
Professor
Biochemistry and Biophysics
+1 415 514-4304
Wallace Marshall, PhD studies the mechanistic origins of cell geometry. He is interested in how cells solve engineering problems, such as the regulation of organelle size and the self-organization of intracellular patterns.
Publications
A scoping study of the whole-cell imaging literature: a foundational corpus, potential for data-mining and research synthesis, and a call for standardization of an emerging field.
bioRxiv : the preprint server for biology
Mitochondrial function regulates cell growth kinetics to actively maintain mitochondrial homeostasis.
bioRxiv : the preprint server for biology
Physical Forces in Regeneration of Cells and Tissues.
Cold Spring Harbor perspectives in biology
Representing Mitochondrial Dynamics with Abstract Algebra.
bioRxiv : the preprint server for biology
The cell biology and genome of Stentor pyriformis, a giant cell that embeds symbiotic algae in a microtubule meshwork.
Molecular biology of the cell
Cellular cognition: How single cells learn using non-neural networks.
Current biology : CB
A receptor-inactivation model for single-celled habituation in Stentor coeruleus.
bioRxiv : the preprint server for biology
Fishnet mesh of centrin-Sfi1 drives ultrafast calcium-activated contraction of the giant cell Spirostomum ambiguum.
bioRxiv : the preprint server for biology
Automated segmentation of soft X-ray tomography: native cellular structure with sub-micron resolution at high throughput for whole-cell quantitative imaging in yeast.
bioRxiv : the preprint server for biology
Where physics and biology meet.
Current biology : CB
Genome-wide analysis of anterior-posterior mRNA localization in Stentor coeruleus reveals a role for the microtubule cytoskeleton.
bioRxiv : the preprint server for biology
Phylogeny, morphology, and behavior of the new ciliate species Stentor stipatus.
bioRxiv : the preprint server for biology
Extraordinary model systems for regeneration.
Development (Cambridge, England)
Chlamydomonas as a model system to study cilia and flagella using genetics, biochemistry, and microscopy.
Frontiers in cell and developmental biology
Modeling homologous chromosome recognition via nonspecific interactions.
Proceedings of the National Academy of Sciences of the United States of America
Cell motility: Bioelectrical control of behavior without neurons.
Current biology : CB
Mitochondrial networks through the lens of mathematics.
Physical biology
Homologous chromosome recognition via nonspecific interactions.
bioRxiv : the preprint server for biology
The flagellar length control system: exploring the physical biology of organelle size.
Physical biology
Cooperative hydrodynamics accompany multicellular-like colonial organization in the unicellular ciliate Stentor.
bioRxiv : the preprint server for biology
Studying Habituation in Stentor coeruleus.
Journal of visualized experiments : JoVE
Role of intraflagellar transport in transcriptional control during flagellar regeneration in Chlamydomonas.
Molecular biology of the cell
Single-cell analysis of habituation in Stentor coeruleus.
Current biology : CB
A unicellular walker controlled by a microtubule-based finite-state machine.
Current biology : CB
Modeling cell biological features of meiotic chromosome pairing to study interlock resolution.
PLoS computational biology
Determining protein polarization proteome-wide using physical dissection of individual Stentor coeruleus cells.
Current biology : CB
Biosynthesis of Linear Protein Nanoarrays Using the Flagellar Axoneme.
ACS synthetic biology
A simple method to generate human airway epithelial organoids with externally orientated apical membranes.
American journal of physiology. Lung cellular and molecular physiology
The short flagella 1 (SHF1) gene in Chlamydomonas encodes a Crescerin TOG-domain protein required for late stages of flagellar growth.
Molecular biology of the cell
Regeneration in Stentor coeruleus.
Frontiers in cell and developmental biology
Analysis of Motility Patterns of Stentor During and After Oral Apparatus Regeneration Using Cell Tracking.
Journal of visualized experiments : JoVE
Deep Convolutional and Recurrent Neural Networks for Cell Motility Discrimination and Prediction.
IEEE/ACM transactions on computational biology and bioinformatics
Drosophila Embryo Preparation and Microinjection for Live Cell Microscopy Performed using an Automated High Content Analyzer.
Journal of visualized experiments : JoVE
Axopodia and the cellular "arms" race.
Cytoskeleton (Hoboken, N.J.)
Scaling of Subcellular Structures.
Annual review of cell and developmental biology
Multi-scale spatial heterogeneity enhances particle clearance in airway ciliary arrays.
Nature physics
Pattern Formation and Complexity in Single Cells.
Current biology : CB
Aging induces aberrant state transition kinetics in murine muscle stem cells.
Development (Cambridge, England)
Speed and Diffusion of Kinesin-2 Are Competing Limiting Factors in Flagellar Length-Control Model.
Biophysical journal
Aurora kinase inhibitors delay regeneration in Stentor coeruleus at an intermediate step.
Matters select
Towards computer-aided design of cellular structure.
Physical biology
Reorganization of complex ciliary flows around regenerating Stentor coeruleus.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Testing the role of intraflagellar transport in flagellar length control using length-altering mutants of Chlamydomonas.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Cellular Cognition: Sequential Logic in a Giant Protist.
Current biology : CB
Dynamics of living cells in a cytomorphological state space.
Proceedings of the National Academy of Sciences of the United States of America
Modeling meiotic chromosome pairing: a tug of war between telomere forces and a pairing-based Brownian ratchet leads to increased pairing fidelity.
Physical biology
Electron cryo-tomography provides insight into procentriole architecture and assembly mechanism.
eLife
Cell learning.
Current biology : CB
A Dilution Model for Embryonic Scaling.
Developmental cell
Methods for the Study of Regeneration in Stentor.
Journal of visualized experiments : JoVE
Diffusion as a Ruler: Modeling Kinesin Diffusion as a Length Sensor for Intraflagellar Transport.
Biophysical journal
Inferring cell state by quantitative motility analysis reveals a dynamic state system and broken detailed balance.
PLoS computational biology
Mechanical Forces Program the Orientation of Cell Division during Airway Tube Morphogenesis.
Developmental cell
Testing the time-of-flight model for flagellar length sensing.
Molecular biology of the cell
Non-model model organisms.
BMC biology
Microfluidic guillotine for single-cell wound repair studies.
Proceedings of the National Academy of Sciences of the United States of America
Self-repairing cells: How single cells heal membrane ruptures and restore lost structures.
Science (New York, N.Y.)
Intraflagellar Transport and Ciliary Dynamics.
Cold Spring Harbor perspectives in biology
Organelles - understanding noise and heterogeneity in cell biology at an intermediate scale.
Journal of cell science
The Macronuclear Genome of Stentor coeruleus Reveals Tiny Introns in a Giant Cell.
Current biology : CB
Cell Geometry: How Cells Count and Measure Size.
Annual review of biophysics
Organelle Size Scaling of the Budding Yeast Vacuole by Relative Growth and Inheritance.
Current biology : CB
Modeling meiotic chromosome pairing: nuclear envelope attachment, telomere-led active random motion, and anomalous diffusion.
Physical biology
Versatile protein tagging in cells with split fluorescent protein.
Nature communications
How Cells Measure Length on Subcellular Scales.
Trends in cell biology
Subcellular size.
Cold Spring Harbor perspectives in biology
A systematic comparison of mathematical models for inherent measurement of ciliary length: how a cell can measure length and volume.
Biophysical journal
Efficient live fluorescence imaging of intraflagellar transport in mammalian primary cilia.
Methods in cell biology
Methods in cilia & flagella. Preface.
Methods in cell biology
Preface. Building a cell from its component parts.
Methods in cell biology
Mechanobiology of Ciliogenesis.
Bioscience
Stentor coeruleus.
Current biology : CB
Actin is required for IFT regulation in Chlamydomonas reinhardtii.
Current biology : CB
Quantitative analysis and modeling of katanin function in flagellar length control.
Molecular biology of the cell
The Golgi is a measuring cup.
Developmental cell
Organelle size scaling of the budding yeast vacuole is tuned by membrane trafficking rates.
Biophysical journal
FAP20 is an inner junction protein of doublet microtubules essential for both the planar asymmetrical waveform and stability of flagella in Chlamydomonas.
Molecular biology of the cell
Visualizing cytoplasmic flow during single-cell wound healing in Stentor coeruleus.
Journal of visualized experiments : JoVE
Ciliary regulation: disassembly takes the spotlight.
Current biology : CB
Ciliary secretion: switching the cellular antenna to 'transmit'.
Current biology : CB
Avalanche-like behavior in ciliary import.
Proceedings of the National Academy of Sciences of the United States of America
Analysis of ciliary assembly and function in planaria.
Methods in enzymology
Chemical screening methods for flagellar phenotypes in Chlamydomonas.
Methods in enzymology
Isolation of mammalian primary cilia.
Methods in enzymology
Methods in Enzymology. Cilia, part A. Preface.
Methods in enzymology
Methods in Enzymology. Cilia, part B. Preface.
Methods in enzymology
What determines cell size?
BMC biology
Statistical method for comparing the level of intracellular organization between cells.
Proceedings of the National Academy of Sciences of the United States of America
Mitochondrial network size scaling in budding yeast.
Science (New York, N.Y.)
Cell biology 2.0.
Trends in cell biology
Centrosome positioning in vertebrate development.
Journal of cell science
Organelle size equalization by a constitutive process.
Current biology : CB
The role of retrograde intraflagellar transport in flagellar assembly, maintenance, and function.
The Journal of cell biology
Centriole asymmetry determines algal cell geometry.
Current opinion in plant biology
How cells know the size of their organelles.
Science (New York, N.Y.)
Organelle size control systems: from cell geometry to organelle-directed medicine.
BioEssays : news and reviews in molecular, cellular and developmental biology
A chemical screen identifies class a g-protein coupled receptors as regulators of cilia.
ACS chemical biology
Proteomic analysis of mammalian primary cilia.
Current biology : CB
Centrosome loss in the evolution of planarians.
Science (New York, N.Y.)
Stages of ciliogenesis and regulation of ciliary length.
Differentiation; research in biological diversity
Three-dimensional structure of basal body triplet revealed by electron cryo-tomography.
The EMBO journal
CLUMPED CHLOROPLASTS 1 is required for plastid separation in Arabidopsis.
Proceedings of the National Academy of Sciences of the United States of America
Origins of cellular geometry.
BMC biology
Centrosome size: scaling without measuring.
Current biology : CB
Control of mitotic spindle angle by the RAS-regulated ERK1/2 pathway determines lung tube shape.
Science (New York, N.Y.)
Ciliogenesis: building the cell's antenna.
Nature reviews. Molecular cell biology
Apparent diffusive motion of centrin foci in living cells: implications for diffusion-based motion in centriole duplication.
Physical biology
A cell-based screen for inhibitors of flagella-driven motility in Chlamydomonas reveals a novel modulator of ciliary length and retrograde actin flow.
Cytoskeleton (Hoboken, N.J.)
Regulation of flagellar motility by the conserved flagellar protein CG34110/Ccdc135/FAP50.
Molecular biology of the cell
Building the centriole.
Current biology : CB
Influence of centriole number on mitotic spindle length and symmetry.
Cytoskeleton (Hoboken, N.J.)
Cilia self-organize in response to planar cell polarity and flow.
Nature cell biology
Scaling properties of cell and organelle size.
Organogenesis
Total internal reflection fluorescence (TIRF) microscopy of Chlamydomonas flagella.
Methods in cell biology
Intraflagellar transport particle size scales inversely with flagellar length: revisiting the balance-point length control model.
The Journal of cell biology
ASQ2 encodes a TBCC-like protein required for mother-daughter centriole linkage and mitotic spindle orientation.
Current biology : CB
Quantitative high-throughput assays for flagella-based motility in chlamydomonas using plate-well image analysis and transmission correlation spectroscopy.
Journal of biomolecular screening
Centriole evolution.
Current opinion in cell biology
Molecular architecture of the centriole proteome: the conserved WD40 domain protein POC1 is required for centriole duplication and length control.
Molecular biology of the cell
Katanin knockdown supports a role for microtubule severing in release of basal bodies before mitosis in Chlamydomonas.
Molecular biology of the cell
Modeling recursive RNA interference.
PLoS computational biology
Controlling size within cells.
Seminars in cell & developmental biology
Building the cell: design principles of cellular architecture.
Nature reviews. Molecular cell biology
Engineering design principles for organelle size control systems.
Seminars in cell & developmental biology
Cilia orientation and the fluid mechanics of development.
Current opinion in cell biology
The cell biological basis of ciliary disease.
The Journal of cell biology
Basal bodies platforms for building cilia.
Current topics in developmental biology
Isolation and proteomic analysis of Chlamydomonas centrioles.
Methods in molecular biology (Clifton, N.J.)
Use of transcriptomic data to support organelle proteomic analysis.
Methods in molecular biology (Clifton, N.J.)
Centriole assembly: the origin of nine-ness.
Current biology : CB
Don'T blink: observing the ultra-fast contraction of spasmonemes.
Biophysical journal
The Chlamydomonas genome reveals the evolution of key animal and plant functions.
Science (New York, N.Y.)
Stability and robustness of an organelle number control system: modeling and measuring homeostatic regulation of centriole abundance.
Biophysical journal
What is the function of centrioles?
Journal of cellular biochemistry
Flagellar length control in chlamydomonas--paradigm for organelle size regulation.
International review of cytology
Quantitative modeling in cell biology: what is it good for?
Developmental cell
Axon guidance by diffusible chemoattractants: a gradient of netrin protein in the developing spinal cord.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Cilia: tuning in to the cell's antenna.
Current biology : CB
Proteomic analysis of isolated chlamydomonas centrioles reveals orthologs of ciliary-disease genes.
Current biology : CB
Genome-wide transcriptional analysis of flagellar regeneration in Chlamydomonas reinhardtii identifies orthologs of ciliary disease genes.
Proceedings of the National Academy of Sciences of the United States of America
Flagellar motility: all pull together.
Current biology : CB
Human cilia proteome contains homolog of zebrafish polycystic kidney disease gene qilin.
Current biology : CB
Flagellar length control system: testing a simple model based on intraflagellar transport and turnover.
Molecular biology of the cell
Centrioles: bad to be bald?
Current biology : CB
Cellular length control systems.
Annual review of cell and developmental biology
Gene expression and nuclear architecture during development and differentiation.
Mechanisms of development
Tubulin superfamily: giving birth to triplets.
Current biology : CB
Size control in dynamic organelles.
Trends in cell biology
Loss of checkpoint proteins: an occupational hazard.
Trends in cell biology
Order and disorder in the nucleus.
Current biology : CB
Polar wind left flapping in the breeze?
Trends in cell biology
Chromosome elasticity and mitotic polar ejection force measured in living Drosophila embryos by four-dimensional microscopy-based motion analysis.
Current biology : CB
Homologous chromosome pairing in Drosophila melanogaster proceeds through multiple independent initiations.
The Journal of cell biology
Interphase chromosomes undergo constrained diffusional motion in living cells.
Current biology : CB
Mitosis in living budding yeast: anaphase A but no metaphase plate.
Science (New York, N.Y.)
Mitochondrial transmission during mating in Saccharomyces cerevisiae is determined by mitochondrial fusion and fission and the intramitochondrial segregation of mitochondrial DNA.
Molecular biology of the cell
Two proteins that cycle asynchronously between centrosomes and nuclear structures: Drosophila CP60 and CP190.
Journal of cell science
Deconstructing the nucleus: global architecture from local interactions.
Current opinion in genetics & development