
Professor
Orthopaedic Surgery
+1 415 502-6523
Tamara Alliston, PhD studies the mechanobiologic mechanisms supporting skeletal health and driving arthritis, osteoporosis, and bone fragility.
Publications
Mass Spectrometry Imaging of the Subchondral Bone in Osteoarthritis Reveals Tissue Remodeling of Extracellular Matrix Proteins that Precede Cartilage Loss.
bioRxiv : the preprint server for biology
Skeletal pathology in mouse models of Gould syndrome is partially alleviated by genetically reducing TGFβ signaling.
Matrix biology : journal of the International Society for Matrix Biology
The osteocytic actions of glucocorticoids on bone mass, mechanical properties, or perilacunar remodeling outcomes are not rescued by PTH(1-34).
Frontiers in endocrinology
Spatial control of perilacunar canalicular remodeling during lactation.
Scientific reports
Effect of passaging on bovine chondrocyte gene expression and engineered cartilage production.
Tissue engineering. Part A
Priming chondrocytes during expansion alters cell behavior and improves matrix production in 3D culture.
Osteoarthritis and Cartilage
Deep learning models to map osteocyte networks can successfully distinguish between young and aged bone.
bioRxiv : the preprint server for biology
Genetic and Gene Expression Resources for Osteoporosis and Bone Biology Research.
Current osteoporosis reports
Senescence and Inflammation: Summary of a Gerontological Society of America and National Institute on Aging-Sponsored Symposium.
The journals of gerontology. Series A, Biological sciences and medical sciences
The Multifaceted Effects of Osteocytic TGFβ Signaling on the Skeletal and Extraskeletal Functions of Bone.
Current osteoporosis reports
Zoledronic acid improves bone quality and muscle function in a high bone turnover state.
bioRxiv : the preprint server for biology
Molecular and Cellular Crosstalk between Bone and Brain: Accessing Bidirectional Neural and Musculoskeletal Signaling during Aging and Disease.
Journal of bone metabolism
Osteocyte Control of Bone Quality and Fragility in Skeletal Aging.
The FASEB Journal
At the Crux of Joint Crosstalk: TGFβ Signaling in the Synovial Joint.
Current rheumatology reports
Prioritization of Genes Relevant to Bone Fragility Through the Unbiased Integration of Aging Mouse Bone Transcriptomics and Human GWAS Analyses.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Mechanosensitive miR-100 coordinates TGFβ and Wnt signaling in osteocytes during fluid shear stress.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Disrupted osteocyte connectivity and pericellular fluid flow in bone with aging and defective TGF-� signaling.
Proceedings of the National Academy of Sciences of the United States of America
Altered canalicular remodeling associated with femur fracture in mice.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Osteocyte-Specific TGFß Signaling Mitigates Obesity-Induced Deregulated Energy Metabolism and Compromised Bone Quality.
Journal of the Endocrine Society
Fluid shear stress generates a unique signaling response by activating multiple TGF� family type I receptors in osteocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Mechanosensitive Control of Articular Cartilage and Subchondral Bone Homeostasis in Mice Requires Osteocytic Transforming Growth Factor � Signaling.
Arthritis & rheumatology (Hoboken, N.J.)
Assessment of Osteocytes: Techniques for Studying Morphological and Molecular Changes Associated with Perilacunar/Canalicular Remodeling of the Bone Matrix.
Methods in molecular biology (Clifton, N.J.)
Quantitative and qualitative bone imaging: A review of synchrotron radiation microtomography analysis in bone research.
Journal of the mechanical behavior of biomedical materials
TGF� Regulation of Perilacunar/Canalicular Remodeling Is Sexually Dimorphic.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
OR29-04 TGFß Regulates Bone Perilacunar/Canalicular Remodeling in a Sexually Dimorphic Manner.
Journal of the Endocrine Society
The importance of diversity, equity, and inclusion in orthopedic research.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Cartilage/Bone Crosstalk in Joint Health and Disease.
Osteoarthritis and Cartilage
Biologically Regulated Marrow Stimulation by Blocking TGF-�1 With Losartan Oral Administration Results in Hyaline-like Cartilage Repair: A Rabbit Osteochondral Defect Model.
The American journal of sports medicine
CYLD, a mechanosensitive deubiquitinase, regulates TGF� signaling in load-induced bone formation.
Bone
Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis.
Bone research
Investigating Osteocytic Perilacunar/Canalicular Remodeling.
Current osteoporosis reports
Improvement of Cartilage Repair With Biologically Regulated Marrow
Stimulation by Blocking TGF-ß1 in A Rabbit Osteochondral Defect
Model.
Orthopaedic Journal of Sports Medicine
Bone Quality Sleuths: Uncovering Tissue-Level Mechanisms of Bone Fragility in Human Type 2 Diabetes.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
T1?-based fibril-reinforced poroviscoelastic constitutive relation of human articular cartilage using inverse finite element technology.
Quantitative imaging in medicine and surgery
Glucocorticoids cause mandibular bone fragility and suppress osteocyte perilacunar-canalicular remodeling.
Bone reports
Bone marrow lesions in osteoarthritis: What lies beneath.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Contributions of Material Properties and Structure to Increased Bone Fragility for a Given Bone Mass in the UCD-T2DM Rat Model of Type 2 Diabetes.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Fatigue as the missing link between bone fragility and fracture.
Nature biomedical engineering
A modular approach to creating large engineered cartilage surfaces.
Journal of biomechanics
Osteocyte-Intrinsic TGF-� Signaling Regulates Bone Quality through Perilacunar/Canalicular Remodeling.
Cell reports
Dynamic imaging demonstrates that pulsed electromagnetic fields (PEMF) suppress IL-6 transcription in bovine nucleus pulposus cells.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Glucocorticoid suppression of osteocyte perilacunar remodeling is associated with subchondral bone degeneration in osteonecrosis.
Scientific reports
Effects of cell type and configuration on anabolic and catabolic activity in 3D co-culture of mesenchymal stem cells and nucleus pulposus cells.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Mechanobiology of TGF� signaling in the skeleton.
Matrix biology : journal of the International Society for Matrix Biology
Correlating high-resolution magic angle spinning NMR spectroscopy and gene analysis in osteoarthritic cartilage.
NMR in biomedicine
Pulsed Electromagnetic Fields (PEMF) Inhibit Matrix Metalloproteinase-13 Expression in Human Annulus Fibrosus Cells.
The Spine Journal
Calluses flex their muscles to align bone fragments during fracture repair.
Developmental cell
Biological regulation of bone quality.
Current osteoporosis reports
How tough is brittle bone? Investigating osteogenesis imperfecta in mouse bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Ligand-independent and tissue-selective androgen receptor inhibition by pyrvinium.
ACS chemical biology
Evolution of a developmental mechanism: Species-specific regulation of the cell cycle and the timing of events during craniofacial osteogenesis.
Developmental biology
Development of a porous poly(DL-lactic acid-co-glycolic acid)-based scaffold for mastoid air-cell regeneration.
The Laryngoscope
Smad3 binds Scleraxis and Mohawk and regulates tendon matrix organization.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Accumulation of exogenous activated TGF-� in the superficial zone of articular cartilage.
Biophysical journal
Regulation of postnatal bone homeostasis by TGF�.
BoneKEy reports
Load regulates bone formation and Sclerostin expression through a TGF�-dependent mechanism.
PloS one
Chondrocyte-intrinsic Smad3 represses Runx2-inducible matrix metalloproteinase 13 expression to maintain articular cartilage and prevent osteoarthritis.
Arthritis and rheumatism
Matrix metalloproteinase-13 is required for osteocytic perilacunar remodeling and maintains bone fracture resistance.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Smad3 Modulates Tendon Gene Expression and Interacts with Key Tendon Transcription Factors Not a clinical study.
The Journal Of Hand Surgery
ECM stiffness primes the TGF� pathway to promote chondrocyte differentiation.
Molecular biology of the cell
150 QUANTITATIVE AND HISTOPATHOLOGICAL ANALYSIS OF OSTEO-ARTHRITIC CARTILAGE USING MRI, HRMAS SPECTROSCOPY AND IMMUNO-HISTOCHEMISTRY.
Osteoarthritis and Cartilage
Age-related changes in the plasticity and toughness of human cortical bone at multiple length scales.
Proceedings of the National Academy of Sciences of the United States of America
TGFß and Runx2 calibration of bone extracellular matrix quality for tissue-specific function.
BoneKEy reports
Structured three-dimensional co-culture of mesenchymal stem cells with chondrocytes promotes chondrogenic differentiation without hypertrophy.
Osteoarthritis and Cartilage
Local tissue properties of human osteoarthritic cartilage correlate with magnetic resonance T(1) rho relaxation times.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
The use of polyacrylamide gels for mechanical calibration of cartilage--a combined nanoindentation and unconfined compression study.
Journal of the mechanical behavior of biomedical materials
Examination of Bone Ossification Markers in Cochlear Development.
The Laryngoscope
Changes in cortical bone response to high-fat diet from adolescence to adulthood in mice.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Chondroitin sulfate and growth factor signaling in the skeleton: Possible links to MPS VI.
Journal of pediatric rehabilitation medicine
Tissue Interactions in Long Bone Development.
Bone and Development
Reduced size-independent mechanical properties of cortical bone in high-fat diet-induced obesity.
Bone
The tissue diagnostic instrument.
The Review of scientific instruments
A tense situation: forcing tumour progression.
Nature reviews. Cancer
Chapter 53 Transforming Growth Factor-ß.
Principles of Bone Biology
Elevated TGF-beta2 signaling in dentin results in sex related enamel defects.
Archives of oral biology
TGF-beta regulation of osteoblast differentiation and bone matrix properties.
Journal of musculoskeletal & neuronal interactions
Smads In Mesenchymal Differentiation.
Smad Signal Transduction
TGF-beta regulates the mechanical properties and composition of bone matrix.
Proceedings of the National Academy of Sciences of the United States of America
Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3.
The EMBO journal
Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1.
The Journal of biological chemistry
Transforming growth factor-beta 1 regulation of collagenase-3 expression in osteoblastic cells by cross-talk between the Smad and MAPK signaling pathways and their components, Smad2 and Runx2.
The Journal of biological chemistry
TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation.
The EMBO journal
Functional and subcellular changes in the A-kinase-signaling pathway: relation to aromatase and Sgk expression during the transition of granulosa cells to luteal cells.
Molecular endocrinology (Baltimore, Md.)
Molecular mechanisms of ovulation and luteinization.
Molecular and cellular endocrinology
Follicle stimulating hormone-regulated expression of serum/glucocorticoid-inducible kinase in rat ovarian granulosa cells: a functional role for the Sp1 family in promoter activity.
Molecular endocrinology (Baltimore, Md.)
Ovarian cell differentiation: a cascade of multiple hormones, cellular signals, and regulated genes.
Recent progress in hormone research