
Professor
Neurology
+1 415 514-4949
Samuel Pleasure, MD, PhD studies the development of the brain, in particular the mechanisms regulating cell proliferation, migration and axon guidance during prenatal development.
Publications
Pediatric post-infectious neuroinflammatory syndromes come to the fore.
Developmental neuroscience
Peripheral blood mononuclear cell transcriptomic trajectories reveal dynamic regulation of inflammatory actors in delirium.
medRxiv : the preprint server for health sciences
Disrupted callosal connectivity underlies long-lasting sensory-motor deficits in an NMDAreceptor antibody encephalitis mouse model.
The Journal of clinical investigation
Anti-RGS8 paraneoplastic cerebellar ataxia is preferentially associated with a particular subtype of Hodgkin's lymphoma.
Journal of neurology
Transcobalamin receptor antibodies in autoimmune vitamin B12 central deficiency.
Science translational medicine
CaMKII autophosphorylation is the only enzymatic event required for synaptic memory.
Proceedings of the National Academy of Sciences of the United States of America
Expanding Spectrum and Therapeutic Insights in Inflammatory Brain Disorders.
Developmental neuroscience
Detection of High-Risk Paraneoplastic Antibodies against TRIM9 and TRIM67 Proteins.
Annals of neurology
CaMKII autophosphorylation but not downstream kinase activity is required for synaptic memory.
bioRxiv : the preprint server for biology
Shh from mossy cells contributes to preventing NSC pool depletion after seizure-induced neurogenesis and in aging.
bioRxiv : the preprint server for biology
Viral co-infection, autoimmunity, and CSF HIV antibody profiles in HIV central nervous system escape.
Journal of neuroimmunology
Synchrony 2022: Epilepsy and Seizures in Autism Spectrum Disorder Roundtable.
Journal of personalized medicine
Dual ankyrinG and subpial autoantibodies in a man with well-controlled HIV infection with steroid-responsive meningoencephalitis: A case report.
Frontiers in neurology
Brain heterotopia formation by ciliopathic breakdown of neuroepithelial and blood-cerebrospinal fluid barriers.
Brain pathology (Zurich, Switzerland)
Anti-SARS-CoV-2 and Autoantibody Profiling of a COVID-19 Patient With Subacute Psychosis Who Remitted After Treatment With Intravenous Immunoglobulin.
Biological psychiatry
The CRHR1/CREB/REST signaling cascade regulates mammalian embryonic neural stem cell properties.
EMBO reports
ZSCAN1 Autoantibodies Are Associated with Pediatric Paraneoplastic ROHHAD.
Annals of neurology
βIV-Spectrin Autoantibodies in 2 Individuals With Neuropathy of Possible Paraneoplastic Origin: A Case Series.
Neurology(R) neuroimmunology & neuroinflammation
Corrigendum: Case Report: A False Negative Case of Anti-Yo Paraneoplastic Myelopathy.
Frontiers in neurology
Risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild COVID-19.
Annals of clinical and translational neurology
Case Report: A False Negative Case of Anti-Yo Paraneoplastic Myelopathy.
Frontiers in neurology
Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms.
Cell reports. Medicine
RETRACTED: Remission of Subacute Psychosis in a COVID-19 Patient With an Antineuronal Autoantibody After Treatment With Intravenous Immunoglobulin.
Biological psychiatry
The Neocortical Progenitor Specification Program Is Established through Combined Modulation of SHH and FGF Signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Non-cell autonomous promotion of astrogenesis at late embryonic stages by constitutive YAP activation.
Scientific reports
ANA Investigates: Pioneering Unbiased Diagnostics.
Annals of neurology
Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis.
The New England journal of medicine
Foxg1 Regulates the Postnatal Development of Cortical Interneurons.
Cerebral cortex (New York, N.Y. : 1991)
Meningeal Bmps Regulate Cortical Layer Formation.
Brain plasticity (Amsterdam, Netherlands)
FoxG1 Directly Represses Dentate Granule Cell Fate During Forebrain Development.
Frontiers in cellular neuroscience
Ttyh1 regulates embryonic neural stem cell properties by enhancing the Notch signaling pathway.
EMBO reports
Sonic Hedgehog Signaling Rises to the Surface: Emerging Roles in Neocortical Development.
Brain plasticity (Amsterdam, Netherlands)
The Dorsal Wave of Neocortical Oligodendrogenesis Begins Embryonically and Requires Multiple Sources of Sonic Hedgehog.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Focal cerebral β-amyloid angiopathy: A distinct clinicopathologic presentation.
Neurology. Clinical practice
Human Cytomegalovirus IE2 Protein Disturbs Brain Development by the Dysregulation of Neural Stem Cell Maintenance and the Polarization of Migrating Neurons.
Journal of virology
TRBP maintains mammalian embryonic neural stem cell properties by acting as a novel transcriptional coactivator of the Notch signaling pathway.
Development (Cambridge, England)
The Crossroads of Neural Stem Cell Development and Tumorigenesis.
Opera medica et physiologica
Loss of Suppressor of Fused in Mid-Corticogenesis Leads to the Expansion of Intermediate Progenitors.
Journal of developmental biology
Cerebrovascular defects in Foxc1 mutants correlate with aberrant WNT and VEGF-A pathways downstream of retinoic acid from the meninges.
Developmental biology
Diverse Functions of Retinoic Acid in Brain Vascular Development.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Cell Type-Specific Circuit Mapping Reveals the Presynaptic Connectivity of Developing Cortical Circuits.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Control of Adult Neurogenesis by Short-Range Morphogenic-Signaling Molecules.
Cold Spring Harbor perspectives in biology
Epithelial cells supply Sonic Hedgehog to the perinatal dentate gyrus via transport by platelets.
eLife
Suppressor of Fused Is Critical for Maintenance of Neuronal Progenitor Identity during Corticogenesis.
Cell reports
A Notch above Sonic Hedgehog.
Developmental cell
Migration of oligodendrocyte progenitor cells is controlled by transforming growth factor β family proteins during corticogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Heterogeneously expressed fezf2 patterns gradient Notch activity in balancing the quiescence, proliferation, and differentiation of adult neural stem cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology.
Nature communications
Wrong place, wrong time: ectopic progenitors cause cortical heterotopias.
Nature neuroscience
Cxcl12/Cxcr4 signaling controls the migration and process orientation of A9-A10 dopaminergic neurons.
Development (Cambridge, England)
The development of hippocampal cellular assemblies.
Wiley interdisciplinary reviews. Developmental biology
Importance and hurdles to drug discovery for neurological disease.
Annals of neurology
The ventral hippocampus is the embryonic origin for adult neural stem cells in the dentate gyrus.
Neuron
Bone morphogenic protein signaling is a major determinant of dentate development.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Dual origins of the mammalian accessory olfactory bulb revealed by an evolutionarily conserved migratory stream.
Nature neuroscience
Wnt signaling regulates intermediate precursor production in the postnatal dentate gyrus by regulating CXCR4 expression.
Developmental neuroscience
The GAP between axon pruning and repulsion.
Developmental cell
Wnt signaling and forebrain development.
Cold Spring Harbor perspectives in biology
A cascade of morphogenic signaling initiated by the meninges controls corpus callosum formation.
Neuron
Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA.
Proceedings of the National Academy of Sciences of the United States of America
Meningeal defects alter the tangential migration of cortical interneurons in Foxc1hith/hith mice.
Neural development
An inducible transgenic Cre mouse line for the study of hippocampal development and adult neurogenesis.
Genesis (New York, N.Y. : 2000)
Oligogenesis and oligodendrocyte progenitor maturation vary in different brain regions and partially correlate with local angiogenesis after ischemic stroke.
Translational stroke research
Wnt signaling regulates neuronal differentiation of cortical intermediate progenitors.
The Journal of neuroscience : the official journal of the Society for Neuroscience
We have got you 'covered': how the meninges control brain development.
Current opinion in genetics & development
Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression.
Proceedings of the National Academy of Sciences of the United States of America
Wnts influence the timing and efficiency of oligodendrocyte precursor cell generation in the telencephalon.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Primary cellular meningeal defects cause neocortical dysplasia and dyslamination.
Annals of neurology
There's no place like home for a neural stem cell.
Cell stem cell
A transgenic Cre mouse line for the study of cortical and hippocampal development.
Genesis (New York, N.Y. : 2000)
Ongoing interplay between the neural network and neurogenesis in the adult hippocampus.
Current opinion in neurobiology
Wnt signaling in development and disease.
Neurobiology of disease
Isoflurane inhibits growth but does not cause cell death in hippocampal neural precursor cells grown in culture.
Anesthesiology
Genes and signaling events that establish regional patterning of the mammalian forebrain.
Seminars in cell & developmental biology
Characterization of the Frizzled10-CreER transgenic mouse: an inducible Cre line for the study of Cajal-Retzius cell development.
Genesis (New York, N.Y. : 2000)
Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signaling.
Development (Cambridge, England)
Ocular coloboma and dorsoventral neuroretinal patterning defects in Lrp6 mutant eyes.
Developmental dynamics : an official publication of the American Association of Anatomists
Generation of Frizzled10-Cre transgenic mouse line: a useful tool for the study of dorsal telencephalic development.
Genesis (New York, N.Y. : 2000)
NMDA receptors inhibit synapse unsilencing during brain development.
Proceedings of the National Academy of Sciences of the United States of America
Regional distribution of cortical interneurons and development of inhibitory tone are regulated by Cxcl12/Cxcr4 signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience
COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling.
Cerebral cortex (New York, N.Y. : 1991)
Hilar mossy cells share developmental influences with dentate granule neurons.
Developmental neuroscience
Cortical dysplasia and skull defects in mice with a Foxc1 allele reveal the role of meningeal differentiation in regulating cortical development.
Proceedings of the National Academy of Sciences of the United States of America
Expression of SDF-1 and CXCR4 during reorganization of the postnatal dentate gyrus.
Developmental neuroscience
Genetic regulation of dentate gyrus morphogenesis.
Progress in brain research
Pneumococcal meningitis induces apoptosis in recently postmitotic immature neurons in the dentate gyrus of neonatal rats.
Developmental neuroscience
Stromal-derived factor-1 (CXCL12) regulates laminar position of Cajal-Retzius cells in normal and dysplastic brains.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Genetic control of hippocampal neurogenesis.
Genome biology
Embryonic and early postnatal abnormalities contributing to the development of hippocampal malformations in a rodent model of dysplasia.
The Journal of comparative neurology
A transgenic marker mouse line labels Cajal-Retzius cells from the cortical hem and thalamocortical axons.
Brain research
A tale of two signals: Wnt and Hedgehog in dentate neurogenesis.
Science's STKE : signal transduction knowledge environment
Aberrant seizure-induced neurogenesis in experimental temporal lobe epilepsy.
Annals of neurology
Hippocampal and visuospatial learning defects in mice with a deletion of frizzled 9, a gene in the Williams syndrome deletion interval.
Development (Cambridge, England)
Frizzled9 protein is regionally expressed in the developing medial cortical wall and the cells derived from this region.
Brain research. Developmental brain research
Morphogenesis of the dentate gyrus: what we are learning from mouse mutants.
Developmental neuroscience
Laminar organization of the mouse dentate gyrus: insights from BETA2/Neuro D mutant mice.
The Journal of comparative neurology
Frizzled-9 promoter drives expression of transgenes in the medial wall of the cortex and its chief derivative the hippocampus.
Genesis (New York, N.Y. : 2000)
Severe defects in dorsal thalamic development in low-density lipoprotein receptor-related protein-6 mutants.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wnt signaling mutants have decreased dentate granule cell production and radial glial scaffolding abnormalities.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Expression of the BMP antagonist Dan during murine forebrain development.
Brain research. Developmental brain research
ATP-binding cassette transporter ABCA2 (ABC2) expression in the developing spinal cord and PNS during myelination.
The Journal of comparative neurology
The chemokine SDF1 regulates migration of dentate granule cells.
Development (Cambridge, England)
PACAP and its receptors exert pleiotropic effects in the nervous system by activating multiple signaling pathways.
Current protein & peptide science
Hippocampal heterotopia with molecular and electrophysiological properties of neocortical neurons.
Neuroscience
Wnt receptors and Wnt inhibitors are expressed in gradients in the developing telencephalon.
Mechanisms of development
Pax-6 regulates expression of SFRP-2 and Wnt-7b in the developing CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience
An arrow hits the Wnt signaling pathway.
Trends in neurosciences
Differential regulation of basic helix-loop-helix mRNAs in the dentate gyrus following status epilepticus.
Neuroscience
Correlation of clinical and neuroimaging findings in a case of rabies encephalitis.
Archives of neurology
Unique expression patterns of cell fate molecules delineate sequential stages of dentate gyrus development.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy.
Proceedings of the National Academy of Sciences of the United States of America
Ventricular volume and transmural pressure gradient in normal pressure hydrocephalus.
Archives of neurology
Spontaneous intracranial hypotension resulting in stupor caused by diencephalic compression.
Neurology
Glial cells of the lamprey nervous system contain keratin-like proteins.
The Journal of comparative neurology
Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides.
Proceedings of the National Academy of Sciences of the United States of America
NTera 2 cells: a human cell line which displays characteristics expected of a human committed neuronal progenitor cell.
Journal of neuroscience research
Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line.
Proceedings of the National Academy of Sciences of the United States of America
Pure, postmitotic, polarized human neurons derived from NTera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Differentiation characteristics of newly established medulloblastoma cell lines (D384 Med, D425 Med, and D458 Med) and their transplantable xenografts.
Laboratory investigation; a journal of technical methods and pathology
Primitive neuroectodermal tumors (PNETs) of the CNS and PNS that express functional nerve growth factor receptors (NGFR) but fail to differentiate in response to NGF.
Progress in clinical and biological research
Introduction of nerve growth factor (NGF) receptors into a medulloblastoma cell line results in expression of high- and low-affinity NGF receptors but not NGF-mediated differentiation.
Proceedings of the National Academy of Sciences of the United States of America
Human central nervous system primitive neuroectodermal tumor expressing nerve growth factor receptors: CHP707m.
Annals of neurology
Site-specific phosphorylation of the middle molecular weight human neurofilament protein in transfected non-neuronal cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Lamprey neurofilaments combine in one subunit the features of each mammalian NF triplet protein but are highly phosphorylated only in large axons.
The Journal of neuroscience : the official journal of the Society for Neuroscience