
Professor
Orofacial Sciences
+1 415 502-7828
Terumi Kohwi-Shigematsu, PhD studies the role of the protein SATB, which functions as a chromatin organizer, during cell development and cancer metastasis.
Publications
The therapeutically actionable long non-coding RNA 'T-RECS' is essential to cancer cells' survival in NRAS/MAPK-driven melanoma.
Molecular cancer
The therapeutically actionable long non-coding RNA 'T-RECS' is essential to cancer cells' survival in NRAS/MAPK-driven melanoma.
Research square
Crucial Roles of SATB1 in Regulation of Thymocyte Migration after Positive Selection.
Journal of immunology (Baltimore, Md. : 1950)
Chromatin organizer SATB1 controls the cell identity of CD4+ CD8+ double-positive thymocytes by regulating the activity of super-enhancers.
Nature communications
SATB1-dependent mitochondrial ROS production controls TCR signaling in CD4 T cells.
Life science alliance
Increased Indoleamine 2,3-Dioxygenase Levels at the Onset of Sjögren's Syndrome in SATB1-Conditional Knockout Mice.
International journal of molecular sciences
Withdrawal: Selective cleavage of BLM, the Bloom syndrome protein, during apoptotic cell death.
The Journal of biological chemistry
Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity.
Nature communications
Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation.
Nature communications
Variable SATB1 Levels Regulate Hematopoietic Stem Cell Heterogeneity with Distinct Lineage Fate.
Cell reports
671 Cross-talk between covalent DNA modifications and chromatin architecture: DNA dioxygenase Tet2 mediates the effects of chromatin architectural protein CTCF on epidermal barrier maintenance, inflammation and tumorigenesis.
Journal of Investigative Dermatology
Addendum: Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment.
Nature immunology
091 5C analysis reveals distinct spatial contact networks between gene-rich and gene-poor TADs at the Epidermal Differentiation Complex in skin epithelial cells.
Journal of Investigative Dermatology
Erratum: Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment.
Nature immunology
Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment.
Nature immunology
Correction: SATB1 Plays a Critical Role in Establishment of Immune Tolerance.
Journal of immunology (Baltimore, Md. : 1950)
SATB1 Plays a Critical Role in Establishment of Immune Tolerance.
Journal of immunology (Baltimore, Md. : 1950)
An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development.
The Journal of experimental medicine
The Satb1 protein directs hematopoietic stem cell differentiation toward lymphoid lineages.
Immunity
A network of genetic repression and derepression specifies projection fates in the developing neocortex.
Proceedings of the National Academy of Sciences of the United States of America
SATB1-mediated functional packaging of chromatin into loops.
Methods (San Diego, Calif.)
Genome organizing function of SATB1 in tumor progression.
Seminars in cancer biology
Satb1 ablation alters temporal expression of immediate early genes and reduces dendritic spine density during postnatal brain development.
Molecular and cellular biology
SATB1 (SATB homeobox 1).
Atlas of Genetics and Cytogenetics in Oncology and Haematology
p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis.
The Journal of cell biology
Re: The role of SATB1 in breast cancer pathogenesis.
Journal of the National Cancer Institute
Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression.
Genes & development
SATB1 defines the developmental context for gene silencing by Xist in lymphoma and embryonic cells.
Developmental cell
New advances in breast cancer metastasis.
Women's health (London, England)
DLX5 expression is monoallelic and Dlx5 is up-regulated in the Mecp2-null frontal cortex.
Journal of cellular and molecular medicine
A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia.
The Journal of clinical investigation
SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes.
Nature genetics
A nuclear targeting determinant for SATB1, a genome organizer in the T cell lineage.
Cell cycle (Georgetown, Tex.)
Mapping the initial DNA breaks in apoptotic Jurkat cells using ligation-mediated PCR.
Cell death and differentiation
Identification of a candidate regulatory region in the human CD8 gene complex by colocalization of DNase I hypersensitive sites and matrix attachment regions which bind SATB1 and GATA-3.
Journal of immunology (Baltimore, Md. : 1950)
Matrix Attachment Regions.
Wiley Encyclopedia of Molecular Medicine
The Bloom Syndrome Protein BLM Is Selectively Cleaved during Apoptotic Cell Death.
TheScientificWorldJournal
The matrix attachment region-binding protein SATB1 interacts with multiple elements within the gp91phox promoter and is down-regulated during myeloid differentiation.
The Journal of biological chemistry
SATB1 cleavage by caspase 6 disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis.
Molecular and cellular biology
Selective cleavage of BLM, the bloom syndrome protein, during apoptotic cell death.
The Journal of biological chemistry
THE BLOOM SYNDROME PROTEIN BLM IS SELECTIVELY CLEAVED DURING APOPTOTIC CELL DEATH.
The Scientific World JOURNAL
Ku acts in a unique way at the mammalian telomere to prevent end joining.
Genes & development
The MAR-binding protein SATB1 orchestrates temporal and spatial expression of multiple genes during T-cell development.
Genes & development
Modulated binding of SATB1, a matrix attachment region protein, to the AT-rich sequence flanking the major breakpoint region of BCL2.
Molecular and cellular biology
Caught in the act: binding of Ku and PARP to MARs reveals novel aspects of their functional interaction.
Critical reviews in eukaryotic gene expression
Linking chromatin architecture to cellular phenotype: BUR-binding proteins in cancer.
Journal of cellular biochemistry. Supplement
Intranuclear relocalization of matrix binding sites during T cell activation detected by amplified fluorescence in situ hybridization.
Methods (San Diego, Calif.)
Poly(ADP-ribose) polymerase and Ku autoantigen form a complex and synergistically bind to matrix attachment sequences.
The Journal of biological chemistry
The genomic sequences bound to special AT-rich sequence-binding protein 1 (SATB1) in vivo in Jurkat T cells are tightly associated with the nuclear matrix at the bases of the chromatin loops.
The Journal of cell biology
Identification of base-unpairing region-binding proteins and characterization of their in vivo binding sequences.
Methods in cell biology
Stress-induced duplex DNA destabilization in scaffold/matrix attachment regions.
Journal of molecular biology
An atypical homeodomain in SATB1 promotes specific recognition of the key structural element in a matrix attachment region.
The Journal of biological chemistry
Association of nuclear matrix proteins with granular and threaded nuclear bodies in cell lines undergoing apoptosis.
Experimental cell research
4 High Unwinding Capability of Matrix Attachment Regions and ATC-Sequence Context-Specific MAR-Binding Proteins.
Nuclear Structure and Gene Expression
Contrasting effects of the SATB1 core nuclear matrix attachment region and flanking sequences of the keratin 18 gene in transgenic mice.
Molecular biology of the cell
A novel matrix attachment region DNA binding motif identified using a random phage peptide library.
The Journal of biological chemistry
[Biological significance of nuclear matrix attachment regions (MAR) and tissue specific MAR-DNA binding proteins].
Seikagaku. The Journal of Japanese Biochemical Society
Nucleolin is a matrix attachment region DNA-binding protein that specifically recognizes a region with high base-unpairing potential.
Molecular and cellular biology
A Novel DNA-Binding Motif in the Nuclear Matrix Attachment DNA-Binding Protein SATB1.
Molecular and cellular biology
A novel DNA-binding motif in the nuclear matrix attachment DNA-binding protein SATB1.
Molecular and cellular biology
A novel DNA-binding motif in the nuclear matrix attachment DNA-binding protein SATB1.
Molecular and cellular biology
The non-B-DNA structure of d(CA/TG)n differs from that of Z-DNA.
Proceedings of the National Academy of Sciences of the United States of America
A single trinucleotide, 5'AGC3'/5'GCT3', of the triplet-repeat disease genes confers metal ion-induced non-B DNA structure.
Nucleic acids research
Structural polymorphism of homopurine-homopyrimidine sequences at neutral pH.
Journal of molecular biology
Intramolecular dG.dG.dC triplex detected in Escherichia coli cells.
Journal of molecular biology
Biological significance of unwinding capability of nuclear matrix-associating DNAs.
Science (New York, N.Y.)
Detection of non-B-DNA structures at specific sites in supercoiled plasmid DNA and chromatin with haloacetaldehyde and diethyl pyrocarbonate.
Methods in enzymology
Altered gene expression correlates with DNA structure.
Genes & development
Detection of triple-helix related structures adopted by poly(dG)-poly(dC) sequences in supercoiled plasmid DNA.
Nucleic acids research
Torsional stress stabilizes extended base unpairing in suppressor sites flanking immunoglobulin heavy chain enhancer.
Biochemistry
Magnesium ion-dependent triple-helix structure formed by homopurine-homopyrimidine sequences in supercoiled plasmid DNA.
Proceedings of the National Academy of Sciences of the United States of America
The chemical carcinogen, chloroacetaldehyde, modifies a specific site within the regulatory sequence of human cytomegalovirus major immediate early gene in vivo.
Molecular carcinogenesis
Unusual conformational effect exerted by Z-DNA upon its neighboring sequences.
Proceedings of the National Academy of Sciences of the United States of America
Human fetal to adult hemoglobin switching: changes in chromatin structure of the beta-globin gene locus.
Proceedings of the National Academy of Sciences of the United States of America
Detection of an altered DNA conformation at specific sites in chromatin and supercoiled DNA.
Proceedings of the National Academy of Sciences of the United States of America
Hydrogen-exchange study of a nucleosome.
FEBS letters
Exposure of DNA bases induced by the interaction of DNA and calf thymus DNA helix-destabilizing protein.
Proceedings of the National Academy of Sciences of the United States of America