Ruby Ghadially, MD

Professor
Dermatology
+1 415 719-5273

Ruby Ghadially, MD is a dermatologist with research interests in skin stem cells and their use for in vivo expansion of keratinocytes for autologous burn and wound therapy.

Publications: 

Clinical presentation of Fibroepithelioma of Pinkus: systematic review of the literature.

Archives of dermatological research

Kim RW, North JP, Ghadially R

Short cell cycle duration is a phenotype of human epidermal stem cells.

Stem cell research & therapy

Xiao T, Eze UC, Charruyer-Reinwald A, Weisenberger T, Khalifa A, Abegaze B, Schwab GK, Elsabagh RH, Parenteau TR, Kochanowski K, Piper M, Xia Y, Cheng JB, Cho RJ, Ghadially R

Classification of human chronic inflammatory skin disease based on single-cell immune profiling.

Science immunology

Liu Y, Wang H, Taylor M, Cook C, Mart?nez-Berdeja A, North JP, Harirchian P, Hailer AA, Zhao Z, Ghadially R, Ricardo-Gonzalez RR, Grekin RC, Mauro TM, Kim E, Choi J, Purdom E, Cho RJ, Cheng JB

Genetic priming of sensory neurons in mice that overexpress PAR2 enhances allergen responsiveness.

Proceedings of the National Academy of Sciences of the United States of America

Braz JM, Dembo T, Charruyer A, Ghadially R, Fassett MS, Basbaum AI

Decreased p53 is associated with a decline in asymmetric stem cell self-renewal in aged human epidermis.

Aging cell

Charruyer A, Weisenberger T, Li H, Khalifa A, Schroeder AW, Belzer A, Ghadially R

Facial psoriasis in a mask-like distribution.

JAAD case reports

Zachary CMB, Belzer A, Fackler NP, Shiu J, Smith J, Ghadially R

Single-Cell Profiling Reveals Divergent, Globally Patterned Immune Responses in Murine Skin Inflammation.

iScience

Liu Y, Cook C, Sedgewick AJ, Zhang S, Fassett MS, Ricardo-Gonzalez RR, Harirchian P, Kashem SW, Hanakawa S, Leistico JR, North JP, Taylor MA, Zhang W, Man MQ, Charruyer A, Beliakova-Bethell N, Benz SC, Ghadially R, Mauro TM, Kaplan DH, Kabashima K, Choi J, Song JS, Cho RJ, Cheng JB

IL-1a, IL-6, and GM-CSF Are Downstream Mediators of IL-17A that Promote Asymmetric Stem Cell Self-Renewal in Human Keratinocytes.

The Journal of investigative dermatology

Li H, Charruyer A, Weisenberger T, Khalifa A, Nguyen R, Ghadially R

Transcriptional Programming of Normal and Inflamed Human Epidermis at Single-Cell Resolution.

Cell reports

Cheng JB, Sedgewick AJ, Finnegan AI, Harirchian P, Lee J, Kwon S, Fassett MS, Golovato J, Gray M, Ghadially R, Liao W, Perez White BE, Mauro TM, Mully T, Kim EA, Sbitany H, Neuhaus IM, Grekin RC, Yu SS, Gray JW, Purdom E, Paus R, Vaske CJ, Benz SC, Song JS, Cho RJ

Influence of pH on Skin Stem Cells and Their Differentiation.

Current problems in dermatology

Charruyer A, Ghadially R

Brief Report: Interleukin-17A-Dependent Asymmetric Stem Cell Divisions Are Increased in Human Psoriasis: A Mechanism Underlying Benign Hyperproliferation.

Stem cells (Dayton, Ohio)

Charruyer A, Fong S, Vitcov GG, Sklar S, Tabernik L, Taneja M, Caputo M, Soeung C, Yue L, Uchida Y, Arron ST, Horton KM, Foster RD, Sano S, North JP, Ghadially R

Targeting ALDH1 to decrease tumorigenicity, growth and metastasis of human melanoma.

Melanoma research

Yue L, Huang ZM, Fong S, Leong S, Jakowatz JG, Charruyer-Reinwald A, Wei M, Ghadially R

The CD44+ ALDH+ population of human keratinocytes is enriched for epidermal stem cells with long-term repopulating ability.

Stem cells (Dayton, Ohio)

Szabo AZ, Fong S, Yue L, Zhang K, Strachan LR, Scalapino K, Mancianti ML, Ghadially R

CD133 is a marker for long-term repopulating murine epidermal stem cells.

The Journal of investigative dermatology

Charruyer A, Strachan LR, Yue L, Toth AS, Cecchini G, Mancianti ML, Ghadially R

25 years of epidermal stem cell research.

The Journal of investigative dermatology

Ghadially R

The role of stem and circulating cells in cancer metastasis.

Journal of surgical oncology

Ghadially R

What's new in dermatology: epidermal stem cells.

Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia

Charruyer A, Ghadially R

Selection of tumorigenic melanoma cells using ALDH.

The Journal of investigative dermatology

Boonyaratanakornkit JB, Yue L, Strachan LR, Scalapino KJ, LeBoit PE, Lu Y, Leong SP, Smith JE, Ghadially R

Limiting dilution analysis of murine epidermal stem cells using an in vivo regeneration assay.

Methods in molecular biology (Clifton, N.J.)

Strachan LR, Ghadially R

Transit-amplifying cell frequency and cell cycle kinetics are altered in aged epidermis.

The Journal of investigative dermatology

Charruyer A, Barland CO, Yue L, Wessendorf HB, Lu Y, Lawrence HJ, Mancianti ML, Ghadially R

Stem cells and tissue-engineered skin.

Skin pharmacology and physiology

Charruyer A, Ghadially R

A new water-based topical carrier with polar skin-lipids.

Lipids in health and disease

Silvander M, Ringstad L, Ghadially R, Sköld T

Epidermal stem cells.

Advances in dermatology

Ghadially R

In search of the elusive epidermal stem cell.

Ernst Schering Research Foundation workshop

Ghadially R

Imiquimod-induced interleukin-1 alpha stimulation improves barrier homeostasis in aged murine epidermis.

The Journal of investigative dermatology

Barland CO, Zettersten E, Brown BS, Ye J, Elias PM, Ghadially R

Measuring stem cell frequency in epidermis: a quantitative in vivo functional assay for long-term repopulating cells.

Proceedings of the National Academy of Sciences of the United States of America

Schneider TE, Barland C, Alex AM, Mancianti ML, Lu Y, Cleaver JE, Lawrence HJ, Ghadially R

The aged epidermal permeability barrier: basis for functional abnormalities.

Clinics in geriatric medicine

Elias PM, Ghadially R

Testosterone perturbs epidermal permeability barrier homeostasis.

The Journal of investigative dermatology

Kao JS, Garg A, Mao-Qiang M, Crumrine D, Ghadially R, Feingold KR, Elias PM

Recessive x-linked ichthyosis: role of cholesterol-sulfate accumulation in the barrier abnormality.

The Journal of investigative dermatology

Zettersten E, Man MQ, Sato J, Denda M, Farrell A, Ghadially R, Williams ML, Feingold KR, Elias PM

Aging and the epidermal permeability barrier: implications for contact dermatitis.

American journal of contact dermatitis : official journal of the American Contact Dermatitis Society

Ghadially R

Optimal ratios of topical stratum corneum lipids improve barrier recovery in chronologically aged skin.

Journal of the American Academy of Dermatology

Zettersten EM, Ghadially R, Feingold KR, Crumrine D, Elias PM

Stratum corneum structure and function correlates with phenotype in psoriasis.

The Journal of investigative dermatology

Ghadially R, Reed JT, Elias PM

Decreased epidermal lipid synthesis accounts for altered barrier function in aged mice.

The Journal of investigative dermatology

Ghadially R, Brown BE, Hanley K, Reed JT, Feingold KR, Elias PM

Tumours of the skin.

IARC scientific publications

Ghadially FN, Ghadially R

The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model.

The Journal of clinical investigation

Ghadially R, Brown BE, Sequeira-Martin SM, Feingold KR, Elias PM

Membrane structural abnormalities in the stratum corneum of the autosomal recessive ichthyoses.

The Journal of investigative dermatology

Ghadially R, Williams ML, Hou SY, Elias PM

Exogenous origin of n-alkanes in pathologic scale.

Archives of dermatology

Williams ML, Vogel JS, Ghadially R, Brown BE, Elias PM

Ichthyoses and hyperkeratotic disorders.

Dermatologic clinics

Ghadially R, Chong LP

Lamellar bodies as delivery systems of hydrolytic enzymes: implications for normal and abnormal desquamation.

The British journal of dermatology

Menon GK, Ghadially R, Williams ML, Elias PM

Effects of petrolatum on stratum corneum structure and function.

Journal of the American Academy of Dermatology

Ghadially R, Halkier-Sorensen L, Elias PM

Membrane structures in normal and essential fatty acid-deficient stratum corneum: characterization by ruthenium tetroxide staining and x-ray diffraction.

The Journal of investigative dermatology

Hou SY, Mitra AK, White SH, Menon GK, Ghadially R, Elias PM

Anchoring fibrils in a spindle cell squamous carcinoma.

Journal of submicroscopic cytology and pathology

Ghadially R, Ghadially FN

Simple method for purification of phospholipase A from cobra venom.

Toxicon : official journal of the International Society on Toxinology

Braganca BM, Sambray YM, Ghadially RC

Myo-Inositol activity of oxidtion products derived from myo-inositol.

Archives of biochemistry and biophysics

JOHNSTON JA, GHADIALLY RC, ROBERTS RN, FUHR BW