
Professor
Surgery
Rong Wang, PhD studies cell signaling in mammalian angiogenesis and arterial venous differentiation in embryos, ischemia, stroke and cancer.
Publications
Metabolic Probing of Sialylated Glycoconjugates with Fluorine-Selenol Displacement Reaction (FSeDR).
ACS bio & med chem Au
Flexible Fluorine-Thiol Displacement Stapled Peptides with Enhanced Membrane Penetration for the Estrogen Receptor/Coactivator Interaction.
The Journal of biological chemistry
Site-specific protein conjugates incorporating Para-Azido-L-Phenylalanine for cellular and in vivo imaging.
Methods (San Diego, Calif.)
Meeting Proceedings from ICBS 2022 - Uncovering Solutions for Diseases.
ACS chemical biology
Nitric oxide synthase and reduced arterial tone contribute to arteriovenous malformation.
Science advances
Monitoring of cell-cell communication and contact history in mammals.
Science (New York, N.Y.)
Endothelial Rbpj deletion normalizes Notch4-induced brain arteriovenous malformation in mice.
The Journal of experimental medicine
Abnormal arterial-venous fusions and fate specification in mouse embryos lacking blood flow.
Scientific reports
Endothelial notch signaling is essential to prevent hepatic vascular malformations in mice.
Hepatology (Baltimore, Md.)
Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels.
Proceedings of the National Academy of Sciences of the United States of America
Endothelial ephrin-B2 is essential for arterial vasodilation in mice.
Microcirculation (New York, N.Y. : 1994)
Deletion of Rbpj from postnatal endothelium leads to abnormal arteriovenous shunting in mice.
Development (Cambridge, England)
Molecular identification of venous progenitors in the dorsal aorta reveals an aortic origin for the cardinal vein in mammals.
Development (Cambridge, England)
Notch4 is required for tumor onset and perfusion.
Vascular cell
Notch4 normalization reduces blood vessel size in arteriovenous malformations.
Science translational medicine
Inefficient skeletal muscle repair in inhibitor of differentiation knockout mice suggests a crucial role for BMP signaling during adult muscle regeneration.
American journal of physiology. Cell physiology
Constitutively active endothelial Notch4 causes lung arteriovenous shunts in mice.
American journal of physiology. Lung cellular and molecular physiology
Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation.
Science (New York, N.Y.)
Endothelial Notch signaling is upregulated in human brain arteriovenous malformations and a mouse model of the disease.
Laboratory investigation; a journal of technical methods and pathology
Cellular and molecular mechanism regulating blood flow recovery in acute versus gradual femoral artery occlusion are distinct in the mouse.
Journal of vascular surgery
Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesis.
Development (Cambridge, England)
Endothelial Notch4 signaling induces hallmarks of brain arteriovenous malformations in mice.
Proceedings of the National Academy of Sciences of the United States of America
Placental rescue reveals a sole requirement for c-Myc in embryonic erythroblast survival and hematopoietic stem cell function.
Development (Cambridge, England)
c-myc in the hematopoietic lineage is crucial for its angiogenic function in the mouse embryo.
Development (Cambridge, England)
Cell-autonomous requirement for beta1 integrin in endothelial cell adhesion, migration and survival during angiogenesis in mice.
Development (Cambridge, England)
Distinct pathways of genomic progression to benign and malignant tumors of the liver.
Proceedings of the National Academy of Sciences of the United States of America
Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation.
The Journal of cell biology
Optimization of adenovirus-mediated endothelial nitric oxide synthase delivery in rat hindlimb ischemia.
Gene therapy
Vascular development of the brain requires beta8 integrin expression in the neuroepithelium.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice.
Proceedings of the National Academy of Sciences of the United States of America
VEGF is crucial for the hepatic vascular development required for lipoprotein uptake.
Development (Cambridge, England)
The effect of gradual or acute arterial occlusion on skeletal muscle blood flow, arteriogenesis, and inflammation in rat hindlimb ischemia.
Journal of vascular surgery
Genomic progression in mouse models for liver tumors.
Cold Spring Harbor symposia on quantitative biology
CCR2-/- knockout mice revascularize normally in response to severe hindlimb ischemia.
Journal of vascular surgery
Adeno-associated viral vector-mediated gene transfer of VEGF normalizes skeletal muscle oxygen tension and induces arteriogenesis in ischemic rat hindlimb.
Molecular therapy : the journal of the American Society of Gene Therapy
Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice.
The Journal of cell biology
European surveillance of infections and risk factors in cancer patients.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Cellular adherence elicits ligand-independent activation of the Met cell-surface receptor.
Proceedings of the National Academy of Sciences of the United States of America
Developmental analysis of bone tumors in polyomavirus transgenic mice.
Laboratory investigation; a journal of technical methods and pathology
Embryonic stem cell-derived cystic embryoid bodies form vascular channels: an in vitro model of blood vessel development.
Development (Cambridge, England)
Isolation and characterization of an established endothelial cell line from transgenic mouse hemangiomas.
Experimental cell research