Professor
Neurology
+1 415 502-5687
Robert Edwards, MD, PhD studies the cellular and molecular mechanisms that regulate neurotransmitter release and how they contribute to synaptic physiology, behavior and disease, particularly Parkinson’s.
Publications
Synaptic vesicles that store monoamines and glutamate differ in protein composition.
bioRxiv : the preprint server for biology
Substrate recognition and allosteric regulation of synaptic vesicle glutamate transporter VGLUT2.
Nature structural & molecular biology
Research Priorities on the Role of α-Synuclein in Parkinson's Disease Pathogenesis.
Movement disorders : official journal of the Movement Disorder Society
Structural and mechanistic insights into a lysosomal membrane enzyme HGSNAT involved in Sanfilippo syndrome.
Nature communications
The role of α-synuclein in exocytosis.
Experimental neurology
Adaptor protein-3 produces synaptic vesicles that release phasic dopamine.
Proceedings of the National Academy of Sciences of the United States of America
Adaptor protein AP-3 produces synaptic vesicles that release at high frequency by recruiting phospholipid flippase ATP8A1.
Nature neuroscience
Adaptor Protein-3 Produces Synaptic Vesicles that Release Phasic Dopamine.
bioRxiv : the preprint server for biology
Synuclein phosphorylation: pathogenic or physiologic?
NPJ Parkinson's disease
Substrate recognition and proton coupling by a bacterial member of solute carrier family 17.
The Journal of biological chemistry
High-speed imaging reveals the bimodal nature of dense core vesicle exocytosis.
Proceedings of the National Academy of Sciences of the United States of America
Diversity of function and mechanism in a family of organic anion transporters.
Current opinion in structural biology
Input-specific control of interneuron numbers in nascent striatal networks.
Proceedings of the National Academy of Sciences of the United States of America
SNX5 targets a monoamine transporter to the TGN for assembly into dense core vesicles by AP-3.
The Journal of cell biology
Whole Endosome Recording of Vesicular Neurotransmitter Transporter Currents.
Methods in molecular biology (Clifton, N.J.)
Allosteric Inhibition of a Vesicular Glutamate Transporter by an Isoform-Specific Antibody.
Biochemistry
The Membrane Interactions of Synuclein: Physiology and Pathology.
Annual review of pathology
A dual role for a-synuclein in facilitation and depression of dopamine release from substantia nigra neurons in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Ion transport and regulation in a synaptic vesicle glutamate transporter.
Science (New York, N.Y.)
Perinatal interference with the serotonergic system affects VTA function in the adult via glutamate co-transmission.
Molecular psychiatry
The mechanism and regulation of vesicular glutamate transport: Coordination with the synaptic vesicle cycle.
Biochimica et biophysica acta. Biomembranes
The physiological role of α-synuclein and its relationship to Parkinson's Disease.
Journal of neurochemistry
Structures suggest a mechanism for energy coupling by a family of organic anion transporters.
PLoS biology
Synaptic Vesicle Recycling Pathway Determines Neurotransmitter Content and Release Properties.
Neuron
Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments.
Molecular psychiatry
A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry.
Nature communications
α-Synuclein promotes dilation of the exocytotic fusion pore.
Nature neuroscience
Endogenous Leucine-Rich Repeat Kinase 2 Slows Synaptic Vesicle Recycling in Striatal Neurons.
Frontiers in synaptic neuroscience
A slow excitatory postsynaptic current mediated by a novel metabotropic glutamate receptor in CA1 pyramidal neurons.
Neuropharmacology
Loss of VGLUT3 Produces Circadian-Dependent Hyperdopaminergia and Ameliorates Motor Dysfunction and l-Dopa-Mediated Dyskinesias in a Model of Parkinson's Disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sex-dependent changes in metabolism and behavior, as well as reduced anxiety after eliminating ventromedial hypothalamus excitatory output.
Molecular metabolism
Is Aspartate an Excitatory Neurotransmitter?
The Journal of neuroscience : the official journal of the Society for Neuroscience
The role of mitochondrially derived ATP in synaptic vesicle recycling.
The Journal of biological chemistry
Mobile binding sites regulate glutamate clearance.
Nature neuroscience
A non-canonical pathway from cochlea to brain signals tissue-damaging noise.
Current biology : CB
Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
A population of glomerular glutamatergic neurons controls sensory information transfer in the mouse olfactory bulb.
Nature communications
Self-assembly of VPS41 promotes sorting required for biogenesis of the regulated secretory pathway.
Developmental cell
Widespread dysregulation of peptide hormone release in mice lacking adaptor protein AP-3.
PLoS genetics
The function of a-synuclein.
Neuron
Multiple dileucine-like motifs direct VGLUT1 trafficking.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ventral tegmental area glutamate neurons: electrophysiological properties and projections.
The Journal of neuroscience : the official journal of the Society for Neuroscience
AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans.
Cell metabolism
Fabs enable single particle cryoEM studies of small proteins.
Structure (London, England : 1993)
Vesicular and plasma membrane transporters for neurotransmitters.
Cold Spring Harbor perspectives in biology
Dopamine dysregulation in a mouse model of paroxysmal nonkinesigenic dyskinesia.
The Journal of clinical investigation
Expression of vesicular glutamate transporters type 1 and 2 in sensory and autonomic neurons innervating the mouse colorectum.
The Journal of comparative neurology
Neurotransmitter corelease: mechanism and physiological role.
Annual review of physiology
Presynaptic regulation of quantal size: K+/H+ exchange stimulates vesicular glutamate transport.
Nature neuroscience
Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein.
The Journal of biological chemistry
RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway.
The Journal of cell biology
Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum corelease glutamate.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Vesicular monoamine and glutamate transporters select distinct synaptic vesicle recycling pathways.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Glutamate co-release at GABA/glycinergic synapses is crucial for the refinement of an inhibitory map.
Nature neuroscience
Dopamine release at individual presynaptic terminals visualized with FFNs.
Journal of visualized experiments : JoVE
Fluorescent false neurotransmitters visualize dopamine release from individual presynaptic terminals.
Science (New York, N.Y.)
What the neuron tells glia.
Neuron
Optical reporters for the conformation of alpha-synuclein reveal a specific interaction with mitochondria.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Fast subplasma membrane Ca2+ transients control exo-endocytosis of synaptic-like microvesicles in astrocytes.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Vesicular glutamate and GABA transporters sort to distinct sets of vesicles in a population of presynaptic terminals.
Cerebral cortex (New York, N.Y. : 1991)
Pharmacology of neurotransmitter transport into secretory vesicles.
Handbook of experimental pharmacology
Vesicular neurotransmitter transporters as targets for endogenous and exogenous toxic substances.
Annual review of pharmacology and toxicology
Physiology versus pathology in Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America
Vesicular glutamate transporter 1 is required for photoreceptor synaptic signaling but not for intrinsic visual functions.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Thyronamines inhibit plasma membrane and vesicular monoamine transport.
ACS chemical biology
Do different endocytic pathways make different synaptic vesicles?
Current opinion in neurobiology
Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Secretion of L-glutamate from osteoclasts through transcytosis.
The EMBO journal
Alpha-synuclein overexpression increases cytosolic catecholamine concentration.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Distribution of vesicular glutamate transporters 1 and 2 in the rat spinal cord, with a note on the spinocervical tract.
The Journal of comparative neurology
Distinct endocytic pathways control the rate and extent of synaptic vesicle protein recycling.
Neuron
PharmGKB submission update: VI. PMT submissions of genetic variations in neurotransmitter transporters (SLC6, SLC17, and SLC18) to the PharmGKB network.
Pharmacological reviews
Changes in purinergic signaling after cerebral injury -- involvement of glutamatergic mechanisms?
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
Functional implications of neurotransmitter co-release: glutamate and GABA share the load.
Current opinion in pharmacology
Neural activity controls the synaptic accumulation of alpha-synuclein.
The Journal of neuroscience : the official journal of the Society for Neuroscience
A combinatorial code for the interaction of alpha-synuclein with membranes.
The Journal of biological chemistry
Expression of the vesicular glutamate transporters during development indicates the widespread corelease of multiple neurotransmitters.
The Journal of comparative neurology
Normal biogenesis and cycling of empty synaptic vesicles in dopamine neurons of vesicular monoamine transporter 2 knockout mice.
Molecular biology of the cell
Evidence that certain retinal bipolar cells use both glutamate and GABA.
The Journal of comparative neurology
Vesicular glutamate transporter 3 expression identifies glutamatergic amacrine cells in the rodent retina.
The Journal of comparative neurology
The effect of rare human sequence variants on the function of vesicular monoamine transporter 2.
Pharmacogenetics
Lipid rafts mediate the synaptic localization of alpha-synuclein.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites.
Science (New York, N.Y.)
VGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate.
Trends in neurosciences
Cellular localization of three vesicular glutamate transporter mRNAs and proteins in rat spinal cord and dorsal root ganglia.
Synapse (New York, N.Y.)
Complementary distribution of vesicular glutamate transporters 1 and 2 in the nucleus accumbens of rat: Relationship to calretinin-containing extrinsic innervation and calbindin-immunoreactive neurons.
The Journal of comparative neurology
Plasma membrane and vesicular glutamate transporter mRNAs/proteins in hypothalamic neurons that regulate body weight.
The European journal of neuroscience
Organic anion transport is the primary function of the SLC17/type I phosphate transporter family.
Pflugers Archiv : European journal of physiology
The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Vesicular neurotransmitter transporter expression in developing postnatal rodent retina: GABA and glycine precede glutamate.
The Journal of neuroscience : the official journal of the Society for Neuroscience
The identification of vesicular glutamate transporter 3 suggests novel modes of signaling by glutamate.
Proceedings of the National Academy of Sciences of the United States of America
Methamphetamine-induced degeneration of dopaminergic neurons involves autophagy and upregulation of dopamine synthesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Cell-specific expression of the glutamine transporter SN1 suggests differences in dependence on the glutamine cycle.
The European journal of neuroscience
The glutamine commute: take the N line and transfer to the A.
The Journal of cell biology
Regulation of the glutamine transporter SN1 by extracellular pH and intracellular sodium ions.
The Journal of physiology
Glutamine uptake by neurons: interaction of protons with system a transporters.
The Journal of neuroscience : the official journal of the Society for Neuroscience