Terumi Kohwi-Shigematsu, PhD | Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF

The therapeutically actionable long non-coding RNA 'T-RECS' is essential to cancer cells' survival in NRAS/MAPK-driven melanoma.

Molecular cancer

Feichtenschlager V, Chen L, Zheng YJ, Ho W, Sanlorenzo M, Vujic I, Fewings E, Lee A, Chen C, Callanan C, Lin K, Qu T, Hohlova D, Vujic M, Hwang Y, Lai K, Chen S, Nguyen T, Muñoz DP, Kohwi Y, Posch C, Daud A, Rappersberger K, Kohwi-Shigematsu T, Coppé JP, Ortiz-Urda S

The therapeutically actionable long non-coding RNA 'T-RECS' is essential to cancer cells' survival in NRAS/MAPK-driven melanoma.

Research square

Feichtenschlager V, Chen L, Zheng YJ, Ho W, Sanlorenzo M, Vujic I, Fewings E, Lee A, Chen C, Callanan C, Lin K, Qu T, Hohlova D, Vujic M, Hwang Y, Lai K, Chen S, Nguyen T, Muñoz DP, Kohwi Y, Posch C, Daud A, Rappersberger K, Kohwi-Shigematsu T, Coppé JP, Ortiz-Urda S

Crucial Roles of SATB1 in Regulation of Thymocyte Migration after Positive Selection.

Journal of immunology (Baltimore, Md. : 1950)

Naito T, Ise M, Tanaka Y, Kohwi-Shigematsu T, Kondo M

Chromatin organizer SATB1 controls the cell identity of CD4+ CD8+ double-positive thymocytes by regulating the activity of super-enhancers.

Nature communications

Feng D, Chen Y, Dai R, Bian S, Xue W, Zhu Y, Li Z, Yang Y, Zhang Y, Zhang J, Bai J, Qin L, Kohwi Y, Shi W, Kohwi-Shigematsu T, Ma J, Liao S, Hao B

SATB1-dependent mitochondrial ROS production controls TCR signaling in CD4 T cells.

Life science alliance

Kuwabara T, Ishikawa F, Ikeda M, Ide T, Kohwi-Shigematsu T, Tanaka Y, Kondo M

Increased Indoleamine 2,3-Dioxygenase Levels at the Onset of Sjögren's Syndrome in SATB1-Conditional Knockout Mice.

International journal of molecular sciences

Tanaka Y, Onozato M, Mikami T, Kohwi-Shigematsu T, Fukushima T, Kondo M

Withdrawal: Selective cleavage of BLM, the Bloom syndrome protein, during apoptotic cell death.

The Journal of biological chemistry

Bischof O, Galande S, Farzaneh F, Kohwi-Shigematsu T, Campisi J

Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity.

Nature communications

Seo W, Shimizu K, Kojo S, Okeke A, Kohwi-Shigematsu T, Fujii SI, Taniuchi I

SATB1 establishes ameloblast cell polarity and regulates directional amelogenin secretion for enamel formation.

BMC biology

Zhang Y, Zheng L, Le M, Nakano Y, Chan B, Huang Y, Torbaty PM, Kohwi Y, Marcucio R, Habelitz S, Den Besten PK, Kohwi-Shigematsu T

Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation.

Nature communications

Yasuda K, Kitagawa Y, Kawakami R, Isaka Y, Watanabe H, Kondoh G, Kohwi-Shigematsu T, Sakaguchi S, Hirota K

Variable SATB1 Levels Regulate Hematopoietic Stem Cell Heterogeneity with Distinct Lineage Fate.

Cell reports

Doi Y, Yokota T, Satoh Y, Okuzaki D, Tokunaga M, Ishibashi T, Sudo T, Ueda T, Shingai Y, Ichii M, Tanimura A, Ezoe S, Shibayama H, Kohwi-Shigematsu T, Takeda J, Oritani K, Kanakura Y

671 Cross-talk between covalent DNA modifications and chromatin architecture: DNA dioxygenase Tet2 mediates the effects of chromatin architectural protein CTCF on epidermal barrier maintenance, inflammation and tumorigenesis.

Journal of Investigative Dermatology

I. Malashchuk, J. Rudolf, T. Vafaee, K. Poterlowicz, A. Sharov, M. Fessing, T. Kohwi-Shigematsu, G. Xu, A. Mardaryev, V. Botchkarev

Addendum: Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment.

Nature immunology

Kitagawa Y, Ohkura N, Kidani Y, Vandenbon A, Hirota K, Kawakami R, Yasuda K, Motooka D, Nakamura S, Kondo M, Taniuchi I, Kohwi-Shigematsu T, Sakaguchi S

091 5C analysis reveals distinct spatial contact networks between gene-rich and gene-poor TADs at the Epidermal Differentiation Complex in skin epithelial cells.

Journal of Investigative Dermatology

K. Poterlowicz, J. Yarker, I. Malashchuk, A.N. Mardaryev, M.R. Gdula, A. sharov, T. Kohwi-Shigematsu, V. Botchkarev, M.Y. Fessing

5C analysis of the Epidermal Differentiation Complex locus reveals distinct chromatin interaction networks between gene-rich and gene-poor TADs in skin epithelial cells.

PLoS genetics

Poterlowicz K, Yarker JL, Malashchuk I, Lajoie BR, Mardaryev AN, Gdula MR, Sharov AA, Kohwi-Shigematsu T, Botchkarev VA, Fessing MY

Erratum: Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment.

Nature immunology

Kitagawa Y, Ohkura N, Kidani Y, Vandenbon A, Hirota K, Kawakami R, Yasuda K, Motooka D, Nakamura S, Kondo M, Taniuchi I, Kohwi-Shigematsu T, Sakaguchi S

Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment.

Nature immunology

Kitagawa Y, Ohkura N, Kidani Y, Vandenbon A, Hirota K, Kawakami R, Yasuda K, Motooka D, Nakamura S, Kondo M, Taniuchi I, Kohwi-Shigematsu T, Sakaguchi S

SATB1 Expression Helps in Identification of the Lymphoid-Lineage-Biased Trajectory of Functionally Fluctuating Hematopoietic Stem Cells.

Blood

Yukiko Doi, Takafumi Yokota, Yusuke Satoh, Tomoaki Ueda, Yasuhiro Shingai, Michiko Ichii, Akira Tanimura, Sachiko Ezoe, Hirohiko Shibayama, Kenji Oritani, Terumi Kohwi-Shigematsu, Yuzuru Kanakura

Satb2 Is Required for the Development of a Spinal Exteroceptive Microcircuit that Modulates Limb Position.

Neuron

Hilde KL, Levine AJ, Hinckley CA, Hayashi M, Montgomery JM, Gullo M, Driscoll SP, Grosschedl R, Kohwi Y, Kohwi-Shigematsu T, Pfaff SL

Correction: SATB1 Plays a Critical Role in Establishment of Immune Tolerance.

Journal of immunology (Baltimore, Md. : 1950)

Kondo M, Tanaka Y, Kuwabara T, Naito T, Kohwi-Shigematsu T, Watanabe A

SATB1 Plays a Critical Role in Establishment of Immune Tolerance.

Journal of immunology (Baltimore, Md. : 1950)

Kondo M, Tanaka Y, Kuwabara T, Naito T, Kohwi-Shigematsu T, Watanabe A

An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development.

The Journal of experimental medicine

Hao B, Naik AK, Watanabe A, Tanaka H, Chen L, Richards HW, Kondo M, Taniuchi I, Kohwi Y, Kohwi-Shigematsu T, Krangel MS

Required enhancer-matrin-3 network interactions for a homeodomain transcription program.

Nature

Skowronska-Krawczyk D, Ma Q, Schwartz M, Scully K, Li W, Liu Z, Taylor H, Tollkuhn J, Ohgi KA, Notani D, Kohwi Y, Kohwi-Shigematsu T, Rosenfeld MG

The Satb1 protein directs hematopoietic stem cell differentiation toward lymphoid lineages.

Immunity

Satoh Y, Yokota T, Sudo T, Kondo M, Lai A, Kincade PW, Kouro T, Iida R, Kokame K, Miyata T, Habuchi Y, Matsui K, Tanaka H, Matsumura I, Oritani K, Kohwi-Shigematsu T, Kanakura Y

ATM suppresses SATB1-induced malignant progression in breast epithelial cells.

PloS one

Ordinario E, Han HJ, Furuta S, Heiser LM, Jakkula LR, Rodier F, Spellman PT, Campisi J, Gray JW, Bissell MJ, Kohwi Y, Kohwi-Shigematsu T

A network of genetic repression and derepression specifies projection fates in the developing neocortex.

Proceedings of the National Academy of Sciences of the United States of America

Srinivasan K, Leone DP, Bateson RK, Dobreva G, Kohwi Y, Kohwi-Shigematsu T, Grosschedl R, McConnell SK

SATB1-mediated functional packaging of chromatin into loops.

Methods (San Diego, Calif.)

Kohwi-Shigematsu T, Kohwi Y, Takahashi K, Richards HW, Ayers SD, Han HJ, Cai S

Genome organizing function of SATB1 in tumor progression.

Seminars in cancer biology

Kohwi-Shigematsu T, Poterlowicz K, Ordinario E, Han HJ, Botchkarev VA, Kohwi Y

Satb1 Determines Hematopoietic Stem Cell Differentiation Toward the Lymphoid Lineages.

Blood

Yusuke Satoh, Takafumi Yokota, Motonari Kondo, Paul W. Kincade, Taku Kouro, Ryuji Iida, Koichi Kokame, Toshiyuki Miyata, Takao Sudo, Hirokazu Tanaka, Itaru Matsumura, Kenji Oritani, Terumi Kohwi-Shigematsu, Yuzuru Kanakura

Satb1 ablation alters temporal expression of immediate early genes and reduces dendritic spine density during postnatal brain development.

Molecular and cellular biology

Balamotis MA, Tamberg N, Woo YJ, Li J, Davy B, Kohwi-Shigematsu T, Kohwi Y

SATB1 (SATB homeobox 1).

Atlas of Genetics and Cytogenetics in Oncology and Haematology

H Richards, T Kohwi-Shigematsu

p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis.

The Journal of cell biology

Fessing MY, Mardaryev AN, Gdula MR, Sharov AA, Sharova TY, Rapisarda V, Gordon KB, Smorodchenko AD, Poterlowicz K, Ferone G, Kohwi Y, Missero C, Kohwi-Shigematsu T, Botchkarev VA

Re: The role of SATB1 in breast cancer pathogenesis.

Journal of the National Cancer Institute

Kohwi-Shigematsu T, Han HJ, Russo J, Kohwi Y

Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression.

Genes & development

Savarese F, Dávila A, Nechanitzky R, De La Rosa-Velazquez I, Pereira CF, Engelke R, Takahashi K, Jenuwein T, Kohwi-Shigematsu T, Fisher AG, Grosschedl R

SATB1 defines the developmental context for gene silencing by Xist in lymphoma and embryonic cells.

Developmental cell

Agrelo R, Souabni A, Novatchkova M, Haslinger C, Leeb M, Komnenovic V, Kishimoto H, Gresh L, Kohwi-Shigematsu T, Kenner L, Wutz A

New advances in breast cancer metastasis.

Women's health (London, England)

Russo J, Han HJ, Kohwi Y, Kohwi-Shigematsu T

DLX5 expression is monoallelic and Dlx5 is up-regulated in the Mecp2-null frontal cortex.

Journal of cellular and molecular medicine

Miyano M, Horike S, Cai S, Oshimura M, Kohwi-Shigematsu T

SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis.

Nature

Han HJ, Russo J, Kohwi Y, Kohwi-Shigematsu T

A Distal Single Nucleotide Polymorphism Disrupts Development-Dependent Long-Range Transcriptional Regulation of the PU.1 Gene through the Chromatin-Remodeling Protein SATB1 in Acute Myeloid Leukemia.

Blood

Ulrich Steidl, Christian Steidl, Alexander Ebralidze, Bjoern Chapuy, Hye-Jung Han, Britta Will, Frank Rosenbauer, Annegret Becker, Katharina Wagner, Steffen Koschmieder, Susumu Kobayashi, Daniel B. Costa, Thomas Schulz, Karen B. O’Brien, Roel G.W. Verhaak, Ruud Delwel, Detlef Haase, Lorenz Trumper, Juergen Krauter, Terumi Kohwi-Shigematsu, Frank Griesinger, Daniel G. Tenen

A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia.

The Journal of clinical investigation

Steidl U, Steidl C, Ebralidze A, Chapuy B, Han HJ, Will B, Rosenbauer F, Becker A, Wagner K, Koschmieder S, Kobayashi S, Costa DB, Schulz T, O'Brien KB, Verhaak RG, Delwel R, Haase D, Trümper L, Krauter J, Kohwi-Shigematsu T, Griesinger F, Tenen DG

SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes.

Nature genetics

Cai S, Lee CC, Kohwi-Shigematsu T

A nuclear targeting determinant for SATB1, a genome organizer in the T cell lineage.

Cell cycle (Georgetown, Tex.)

Nakayama Y, Mian IS, Kohwi-Shigematsu T, Ogawa T

SATB1 family protein expressed during early erythroid differentiation modifies globin gene expression.

Blood

Wen J, Huang S, Rogers H, Dickinson LA, Kohwi-Shigematsu T, Noguchi CT

Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome.

Nature genetics

Horike S, Cai S, Miyano M, Cheng JF, Kohwi-Shigematsu T

Tissue-specific nuclear architecture and gene expression regulated by SATB1.

Nature genetics

Cai S, Han HJ, Kohwi-Shigematsu T

Mapping the initial DNA breaks in apoptotic Jurkat cells using ligation-mediated PCR.

Cell death and differentiation

Liu QY, Ribecco-Lutkiewicz M, Carson C, Testolin L, Bergeron D, Kohwi-Shigematsu T, Walker PR, Sikorska M

SATB1 targets chromatin remodelling to regulate genes over long distances.

Nature

Yasui D, Miyano M, Cai S, Varga-Weisz P, Kohwi-Shigematsu T

Identification of a candidate regulatory region in the human CD8 gene complex by colocalization of DNase I hypersensitive sites and matrix attachment regions which bind SATB1 and GATA-3.

Journal of immunology (Baltimore, Md. : 1950)

Kieffer LJ, Greally JM, Landres I, Nag S, Nakajima Y, Kohwi-Shigematsu T, Kavathas PB

Matrix Attachment Regions.

Wiley Encyclopedia of Molecular Medicine

Terumi Kohwi-Shigematsu, Yoshinori Kohwi

The Bloom Syndrome Protein BLM Is Selectively Cleaved during Apoptotic Cell Death.

TheScientificWorldJournal

Bischof O, Galande S, Kohwi-Shigematsu T, Campisi J, Dejean A

The matrix attachment region-binding protein SATB1 interacts with multiple elements within the gp91phox promoter and is down-regulated during myeloid differentiation.

The Journal of biological chemistry

Hawkins SM, Kohwi-Shigematsu T, Skalnik DG

SATB1 cleavage by caspase 6 disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis.

Molecular and cellular biology

Galande S, Dickinson LA, Mian IS, Sikorska M, Kohwi-Shigematsu T

Modulated binding of SATB1, a matrix attachment region protein, to the AT-rich sequence flanking the major breakpoint region of BCL2.

Molecular and cellular biology

Ramakrishnan M, Liu WM, DiCroce PA, Posner A, Zheng J, Kohwi-Shigematsu T, Krontiris TG

Caught in the act: binding of Ku and PARP to MARs reveals novel aspects of their functional interaction.

Critical reviews in eukaryotic gene expression

Galande S, Kohwi-Shigematsu T

Linking chromatin architecture to cellular phenotype: BUR-binding proteins in cancer.

Journal of cellular biochemistry. Supplement

Galande S, Kohwi-Shigematsu T

HMG-I(Y) recognizes base-unpairing regions of matrix attachment sequences and its increased expression is directly linked to metastatic breast cancer phenotype.

Cancer research

Liu WM, Guerra-Vladusic FK, Kurakata S, Lupu R, Kohwi-Shigematsu T

Intranuclear relocalization of matrix binding sites during T cell activation detected by amplified fluorescence in situ hybridization.

Methods (San Diego, Calif.)

Cai S, Kohwi-Shigematsu T

Poly(ADP-ribose) polymerase and Ku autoantigen form a complex and synergistically bind to matrix attachment sequences.

The Journal of biological chemistry

Galande S, Kohwi-Shigematsu T

The genomic sequences bound to special AT-rich sequence-binding protein 1 (SATB1) in vivo in Jurkat T cells are tightly associated with the nuclear matrix at the bases of the chromatin loops.

The Journal of cell biology

de Belle I, Cai S, Kohwi-Shigematsu T

An atypical homeodomain in SATB1 promotes specific recognition of the key structural element in a matrix attachment region.

The Journal of biological chemistry

Dickinson LA, Dickinson CD, Kohwi-Shigematsu T

Association of nuclear matrix proteins with granular and threaded nuclear bodies in cell lines undergoing apoptosis.

Experimental cell research

Zweyer M, Riederer BM, Ochs RL, Fackelmayer FO, Kohwi-Shigematsu T, Bareggi R, Narducci P, Martelli AM

4 High Unwinding Capability of Matrix Attachment Regions and ATC-Sequence Context-Specific MAR-Binding Proteins.

Nuclear Structure and Gene Expression

Terumi Kohwi-Shigematsu, Yoshinori Kohwi

Contrasting effects of the SATB1 core nuclear matrix attachment region and flanking sequences of the keratin 18 gene in transgenic mice.

Molecular biology of the cell

Neznanov N, Kohwi-Shigematsu T, Oshima RG

A matrix attachment region (MAR)-binding activity due to a p114 kilodalton protein is found only in human breast carcinomas and not in normal and benign breast disease tissues.

Cancer research

Yanagisawa J, Ando J, Nakayama J, Kohwi Y, Kohwi-Shigematsu T

A novel matrix attachment region DNA binding motif identified using a random phage peptide library.

The Journal of biological chemistry

Wang B, Dickinson LA, Koivunen E, Ruoslahti E, Kohwi-Shigematsu T

[Biological significance of nuclear matrix attachment regions (MAR) and tissue specific MAR-DNA binding proteins].

Seikagaku. The Journal of Japanese Biochemical Society

Kohwi Y, Kohwi-Shigematsu T

Nucleolin is a matrix attachment region DNA-binding protein that specifically recognizes a region with high base-unpairing potential.

Molecular and cellular biology

Dickinson LA, Kohwi-Shigematsu T

A single trinucleotide, 5'AGC3'/5'GCT3', of the triplet-repeat disease genes confers metal ion-induced non-B DNA structure.

Nucleic acids research

Kohwi Y, Wang H, Kohwi-Shigematsu T

Detection of non-B-DNA structures at specific sites in supercoiled plasmid DNA and chromatin with haloacetaldehyde and diethyl pyrocarbonate.

Methods in enzymology

Kohwi-Shigematsu T, Kohwi Y

Hierarchical binding of DNA fragments derived from scaffold-attached regions: correlation of properties in vitro and function in vivo.

Biochemistry

Mielke C, Kohwi Y, Kohwi-Shigematsu T, Bode J

Magnesium ion-dependent triple-helix structure formed by homopurine-homopyrimidine sequences in supercoiled plasmid DNA.

Proceedings of the National Academy of Sciences of the United States of America

Kohwi Y, Kohwi-Shigematsu T

An ultimate chemical carcinogen, N-acetoxy-2-acetylaminofluorene, detects non-B DNA structures that are reactive with chloroacetaldehyde in supercoiled plasmid DNA.

Carcinogenesis

Kohwi-Shigematsu T, Scribner N, Kohwi Y

The chemical carcinogen, chloroacetaldehyde, modifies a specific site within the regulatory sequence of human cytomegalovirus major immediate early gene in vivo.

Molecular carcinogenesis

Kohwi-Shigematsu T, Nelson JA

Publications