
Professor
Laboratory Medicine
+1 415 502-1634
Shibani Pati, MD, PhD studies the role of endothelial dysfunction and vascular compromise in the pathogenesis of human disease. Her specific areas of investigation involve the use of stem cells and novel resuscitative modalities that can mitigate endothelial dysfunction in traumatic injury.
Publications
Immediate use cryoprecipitate products provide lasting organ protection in a rodent model of trauma/hemorrhagic shock and prolonged hypotensive resuscitation.
The journal of trauma and acute care surgery
Early lyophilized cryoprecipitate enhances the ADAMTS13/VWF ratio to reduce systemic endotheliopathy and lessen lung injury in a mouse multiple-trauma hemorrhage model.
The journal of trauma and acute care surgery
Histone deacetylase-6 modulates the effects of 4°C platelets on vascular endothelial permeability.
Blood advances
RECOVERY OF ENDOTHELIOPATHY AT 24 HOURS IN AN ESTABLISHED MOUSE MODEL OF HEMORRHAGIC SHOCK AND TRAUMA.
Shock (Augusta, Ga.)
Biomarkers of endothelial cell dysfunction persist beyond resuscitation in patients with hemorrhagic shock.
The journal of trauma and acute care surgery
Lyophilized plasma resuscitation downregulates inflammatory gene expression in a mouse model of sepsis.
The journal of trauma and acute care surgery
FFP maintains normal coagulation while Kcentra induces a hypercoagulable state in a porcine model of pulmonary contusion and hemorrhagic shock.
The journal of trauma and acute care surgery
Mesenchymal stem cell extracellular vesicles mitigate vascular permeability and injury in the small intestine and lung in a mouse model of hemorrhagic shock and trauma.
The journal of trauma and acute care surgery
Cryoprecipitate attenuates the endotheliopathy of trauma in mice subjected to hemorrhagic shock and trauma.
The journal of trauma and acute care surgery
Evidence-Based and Clinically Relevant Outcomes for Hemorrhage Control Trauma Trials.
Annals of surgery
Freeze-dried platelets promote clot formation, attenuate endothelial cell permeability, and decrease pulmonary vascular leak in a murine model of hemorrhagic shock.
The journal of trauma and acute care surgery
The effects of human prothrombin complex concentrate on hemorrhagic shock-induced lung injury in rats: Implications for testing human blood products in rodents.
The journal of trauma and acute care surgery
Fresh frozen plasma attenuates lung injury in a novel model of prolonged hypotensive resuscitation.
The journal of trauma and acute care surgery
Resuscitative Strategies to Modulate the Endotheliopathy of Trauma: From Cell to Patient.
Shock (Augusta, Ga.)
Aggressive treatment of acute kidney injury and hyperkalemia improves survival in a combat relevant trauma model in swine.
American journal of surgery
Is all plasma created equal? A pilot study of the effect of interdonor variability.
The journal of trauma and acute care surgery
Platelet-derived- Extracellular Vesicles Promote Hemostasis and Prevent the Development of Hemorrhagic Shock.
Scientific reports
Regulation of endothelial cell permeability by platelet-derived extracellular vesicles.
The journal of trauma and acute care surgery
Bone marrow donor selection and characterization of MSCs is critical for pre-clinical and clinical cell dose production.
Journal of translational medicine
Regulation of Endothelial Cell Permeability by Platelet-Derived Extracellular Vesicles.
The journal of trauma and acute care surgery
Introduction to the supplement on cellular therapies in trauma and critical care medicine.
Transfusion
Barriers to clinical research in trauma.
Transfusion
Multipotent Adult Progenitor Cells, but Not Tissue Inhibitor of Matrix Metalloproteinase-3, Increase Tissue Sparing and Reduce Urological Complications following Spinal Cord Injury.
Journal of neurotrauma
A combat relevant model for the creation of acute lung injury in swine.
The journal of trauma and acute care surgery
Elevated plasma levels of TIMP-3 are associated with a higher risk of acute respiratory distress syndrome and death following severe isolated traumatic brain injury.
Trauma surgery & acute care open
Platelet-Derived Microvesicles: A Potential Therapy for Trauma-Induced Coagulopathy.
Shock (Augusta, Ga.)
Cellular therapies and stem cell applications in trauma.
American journal of surgery
Mesenchymal stem cell-derived extracellular vesicles attenuate pulmonary vascular permeability and lung injury induced by hemorrhagic shock and trauma.
The journal of trauma and acute care surgery
Plasma Resuscitation Improved Survival in a Cecal Ligation and Puncture Rat Model of Sepsis.
Shock (Augusta, Ga.)
Concise Review: Mesenchymal Stem (Stromal) Cells: Biology and Preclinical Evidence for Therapeutic Potential for Organ Dysfunction Following Trauma or Sepsis.
Stem cells (Dayton, Ohio)
Lack of species-specific difference in pulmonary function when using mouse versus human plasma in a mouse model of hemorrhagic shock.
The journal of trauma and acute care surgery
Plasma Transfusion: History, Current Realities, and Novel Improvements.
Shock (Augusta, Ga.)
Wnt3a, a Protein Secreted by Mesenchymal Stem Cells Is Neuroprotective and Promotes Neurocognitive Recovery Following Traumatic Brain Injury.
Stem cells (Dayton, Ohio)
Modulating the endotheliopathy of trauma: Factor concentrate versus fresh frozen plasma.
The journal of trauma and acute care surgery
The effects of 22°C and 4°C storage of platelets on vascular endothelial integrity and function.
Transfusion
Cellular Therapies in Trauma and Critical Care Medicine: Forging New Frontiers.
Shock (Augusta, Ga.)
Plasma-Mediated Gut Protection After Hemorrhagic Shock is Lessened in Syndecan-1-/- Mice.
Shock (Augusta, Ga.)
TIMP3 Attenuates the Loss of Neural Stem Cells, Mature Neurons and Neurocognitive Dysfunction in Traumatic Brain Injury.
Stem cells (Dayton, Ohio)
Fresh frozen plasma and spray-dried plasma mitigate pulmonary vascular permeability and inflammation in hemorrhagic shock.
The journal of trauma and acute care surgery
Syndecan-1 restitution by plasma after hemorrhagic shock.
The journal of trauma and acute care surgery
Endothelial glycocalyx shedding and vascular permeability in severely injured trauma patients.
Journal of translational medicine
The whole is greater than the sum of its parts: hemostatic profiles of whole blood variants.
The journal of trauma and acute care surgery
Never-frozen liquid plasma blocks endothelial permeability as effectively as thawed fresh frozen plasma.
The journal of trauma and acute care surgery
Trauma hemostasis and oxygenation research position paper on remote damage control resuscitation: definitions, current practice, and knowledge gaps.
Shock (Augusta, Ga.)
Autologous bone marrow mononuclear cells therapy attenuates activated microglial/macrophage response and improves spatial learning after traumatic brain injury.
The journal of trauma and acute care surgery
Fresh frozen plasma lessens pulmonary endothelial inflammation and hyperpermeability after hemorrhagic shock and is associated with loss of syndecan 1.
Shock (Augusta, Ga.)
Coronary microvascular pericytes are the cellular target of sunitinib malate-induced cardiotoxicity.
Science translational medicine
Optimal trauma resuscitation with plasma as the primary resuscitative fluid: the surgeon's perspective.
Hematology. American Society of Hematology. Education Program
Mesenchymal stem cells regulate blood-brain barrier integrity through TIMP3 release after traumatic brain injury.
Science translational medicine
Human mesenchymal stem cells inhibit endothelial proliferation and angiogenesis via cell-cell contact through modulation of the VE-Cadherin/β-catenin signaling pathway.
Stem cells and development
Caffeic Acid phenethyl ester protects blood-brain barrier integrity and reduces contusion volume in rodent models of traumatic brain injury.
Journal of neurotrauma
Aged plasma transfusion increases mortality in a rat model of uncontrolled hemorrhage.
The Journal of trauma
Increased platelet:RBC ratios are associated with improved survival after massive transfusion.
The Journal of trauma
Increased transforming growth factor β contributes to deterioration of refrigerated fresh frozen plasma's effects in vitro on endothelial cells.
Shock (Augusta, Ga.)
Plasma restoration of endothelial glycocalyx in a rodent model of hemorrhagic shock.
Anesthesia and analgesia
Human Bone Marrow Derived Mesenchymal Stem Cells Regulate Leukocyte-Endothelial Interactions and Activation of Transcription Factor NF-Kappa B.
Journal of tissue science & engineering
Human mesenchymal stem cells inhibit vascular permeability by modulating vascular endothelial cadherin/β-catenin signaling.
Stem cells and development
Mesenchymal stem cells stimulate protective genetic reprogramming of injured cardiac ventricular myocytes.
Journal of molecular and cellular cardiology
Intravenous multipotent adult progenitor cell therapy for traumatic brain injury: preserving the blood brain barrier via an interaction with splenocytes.
Experimental neurology
Direct intrathecal implantation of mesenchymal stromal cells leads to enhanced neuroprotection via an NFkappaB-mediated increase in interleukin-6 production.
Stem cells and development
Fresh frozen plasma increases adhesion molecule expression on human pulmonary endothelial cells.
The Journal of surgical research
Cardiomyocyte PDGFR-beta signaling is an essential component of the mouse cardiac response to load-induced stress.
The Journal of clinical investigation
Intra-hippocampal administration of the VEGF receptor blocker PTK787/ZK222584 impairs long-term memory.
Brain research
Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma.
The Journal of experimental medicine
Suppression of MIP-1beta transcription in human T cells is regulated by inducible cAMP early repressor (ICER).
Journal of leukocyte biology
Tumorigenesis by human herpesvirus 8 vGPCR is accelerated by human immunodeficiency virus type 1 Tat.
Journal of virology
Human herpesvirus 8-encoded vGPCR activates nuclear factor of activated T cells and collaborates with human immunodeficiency virus type 1 Tat.
Journal of virology
Activation of NF-kappaB by the human herpesvirus 8 chemokine receptor ORF74: evidence for a paracrine model of Kaposi's sarcoma pathogenesis.
Journal of virology
Human herpesvirus 8 K1-associated nuclear factor-kappa B-dependent promoter activity: role in Kaposi's sarcoma inflammation?
Journal of the National Cancer Institute. Monographs
Urinary proteins with pro-apoptotic and antitumor activity.
Apoptosis : an international journal on programmed cell death
HIV-1 protease inhibitor ritonavir modulates susceptibility to apoptosis of uninfected T cells.
Journal of human virology
Gain of function mutations in p53.
Nature genetics