Scott Kogan, MD

Abstract 2281: The interrelationship between maternal periconception folate nutritional intake and child’s genetic liability in the etiology of childhood acute lymphoblastic leukemia.

Cancer research

Yijin Xiang, Catherine Metayer, Scott Kogan, Xiaomei Ma, Joseph Wiemels

Effective Treatment of Disseminated Prostate Cancer Using CD46-Targeted 225Ac Therapy.

Clinical cancer research : an official journal of the American Association for Cancer Research

Bidkar AP, Peter R, Wadhwa A, Bobba KN, Bidlingmaier S, Meher N, Chou J, Greenland N, Dasari C, Naik S, Raveendran A, Basak M, Camara Serrano JA, Steri V, Kogan S, Oskowitz A, He J, Wilson DM, Aggarwal R, Sriram R, VanBrocklin HF, Seo Y, Liu B, Flavell RR

Thirdhand Smoke As a Risk Factor for Pediatric Lymphoblastic Leukemia: Accelerated Leukemia in Female Pax5-P80R Mice.

Blood

Mi Zhou, Antoine M Snijders, Jian-Hua Mao, Joseph L. Wiemels, Scott C Kogan

Early-life tobacco exposure is causally implicated in aberrant RAG-mediated recombination in childhood acute lymphoblastic leukemia.

Leukemia

Liu T, Xu K, Pardeshi A, Myint SS, Kang AY, Morimoto LM, Lieber MR, Wiemels JL, Kogan SC, Metayer C, de Smith AJ

Efficacy of the Allosteric MEK Inhibitor Trametinib in Relapsed and Refractory Juvenile Myelomonocytic Leukemia: a Report from the Children's Oncology Group.

Cancer discovery

Stieglitz E, Lee AG, Angus SP, Davis C, Barkauskas DA, Hall D, Kogan SC, Meyer J, Rhodes SD, Tasian SK, Xuei X, Shannon K, Loh ML, Fox E, Weigel BJ

LNK/SH2B3 as a novel driver in juvenile myelomonocytic leukemia.

Haematologica

Wintering A, Hecht A, Meyer J, Wong EB, Hübner J, Abelson S, Feldman K, Kennedy VE, Peretz CAC, French DL, Maguire JA, Jobaliya C, Vasquez MR, Desai S, Dulman R, Nemecek E, Haines H, Hammad M, El Haddad A, Kogan SC, Abdullaev Z, Chehab FF, Tasian SK, Smith CC, Loh ML, Stieglitz E

Early-life tobacco exposure is causally implicated in aberrant RAG-mediated recombination in childhood acute lymphoblastic leukemia.

Research square

de Smith A, Liu T, Xu K, Pardeshi A, Myint SS, Kang A, Morimoto L, Lieber M, Wiemels J, Kogan S, Metayer C

Gene-Environment Analyses Reveal Novel Genetic Candidates with Prenatal Tobacco Exposure in Relation to Risk for Childhood Acute Lymphoblastic Leukemia.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Zhong C, Li S, Arroyo K, Morimoto LM, de Smith AJ, Metayer C, Ma X, Kogan SC, Gauderman WJ, Wiemels JL

Impact of pinworm infection on the development of murine B-cell leukemia/lymphoma in the presence and absence of ETV6::RUNX1.

Haematologica

Fitch BA, Situ J, Wiemels JL, Kogan SC, Zhou M

Efficacy of the Allosteric MEK Inhibitor Trametinib in Relapsed and Refractory Juvenile Myelomonocytic Leukemia: A Report from the Children's Oncology Group.

Blood

Elliot Stieglitz, Alex Lee, Steven P. Angus, Christopher Davis, Donald Barkauskas, David Hall, Scott C. Kogan, Julia Meyer, Steven D. Rhodes, Xiaoling Xuei, Kevin Shannon, Mignon L. Loh, Elizabeth Fox, Brenda J. Weigel

Genetic architecture of the acute and persistent immune cell response after radiation exposure.

Cell genomics

He L, Zhong C, Chang H, Inman JL, Celniker SE, Ioakeim-Ioannidou M, Liu KX, Haas-Kogan D, MacDonald SM, Threadgill DW, Kogan SC, Mao JH, Snijders AM

The SWI/SNF chromatin-remodeling subunit DPF2 facilitates NRF2-dependent antiinflammatory and antioxidant gene expression.

The Journal of clinical investigation

Mas G, Man N, Nakata Y, Martinez-Caja C, Karl D, Beckedorff F, Tamiro F, Chen C, Duffort S, Itonaga H, Mookhtiar AK, Kunkalla K, Valencia AM, Collings CK, Kadoch C, Vega F, Kogan SC, Shiekhattar R, Morey L, Bilbao D, Nimer SD

Dapsone-induced methemoglobinemia and hemolysis in a woman without G6PD deficiency presenting with idiopathic urticaria.

Hematology (Amsterdam, Netherlands)

Hu Y, Geere M, Awan M, Leavitt AD, Brown LE, Pearson HJ, Gandelman JS, Kogan SC

Cytomegalovirus proteins, maternal pregnancy cytokines, and their impact on neonatal immune cytokine profiles and acute lymphoblastic leukemogenesis in children.

Haematologica

Wiemels JL, Wang R, Zhou M, Hansen H, Gallant R, Jung J, Mancuso N, De Smith AJ, Metayer C, Kogan SC, Ma X

RASA2 ablation in T cells boosts antigen sensitivity and long-term function.

Nature

Carnevale J, Shifrut E, Kale N, Nyberg WA, Blaeschke F, Chen YY, Li Z, Bapat SP, Diolaiti ME, O'Leary P, Vedova S, Belk J, Daniel B, Roth TL, Bachl S, Anido AA, Prinzing B, Ibañez-Vega J, Lange S, Haydar D, Luetke-Eversloh M, Born-Bony M, Hegde B, Kogan S, Feuchtinger T, Okada H, Satpathy AT, Shannon K, Gottschalk S, Eyquem J, Krenciute G, Ashworth A, Marson A

Genomic Features of Interstitial Deletions of Chromosome 9q in Acute Myeloid Leukemia.

Cytogenetic and genome research

Qi Z, Wen KW, Ki A, Prakash S, Kogan S, Yu J

Apixaban Concentrations in Routine Clinical Care of Older Adults With Nonvalvular Atrial Fibrillation.

JACC. Advances

Thomas A, Fang MC, Kogan S, Hubbard CC, Friedman PN, Gong L, Klein TE, Nutescu EA, O'Brien TJ, Tuck M, Perera MA, Schwartz JB

Clinical characteristics of cytomegalovirus-positive pediatric acute lymphoblastic leukemia at diagnosis.

American journal of hematology

Gallant RE, Arroyo K, Bracci PM, Li S, Metayer C, Kogan SC, Wendt GA, Francis SS, de Smith AJ, Wiemels JL

Decreased IL-10 accelerates B-cell leukemia/lymphoma in a mouse model of pediatric lymphoid leukemia.

Blood advances

Fitch BA, Zhou M, Situ J, Surianarayanan S, Reeves MQ, Hermiston ML, Wiemels JL, Kogan SC

Preventing Bleeding With Direct-Acting Oral Anticoagulants.

Journal of the American College of Cardiology

Schwartz JB, Kogan SC, Fang MC

Nf1 and Sh2b3 mutations cooperate in vivo in a mouse model of juvenile myelomonocytic leukemia.

Blood advances

Morales CE, Stieglitz E, Kogan SC, Loh ML, Braun BS

Cytokine Levels at Birth in Children Who Developed Acute Lymphoblastic Leukemia.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Whitehead TP, Wiemels JL, Zhou M, Kang AY, McCoy LS, Wang R, Fitch B, Petrick LM, Yano Y, Imani P, Rappaport SM, Dahl GV, Kogan SC, Ma X, Metayer C

Epigenetic Biomarkers of Prenatal Tobacco Smoke Exposure Are Associated with Gene Deletions in Childhood Acute Lymphoblastic Leukemia.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Xu K, Li S, Whitehead TP, Pandey P, Kang AY, Morimoto LM, Kogan SC, Metayer C, Wiemels JL, de Smith AJ

Anti-factor Xa activity assays of direct-acting oral anticoagulants during clinical care: An observational study.

Research and practice in thrombosis and haemostasis

Sukumar S, Cabero M, Tiu S, Fang MC, Kogan SC, Schwartz JB

In utero and early-life exposure to thirdhand smoke causes profound changes to the immune system.

Clinical science (London, England : 1979)

Snijders AM, Zhou M, Whitehead TP, Fitch B, Pandey P, Hechmer A, Huang A, Schick SF, de Smith AJ, Olshen AB, Metayer C, Mao JH, Wiemels JL, Kogan SC

Trends in Acute Lymphoblastic Leukemia Incidence in the United States by Race/Ethnicity From 2000 to 2016.

American journal of epidemiology

Feng Q, de Smith AJ, Vergara-Lluri M, Muskens IS, McKean-Cowdin R, Kogan S, Brynes R, Wiemels JL

PML-RARα: changing myeloid networks.

Blood

Kogan SC

KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice.

JCI insight

Wong JC, Perez-Mancera PA, Huang TQ, Kim J, Grego-Bessa J, Del Pilar Alzamora M, Kogan SC, Sharir A, Keefe SH, Morales CE, Schanze D, Castel P, Hirose K, Huang GN, Zenker M, Sheppard D, Klein OD, Tuveson DA, Braun BS, Shannon K

The Baf Subunit Dpf2 Regulates Resolution of Inflammation By Controlling Macrophage Differentiation Transcription Factor Networks.

Blood

Gloria Mas Martin, Na Man, Daniel Karl, Concepcion Martinez, Stephanie Duffort, Hidehiro Itonaga, Adnan K Mookhtiar, Daniel Bilbao, Kranthi Kunkalla, Alfredo M Valencia, Clayton Collings, Cigall Kadoch, Francisco Vega, Scott C. Kogan, Stephen Nimer

History of Early Childhood Infections and Acute Lymphoblastic Leukemia Risk Among Children in a US Integrated Health-Care System.

American journal of epidemiology

Morimoto LM, Kwan ML, Deosaransingh K, Munneke JR, Kang AY, Quesenberry C, Kogan S, de Smith AJ, Metayer C, Wiemels JL

Human pediatric B-cell acute lymphoblastic leukemias can be classified as B-1 or B-2-like based on a minimal transcriptional signature.

Experimental hematology

Fitch B, Roy R, Geng H, Montecino-Rodriguez E, Bengtsson H, Gaillard C, Hiam K, Casero D, Olshen AB, Dorshkind K, Kogan SC

Abstract A105: Trends in acute lymphocytic leukemia (ALL) incidence in the US from 2000-2016.

Cancer Epidemiology Biomarkers & Prevention

Qianxi Feng, Maria Vergara-Lluri, Ivo Muskens, Roberta McKean-Cowdin, Scott Kogan, Russell Brynes, Adam de Smith, Joseph Wiemels

Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice.

Blood

Zambetti NA, Firestone AJ, Remsberg JR, Huang BJ, Wong JC, Long AM, Predovic M, Suciu RM, Inguva A, Kogan SC, Haigis KM, Cravatt BF, Shannon K

Abstract A23: A second site KrasG12D mutation that impairs PI3K binding rescues embryonic lethality, abrogates myeloproliferative disease, and delays lung tumorigenesis.

Molecular Cancer Research

Jasmine C. Wong, Pedro A. Perez-Mancera, Jangkyung Kim, Kuang-Yu Jen, Scott C. Kogan, Ari J. Firestone, Eric A. Collisson, David A. Tuveson, Kevin Shannon

Loss of glucocorticoid receptor expression mediates in vivo dexamethasone resistance in T-cell acute lymphoblastic leukemia.

Leukemia

Wandler AM, Huang BJ, Craig JW, Hayes K, Yan H, Meyer LK, Scacchetti A, Monsalve G, Dail M, Li Q, Wong JC, Weinberg O, Hasserjian RP, Kogan SC, Jonsson P, Yamamoto K, Sampath D, Nakitandwe J, Downing JR, Zhang J, Aster JC, Taylor BS, Shannon K

Increased neonatal level of arginase 2 in cases of childhood acute lymphoblastic leukemia implicates immunosuppression in the etiology.

Haematologica

Nielsen AB, Zhou M, de Smith AJ, Wang R, McCoy L, Hansen H, Morimoto L, Grønbæk K, Johansen C, Kogan SC, Metayer C, Bracci PM, Ma X, Wiemels JL

FLT3-ITD impedes retinoic acid, but not arsenic, responses in murine acute promyelocytic leukemias.

Blood

Esnault C, Rahmé R, Rice KL, Berthier C, Gaillard C, Quentin S, Maubert AL, Kogan S, de Thé H

Identification of IRF8 as a potent tumor suppressor in murine acute promyelocytic leukemia.

Blood advances

Gaillard C, Surianarayanan S, Bentley T, Warr MR, Fitch B, Geng H, Passegué E, de Thé H, Kogan SC

Dilute Russell viper venom time interpretation and clinical correlation: A two-year retrospective institutional review.

International journal of laboratory hematology

Jacquot C, Wool GD, Kogan SC

TCEA1 regulates the proliferative potential of mouse myeloid cells.

Experimental cell research

Yang T, Cui H, Wen M, Zuber J, Kogan SC, Wei G

Abstract 3241: Children with acute lymphoblastic leukemia have increased arginase 2 at birth, implicating immunosuppression in leukemogenesis.

Epidemiology

Amalie B. Nielsen, Mi Zhou, Adam de Smith, Lucie McCoy, Helen Hansen, Paige Bracci, Libby Morimoto, Scott Kogan, Catherine Metayer, Xiaomei Ma, Joseph Wiemels

Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin.

Cellular and molecular gastroenterology and hepatology

Fuqua BK, Lu Y, Frazer DM, Darshan D, Wilkins SJ, Dunn L, Loguinov AV, Kogan SC, Matak P, Chen H, Dunaief JL, Vulpe CD, Anderson GJ

Age-Related Impaired Efficacy of Bone Marrow Cell Therapy for Myocardial Infarction Reflects a Decrease in B Lymphocytes.

Molecular therapy : the journal of the American Society of Gene Therapy

An S, Wang X, Ruck MA, Rodriguez HJ, Kostyushev DS, Varga M, Luu E, Derakhshandeh R, Suchkov SV, Kogan SC, Hermiston ML, Springer ML

Dual origin of relapses in retinoic-acid resistant acute promyelocytic leukemia.

Nature communications

Lehmann-Che J, Bally C, Letouzé E, Berthier C, Yuan H, Jollivet F, Ades L, Cassinat B, Hirsch P, Pigneux A, Mozziconacci MJ, Kogan S, Fenaux P, de Thé H

Pml nuclear body disruption cooperates in APL pathogenesis and impairs DNA damage repair pathways in mice.

Blood

Voisset E, Moravcsik E, Stratford EW, Jaye A, Palgrave CJ, Hills RK, Salomoni P, Kogan SC, Solomon E, Grimwade D

Acute myeloid leukemia with t(14;21) involving RUNX1 and SYNE2: A novel favorable-risk translocation?

Cancer genetics

Foley N, Van Ziffle J, Yu J, Qi Z, Grenert JP, Yeh I, Bastian B, Kogan S, Mannis GN

In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia.

Blood

Francis SS, Wallace AD, Wendt GA, Li L, Liu F, Riley LW, Kogan S, Walsh KM, de Smith AJ, Dahl GV, Ma X, Delwart E, Metayer C, Wiemels JL

Dilute Russell Viper Venom Time Interpretation and Clinical Correlation: A Two-Year Retrospective Institutional Review.

Blood

Cyril Jacquot, Geoffrey D. Wool, Scott C. Kogan

Genetic Subtypes of Human Pediatric ALLs Show Gene Expression Differences That Parallel Those Observed in Mouse B1 and B2 Progenitors, Suggesting Divergent Developmental Origins.

Blood

Scott C. Kogan, Huimin Geng, Ritu Roy, Encarnacion Montecino-Rodriguez, Coline M Gaillard, Kamir Hiam, Henrik Bengtsson, David Casero, Adam B Olshen, Kenneth Dorshkind

Identification of IRF8 As a Potent Tumor Suppressor in Murine Acute Promyelocytic Leukemia.

Blood

Sangeetha Surianarayanan, Coline M Gaillard, Trevor Bentley, Matthew R. Warr, Briana Fitch, Huimin Geng, Emmanuelle Passegue, Hugues de Thé, Scott C. Kogan

Mechanism of IL-10 Protective Effect in Development of Childhood B Cell Acute Lymphoblastic Leukemia.

Blood

Briana Fitch, Michelle L. Hermiston, Joseph L. Wiemels, Scott C. Kogan

Pml Nuclear Body Disruption Cooperates in APL Pathogenesis, Impacting DNA Damage Repair Pathways.

Blood

Edwige Voisset, Eva Moravcsik, Eva W Stratford, Amie Jaye, Christopher J Palgrave, Robert K Hills, Paolo Salomoni, Scott C. Kogan, Ellen Solomon, David Grimwade

Resistant T-Cell Acute Lymphoblastic Leukemias That Emerge after In Vivo Treatment with Dexamethasone Frequently Down-Regulate Glucocorticoid Receptor Protein Expression.

Blood

Anica M. Wandler, Benjamin Huang, Alessandro Scacchetti, Jeff Craig, Hannah Yan, Gabriela Monsalve, Qing Li, Monique Dail, Jasmine C. Wong, Joy Nakitandwe, Olga Weinberg, Robert P. Hasserjian, Scott C. Kogan, Deepak Sampath, James R. Downing, Keith Yamamoto, Barry S. Taylor, Jon C. Aster, Jinghui Zhang, Kevin Shannon

Co-operative leukemogenesis in acute myeloid leukemia and acute promyelocytic leukemia reveals C/EBPα as a common target of TRIB1 and PML/RARA.

Haematologica

Keeshan K, Vieugué P, Chaudhury S, Rishi L, Gaillard C, Liang L, Garcia E, Nakamura T, Omidvar N, Kogan SC

DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia.

Cancer discovery

Meyer SE, Qin T, Muench DE, Masuda K, Venkatasubramanian M, Orr E, Suarez L, Gore SD, Delwel R, Paietta E, Tallman MS, Fernandez H, Melnick A, Le Beau MM, Kogan S, Salomonis N, Figueroa ME, Grimes HL

Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice.

The Journal of clinical investigation

Chang T, Krisman K, Theobald EH, Xu J, Akutagawa J, Lauchle JO, Kogan S, Braun BS, Shannon K

Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis.

eLife

Wong JC, Weinfurtner KM, Alzamora Mdel P, Kogan SC, Burgess MR, Zhang Y, Nakitandwe J, Ma J, Cheng J, Chen SC, Ho TT, Flach J, Reynaud D, Passegué E, Downing JR, Shannon K

Transcription and methylation analyses of preleukemic promyelocytes indicate a dual role for PML/RARA in leukemia initiation.

Haematologica

Gaillard C, Tokuyasu TA, Rosen G, Sotzen J, Vitaliano-Prunier A, Roy R, Passegué E, de Thé H, Figueroa ME, Kogan SC

Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia.

Nature immunology

Swaminathan S, Klemm L, Park E, Papaemmanuil E, Ford A, Kweon SM, Trageser D, Hasselfeld B, Henke N, Mooster J, Geng H, Schwarz K, Kogan SC, Casellas R, Schatz DG, Lieber MR, Greaves MF, Müschen M

Direct and indirect targeting of MYC to treat acute myeloid leukemia.

Cancer chemotherapy and pharmacology

Brondfield S, Umesh S, Corella A, Zuber J, Rappaport AR, Gaillard C, Lowe SW, Goga A, Kogan SC

Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis.

Nature genetics

Zhao Z, Chen CC, Rillahan CD, Shen R, Kitzing T, McNerney ME, Diaz-Flores E, Zuber J, Shannon K, Le Beau MM, Spector MS, Kogan SC, Lowe SW

Aberrant Hematopoietic Stem Cell Function in Mice Haploinsufficient for a 2 Mb Deletion of Chromosome 5A3 Syntenic to a Region of Human 7q22 Frequently Deleted in Myelodysplastic Syndromes.

Blood

Jasmine C. Wong, Kelley Weinfurtner, Pilar Alzamora, Scott C. Kogan, Michael R. Burgess, Yan Zhang, Joy Nakitandwe, Jing Ma, Jinjun Cheng, Shann-Ching Chen, Johanna Flach, Damien Reynaud, Emmanuelle Passegue, James R Downing, Kevin Shannon

Preclinical Efficacy of MEK Inhibition in Nras Mutant Acute Myeloid Leukemia.

Blood

Michael R. Burgess, Eugene Hwang, Ari J Firestone, Tannie Huang, Jin Xu, Johannes Zuber, Natacha Bohin, Tiffany Wen, Scott C. Kogan, Kevin M. Haigis, Scott W. Lowe, Kevin Shannon, Qing Li

Preclinical efficacy of MEK inhibition in Nras-mutant AML.

Blood

Burgess MR, Hwang E, Firestone AJ, Huang T, Xu J, Zuber J, Bohin N, Wen T, Kogan SC, Haigis KM, Sampath D, Lowe S, Shannon K, Li Q

MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia.

Cancer cell

Chen C, Liu Y, Rappaport AR, Kitzing T, Schultz N, Zhao Z, Shroff AS, Dickins RA, Vakoc CR, Bradner JE, Stock W, LeBeau MM, Shannon KM, Kogan S, Zuber J, Lowe SW

Crenolanib is a selective type I pan-FLT3 inhibitor.

Proceedings of the National Academy of Sciences of the United States of America

Smith CC, Lasater EA, Lin KC, Wang Q, McCreery MQ, Stewart WK, Damon LE, Perl AE, Jeschke GR, Sugita M, Carroll M, Kogan SC, Kuriyan J, Shah NP

CUL4A induces epithelial-mesenchymal transition and promotes cancer metastasis by regulating ZEB1 expression.

Cancer research

Wang Y, Wen M, Kwon Y, Xu Y, Liu Y, Zhang P, He X, Wang Q, Huang Y, Jen KY, LaBarge MA, You L, Kogan SC, Gray JW, Mao JH, Wei G

Disruption Of PML Nuclear Bodies Cooperates In The Pathogenesis Of Acute Promyelocytic Leukemia.

Blood

Eva Moravcsik, Melanie Joannides, Edwige Voisset, Eva Wessel Stratford, Bernd B. Zeisig, Jo Morris, Ruth Densham, Chris Palgrave, Gordon Stamp, Emma Nye, Robert K. Hills, Paolo Salomoni, Chi Wai Eric So, Scott C. Kogan, Ellen Solomon, David Grimwade

The Challenge Of Russell’s Viper Venom Time Interpretation For Lupus Anticoagulant Diagnosis: A Two-Year Retrospective Institutional Review.

Blood

Geoffrey D. Wool, Scott C. Kogan

Pten loss in the bone marrow leads to G-CSF-mediated HSC mobilization.

The Journal of experimental medicine

Tesio M, Oser GM, Baccelli I, Blanco-Bose W, Wu H, Göthert JR, Kogan SC, Trumpp A

The histone demethylase PHF8 governs retinoic acid response in acute promyelocytic leukemia.

Cancer cell

Arteaga MF, Mikesch JH, Qiu J, Christensen J, Helin K, Kogan SC, Dong S, So CW

Initially disadvantaged, TEL-AML1 cells expand and initiate leukemia in response to irradiation and cooperating mutations.

Leukemia

Li M, Jones L, Gaillard C, Binnewies M, Ochoa R, Garcia E, Lam V, Wei G, Yang W, Lobe C, Hermiston M, Passegu? E, Kogan SC

Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice.

The Journal of clinical investigation

Chang T, Krisman K, Theobald EH, Xu J, Akutagawa J, Lauchle JO, Kogan S, Braun BS, Shannon K

Crenolanib (CP-868,596) Is a Potent and Selective Type I FLT3 Inhibitor That Retains Activity Against AC220 Resistance-Causing FLT3 Kinase Domain Mutants.

Blood

Catherine C Smith, Elisabeth Lasater, Melissa Mccreery, Kimberly Lin, Whitney Stewart, Lauren E Damon, Alexander E Perl, Grace R Jeschke, Mayumi Sugita, Martin Carroll, Scott C. Kogan, Neil Shah

Evaluation of Patients with Bleeding Symptoms Using a Novel Perfusion Chamber Assay (PCA).

Blood

Matthew F. Gorman, Scott C. Kogan, James Huang, Gillian Stephens

PML-RARa Deregulates an Unexpectedly Small Number of Genes in Pre-Leukemic Promyelocytes.

Blood

Coline M Gaillard, Taku A Tokuyasu, Emmanuelle Passegue´, Scott C. Kogan

PML-RARα co-operates with Sox4 in acute myeloid leukemia development in mice.

Haematologica

Omidvar N, Maunakea ML, Jones L, Sevcikova S, Yin B, Himmel KL, Tennant TR, Le Beau MM, Largaespada DA, Kogan SC

A dominantly acting murine allele of Mcm4 causes chromosomal abnormalities and promotes tumorigenesis.

PLoS genetics

Bagley BN, Keane TM, Maklakova VI, Marshall JG, Lester RA, Cancel MM, Paulsen AR, Bendzick LE, Been RA, Kogan SC, Cormier RT, Kendziorski C, Adams DJ, Collier LS

Genetically mediated Nf1 loss in mice promotes diverse radiation-induced tumors modeling second malignant neoplasms.

Cancer research

Choi G, Huang B, Pinarbasi E, Braunstein SE, Horvai AE, Kogan S, Bhatia S, Faddegon B, Nakamura JL

An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model.

Blood

Bergerson RJ, Collier LS, Sarver AL, Been RA, Lugthart S, Diers MD, Zuber J, Rappaport AR, Nixon MJ, Silverstein KA, Fan D, Lamblin AF, Wolff L, Kersey JH, Delwel R, Lowe SW, O'Sullivan MG, Kogan SC, Adams DJ, Largaespada DA

Heterozygous Germ Line Deletion of a 2Mb Interval in Mice That Models Loss of 7q22 in Human Myeloid Malignancies Results in Defective Hematopoietic Stem Cell Function Reminiscent of Premature Aging.

Blood

Jasmine C. Wong, Kelley Weinfurtner, Yan Zhang, Pilar Alzamora, Eugene Hwang, Scott C. Kogan, Kevin M. Shannon

Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity.

Genes & development

Chien Y, Scuoppo C, Wang X, Fang X, Balgley B, Bolden JE, Premsrirut P, Luo W, Chicas A, Lee CS, Kogan SC, Lowe SW

PML-RARα enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway.

Autophagy

Huang Y, Hou JK, Chen TT, Zhao XY, Yan ZW, Zhang J, Yang J, Kogan SC, Chen GQ

Abstract A37: A dominantly acting allele of murine Mcm4 causes chromosome instability and promotes leukemiogenesis.

Cancer Genomics

Bruce N. Bagley, Vilena Maklakova, Christina Kendziorski, David J. Adams, Lara S. Collier, Jonathon G. Marshall, Rachael A. Lester, Michelle M. Cancel, Laura G. Bendzick, Thomas Keane, Scott C. Kogan, Ruth Sullivan, Robert Cormier

Donor myocardial infarction impairs the therapeutic potential of bone marrow cells by an interleukin-1-mediated inflammatory response.

Science translational medicine

Wang X, Takagawa J, Lam VC, Haddad DJ, Tobler DL, Mok PY, Zhang Y, Clifford BT, Pinnamaneni K, Saini SA, Su R, Bartel MJ, Sievers RE, Carbone L, Kogan S, Yeghiazarians Y, Hermiston M, Springer ML

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia.

Nature

Zuber J, Shi J, Wang E, Rappaport AR, Herrmann H, Sison EA, Magoon D, Qi J, Blatt K, Wunderlich M, Taylor MJ, Johns C, Chicas A, Mulloy JC, Kogan SC, Brown P, Valent P, Bradner JE, Lowe SW, Vakoc CR

An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance.

Genes & development

Zuber J, Rappaport AR, Luo W, Wang E, Chen C, Vaseva AV, Shi J, Weissmueller S, Fellmann C, Fellman C, Taylor MJ, Weissenboeck M, Graeber TG, Kogan SC, Vakoc CR, Lowe SW

A rapid and scalable system for studying gene function in mice using conditional RNA interference.

Cell

Premsrirut PK, Dow LE, Kim SY, Camiolo M, Malone CD, Miething C, Scuoppo C, Zuber J, Dickins RA, Kogan SC, Shroyer KR, Sordella R, Hannon GJ, Lowe SW

Treatment with 5-azacytidine accelerates acute promyelocytic leukemia leukemogenesis in a transgenic mouse model.

Genes & cancer

Scaglioni PP, Cai LF, Majid SM, Yung TM, Socci ND, Kogan SC, Kopelovich L, Pandolfi PP

Dose-dependent effects of focal fractionated irradiation on secondary malignant neoplasms in Nf1 mutant mice.

Cancer research

Nakamura JL, Phong C, Pinarbasi E, Kogan SC, Vandenberg S, Horvai AE, Faddegon BA, Fiedler D, Shokat K, Houseman BT, Chao R, Pieper RO, Shannon K

Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus.

Blood

Li Q, Haigis KM, McDaniel A, Harding-Theobald E, Kogan SC, Akagi K, Wong JC, Braun BS, Wolff L, Jacks T, Shannon K

ABT-737 Targets Leukemic Stem Cells In Mouse Models of Mutant NRASD12/hBCL-2- Mediated Acute Myeloid Leukemia Progression with Increased Survival.

Blood

Rose Ann Padua, Stephanie Beurlet, Patricia Krief, Nader Omidvar, Carole Le Pogam, Didier Auboeuf, Pierre de la Grange, Annie Soulie, Anne Janin, Maria-Elena Noguera, Pascal Merlet, Laure Sarda-Mantel, Pierre Fenaux, Marina Konopleva, Michael Andreeff, Andrea Tu, Phoebe Yang, Alice C. Fan, Scott C. Kogan, Irving L. Weissman, Dean W. Felsher, Marika Pla, Robert West, Christine Chomienne

Mutant BCL2 Co-Operates with CBFß/PEBP2ß-MYH11 to Promote Expansion of Leukemia Initiating Cells with a Predominantly Pro-Apoptotic Mechanism Via Recruitment of Ras-GTP In a Mouse Model of Progressive Acute Myeloid Leukemia.

Blood

Nader Omidvar, Carole Le Pogam, Stephanie Beurlet, Maria-Elena Noguera, Ann Janin, Scott C. Kogan, Irving L. Weissman, Marika Pla, Christine Chomienne, Rose Ann Padua

Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia.

The Journal of experimental medicine

Jones L, Wei G, Sevcikova S, Phan V, Jain S, Shieh A, Wong JC, Li M, Dubansky J, Maunakea ML, Ochoa R, Zhu G, Tennant TR, Shannon KM, Lowe SW, Le Beau MM, Kogan SC

PML-RAR{alpha} and Dnmt3a1 cooperate in vivo to promote acute promyelocytic leukemia.

Cancer research

Subramanyam D, Belair CD, Barry-Holson KQ, Lin H, Kogan SC, Passegu? E, Blelloch R

p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal.

Genes & development

Zhao Z, Zuber J, Diaz-Flores E, Lintault L, Kogan SC, Shannon K, Lowe SW

Abstract 3427A: Focal fractionated irradiation induces specific malignancies in a dose-dependent manner in Nf1 mutant mice.

Clinical Research

Jean L. Nakamura, Connie Phong, Emile Pinarbasi, Scott C. Kogan, Scott Vandenberg, Andrew E. Horvai, Bruce A. Faddegon, Benjamin T. Houseman, Russell O. Pieper, Kevin Shannon

Medicine. Poisonous contacts.

Science (New York, N.Y.)

Kogan SC

Use of chromosome engineering to model a segmental deletion of chromosome band 7q22 found in myeloid malignancies.

Blood

Wong JC, Zhang Y, Lieuw KH, Tran MT, Forgo E, Weinfurtner K, Alzamora P, Kogan SC, Akagi K, Wolff L, Le Beau MM, Killeen N, Shannon K

Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents.

Proceedings of the National Academy of Sciences of the United States of America

Dail M, Li Q, McDaniel A, Wong J, Akagi K, Huang B, Kang HC, Kogan SC, Shokat K, Wolff L, Braun BS, Shannon K

An Insertional Mutagenesis Screen for Genes That Cooperate with Mll-AF9 in Leukemogenesis.

Blood

Rachel Joy Bergerson, Lara S Collier, Sanne Lugthart, Raha Allaei, Molly J Nixon, Kevin A.T. Silverstein, Aaron Sarver, Danhua Flora Fan, Anne-Francoise J Lamblin, Linda Wolff, John H. Kersey, M. Gerard O'Sullivan, Ruud Delwel, Scott C. Kogan, David J Adams, David Largaespada

Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras.

Nature

Lauchle JO, Kim D, Le DT, Akagi K, Crone M, Krisman K, Warner K, Bonifas JM, Li Q, Coakley KM, Diaz-Flores E, Gorman M, Przybranowski S, Tran M, Kogan SC, Roose JP, Copeland NG, Jenkins NA, Parada L, Wolff L, Sebolt-Leopold J, Shannon K

Mouse models of human AML accurately predict chemotherapy response.

Genes & development

Zuber J, Radtke I, Pardee TS, Zhao Z, Rappaport AR, Luo W, McCurrach ME, Yang MM, Dolan ME, Kogan SC, Downing JR, Lowe SW

Curing APL: differentiation or destruction?

Cancer cell

Kogan SC

ABT-737 Targets Intrinsic Apoptosis during Cooperation of BCL-2 and Oncogenic NRAS in An in Vivo Progression Model of Myelodysplasia/Acute Myeloid Leukaemia.

Blood

Nader Omidvar, Stephanie Beurlet, Carole Le Pogam, Anne Janin, Christophe Leboeuf, Annie Soulie, Niclas Setterblad, Maria-Elena Noguera, Laure Sarda-Mantel, Pascal Merlet, Marika Pla, Scott C. Kogan, Irving L Weissman, Marina Konopleva, William Bormann, Michael Andreeff, Christine Chomienne, Rose Ann Padua

Myc Drives Chromosomal Gain in Acute Myeloid Leukemia.

Blood

Letetia Jones, Sabina Sevcikova, Vernon Phan, Sachi Jain, Angell Shieh, Joshua Dubansky, Min Li, Mei Lin Maunakea, George Zhu, Thelma R Tennant, Scott Lowe, Michelle M. Le, Scott C. Kogan

Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family.

Cell stem cell

Viatour P, Somervaille TC, Venkatasubrahmanyam S, Kogan S, McLaughlin ME, Weissman IL, Butte AJ, Passegué E, Sage J

Fractionated Cranial Irradiation Induces a Distinctive Pattern of Second Malignant Neoplasms in Nf1 Mutant Mice.

International Journal of Radiation Oncology • Biology • Physics

J.L. Nakamura, C. Phong, S. Kogan, S. Vandenberg, R.O. Pieper, K. Shannon

mTORC1 promotes survival through translational control of Mcl-1.

Proceedings of the National Academy of Sciences of the United States of America

Mills JR, Hippo Y, Robert F, Chen SM, Malina A, Lin CJ, Trojahn U, Wendel HG, Charest A, Bronson RT, Kogan SC, Nadon R, Housman DE, Lowe SW, Pelletier J

Survival and tumorigenesis in O6-methylguanine DNA methyltransferase-deficient mice following cyclophosphamide exposure.

Mutagenesis

Nagasubramanian R, Hansen RJ, Delaney SM, Cherian MM, Samson LD, Kogan SC, Dolan ME

The protective effect of KCNMB1 E65K against hypertension is restricted to blood pressure treatment with beta-blockade.

Journal of human hypertension

Kelley-Hedgepeth A, Peter I, Kip K, Montefusco M, Kogan S, Cox D, Ordovas J, Levy D, Reis S, Mendelsohn M, Housman D, Huggins G

BCL-2 and mutant NRAS interact physically and functionally in a mouse model of progressive myelodysplasia.

Cancer research

Omidvar N, Kogan S, Beurlet S, le Pogam C, Janin A, West R, Noguera ME, Reboul M, Soulie A, Leboeuf C, Setterblad N, Felsher D, Lagasse E, Mohamedali A, Thomas NS, Fenaux P, Fontenay M, Pla M, Mufti GJ, Weissman I, Chomienne C, Padua RA

Expressing N-RasG12D from the Endogenous Promoter Induces Myeloproliferative Disease (MPD) and Cooperates with Retroviral Insertional Mutagenesis (RIM) To Generate Acute Myeloid Leukemia (AML).

Blood

Qing Li, Kevin Haigis, Andrew McDaniel, Benjamin Huang, Michelle Miller, Angell Shieh, Scott Kogan, Lynda Wolff, Tyler Jacks, Kevin Shannon

Novel Mll-AF9 Cooperating Genes Identified in a Leukemogenesis Screen Using Retroviral Mutagenesis.

Blood

Rachel J. Bergerson, Lara S. Collier, Raha Allaei, Kevin A. Silverstein, Anne-Francoise F. Lamblin, Linda Wolff, Scott C. Kogan, John H. Kersey, David J. Adams, David A. Largaespada

PPARgamma-active triterpenoid CDDO enhances ATRA-induced differentiation in APL.

Cancer biology & therapy

Tabe Y, Konopleva M, Kondo Y, Contractor R, Tsao T, Konoplev S, Shi Y, Ling X, Watt JC, Tsutsumi-Ishii Y, Ohsaka A, Nagaoka I, Issa JP, Kogan SC, Andreeff M

Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disorders.

Blood

Joslin JM, Fernald AA, Tennant TR, Davis EM, Kogan SC, Anastasi J, Crispino JD, Le Beau MM

Mouse models of acute promyelocytic leukemia.

Current topics in microbiology and immunology

Kogan SC

Dual treatment with FLT3 inhibitor SU11657 and doxorubicin increases survival of leukemic mice.

Leukemia research

Lee BD, Sevcikova S, Kogan SC

Acute Promyelocytic Leukemia Stem Cell Derived from Leukemic Progenitor.

Blood

Galit P. Rosen, Scott C. Kogan

SU11657 Cooperates with Doxorubicin To Increase Survival of Leukemic Mice.

Blood

Sabina Sevcikova, Brian D. Lee, Scott C. Kogan

Beta common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice.

Blood

Kim A, Morgan K, Hasz DE, Wiesner SM, Lauchle JO, Geurts JL, Diers MD, Le DT, Kogan SC, Parada LF, Shannon K, Largaespada DA

Determinants of sensitivity and resistance to rapamycin-chemotherapy drug combinations in vivo.

Cancer research

Wendel HG, Malina A, Zhao Z, Zender L, Kogan SC, Cordon-Cardo C, Pelletier J, Lowe SW

New evidence supporting megakaryocyte-erythrocyte potential of flk2/flt3+ multipotent hematopoietic progenitors.

Cell

Forsberg EC, Serwold T, Kogan S, Weissman IL, Passegué E

CCAAT/enhancer binding proteins alpha and epsilon cooperate with all-trans retinoic acid in therapy but differ in their antileukemic activities.

Blood

Lee YJ, Jones LC, Timchenko NA, Perrotti D, Tenen DG, Kogan SC

Loss of p53 impedes the antileukemic response to BCR-ABL inhibition.

Proceedings of the National Academy of Sciences of the United States of America

Wendel HG, de Stanchina E, Cepero E, Ray S, Emig M, Fridman JS, Veach DR, Bornmann WG, Clarkson B, McCombie WR, Kogan SC, Hochhaus A, Lowe SW

Trp53 loss during in vitro selection contributes to acquired Ara-C resistance in acute myeloid leukemia.

Experimental hematology

Yin B, Kogan SC, Dickins RA, Lowe SW, Largaespada DA

Leukemia with distinct phenotypes in transgenic mice expressing PML/RAR alpha, PLZF/RAR alpha or NPM/RAR alpha.

Oncogene

Rego EM, Ruggero D, Tribioli C, Cattoretti G, Kogan S, Redner RL, Pandolfi PP

Increased CCAAT enhancer-binding protein epsilon (C/EBPepsilon) expression and premature apoptosis in myeloid cells expressing Gfi-1 N382S mutant associated with severe congenital neutropenia.

The Journal of biological chemistry

Zhuang D, Qiu Y, Kogan SC, Dong F

Forced retinoic acid receptor alpha homodimers prime mice for APL-like leukemia.

Cancer cell

Sternsdorf T, Phan VT, Maunakea ML, Ocampo CB, Sohal J, Silletto A, Galimi F, Le Beau MM, Evans RM, Kogan SC

Cbf beta-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia.

Cancer cell

Kuo YH, Landrette SF, Heilman SA, Perrat PN, Garrett L, Liu PP, Le Beau MM, Kogan SC, Castilla LH

Investigation of Hematopoietic Stem Cell and Progenitor Populations: Implication for Cell Fate Determination and Lineage Commitment.

Blood

Emmanuelle Passegue, Camilla Forsberg, Thomas Serwold, Scott Kogan, Irving L. Weissman

Haploinsufficiency of Runx1/AML1 promotes myeloid features and leukaemogenesis in BXH2 mice.

British journal of haematology

Yamashita N, Osato M, Huang L, Yanagida M, Kogan SC, Iwasaki M, Nakamura T, Shigesada K, Asou N, Ito Y

Opinion: how patients have benefited from mouse models of acute promyelocytic leukaemia.

Nature reviews. Cancer

Lallemand-Breitenbach V, Zhu J, Kogan S, Chen Z, de Thé H

Therapy-induced malignant neoplasms in Nf1 mutant mice.

Cancer cell

Chao RC, Pyzel U, Fridlyand J, Kuo YM, Teel L, Haaga J, Borowsky A, Horvai A, Kogan SC, Bonifas J, Huey B, Jacks TE, Albertson DG, Shannon KM

Induction of tumor arrest and differentiation with prolonged survival by intermittent hypoxia in a mouse model of acute myeloid leukemia.

Blood

Liu W, Guo M, Xu YB, Li D, Zhou ZN, Wu YL, Chen Z, Kogan SC, Chen GQ

Role of O6-alkylguanine-DNA alkyltransferase in protecting against 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-induced long-term toxicities.

The Journal of pharmacology and experimental therapeutics

Hansen RJ, Nagasubramanian R, Delaney SM, Cherian MM, Lin S, Kogan SC, Dolan ME

Cooperation of Cytokine Signaling with Chimeric Transcription Factors in Leukemogenesis: PML-Retinoic Acid Receptor Alpha Blocks Growth Factor-Mediated Differentiation.

Molecular and cellular biology

Vernon T. Phan, David B. Shultz, Bao-Tran H. Truong, Timothy J. Blake, Anna L. Brown, Thomas J. Gonda, Michelle M. Le Beau, Scott C. Kogan

A sumoylation site in PML/RARA is essential for leukemic transformation.

Cancer cell

Zhu J, Zhou J, Peres L, Riaucoux F, Honoré N, Kogan S, de Thé H

Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease.

The EMBO journal

Wang J, Iwasaki H, Krivtsov A, Febbo PG, Thorner AR, Ernst P, Anastasiadou E, Kutok JL, Kogan SC, Zinkel SS, Fisher JK, Hess JL, Golub TR, Armstrong SA, Akashi K, Korsmeyer SJ

O-14 A reversible two-step model ofMDS/preleukemia: Transgenic mice expressing inducible BCL2 and mutant NRAS.

Leukemia research

R.A. Padua, N. Omidvar, S. Kogan, T.-H. Phan, R. West, D. Felsher, I. Weissmann, S. Thomas, J. Whittaker, A. Janin, M. Pla, G. Muftis, J.M. Bishop, C. Chomienne

Cbfb-MYH11 Induces Expansion of a Lin-Kit+Sca1- Abnormal Progenitor Compartment that Predisposes Acute Myeloid Leukemia in Mice.

Blood

Ya-Huei Kuo, Susan Heilman, Amy Chen, Pu P. Liu, Rachel Gernstein, Scott Kogan, Lucio H. Castilla

Cooperative Pathways to Acute Myeloid Leukemia Include the Combining of Transcription Factor Alterations: PML-RARa Cooperates with SOX4.

Blood

Scott C. Kogan, Mei Lin Maunakea, Karen L. Himmel, Bin Yin, Michelle M. Le Beau, David A. Largaespada

Discovery of Genes Involved in Experimental Pre-Leukemia to Leukemia Transition in Mice Using Expression Arrays.

Blood

Igor A. Entin, Scott C. Kogan

Homodimerization of Retinoic Acid Receptor alpha through its Fusion Partners Underlies Pathogenesis of Acute Promyelocytic Leukemia.

Blood

Scott C. Kogan, Vernon T. Phan, Thomas Sternsdorf, Mei Lin Maunakea, Jastinder Sohal, Angela Silletto, Francesco Galimi, Ronald M. Evans

Identification of Cooperating Genetic Alterations in RUNX Leukemia Using the Mouse Model for the Human Familial Leukemia, FPD/AML.

Blood

Motomi Osato, Namiko Yamashita, Masatoshi Yanagida, Liqun Huang, Scott Kogan, Masayuki Iwasaki, Takuro Nakamura, Katsuya Shigesada, Norio Asou, Yoshiaki Ito

Increased DNA Damage and Error-Prone Repair in MPD/MDS Mice with Disease Progression: Key Indicators for Increased Genomic Instability.

Blood

Feyruz V. Rassool, Terry J. Gaymes, Nicola Brady, Nicholas Lea, Marika Pla, Thi Hai Phan, Scott Kogan, Christine Chomienne, Nicholas S. Thomas, Ghulam J. Mafti, Rose Ann Padua

HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo.

Blood

Fischbach NA, Rozenfeld S, Shen W, Fong S, Chrobak D, Ginzinger D, Kogan SC, Radhakrishnan A, Le Beau MM, Largman C, Lawrence HJ

Myeloid Malignancies.

Mouse Models of Human Cancer

Scott C. Kogan

Mouse models of human cancers (part 3).

Comparative medicine

Borowsky AD, Munn RJ, Galvez JJ, Cardiff RD, Ward JM, Morse HC, Kogan SC, Aldape KD, Louis DN, Bosenberg MW

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy.

Nature

Wendel HG, De Stanchina E, Fridman JS, Malina A, Ray S, Kogan S, Cordon-Cardo C, Pelletier J, Lowe SW

Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder.

Blood

Le DT, Kong N, Zhu Y, Lauchle JO, Aiyigari A, Braun BS, Wang E, Kogan SC, Le Beau MM, Parada L, Shannon KM

The role of p53 in suppression of KSHV cyclin-induced lymphomagenesis.

Cancer research

Verschuren EW, Hodgson JG, Gray JW, Kogan S, Jones N, Evan GI

Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder.

Proceedings of the National Academy of Sciences of the United States of America

Braun BS, Tuveson DA, Kong N, Le DT, Kogan SC, Rozmus J, Le Beau MM, Jacks TE, Shannon KM

PML-RARA-targeted DNA vaccine induces protective immunity in a mouse model of leukemia.

Nature medicine

Padua RA, Larghero J, Robin M, le Pogam C, Schlageter MH, Muszlak S, Fric J, West R, Rousselot P, Phan TH, Mudde L, Teisserenc H, Carpentier AF, Kogan S, Degos L, Pla M, Bishop JM, Stevenson F, Charron D, Chomienne C

A PMLRARA transgene results in a retinoid-deficient phenotype associated with enhanced susceptibility to skin tumorigenesis.

Cancer research

Hansen LA, Brown D, Virador V, Tanaka T, Andreola F, Strain K, Dancheck B, Riley R, Arbeit JM, De Luca LM, Kogan S, Yuspa SH

Cooperation of cytokine signaling with chimeric transcription factors in leukemogenesis: PML-retinoic acid receptor alpha blocks growth factor-mediated differentiation.

Molecular and cellular biology

Phan VT, Shultz DB, Truong BT, Blake TJ, Brown AL, Gonda TJ, Le Beau MM, Kogan SC

Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice identify cooperating events and genetic pathways to acute promyelocytic leukemia.

Blood

Le Beau MM, Davis EM, Patel B, Phan VT, Sohal J, Kogan SC

A model of APL with FLT3 mutation is responsive to retinoic acid and a receptor tyrosine kinase inhibitor, SU11657.

Blood

Sohal J, Phan VT, Chan PV, Davis EM, Patel B, Kelly LM, Abrams TJ, O'Farrell AM, Gilliland DG, Le Beau MM, Kogan SC

In vivo activation of cAMP signaling induces growth arrest and differentiation in acute promyelocytic leukemia.

The Journal of experimental medicine

Guillemin MC, Raffoux E, Vitoux D, Kogan S, Soilihi H, Lallemand-Breitenbach V, Zhu J, Janin A, Daniel MT, Gourmel B, Degos L, Dombret H, Lanotte M, De Thé H

CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia.

Blood

Truong BT, Lee YJ, Lodie TA, Park DJ, Perrotti D, Watanabe N, Koeffler HP, Nakajima H, Tenen DG, Kogan SC

Bethesda proposals for classification of lymphoid neoplasms in mice.

Blood

Morse HC, Anver MR, Fredrickson TN, Haines DC, Harris AW, Harris NL, Jaffe ES, Kogan SC, MacLennan IC, Pattengale PK, Ward JM, Hematopathology subcommittee of the Mouse Models of Human Cancers Consortium

Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice.

Blood

Kogan SC, Ward JM, Anver MR, Berman JJ, Brayton C, Cardiff RD, Carter JS, de Coronado S, Downing JR, Fredrickson TN, Haines DC, Harris AW, Harris NL, Hiai H, Jaffe ES, MacLennan IC, Pandolfi PP, Pattengale PK, Perkins AS, Simpson RM, Tuttle MS, Wong JF, Morse HC, Hematopathology subcommittee of the Mouse Models of Human Cancers Consortium