
Professor
Pediatrics
+1 415 502-3460
Xianhua Piao, MD, PhD studies the role of cell-cell and cell-matrix interactions in brain development and disorders.
Publications
Spatiotemporal profiling of adhesion G protein-coupled receptors in developing mouse and human pancreas reveals a role for GPR56 in islet development.
Cellular and molecular life sciences : CMLS
Genetic deletion of G protein-coupled receptor 56 aggravates traumatic brain injury through the microglial CCL3/4/5 upregulation targeted to CCR5.
Cell death & disease
Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1.
bioRxiv : the preprint server for biology
Adhesion G protein-coupled receptor ADGRG1 promotes protective microglial response in Alzheimer's disease.
bioRxiv : the preprint server for biology
Loss of cardiomyocyte-specific adhesion G-protein-coupled receptor G1 (ADGRG1/GPR56) promotes pressure overload-induced heart failure.
Bioscience reports
Assessing for prenatal risk factors associated with infant neurologic morbidity using a multivariate analysis.
Journal of perinatology : official journal of the California Perinatal Association
Cytokine responses to SARS-COV2 infection in mother-infant dyads: a systematic review and meta-analysis.
Frontiers in pediatrics
Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficits.
Science advances
Phospholipid-flippase chaperone CDC50A is required for synapse maintenance by regulating phosphatidylserine exposure.
The EMBO journal
Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids.
Cell stem cell
The association of COVID-19 infection in pregnancy with preterm birth: A retrospective cohort study in California.
Lancet regional health. Americas
Association of Maternal Immune Activation during Pregnancy and Neurologic Outcomes in Offspring.
The Journal of pediatrics
Unexpected redundancy of Gpr56 and Gpr97 during hematopoietic cell development and differentiation.
Blood advances
GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force.
Proceedings of the National Academy of Sciences of the United States of America
A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding.
The EMBO journal
GAIN domain-mediated cleavage is required for activation of G protein-coupled receptor 56 (GPR56) by its natural ligands and a small-molecule agonist.
The Journal of biological chemistry
The expanding functional roles and signaling mechanisms of adhesion G protein-coupled receptors.
Annals of the New York Academy of Sciences
Long noncoding RNAs interact with mRNAs: A new perspective on the mechanism of premature brain injury.
Neuroscience letters
Adhesion G Protein-Coupled Receptors as Drug Targets for Neurological Diseases.
Trends in pharmacological sciences
The adhesion receptor GPR56 is activated by extracellular matrix collagen III to improve β-cell function.
Cellular and molecular life sciences : CMLS
GPR56/ADGRG1 regulates development and maintenance of peripheral myelin.
The Journal of experimental medicine
Adhesion G-protein coupled receptors and extracellular matrix proteins: Roles in myelination and glial cell development.
Developmental dynamics : an official publication of the American Association of Anatomists
Gpr126/Adgrg6 Has Schwann Cell Autonomous and Nonautonomous Functions in Peripheral Nerve Injury and Repair.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Structural Basis for Regulation of GPR56/ADGRG1 by Its Alternatively Spliced Extracellular Domains.
Neuron
Adhesion G protein-coupled receptors in nervous system development and disease.
Nature reviews. Neuroscience
Adhesion GPCRs as Novel Actors in Neural and Glial Cell Functions: From Synaptogenesis to Myelination.
Handbook of experimental pharmacology
Role of macrophages in Wallerian degeneration and axonal regeneration after peripheral nerve injury.
Acta neuropathologica
Tethered agonists: a new mechanism underlying adhesion G protein-coupled receptor activation.
Journal of receptor and signal transduction research
High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice.
Stem cell research
The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development.
Nature communications
The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA.
Nature communications
International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.
Pharmacological reviews
New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors.
Annals of the New York Academy of Sciences
G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy.
Proceedings of the National Academy of Sciences of the United States of America
Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning.
Science (New York, N.Y.)
Dissecting signaling and functions of adhesion G protein-coupled receptors.
Annals of the New York Academy of Sciences
GPR56 and the developing cerebral cortex: cells, matrix, and neuronal migration.
Molecular neurobiology
Characterization of G protein-coupled receptor 56 protein expression in the mouse developing neocortex.
The Journal of comparative neurology
Loss of Col3a1, the gene for Ehlers-Danlos syndrome type IV, results in neocortical dyslamination.
PloS one
G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination.
Proceedings of the National Academy of Sciences of the United States of America
A novel GPR56 mutation causes bilateral frontoparietal polymicrogyria.
Pediatric neurology
G protein-coupled receptor56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination
Proc Natl Acad Sci USA, 108(31), 12925-30.
Adhesion-GPCRs in the CNS.
Advances in experimental medicine and biology
GPR56 and its related diseases.
Progress in molecular biology and translational science
GPR56-regulated granule cell adhesion is essential for rostral cerebellar development.
The Journal of neuroscience : the official journal of the Society for Neuroscience
GPR56 regulates pial basement membrane integrity and cortical lamination.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Disease-associated mutations affect GPR56 protein trafficking and cell surface expression.
Human molecular genetics
Genotype-phenotype analysis of human frontoparietal polymicrogyria syndromes.
Annals of neurology
A novel signaling mechanism in brain development.
Pediatric research
G protein-coupled receptor-dependent development of human frontal cortex.
Science (New York, N.Y.)
Bilateral frontoparietal polymicrogyria: clinical and radiological features in 10 families with linkage to chromosome 16.
Annals of neurology
An autosomal recessive form of bilateral frontoparietal polymicrogyria maps to chromosome 16q12.2-21.
American journal of human genetics
recessive spotting: a linked locus that interacts with W/Kit but is not allelic.
Genes to cells : devoted to molecular & cellular mechanisms
Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1.
Proceedings of the National Academy of Sciences of the United States of America
Minimal residual disease in bone marrow transplant recipients with chronic myeloid leukemia.
Bone marrow transplantation
The preliminary observation on immunosuppressive effect of norcantharidin in mice.
Immunopharmacology and immunotoxicology