
Professor
Pathology
+1 415 502-6116
Thea Tlsty, PhD studies the identity and role of cancer stem cells in the development and progression of breast cancer. She also has a research program on the characterization of genomic instability in cancer initiation and progression.
Publications
Paired mutation calling and spatial transcriptomics identify cellular neighbourhoods dictating the neoplastic outcome of colitis.
Research square
Proteomic Analysis of Breast Cancer Subtypes Identifies Stromal Contributions that Dictate Aggressive Malignant Behavior.
bioRxiv : the preprint server for biology
A hybrid epithelial-mesenchymal transition program enables basal epithelial cells to bypass stress-induced stasis and contributes to a metaplastic breast cancer progenitor state.
Breast cancer research : BCR
Defining precancer: a grand challenge for the cancer community.
Nature reviews. Cancer
Higher Nodal expression is often associated with poorer survival in patients diagnosed with melanoma and treated with anti-PD1 therapy.
Pathology oncology research : POR
Extracellular Matrix Orchestration of Tissue Remodeling in the Chronically Inflamed Mouse Colon.
Cellular and molecular gastroenterology and hepatology
Loss of PPARγ activity characterizes early protumorigenic stromal reprogramming and dictates the therapeutic window of opportunity.
Proceedings of the National Academy of Sciences of the United States of America
Concerted epithelial and stromal changes during progression of Barrett's Esophagus to invasive adenocarcinoma exposed by multi-scale, multi-omics analysis.
bioRxiv : the preprint server for biology
Apposition of Fibroblasts With Metaplastic Gastric Cells Promotes Dysplastic Transition.
Gastroenterology
Epithelial-Stromal Interactions in Barrett's Esophagus Modeled in Human Organ Chips.
Gastro hep advances
Antigen-Dependent Inducible T-Cell Reporter System for PET Imaging of Breast Cancer and Glioblastoma.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Mapping hormone-regulated cell-cell interaction networks in the human breast at single-cell resolution.
Cell systems
Remaining true to one's identity.
Nature aging
A framework for advancing our understanding of cancer-associated fibroblasts.
Nature reviews. Cancer
Stromal directives can control cancer.
Science (New York, N.Y.)
Introducing cancer convergence.
Cancer convergence
Metastatic State of Cancer Cells May Be Indicated by Adhesion Strength.
Biophysical journal
SOX2, OCT3/4 and NANOG expression and cellular plasticity in rare human somatic cells requires CD73.
Cellular signalling
Risk prediction for local versus regional/metastatic tumors after initial ductal carcinoma in situ diagnosis treated by lumpectomy.
Breast cancer research and treatment
Carcinoma-associated fibroblasts: orchestrating the composition of malignancy.
Genes & development
Novel insights from 3D models: the pivotal role of physical symmetry in epithelial organization.
Scientific reports
Towards aspirin-inspired self-immolating molecules which target the cyclooxygenases.
Organic & biomolecular chemistry
Epigenetic and transcriptional determinants of the human breast.
Nature communications
Intermediate DNA methylation is a conserved signature of genome regulation.
Nature communications
Regulatory network decoded from epigenomes of surface ectoderm-derived cell types.
Nature communications
Stress signaling from human mammary epithelial cells contributes to phenotypes of mammographic density.
Cancer research
Evolutionary game theory for physical and biological scientists. I. Training and validating population dynamics equations.
Interface focus
Evolutionary game theory for physical and biological scientists. II. Population dynamics equations can be associated with interpretations.
Interface focus
Game theory in the death galaxy: interaction of cancer and stromal cells in tumour microenvironment.
Interface focus
Cell motility and drug gradients in the emergence of resistance to chemotherapy.
Proceedings of the National Academy of Sciences of the United States of America
Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm.
Genome research
DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape.
Nature genetics
Coordinate transcriptional and translational repression of p53 by TGF-β1 impairs the stress response.
Molecular cell
Rare somatic cells from human breast tissue exhibit extensive lineage plasticity.
Proceedings of the National Academy of Sciences of the United States of America
Breast fibroblasts modulate early dissemination, tumorigenesis, and metastasis through alteration of extracellular matrix characteristics.
Neoplasia (New York, N.Y.)
A physical sciences network characterization of non-tumorigenic and metastatic cells.
Scientific reports
Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes.
Breast cancer research : BCR
Hello out there...is anybody listening?
Cancer discovery
Generalized principles of stochasticity can be used to control dynamic heterogeneity.
Physical biology
CD36 repression activates a multicellular stromal program shared by high mammographic density and tumor tissues.
Cancer discovery
p16(INK4a) expression and breast cancer risk in women with atypical hyperplasia.
Cancer prevention research (Philadelphia, Pa.)
An analogy between the evolution of drug resistance in bacterial communities and malignant tissues.
Nature reviews. Cancer
Tumor microenvironment and progression.
Journal of surgical oncology
A twist of cell fate.
Cell stem cell
Biomarker expression and risk of subsequent tumors after initial ductal carcinoma in situ diagnosis.
Journal of the National Cancer Institute
Premalignant breast neoplasia: a paradigm of interlesional and intralesional molecular heterogeneity and its biological and clinical ramifications.
Cancer prevention research (Philadelphia, Pa.)
Primary cilia regulate branching morphogenesis during mammary gland development.
Current biology : CB
Unprecedented opportunities and promise for cancer prevention research.
Cancer prevention research (Philadelphia, Pa.)
DNA damage drives an activin a-dependent induction of cyclooxygenase-2 in premalignant cells and lesions.
Cancer prevention research (Philadelphia, Pa.)
Human mammary cancer progression model recapitulates methylation events associated with breast premalignancy.
Breast cancer research : BCR
Reflections on miR-ing effects in metastasis.
Cancer cell
Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers.
Proceedings of the National Academy of Sciences of the United States of America
Graphical methods for quantifying macromolecules through bright field imaging.
Bioinformatics (Oxford, England)
Morphologically normal-appearing mammary epithelial cells obtained from high-risk women exhibit methylation silencing of INK4a/ARF.
Clinical cancer research : an official journal of the American Association for Cancer Research
Stratification of breast cancer risk in women with atypia: a Mayo cohort study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Inactivation of p53 function in cultured human mammary epithelial cells turns the telomere-length dependent senescence barrier from agonescence into crisis.
Cell cycle (Georgetown, Tex.)
Luminal cells GATA have it.
Nature cell biology
Simulating properties of in vitro epithelial cell morphogenesis.
PLoS computational biology
Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells.
The Journal of biological chemistry
Tumor stroma and regulation of cancer development.
Annual review of pathology
Benign breast disease and the risk of breast cancer.
The New England journal of medicine
p38 regulates cyclooxygenase-2 in human mammary epithelial cells and is activated in premalignant tissue.
Cancer research
Genetic and epigenetic changes in mammary epithelial cells identify a subpopulation of cells involved in early carcinogenesis.
Cold Spring Harbor symposia on quantitative biology
Genetic and epigenetic changes in mammary epithelial cells may mimic early events in carcinogenesis.
Journal of mammary gland biology and neoplasia
Cyclooxygenase-2 expression is related to nuclear grade in ductal carcinoma in situ and is increased in its normal adjacent epithelium.
Cancer research
Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia.
Cancer research
Functions of p53 suppress critical consequences of damage and repair in the initiation of cancer.
Cancer cell
Induction of tubulogenesis in telomerase-immortalized human microvascular endothelial cells by glioblastoma cells.
Experimental cell research
Minichromosome maintenance protein 2 expression in prostate: characterization and association with outcome after therapy for cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research
DNA replication licensing and human cell proliferation.
Journal of cell science
Loss of chromosomal integrity in human mammary epithelial cells subsequent to escape from senescence.
Journal of mammary gland biology and neoplasia
Stromal cells can contribute oncogenic signals.
Seminars in cancer biology
Know thy neighbor: stromal cells can contribute oncogenic signals.
Current opinion in genetics & development
Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes.
Nature
Searching for targets: the power of somatic cell genetics.
Genome research
Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America
Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium.
Cancer research
A molecular blueprint for targeting cancer?
Nature genetics
Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype.
Nature genetics
Cell-adhesion-dependent influences on genomic instability and carcinogenesis.
Current opinion in cell biology
Genetic and epigenetic influences in prostatic carcinogenesis (review).
International journal of oncology
An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control.
Proceedings of the National Academy of Sciences of the United States of America
Identification of additional complementation groups that regulate genomic instability.
Genes, chromosomes & cancer
Genomic instability and its role in neoplasia.
Current topics in microbiology and immunology
Separate pathways for p53 induction by ionizing radiation and N-(phosphonoacetyl)-L-aspartate.
Cancer research
Alteration of cell cycle kinase complexes in human papillomavirus E6- and E7-expressing fibroblasts precedes neoplastic transformation.
Journal of virology
Regulation of genomic instability in preneoplastic cells.
Cancer surveys
Genomic instability and cancer.
Mutation research
Defective G2 checkpoint function in cells from individuals with familial cancer syndromes.
Cancer research
Analysis of cell cycle checkpoint status in mammalian cells.
Methods in enzymology
Clonal variation of tumorigenic potential in v-Ha-ras-transformed human bronchial epithelial cells: relationship to ras oncogene expression and CAD gene amplification.
Molecular carcinogenesis
Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins.
Genes & development
Genomic integrity and the genetics of cancer.
Cold Spring Harbor symposia on quantitative biology
Multiple mechanisms of N-(phosphonoacetyl)-L-aspartate drug resistance in SV40-infected precrisis human fibroblasts.
Cancer research
Amplification potential in preneoplastic and neoplastic Syrian hamster embryo fibroblasts transformed by various carcinogens.
Cancer research
Loss of chromosomal integrity in neoplasia.
Cold Spring Harbor symposia on quantitative biology
Suppression of gene amplification in human cell hybrids.
Science (New York, N.Y.)
Replication of the dihydrofolate reductase genes on double minute chromosomes in a murine cell line.
Experimental cell research
Normal diploid human and rodent cells lack a detectable frequency of gene amplification.
Proceedings of the National Academy of Sciences of the United States of America
Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbrück fluctuation analysis.
Proceedings of the National Academy of Sciences of the United States of America
1-beta-D-arabinofuranosylcytosine enhancement of resistance to several antineoplastic drugs in mammalian tissue culture cells.
Molecular pharmacology
Increased incidence of CAD gene amplification in tumorigenic rat lines as an indicator of genomic instability of neoplastic cells.
The Journal of biological chemistry
UV radiation facilitates methotrexate resistance and amplification of the dihydrofolate reductase gene in cultured 3T6 mouse cells.
Molecular and cellular biology
Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyurea.
Molecular and cellular biology
Analysis of spontaneous deletions and gene amplification in the lac region of Escherichia coli.
Cold Spring Harbor symposia on quantitative biology
Insertion, excision, and inversion of Tn5.
Cold Spring Harbor symposia on quantitative biology