Seyedeh Faranak Fattahi, PhD

Assistant Professor
Cellular Molecular Pharmacology
[email protected]
+1 415 476-6737

Faranak Fattahi, PhD uses human pluripotent stem cells to study the peripheral nervous system in health and disease with the goal of developing novel therapies through drug discovery and regenerative medicine.

Publications: 

Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy.

Cell stem cell

Majd H, Amin S, Ghazizadeh Z, Cesiulis A, Arroyo E, Lankford K, Majd A, Farahvashi S, Chemel AK, Okoye M, Scantlen MD, Tchieu J, Calder EL, Le Rouzic V, Shibata B, Arab A, Goodarzi H, Pasternak G, Kocsis JD, Chen S, Studer L, Fattahi F

Generation of Schwann cell derived melanocytes from hPSCs identifies pro-metastatic factors in melanoma.

bioRxiv : the preprint server for biology

Samuel RM, Navickas A, Maynard A, Gaylord EA, Garcia K, Bhat S, Majd H, Richter MN, Elder N, Le D, Nguyen P, Shibata B, Llabata ML, Selleri L, Laird DJ, Darmanis S, Goodarzi H, Fattahi F

Programming multicellular assembly with synthetic cell adhesion molecules.

Nature

Stevens AJ, Harris AR, Gerdts J, Kim KH, Trentesaux C, Ramirez JT, McKeithan WL, Fattahi F, Klein OD, Fletcher DA, Lim WA

Diseased, differentiated and difficult: Strategies for improved engineering of in vitro neurological systems.

Frontiers in cellular neuroscience

Elder N, Fattahi F, McDevitt TC, Zholudeva LV

Androgens increase excitement in brain organoid research.

Cell stem cell

Samuel RM, Majd H, Richter MN, Fattahi F

A dual SHOX2:GFP; MYH6:mCherry knockin hESC reporter line for derivation of human SAN-like cells.

iScience

Ghazizadeh Z, Zhu J, Fattahi F, Tang A, Sun X, Amin S, Tsai SY, Khalaj M, Zhou T, Samuel RM, Zhang T, Ortega FA, Gordillo M, Moroziewicz D, NYSCF Global Stem Cell Array? Team, Paull D, Noggle SA, Xiang JZ, Studer L, Christini DJ, Pitt GS, Evans T, Chen S

5-Fluorouracil: A Narrative Review on the Role of Regulatory Mechanisms in Driving Resistance to This Chemotherapeutic Agent.

Frontiers in oncology

Ghafouri-Fard S, Abak A, Tondro Anamag F, Shoorei H, Fattahi F, Javadinia SA, Basiri A, Taheri M

The interaction between miRNAs/lncRNAs and nuclear factor-?B (NF-?B) in human disorders.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Ghafouri-Fard S, Abak A, Fattahi F, Hussen BM, Bahroudi Z, Shoorei H, Taheri M

Surface Proteomics Reveals CD72 as a Target for In Vitro-Evolved Nanobody-Based CAR-T Cells in KMT2A/MLL1-Rearranged B-ALL.

Cancer discovery

Nix MA, Mandal K, Geng H, Paranjape N, Lin YT, Rivera JM, Marcoulis M, White KL, Whitman JD, Bapat SP, Parker KR, Ramirez J, Deucher A, Phojanokong P, Steri V, Fattahi F, Hann BC, Satpathy AT, Manglik A, Stieglitz E, Wiita AP

Prospective Isolation of ISL1+ Cardiac Progenitors from Human ESCs for Myocardial Infarction Therapy.

Stem cell reports

Ghazizadeh Z, Fattahi F, Mirzaei M, Bayersaikhan D, Lee J, Chae S, Hwang D, Byun K, Tabar MS, Taleahmad S, Mirshahvaladi S, Shabani P, Fonoudi H, Haynes PA, Baharvand H, Aghdami N, Evans T, Lee B, Salekdeh GH

Human Induced Pluripotent Stem Cell Derived Sensory Neurons are Sensitive to the Neurotoxic Effects of Paclitaxel.

Clinical and translational science

Xiong C, Chua KC, Stage TB, Priotti J, Kim J, Altman-Merino A, Chan D, Saraf K, Canato Ferracini A, Fattahi F, Kroetz DL

Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men.

Cell stem cell

Samuel RM, Majd H, Richter MN, Ghazizadeh Z, Zekavat SM, Navickas A, Ramirez JT, Asgharian H, Simoneau CR, Bonser LR, Koh KD, Garcia-Knight M, Tassetto M, Sunshine S, Farahvashi S, Kalantari A, Liu W, Andino R, Zhao H, Natarajan P, Erle DJ, Ott M, Goodarzi H, Fattahi F

Androgen Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men.

bioRxiv : the preprint server for biology

Ghazizadeh Z, Majd H, Richter M, Samuel R, Zekavat SM, Asgharian H, Farahvashi S, Kalantari A, Ramirez J, Zhao H, Natarajan P, Goodarzi H, Fattahi F

Roadmap for the Emerging Field of Cancer Neuroscience.

Cell

Monje M, Borniger JC, D'Silva NJ, Deneen B, Dirks PB, Fattahi F, Frenette PS, Garzia L, Gutmann DH, Hanahan D, Hervey-Jumper SL, Hondermarck H, Hurov JB, Kepecs A, Knox SM, Lloyd AC, Magnon C, Saloman JL, Segal RA, Sloan EK, Sun X, Taylor MD, Tracey KJ, Trotman LC, Tuveson DA, Wang TC, White RA, Winkler F

Generation of Knockout Gene-Edited Human Intestinal Organoids.

Methods in molecular biology (Clifton, N.J.)

Rajendra C, Wald T, Barber K, Spence JR, Fattahi F, Klein OD

Derivation of enteric neuron lineages from human pluripotent stem cells.

Nature protocols

Barber K, Studer L, Fattahi F

HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons.

Nature communications

Kishinevsky S, Wang T, Rodina A, Chung SY, Xu C, Philip J, Taldone T, Joshi S, Alpaugh ML, Bolaender A, Gutbier S, Sandhu D, Fattahi F, Zimmer B, Shah SK, Chang E, Inda C, Koren J, Saurat NG, Leist M, Gross SS, Seshan VE, Klein C, Tomishima MJ, Erdjument-Bromage H, Neubert TA, Henrickson RC, Chiosis G, Studer L

Prospective Isolation of ISL1+ Cardiac Progenitors from Human ESCs for�Myocardial Infarction Therapy.

Stem cell reports

Ghazizadeh Z, Fattahi F, Mirzaei M, Bayersaikhan D, Lee J, Chae S, Hwang D, Byun K, Tabar MS, Taleahmad S, Mirshahvaladi S, Shabani P, Fonoudi H, Haynes PA, Baharvand H, Aghdami N, Evans T, Lee B, Salekdeh GH

A Modular Platform for Differentiation of Human PSCs into All Major Ectodermal Lineages.

Cell stem cell

Tchieu J, Zimmer B, Fattahi F, Amin S, Zeltner N, Chen S, Studer L

Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells.

Nature biotechnology

Qi Y, Zhang XJ, Renier N, Wu Z, Atkin T, Sun Z, Ozair MZ, Tchieu J, Zimmer B, Fattahi F, Ganat Y, Azevedo R, Zeltner N, Brivanlou AH, Karayiorgou M, Gogos J, Tomishima M, Tessier-Lavigne M, Shi SH, Studer L

Capturing the biology of disease severity in a PSC-based model of familial dysautonomia.

Nature medicine

Zeltner N, Fattahi F, Dubois NC, Saurat N, Lafaille F, Shang L, Zimmer B, Tchieu J, Soliman MA, Lee G, Casanova JL, Studer L

Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease.

Nature

Fattahi F, Steinbeck JA, Kriks S, Tchieu J, Zimmer B, Kishinevsky S, Zeltner N, Mica Y, El-Nachef W, Zhao H, de Stanchina E, Gershon MD, Grikscheit TC, Chen S, Studer L

Isolation and characterization of cardiogenic, stem-like cardiac precursors from heart samples of patients with congenital heart disease.

Life sciences

Ghazizadeh Z, Vahdat S, Fattahi F, Fonoudi H, Omrani G, Gholampour M, Aghdami N

Neural Crest Cells from Dual SMAD Inhibition.

Current protocols in stem cell biology

Fattahi F, Studer L, Tomishima MJ

Feeder-free derivation of neural crest progenitor cells from human pluripotent stem cells.

Journal of visualized experiments : JoVE

Zeltner N, Lafaille FG, Fattahi F, Studer L

Ankyloglossia and tongue mobility.

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry

Jamilian A, Fattahi FH, Kootanayi NG

Disease-corrected hepatocyte-like cells from familial hypercholesterolemia-induced pluripotent stem cells.

Molecular biotechnology

Fattahi F, Asgari S, Pournasr B, Seifinejad A, Totonchi M, Taei A, Aghdami N, Salekdeh GH, Baharvand H

ISL1 protein transduction promotes cardiomyocyte differentiation from human embryonic stem cells.

PloS one

Fonoudi H, Yeganeh M, Fattahi F, Ghazizadeh Z, Rassouli H, Alikhani M, Mojarad BA, Baharvand H, Salekdeh GH, Aghdami N

Comprehensive gene expression analysis of human embryonic stem cells during differentiation into neural cells.

PloS one

Fathi A, Hatami M, Hajihosseini V, Fattahi F, Kiani S, Baharvand H, Salekdeh GH