
            
      
      Ets transcription factor Pointed promotes the generation of intermediate neural progenitors in Drosophila larval brains.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity.
Journal of molecular medicine (Berlin, Germany)
      
            
      
      Pathogenic polyglutamine proteins cause dendrite defects associated with specific actin cytoskeletal alterations in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Light-induced structural and functional plasticity in Drosophila larval visual system.
Science (New York, N.Y.)
      
            
      
      Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila.
Development (Cambridge, England)
      
            
      
      Enhancer-driven membrane markers for analysis of nonautonomous mechanisms reveal neuron-glia interactions in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Differential regulation of dendritic and axonal development by the novel Kr�ppel-like factor Dar1.
The Journal of neuroscience : the official journal of the Society for Neuroscience
      
            
      
      Neuronal remodeling and apoptosis require VCP-dependent degradation of the apoptosis inhibitor DIAP1.
Development (Cambridge, England)
      
            
      
      Altered ultrasonic vocalizations in a tuberous sclerosis mouse model of autism.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Branching out: mechanisms of dendritic arborization.
Nature reviews. Neuroscience
      
            
      
      Studies on expression and function of the TMEM16A calcium-activated chloride channel.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Patterning and organization of motor neuron dendrites in the Drosophila larva.
Developmental biology
      
            
      
      Drosophila IKK-related kinase Ik2 and Katanin p60-like 1 regulate dendrite pruning of sensory neuron during metamorphosis.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Control of the postmating behavioral switch in Drosophila females by internal sensory neurons.
Neuron
      
            
      
      G protein-activated inwardly rectifying potassium channels mediate depotentiation of long-term potentiation.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Neuronal activity regulates phosphorylation-dependent surface delivery of G protein-activated inwardly rectifying potassium channels.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Dividing glial cells maintain differentiated properties including complex morphology and functional synapses.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      The Tsc1-Tsc2 complex influences neuronal polarity by modulating TORC1 activity and SAD levels.
Genes & development
      
            
      
      Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons.
Nature cell biology
      
            
      
      Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosis.
Genes & development
      
            
      
      Drosophila egg-laying site selection as a system to study simple decision-making processes.
Science (New York, N.Y.)
      
            
      
      Retrospective: Seymour Benzer (1921-2007).
Science (New York, N.Y.)
      
            
      
      Identification of yeast proteins necessary for cell-surface function of a potassium channel.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors.
Nature neuroscience
      
            
      
      Polycomb genes interact with the tumor suppressor genes hippo and warts in the maintenance of Drosophila sensory neuron dendrites.
Genes & development
      
            
      
      Peripheral multidendritic sensory neurons are necessary for rhythmic locomotion behavior in Drosophila larvae.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Mechanisms that regulate establishment, maintenance, and remodeling of dendritic fields.
Annual review of neuroscience
      
            
      
      Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphology.
Development (Cambridge, England)
      
            
      
      SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      The secretory pathway and neuron polarization.
The Journal of neuroscience : the official journal of the Society for Neuroscience
      
            
      
      Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites.
Science (New York, N.Y.)
      
            
      
      The bHLH-PAS protein Spineless is necessary for the diversification of dendrite morphology of Drosophila dendritic arborization neurons.
Genes & development
      
            
      
      Electrostatic interactions in the channel cavity as an important determinant of potassium channel selectivity.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      K+ channel selectivity depends on kinetic as well as thermodynamic factors.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Polarized axonal surface expression of neuronal KCNQ channels is mediated by multiple signals in the KCNQ2 and KCNQ3 C-terminal domains.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      The coiled-coil protein shrub controls neuronal morphogenesis in Drosophila.
Current biology : CB
      
            
      
      Visualizing the breaking of symmetry.
Developmental cell
      
            
      
      Genome-wide analyses identify transcription factors required for proper morphogenesis of Drosophila sensory neuron dendrites.
Genes & development
      
            
      
      Identification by mass spectrometry and functional characterization of two phosphorylation sites of KCNQ2/KCNQ3 channels.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Dendrite-specific remodeling of Drosophila sensory neurons requires matrix metalloproteases, ubiquitin-proteasome, and ecdysone signaling.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      The development of neuronal morphology in insects.
Current biology : CB
      
            
      
      The hand that rocks the spindle.
Nature cell biology
      
            
      
      The S4 voltage sensor packs against the pore domain in the KAT1 voltage-gated potassium channel.
Neuron
      
            
      
      Drosophila Mob family proteins interact with the related tricornered (Trc) and warts (Wts) kinases.
Molecular biology of the cell
      
            
      
      Mammalian electrophysiology on a microfluidic platform.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Regulation of membrane localization of Sanpodo by lethal giant larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organs.
Molecular biology of the cell
      
            
      
      The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta.
Development (Cambridge, England)
      
            
      
      Function and regulation of Tumbleweed (RacGAP50C) in neuroblast proliferation and neuronal morphogenesis.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      The cadherin superfamily and dendrite development.
Trends in cell biology
      
            
      
      A fluorescent probe designed for studying protein conformational change.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      The Notch regulator Numb links the Notch and TCR signaling pathways.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization.
Genes & development
      
            
      
      A quantitative assessment of models for voltage-dependent gating of ion channels.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      The tricornered Ser/Thr protein kinase is regulated by phosphorylation and interacts with furry during Drosophila wing hair development.
Molecular biology of the cell
      
            
      
      APC and GSK-3beta are involved in mPar3 targeting to the nascent axon and establishment of neuronal polarity.
Current biology : CB
      
            
      
      Control of dendrite arborization by an Ig family member, dendrite arborization and synapse maturation 1 (Dasm1).
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      The immunoglobulin family member dendrite arborization and synapse maturation 1 (Dasm1) controls excitatory synapse maturation.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      NO stimulation of ATP-sensitive potassium channels: Involvement of Ras/mitogen-activated protein kinase pathway and contribution to neuroprotection.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Asymmetric cell division.
Current opinion in cell biology
      
            
      
      Evolving potassium channels by means of yeast selection reveals structural elements important for selectivity.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Conversion of neurons and glia to external-cell fates in the external sensory organs of Drosophila hamlet mutants by a cousin-cousin cell-type respecification.
Genes & development
      
            
      
      Nanos and Pumilio are essential for dendrite morphogenesis in Drosophila peripheral neurons.
Current biology : CB
      
            
      
      Dendritic development: lessons from Drosophila and related branches.
Current opinion in neurobiology
      
            
      
      Comparing genomic expression patterns across species identifies shared transcriptional profile in aging.
Nature genetics
      
            
      
      Distinct roles of Bazooka and Stardust in the specification of Drosophila photoreceptor membrane architecture.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Conserved and divergent functions of Drosophila atonal, amphibian, and mammalian Ath5 genes.
Evolution & development
      
            
      
      A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels.
Science (New York, N.Y.)
      
            
      
      Yuh-Nung Jan.
Current biology : CB
      
            
      
      Bazooka is a permissive factor for the invasive behavior of discs large tumor cells in Drosophila ovarian follicular epithelia.
Development (Cambridge, England)
      
            
      
      Lethal giant larvae acts together with numb in notch inhibition and cell fate specification in the Drosophila adult sensory organ precursor lineage.
Current biology : CB
      
            
      
      Dendrites of distinct classes of Drosophila sensory neurons show different capacities for homotypic repulsion.
Current biology : CB
      
            
      
      A lethal giant kinase in cell polarity.
Nature cell biology
      
            
      
      The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts.
Developmental cell
      
            
      
      Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity.
Cell
      
            
      
      Asymmetric Numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts.
Development (Cambridge, England)
      
            
      
      Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice.
Current biology : CB
      
            
      
      salvador--The persistence of proliferation.
Cancer cell
      
            
      
      hamlet, a binary genetic switch between single- and multiple- dendrite neuron morphology.
Science (New York, N.Y.)
      
            
      
      Tiling of the Drosophila epidermis by multidendritic sensory neurons.
Development (Cambridge, England)
      
            
      
      Probing protein electrostatics with a synthetic fluorescent amino acid.
Science (New York, N.Y.)
      
            
      
      Variations on the Notch pathway in neural development.
Current opinion in neurobiology
      
            
      
      M channel KCNQ2 subunits are localized to key sites for control of neuronal network oscillations and synchronization in mouse brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience
      
            
      
      Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts.
Nature
      
            
      
      Bazooka and atypical protein kinase C are required to regulate oocyte differentiation in the Drosophila ovary.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Bazooka is required for localization of determinants and controlling proliferation in the sensory organ precursor cell lineage in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Function of GB1 and GB2 subunits in G protein coupling of GABA(B) receptors.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Ligand-induced signal transduction within heterodimeric GABA(B) receptor.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Asymmetric cell division in the Drosophila nervous system.
Nature reviews. Neuroscience
      
            
      
      Sequoia, a tramtrack-related zinc finger protein, functions as a pan-neural regulator for dendrite and axon morphogenesis in Drosophila.
Developmental cell
      
            
      
      Dendrites.
Genes & development
      
            
      
      Expression Profile of Aging and Oxidative Stress Response in Drosophila melanogaster.
TheScientificWorldJournal
      
            
      
      Positional cloning of heart and soul reveals multiple roles for PKC lambda in zebrafish organogenesis.
Current biology : CB
      
            
      
      Controlling potassium channel activities: Interplay between the membrane and intracellular factors.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
Nature cell biology
      
            
      
      Analysis of endoplasmic reticulum trafficking signals by combinatorial screening in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Drosophila par-1 is required for oocyte differentiation and microtubule organization.
Current biology : CB
      
            
      
      Role of ER export signals in controlling surface potassium channel numbers.
Science (New York, N.Y.)
      
            
      
      Two types of asymmetric divisions in the Drosophila sensory organ precursor cell lineage.
Nature cell biology
      
            
      
      Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the beta 3 integrin through its extracellular domain.
The Journal of biological chemistry
      
            
      
      Genome-wide study of aging and oxidative stress response in Drosophila melanogaster.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      A genomewide survey of basic helix-loop-helix factors in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Heartfelt crosstalk: desensitization of the GIRK current.
Nature cell biology
      
            
      
      Ectopic scute induces Drosophila ommatidia development without R8 founder photoreceptors.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Mouse numb is an essential gene involved in cortical neurogenesis.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Staufen: a common component of mRNA transport in oocytes and neurons?
Trends in cell biology
      
            
      
      Colocalization and coassembly of two human brain M-type potassium channel subunits that are mutated in epilepsy.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      An artificial tetramerization domain restores efficient assembly of functional Shaker channels lacking T1.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Regulation of ATP-sensitive potassium channel function by protein kinase A-mediated phosphorylation in transfected HEK293 cells.
The EMBO journal
      
            
      
      atonal regulates neurite arborization but does not act as a proneural gene in the Drosophila brain.
Neuron
      
            
      
      Control of cell divisions in the nervous system: symmetry and asymmetry.
Annual review of neuroscience
      
            
      
      Modes of protein movement that lead to the asymmetric localization of partner of Numb during Drosophila neuroblast division.
Molecular cell
      
            
      
      Flamingo controls the planar polarity of sensory bristles and asymmetric division of sensory organ precursors in Drosophila.
Current biology : CB
      
            
      
      Conservation of neurogenic genes and mechanisms.
Current opinion in neurobiology
      
            
      
      Genes regulating dendritic outgrowth, branching, and routing in Drosophila.
Genes & development
      
            
      
      Asymmetry across species.
Nature cell biology
      
            
      
      A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels.
Neuron
      
            
      
      Deletion analysis of the Drosophila Inscuteable protein reveals domains for cortical localization and asymmetric localization.
Current biology : CB
      
            
      
      Evidence that the nucleotide exchange and hydrolysis cycle of G proteins causes acute desensitization of G-protein gated inward rectifier K+ channels.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      The Drosophila LIM-only gene, dLMO, is mutated in Beadex alleles and might represent an evolutionarily conserved function in appendage development.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Transcriptional regulation of atonal during development of the Drosophila peripheral nervous system.
Development (Cambridge, England)
      
            
      
      Asymmetric cell division: lessons from flies and worms.
Current opinion in genetics & development
      
            
      
      Miranda as a multidomain adapter linking apically localized Inscuteable and basally localized Staufen and Prospero during asymmetric cell division in Drosophila.
Genes & development
      
            
      
      Asymmetric cell division.
Nature
      
            
      
      Delta and Serrate are redundant Notch ligands required for asymmetric cell divisions within the Drosophila sensory organ lineage.
Genes & development
      
            
      
      Presynaptic localization of Kv1.4-containing A-type potassium channels near excitatory synapses in the hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
      
            
      
      Humble starts and conserved themes in neurogenetic studies.
Harvey lectures
      
            
      
      Numb-associated kinase interacts with the phosphotyrosine binding domain of Numb and antagonizes the function of Numb in vivo.
Molecular and cellular biology
      
            
      
      Serendipity, the principle of limited sloppiness, and neural development.
The International journal of developmental biology
      
            
      
      Ways and means for left shifts in the MaxiK channel.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Voltage-gated and inwardly rectifying potassium channels.
The Journal of physiology
      
            
      
      Genghis Khan (Gek) as a putative effector for Drosophila Cdc42 and regulator of actin polymerization.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      The N terminus of the Drosophila Numb protein directs membrane association and actin-dependent asymmetric localization.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Breaking symmetry in the CNS.
Trends in cell biology
      
            
      
      Only a subset of the binary cell fate decisions mediated by Numb/Notch signaling in Drosophila sensory organ lineage requires Suppressor of Hairless.
Development (Cambridge, England)
      
            
      
      Defective gamma-aminobutyric acid type B receptor-activated inwardly rectifying K+ currents in cerebellar granule cells isolated from weaver and Girk2 null mutant mice.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      The Drosophila neurogenic gene big brain, which encodes a membrane-associated protein, acts cell autonomously and can act synergistically with Notch and Delta.
Development (Cambridge, England)
      
            
      
      Scanning mutagenesis of the putative transmembrane segments of Kir2.1, an inward rectifier potassium channel.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis.
Development (Cambridge, England)
      
            
      
      Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels.
FEBS letters
      
            
      
      Receptor-regulated ion channels.
Current opinion in cell biology
      
            
      
      Requirement for EGF receptor signalling in neural recruitment during formation of Drosophila chordotonal sense organ clusters.
Current biology : CB
      
            
      
      Stabilization of ion selectivity filter by pore loop ion pairs in an inwardly rectifying potassium channel.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Development. The end of the beginning?
Current opinion in neurobiology
      
            
      
      Rho family GTP-binding proteins in growth cone signalling.
Current opinion in neurobiology
      
            
      
      Asymmetric segregation of the Drosophila numb protein during mitosis: facts and speculations.
Cold Spring Harbor symposia on quantitative biology
      
            
      
      Cloned potassium channels from eukaryotes and prokaryotes.
Annual review of neuroscience
      
            
      
      Reciprocal localization of Nod and kinesin fusion proteins indicates microtubule polarity in the Drosophila oocyte, epithelium, neuron and muscle.
Development (Cambridge, England)
      
            
      
      Dacapo, a cyclin-dependent kinase inhibitor, stops cell proliferation during Drosophila development.
Cell
      
            
      
      Heteromultimerization of G-protein-gated inwardly rectifying K+ channel proteins GIRK1 and GIRK2 and their altered expression in weaver brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience
      
            
      
      Neuronal type information encoded in the basic-helix-loop-helix domain of proneural genes.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Membrane permeability.
Current opinion in cell biology
      
            
      
      Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines.
Nature
      
            
      
      Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation.
Genes & development
      
            
      
      Contributions of a negatively charged residue in the hydrophobic domain of the IRK1 inwardly rectifying K+ channel to K(+)-selective permeation.
Biophysical journal
      
            
      
      Functional effects of the mouse weaver mutation on G protein-gated inwardly rectifying K+ channels.
Neuron
      
            
      
      A strongly inwardly rectifying K+ channel that is sensitive to ATP.
The Journal of neuroscience : the official journal of the Society for Neuroscience
      
            
      
      Small GTPases in axon outgrowth.
Perspectives on developmental neurobiology
      
            
      
      Identification of structural elements involved in G protein gating of the GIRK1 potassium channel.
Neuron
      
            
      
      dpa, a member of the MCM family, is required for mitotic DNA replication but not endoreplication in Drosophila.
The EMBO journal
      
            
      
      Assembly of voltage-gated potassium channels. Conserved hydrophilic motifs determine subfamily-specific interactions between the alpha-subunits.
The Journal of biological chemistry
      
            
      
      CDC42 and Rac1 control different actin-dependent processes in the Drosophila wing disc epithelium.
The Journal of cell biology
      
            
      
      Role of the proneural gene, atonal, in formation of Drosophila chordotonal organs and photoreceptors.
Development (Cambridge, England)
      
            
      
      The molecular organization of voltage-dependent K+ channels in vivo.
Progress in brain research
      
            
      
      Germ cell-less encodes a cell type-specific nuclear pore-associated protein and functions early in the germ-cell specification pathway of Drosophila.
Genes & development
      
            
      
      Evidence for presynaptic N-methyl-D-aspartate autoreceptors in the spinal cord dorsal horn.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion.
Genes & development
      
            
      
      lola encodes a putative transcription factor required for axon growth and guidance in Drosophila.
Development (Cambridge, England)
      
            
      
      Contrasting subcellular localization of the Kv1.2 K+ channel subunit in different neurons of rat brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience
      
            
      
      Transient posterior localization of a kinesin fusion protein reflects anteroposterior polarity of the Drosophila oocyte.
Current biology : CB
      
            
      
      daughterless is essential for neuronal precursor differentiation but not for initiation of neuronal precursor formation in Drosophila embryo.
Development (Cambridge, England)
      
            
      
      The role of gene cassettes in axis formation during Drosophila oogenesis.
Trends in genetics : TIG
      
            
      
      Images of purified Shaker potassium channels.
Current biology : CB
      
            
      
      Neuronal cell fate specification in Drosophila.
Current opinion in neurobiology
      
            
      
      Evidence that the S6 segment of the Shaker voltage-gated K+ channel comprises part of the pore.
Nature
      
            
      
      Genetic control of cell fate specification in Drosophila peripheral nervous system.
Annual review of genetics
      
            
      
      Assembly of potassium channels.
Annals of the New York Academy of Sciences
      
            
      
      pipsqueak, an early acting member of the posterior group of genes, affects vasa level and germ cell-somatic cell interaction in the developing egg chamber.
Development (Cambridge, England)
      
            
      
      Functional gene cassettes in development.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      The regulation and function of the helix-loop-helix gene, asense, in Drosophila neural precursors.
Development (Cambridge, England)
      
            
      
      asense is a Drosophila neural precursor gene and is capable of initiating sense organ formation.
Development (Cambridge, England)
      
            
      
      Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channel.
Nature
      
            
      
      A central role for microtubules in the differentiation of Drosophila oocytes.
Development (Cambridge, England)
      
            
      
      A late role for a subset of neurogenic genes to limit sensory precursor recruitments in Drosophila embryos.
Roux's archives of developmental biology : the official organ of the EDBO
      
            
      
      The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons.
The EMBO journal
      
            
      
      Cell interactions and gene interactions in peripheral neurogenesis.
Genes & development
      
            
      
      Tracing neurons with a kinesin-�-galactosidase fusion protein.
Roux's archives of developmental biology : the official organ of the EDBO
      
            
      
      Postembryonic patterns of expression of cut, a locus regulating sensory organ identity in Drosophila.
Development (Cambridge, England)
      
            
      
      Specifying the path of the intersegmental nerve of the Drosophila embryo: a role for Delta and Notch.
Development (Cambridge, England)
      
            
      
      A rat gene with sequence homology to the Drosophila gene hairy is rapidly induced by growth factors known to influence neuronal differentiation.
Molecular and cellular biology
      
            
      
      deadpan, an essential pan-neural gene in Drosophila, encodes a helix-loop-helix protein similar to the hairy gene product.
Genes & development
      
            
      
      The big brain gene of Drosophila functions to control the number of neuronal precursors in the peripheral nervous system.
Development (Cambridge, England)
      
            
      
      Specification of subunit assembly by the hydrophilic amino-terminal domain of the Shaker potassium channel.
Science (New York, N.Y.)
      
            
      
      Neuronal specification.
Current opinion in genetics & development
      
            
      
      The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis.
Genes & development
      
            
      
      Studying Drosophila embryogenesis with P-lacZ enhancer trap lines.
Roux's archives of developmental biology : the official organ of the EDBO
      
            
      
      Structural elements involved in specific K+ channel functions.
Annual review of physiology
      
            
      
      The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons.
The EMBO journal
      
            
      
      Neuroectoderm in Drosophila embryos is dependent on the mesoderm for positioning but not for formation.
Genes & development
      
            
      
      Transformation of sensory organ identity by ectopic expression of Cut in Drosophila.
Genes & development
      
            
      
      Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence.
Nature
      
            
      
      Genetic and molecular bases of neurogenesis in Drosophila melanogaster.
Annual review of neuroscience
      
            
      
      Genes required for specifying cell fates in Drosophila embryonic sensory nervous system.
Trends in neurosciences
      
            
      
      A new homeobox-containing gene, msh-2, is transiently expressed early during mesoderm formation of Drosophila.
Development (Cambridge, England)
      
            
      
      How might the diversity of potassium channels be generated?
Trends in neurosciences
      
            
      
      Differentiation-related alterations in the plasma membranes of chemically transformed murine fibroblasts.
Anticancer research
      
            
      
      Patterns of expression of cut, a protein required for external sensory organ development in wild-type and cut mutant Drosophila embryos.
Genes & development
      
            
      
      Localization of vasa, a component of Drosophila polar granules, in maternal-effect mutants that alter embryonic anteroposterior polarity.
Development (Cambridge, England)
      
            
      
      rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster.
Genes & development
      
            
      
      Molecular studies of voltage-gated potassium channels.
Cold Spring Harbor symposia on quantitative biology
      
            
      
      Role of helix-loop-helix proteins in Drosophila neurogenesis.
Cold Spring Harbor symposia on quantitative biology
      
            
      
      Fibronectin/laminin and their receptors in aberrant growth control in FR3T3 cells transformed by Ha-ras oncogene and epidermal growth factor gene.
International journal of cancer
      
            
      
      Diverse cellular responses elicited from human colon carcinoma cells by transforming growth factor-beta.
Cancer research
      
            
      
      The determination of sense organs in Drosophila: interaction of scute with daughterless.
Roux's archives of developmental biology : the official organ of the EDBO
      
            
      
      A carbohydrate epitope expressed uniquely on the cell surface of Drosophila neurons is altered in the mutant nac (neurally altered carbohydrate).
The EMBO journal
      
            
      
      Identification of a component of Drosophila polar granules.
Development (Cambridge, England)
      
            
      
      The maternal sex determination gene daughterless has zygotic activity necessary for the formation of peripheral neurons in Drosophila.
Genes & development
      
            
      
      Identification and characterization of a neuron-specific nuclear antigen in Drosophila.
Science (New York, N.Y.)
      
            
      
      Neurotoxins from Plectreurys spider venom are potent presynaptic blockers in Drosophila.
The Journal of neuroscience : the official journal of the Society for Neuroscience
      
            
      
      Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Drosophila.
Science (New York, N.Y.)
      
            
      
      Sequence of a probable potassium channel component encoded at Shaker locus of Drosophila.
Science (New York, N.Y.)
      
            
      
      Identification and purification of an irreversible presynaptic neurotoxin from the venom of the spider Hololena curta.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Morphological differentiation of the embryonic peripheral neurons in Drosophila.
Roux's archives of developmental biology : the official organ of the EDBO
      
            
      
      Muscle connections between imaginal discs in Drosophila.
Developmental biology
      
            
      
      The LHRH family of peptide messengers in the frog nervous system.
Progress in brain research
      
            
      
      Formation of neuronal pathways in the imaginal discs of Drosophila melanogaster.
The Journal of neuroscience : the official journal of the Society for Neuroscience
      
            
      
      Mutating a gene for a potassium channel by hybrid dysgenesis: an approach to the cloning of the Shaker locus in Drosophila.
Cold Spring Harbor symposia on quantitative biology
      
            
      
      Peptides in neuronal function: studies using frog autonomic ganglia.
Cold Spring Harbor symposia on quantitative biology
      
            
      
      Some features of peptidergic transmission.
Progress in brain research
      
            
      
      Peptidergic transmission in sympathetic ganglia of the frog.
The Journal of physiology
      
            
      
      Antibodies to horseradish peroxidase as specific neuronal markers in Drosophila and in grasshopper embryos.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Role of an LHRH-like peptide as a neurotransmitter is sympathetic ganglia of the frog.
Federation proceedings
      
            
      
      Further evidence for peptidergic transmission in sympathetic ganglia.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Synaptic vesicle exocytosis captured by quick freezing and correlated with quantal transmitter release.
The Journal of cell biology
      
            
      
      A Drosophila mutant with a temperature-sensitive block in nerve conduction.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Genetic dissection of short-term and long-term facilitation at the Drosophila neuromuscular junction.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Two mutations of synaptic transmission in Drosophila.
Proceedings of the Royal Society of London. Series B, Biological sciences
      
            
      
      L-glutamate as an excitatory transmitter at the Drosophila larval neuromuscular junction.
The Journal of physiology
      
            
      
      Properties of the larval neuromuscular junction in Drosophila melanogaster.
The Journal of physiology
      
            
      
      dunce, a mutant of Drosophila deficient in learning.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Avoidance response, house response, and wind responses of the sporangiophore of Phycomyces.
The Journal of general physiology
      
            
      
      [Bacterial endocarditis in children associated with congenital cardiopathies: clinical aspects and outcome. Apropos of 22 cases].
Archives francaises de pediatrie