
Professor
Laboratory Medicine
+1 415 514-0815
Scott Kogan, MD studies leukemia stem cells in mouse models and is interested in devising better therapies that target these cells.
Publications
The Interrelationship between Preconception Folate Nutritional Intake and Child Genetic Liability in the Risk of Childhood Acute Lymphoblastic Leukemia.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Effective Treatment of Disseminated Prostate Cancer Using CD46-Targeted 225Ac Therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research
Early-life tobacco exposure is causally implicated in aberrant RAG-mediated recombination in childhood acute lymphoblastic leukemia.
Research square
Gene-Environment Analyses Reveal Novel Genetic Candidates with Prenatal Tobacco Exposure in Relation to Risk for Childhood Acute Lymphoblastic Leukemia.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Impact of pinworm infection on the development of murine B-cell leukemia/lymphoma in the presence and absence of ETV6::RUNX1.
Haematologica
Genetic architecture of the acute and persistent immune cell response after radiation exposure.
Cell genomics
The SWI/SNF chromatin-remodeling subunit DPF2 facilitates NRF2-dependent antiinflammatory and antioxidant gene expression.
The Journal of clinical investigation
Dapsone-induced methemoglobinemia and hemolysis in a woman without G6PD deficiency presenting with idiopathic urticaria.
Hematology (Amsterdam, Netherlands)
Genomic Features of Interstitial Deletions of Chromosome 9q in Acute Myeloid Leukemia.
Cytogenetic and genome research
Apixaban Concentrations in Routine Clinical Care of Older Adults With Nonvalvular Atrial Fibrillation.
JACC. Advances
Clinical characteristics of cytomegalovirus-positive pediatric acute lymphoblastic leukemia at diagnosis.
American journal of hematology
Decreased IL-10 accelerates B-cell leukemia/lymphoma in a mouse model of pediatric lymphoid leukemia.
Blood advances
Preventing Bleeding With Direct-Acting Oral Anticoagulants.
Journal of the American College of Cardiology
Nf1 and Sh2b3 mutations cooperate in vivo in a mouse model of juvenile myelomonocytic leukemia.
Blood advances
Cytokine Levels at Birth in Children Who Developed Acute Lymphoblastic Leukemia.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Epigenetic Biomarkers of Prenatal Tobacco Smoke Exposure Are Associated with Gene Deletions in Childhood Acute Lymphoblastic Leukemia.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Anti-factor Xa activity assays of direct-acting oral anticoagulants during clinical care: An observational study.
Research and practice in thrombosis and haemostasis
In utero and early-life exposure to thirdhand smoke causes profound changes to the immune system.
Clinical science (London, England : 1979)
Trends in Acute Lymphoblastic Leukemia Incidence in the United States by Race/Ethnicity From 2000 to 2016.
American journal of epidemiology
History of Early Childhood Infections and Acute Lymphoblastic Leukemia Risk Among Children in a US Integrated Health-Care System.
American journal of epidemiology
Human pediatric B-cell acute lymphoblastic leukemias can be classified as B-1 or B-2-like based on a minimal transcriptional signature.
Experimental hematology
Abstract A105: Trends in acute lymphocytic leukemia (ALL) incidence in the US from 2000-2016.
Cancer Epidemiology Biomarkers & Prevention
Abstract A23: A second site KrasG12D mutation that impairs PI3K binding rescues embryonic lethality, abrogates myeloproliferative disease, and delays lung tumorigenesis.
Molecular Cancer Research
FLT3-ITD impedes retinoic acid, but not arsenic, responses in murine acute promyelocytic leukemias.
Blood
Identification of IRF8 as a potent tumor suppressor in murine acute promyelocytic leukemia.
Blood advances
Dilute Russell viper venom time interpretation and clinical correlation: A two-year retrospective institutional review.
International journal of laboratory hematology
TCEA1 regulates the proliferative potential of mouse myeloid cells.
Experimental cell research
Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin.
Cellular and molecular gastroenterology and hepatology
Age-Related Impaired Efficacy of Bone Marrow Cell Therapy for Myocardial Infarction Reflects a Decrease in B Lymphocytes.
Molecular therapy : the journal of the American Society of Gene Therapy
Dual origin of relapses in retinoic-acid resistant acute promyelocytic leukemia.
Nature communications
Acute myeloid leukemia with t(14;21) involving RUNX1 and SYNE2: A novel favorable-risk translocation?
Cancer genetics
Pml Nuclear Body Disruption Cooperates in APL Pathogenesis, Impacting DNA Damage Repair Pathways.
Blood
DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia.
Cancer discovery
Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice.
The Journal of clinical investigation
Transcription and methylation analyses of preleukemic promyelocytes indicate a dual role for PML/RARA in leukemia initiation.
Haematologica
Direct and indirect targeting of MYC to treat acute myeloid leukemia.
Cancer chemotherapy and pharmacology
Crenolanib is a selective type I pan-FLT3 inhibitor.
Proceedings of the National Academy of Sciences of the United States of America
CUL4A induces epithelial-mesenchymal transition and promotes cancer metastasis by regulating ZEB1 expression.
Cancer research
Disruption Of PML Nuclear Bodies Cooperates In The Pathogenesis Of Acute Promyelocytic Leukemia.
Blood
Pten loss in the bone marrow leads to G-CSF-mediated HSC mobilization.
The Journal of experimental medicine
The histone demethylase PHF8 governs retinoic acid response in acute promyelocytic leukemia.
Cancer cell
Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice.
The Journal of clinical investigation
A dominantly acting murine allele of Mcm4 causes chromosomal abnormalities and promotes tumorigenesis.
PLoS genetics
Genetically mediated Nf1 loss in mice promotes diverse radiation-induced tumors modeling second malignant neoplasms.
Cancer research
Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity.
Genes & development
PML-RARα enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway.
Autophagy
Abstract A37: A dominantly acting allele of murine Mcm4 causes chromosome instability and promotes leukemiogenesis.
Cancer Genomics
Donor myocardial infarction impairs the therapeutic potential of bone marrow cells by an interleukin-1-mediated inflammatory response.
Science translational medicine
An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance.
Genes & development
A rapid and scalable system for studying gene function in mice using conditional RNA interference.
Cell
Treatment with 5-azacytidine accelerates acute promyelocytic leukemia leukemogenesis in a transgenic mouse model.
Genes & cancer
Dose-dependent effects of focal fractionated irradiation on secondary malignant neoplasms in Nf1 mutant mice.
Cancer research
Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus.
Blood
Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia.
The Journal of experimental medicine
PML-RAR{alpha} and Dnmt3a1 cooperate in vivo to promote acute promyelocytic leukemia.
Cancer research
p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal.
Genes & development
Abstract 3427A: Focal fractionated irradiation induces specific malignancies in a dose-dependent manner in Nf1 mutant mice.
Clinical Research
Medicine. Poisonous contacts.
Science (New York, N.Y.)
Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents.
Proceedings of the National Academy of Sciences of the United States of America
Mouse models of human AML accurately predict chemotherapy response.
Genes & development
Curing APL: differentiation or destruction?
Cancer cell
Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family.
Cell stem cell
Fractionated Cranial Irradiation Induces a Distinctive Pattern of Second Malignant Neoplasms in Nf1 Mutant Mice.
International Journal of Radiation Oncology • Biology • Physics
mTORC1 promotes survival through translational control of Mcl-1.
Proceedings of the National Academy of Sciences of the United States of America
The protective effect of KCNMB1 E65K against hypertension is restricted to blood pressure treatment with beta-blockade.
Journal of human hypertension
BCL-2 and mutant NRAS interact physically and functionally in a mouse model of progressive myelodysplasia.
Cancer research
Novel Mll-AF9 Cooperating Genes Identified in a Leukemogenesis Screen Using Retroviral Mutagenesis.
Blood
PPARgamma-active triterpenoid CDDO enhances ATRA-induced differentiation in APL.
Cancer biology & therapy
Mouse models of acute promyelocytic leukemia.
Current topics in microbiology and immunology
Dual treatment with FLT3 inhibitor SU11657 and doxorubicin increases survival of leukemic mice.
Leukemia research
Determinants of sensitivity and resistance to rapamycin-chemotherapy drug combinations in vivo.
Cancer research
Loss of p53 impedes the antileukemic response to BCR-ABL inhibition.
Proceedings of the National Academy of Sciences of the United States of America
Trp53 loss during in vitro selection contributes to acquired Ara-C resistance in acute myeloid leukemia.
Experimental hematology
Increased CCAAT enhancer-binding protein epsilon (C/EBPepsilon) expression and premature apoptosis in myeloid cells expressing Gfi-1 N382S mutant associated with severe congenital neutropenia.
The Journal of biological chemistry
Cbf beta-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia.
Cancer cell
Haploinsufficiency of Runx1/AML1 promotes myeloid features and leukaemogenesis in BXH2 mice.
British journal of haematology
Opinion: how patients have benefited from mouse models of acute promyelocytic leukaemia.
Nature reviews. Cancer
Role of O6-alkylguanine-DNA alkyltransferase in protecting against 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-induced long-term toxicities.
The Journal of pharmacology and experimental therapeutics
Cooperation of Cytokine Signaling with Chimeric Transcription Factors in Leukemogenesis: PML-Retinoic Acid Receptor Alpha Blocks Growth Factor-Mediated Differentiation.
Molecular and cellular biology
Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease.
The EMBO journal
O-14 A reversible two-step model ofMDS/preleukemia: Transgenic mice expressing inducible BCL2 and mutant NRAS.
Leukemia research
Myeloid Malignancies.
Mouse Models of Human Cancer
Mouse models of human cancers (part 3).
Comparative medicine
Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder.
Proceedings of the National Academy of Sciences of the United States of America
PML-RARA-targeted DNA vaccine induces protective immunity in a mouse model of leukemia.
Nature medicine
A PMLRARA transgene results in a retinoid-deficient phenotype associated with enhanced susceptibility to skin tumorigenesis.
Cancer research
Cooperation of cytokine signaling with chimeric transcription factors in leukemogenesis: PML-retinoic acid receptor alpha blocks growth factor-mediated differentiation.
Molecular and cellular biology
In vivo activation of cAMP signaling induces growth arrest and differentiation in acute promyelocytic leukemia.
The Journal of experimental medicine
Characteristics of consumer terminology for health information retrieval.
Methods of information in medicine
Retroviral integration at the Epi1 locus cooperates with Nf1 gene loss in the progression to acute myeloid leukemia.
Journal of virology
Mouse intestinal goblet cells expressing SV40 T antigen directed by the MUC2 mucin gene promoter undergo apoptosis upon migration to the villi.
Cancer research
BCL-2 cooperates with promyelocytic leukemia retinoic acid receptor alpha chimeric protein (PMLRARalpha) to block neutrophil differentiation and initiate acute leukemia.
The Journal of experimental medicine
Patient and clinician vocabulary: how different are they?
Studies in health technology and informatics
Problems and challenges in patient information retrieval: a descriptive study.
Proceedings. AMIA Symposium
Acute promyelocytic leukemia: a view from a mouse.
Blood cells, molecules & diseases
Images in clinical medicine. Indinavir crystalluria.
The New England journal of medicine
Retinoic acid and arsenic synergize to eradicate leukemic cells in a mouse model of acute promyelocytic leukemia.
The Journal of experimental medicine
The PEBP2betaMYH11 fusion created by Inv(16)(p13;q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasia.
Proceedings of the National Academy of Sciences of the United States of America
A PMLRARalpha transgene initiates murine acute promyelocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America
6 The effect of fractionated radiotherapy in glioblastoma depends on P53 function.
International Journal of Radiation Oncology • Biology • Physics
Inhibition of apoptosis by the retinoblastoma gene product.
The EMBO journal
157 P53-dependent G1 arrest and P53-independent apoptosis influence the radiobiologic response of glioblastoma.
International Journal of Radiation Oncology • Biology • Physics
Genitourinary malformations associated with agenesis of the corpus callosum.
The Journal of urology
Genetic basis of hemophilia A.
Thrombosis and haemostasis
Mutations and a polymorphism in the factor VIII gene discovered by denaturing gradient gel electrophoresis.
Proceedings of the National Academy of Sciences of the United States of America
35 GENETIC PREDICTION OF HEMOPHILIA A.
PCR Protocols
Accurate prenatal diagnosis with novel polymerase chain reaction primers in a family with sporadic hemophilia A.
Obstetrics and gynecology
An Improved Method for Prenatal Diagnosis of Genetic Diseases by Analysis of Amplified DNA Sequences.
Obstetrical & Gynecological Survey
An Improved Method for Prenatal Diagnosis of Genetic Diseases by Analysis of Amplified DNA Sequences.
Obstetrical & Gynecological Survey
An improved method for prenatal diagnosis of genetic diseases by analysis of amplified DNA sequences. Application to hemophilia A.
The New England journal of medicine