Robert Edwards, MD

Professor
Neurology
+1 415 502-5687

Robert Edwards, MD, PhD studies the cellular and molecular mechanisms that regulate neurotransmitter release and how they contribute to synaptic physiology, behavior and disease, particularly Parkinson’s.

Publications: 

The role of α-synuclein in exocytosis.

Experimental neurology

Runwal GM, Edwards RH

Adaptor protein-3 produces synaptic vesicles that release phasic dopamine.

Proceedings of the National Academy of Sciences of the United States of America

Jain S, Yee AG, Maas J, Gierok S, Xu H, Stansil J, Eriksen J, Nelson AB, Silm K, Ford CP, Edwards RH

Adaptor protein AP-3 produces synaptic vesicles that release at high frequency by recruiting phospholipid flippase ATP8A1.

Nature neuroscience

Xu H, Oses-Prieto JA, Khvotchev M, Jain S, Liang J, Burlingame A, Edwards RH

Adaptor Protein-3 Produces Synaptic Vesicles that Release Phasic Dopamine.

bioRxiv : the preprint server for biology

Jain S, Yee AG, Maas J, Gierok S, Xu H, Stansil J, Eriksen J, Nelson A, Silm K, Ford CP, Edwards RH

Synuclein phosphorylation: pathogenic or physiologic?

NPJ Parkinson's disease

Kontaxi C, Edwards RH

Substrate recognition and proton coupling by a bacterial member of solute carrier family 17.

The Journal of biological chemistry

Batarni S, Nayak N, Chang A, Li F, Hareendranath S, Zhou L, Xu H, Stroud R, Eriksen J, Edwards RH

High-speed imaging reveals the bimodal nature of dense core vesicle exocytosis.

Proceedings of the National Academy of Sciences of the United States of America

Zhang P, Rumschitzki D, Edwards RH

Diversity of function and mechanism in a family of organic anion transporters.

Current opinion in structural biology

Li F, Eriksen J, Finer-Moore J, Stroud RM, Edwards RH

SNX5 targets a monoamine transporter to the TGN for assembly into dense core vesicles by AP-3.

The Journal of cell biology

Xu H, Chang F, Jain S, Heller BA, Han X, Liu Y, Edwards RH

Whole Endosome Recording of Vesicular Neurotransmitter Transporter Currents.

Methods in molecular biology (Clifton, N.J.)

Chang R, Edwards RH

The Membrane Interactions of Synuclein: Physiology and Pathology.

Annual review of pathology

Runwal G, Edwards RH

A dual role for a-synuclein in facilitation and depression of dopamine release from substantia nigra neurons in vivo.

Proceedings of the National Academy of Sciences of the United States of America

Somayaji M, Cataldi S, Choi SJ, Edwards RH, Mosharov EV, Sulzer D

Ion transport and regulation in a synaptic vesicle glutamate transporter.

Science (New York, N.Y.)

Li F, Eriksen J, Finer-Moore J, Chang R, Nguyen P, Bowen A, Myasnikov A, Yu Z, Bulkley D, Cheng Y, Edwards RH, Stroud RM

The mechanism and regulation of vesicular glutamate transport: Coordination with the synaptic vesicle cycle.

Biochimica et biophysica acta. Biomembranes

Eriksen J, Li F, Edwards RH

Structures suggest a mechanism for energy coupling by a family of organic anion transporters.

PLoS biology

Leano JB, Batarni S, Eriksen J, Juge N, Pak JE, Kimura-Someya T, Robles-Colmenares Y, Moriyama Y, Stroud RM, Edwards RH

Synaptic Vesicle Recycling Pathway Determines Neurotransmitter Content and Release Properties.

Neuron

Silm K, Yang J, Marcott PF, Asensio CS, Eriksen J, Guthrie DA, Newman AH, Ford CP, Edwards RH

A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry.

Nature communications

Ullman JC, Yang J, Sullivan M, Bendor J, Levy J, Pham E, Silm K, Seifikar H, Sohal VS, Nicoll RA, Edwards RH

Loss of a-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons.

eNeuro

Pathak D, Berthet A, Bendor JT, Yu K, Sellnow RC, Orr AL, Nguyen MK, Edwards RH, Manfredsson FP, Nakamura K

α-Synuclein promotes dilation of the exocytotic fusion pore.

Nature neuroscience

Logan T, Bendor J, Toupin C, Thorn K, Edwards RH

Endogenous Leucine-Rich Repeat Kinase 2 Slows Synaptic Vesicle Recycling in Striatal Neurons.

Frontiers in synaptic neuroscience

Maas JW, Yang J, Edwards RH

Sensory-Derived Glutamate Regulates Presynaptic Inhibitory Terminals in Mouse Spinal Cord.

Neuron

Mende M, Fletcher EV, Belluardo JL, Pierce JP, Bommareddy PK, Weinrich JA, Kabir ZD, Schierberl KC, Pagiazitis JG, Mendelsohn AI, Francesconi A, Edwards RH, Milner TA, Rajadhyaksha AM, van Roessel PJ, Mentis GZ, Kaltschmidt JA

Protons Regulate Vesicular Glutamate Transporters through an Allosteric Mechanism.

Neuron

Eriksen J, Chang R, McGregor M, Silm K, Suzuki T, Edwards RH

Sex-dependent changes in metabolism and behavior, as well as reduced anxiety after eliminating ventromedial hypothalamus excitatory output.

Molecular metabolism

Cheung CC, Krause WC, Edwards RH, Yang CF, Shah NM, Hnasko TS, Ingraham HA

The role of mitochondrially derived ATP in synaptic vesicle recycling.

The Journal of biological chemistry

Pathak D, Shields LY, Mendelsohn BA, Haddad D, Lin W, Gerencser AA, Kim H, Brand MD, Edwards RH, Nakamura K

Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Berthet A, Margolis EB, Zhang J, Hsieh I, Zhang J, Hnasko TS, Ahmad J, Edwards RH, Sesaki H, Huang EJ, Nakamura K

Efficient, complete deletion of synaptic proteins using CRISPR.

Neuron

Incontro S, Asensio CS, Edwards RH, Nicoll RA

Self-assembly of VPS41 promotes sorting required for biogenesis of the regulated secretory pathway.

Developmental cell

Asensio CS, Sirkis DW, Maas JW, Egami K, To TL, Brodsky FM, Shu X, Cheng Y, Edwards RH

The function of a-synuclein.

Neuron

Bendor JT, Logan TP, Edwards RH

Multiple dileucine-like motifs direct VGLUT1 trafficking.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Foss SM, Li H, Santos MS, Edwards RH, Voglmaier SM

Ventral tegmental area glutamate neurons: electrophysiological properties and projections.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Hnasko TS, Hjelmstad GO, Fields HL, Edwards RH

Restoration of hearing in the VGLUT3 knockout mouse using virally mediated gene therapy.

Neuron

Akil O, Seal RP, Burke K, Wang C, Alemi A, During M, Edwards RH, Lustig LR

AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans.

Cell metabolism

Cunningham KA, Hua Z, Srinivasan S, Liu J, Lee BH, Edwards RH, Ashrafi K

Fabs enable single particle cryoEM studies of small proteins.

Structure (London, England : 1993)

Wu S, Avila-Sakar A, Kim J, Booth DS, Greenberg CH, Rossi A, Liao M, Li X, Alian A, Griner SL, Juge N, Yu Y, Mergel CM, Chaparro-Riggers J, Strop P, Tamp? R, Edwards RH, Stroud RM, Craik CS, Cheng Y

Vesicular and plasma membrane transporters for neurotransmitters.

Cold Spring Harbor perspectives in biology

Blakely RD, Edwards RH

Dopamine dysregulation in a mouse model of paroxysmal nonkinesigenic dyskinesia.

The Journal of clinical investigation

Lee HY, Nakayama J, Xu Y, Fan X, Karouani M, Shen Y, Pothos EN, Hess EJ, Fu YH, Edwards RH, Pt?cek LJ

Neurotransmitter corelease: mechanism and physiological role.

Annual review of physiology

Hnasko TS, Edwards RH

Presynaptic regulation of quantal size: K+/H+ exchange stimulates vesicular glutamate transport.

Nature neuroscience

Goh GY, Huang H, Ullman J, Borre L, Hnasko TS, Trussell LO, Edwards RH

v-SNARE composition distinguishes synaptic vesicle pools.

Neuron

Hua Z, Leal-Ortiz S, Foss SM, Waites CL, Garner CC, Voglmaier SM, Edwards RH

Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein.

The Journal of biological chemistry

Nakamura K, Nemani VM, Azarbal F, Skibinski G, Levy JM, Egami K, Munishkina L, Zhang J, Gardner B, Wakabayashi J, Sesaki H, Cheng Y, Finkbeiner S, Nussbaum RL, Masliah E, Edwards RH

Metabolic control of vesicular glutamate transport and release.

Neuron

Juge N, Gray JA, Omote H, Miyaji T, Inoue T, Hara C, Uneyama H, Edwards RH, Nicoll RA, Moriyama Y

Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum corelease glutamate.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Stuber GD, Hnasko TS, Britt JP, Edwards RH, Bonci A

Vesicular monoamine and glutamate transporters select distinct synaptic vesicle recycling pathways.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Onoa B, Li H, Gagnon-Bartsch JA, Elias LA, Edwards RH

Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo.

Neuron

Hnasko TS, Chuhma N, Zhang H, Goh GY, Sulzer D, Palmiter RD, Rayport S, Edwards RH

Glutamate co-release at GABA/glycinergic synapses is crucial for the refinement of an inhibitory map.

Nature neuroscience

Noh J, Seal RP, Garver JA, Edwards RH, Kandler K

Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis.

Neuron

Nemani VM, Lu W, Berge V, Nakamura K, Onoa B, Lee MK, Chaudhry FA, Nicoll RA, Edwards RH

Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors.

Nature

Seal RP, Wang X, Guan Y, Raja SN, Woodbury CJ, Basbaum AI, Edwards RH

Fluorescent false neurotransmitters visualize dopamine release from individual presynaptic terminals.

Science (New York, N.Y.)

Gubernator NG, Zhang H, Staal RG, Mosharov EV, Pereira DB, Yue M, Balsanek V, Vadola PA, Mukherjee B, Edwards RH, Sulzer D, Sames D

Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons.

Neuron

Mosharov EV, Larsen KE, Kanter E, Phillips KA, Wilson K, Schmitz Y, Krantz DE, Kobayashi K, Edwards RH, Sulzer D

Synaptic and extrasynaptic factors governing glutamatergic retinal waves.

Neuron

Blankenship AG, Ford KJ, Johnson J, Seal RP, Edwards RH, Copenhagen DR, Feller MB

What the neuron tells glia.

Neuron

Edwards R

Optical reporters for the conformation of alpha-synuclein reveal a specific interaction with mitochondria.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Nakamura K, Nemani VM, Wallender EK, Kaehlcke K, Ott M, Edwards RH

Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3.

Neuron

Seal RP, Akil O, Yi E, Weber CM, Grant L, Yoo J, Clause A, Kandler K, Noebels JL, Glowatzki E, Lustig LR, Edwards RH

Pharmacology of neurotransmitter transport into secretory vesicles.

Handbook of experimental pharmacology

Chaudhry FA, Boulland JL, Jenstad M, Bredahl MK, Edwards RH

Vesicular neurotransmitter transporters as targets for endogenous and exogenous toxic substances.

Annual review of pharmacology and toxicology

Chaudhry FA, Edwards RH, Fonnum F

Physiology versus pathology in Parkinson's disease.

Proceedings of the National Academy of Sciences of the United States of America

Nakamura K, Edwards RH

Vesicular glutamate transporter 1 is required for photoreceptor synaptic signaling but not for intrinsic visual functions.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Johnson J, Fremeau RT, Duncan JL, Rentería RC, Yang H, Hua Z, Liu X, LaVail MM, Edwards RH, Copenhagen DR

Thyronamines inhibit plasma membrane and vesicular monoamine transport.

ACS chemical biology

Snead AN, Santos MS, Seal RP, Miyakawa M, Edwards RH, Scanlan TS

Do different endocytic pathways make different synaptic vesicles?

Current opinion in neurobiology

Voglmaier SM, Edwards RH

Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Larsen KE, Schmitz Y, Troyer MD, Mosharov E, Dietrich P, Quazi AZ, Savalle M, Nemani V, Chaudhry FA, Edwards RH, Stefanis L, Sulzer D

Synaptic vesicles: half full or half empty?

Neuron

Hnasko TS, Edwards RH

Distinct endocytic pathways control the rate and extent of synaptic vesicle protein recycling.

Neuron

Voglmaier SM, Kam K, Yang H, Fortin DL, Hua Z, Nicoll RA, Edwards RH

PharmGKB submission update: VI. PMT submissions of genetic variations in neurotransmitter transporters (SLC6, SLC17, and SLC18) to the PharmGKB network.

Pharmacological reviews

Badagnani I, Sorani M, Edwards RH, Brown C, Castro RA, Huang CC, Stryke D, Kawamoto M, Johns SJ, Carlson EJ, Taylor T, Chan W, De La Cruz M, Ferrin TE, Burchard EG, Herskowitz I, Kroetz DL, Giacomini KM

Neural activity controls the synaptic accumulation of alpha-synuclein.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Fortin DL, Nemani VM, Voglmaier SM, Anthony MD, Ryan TA, Edwards RH

A combinatorial code for the interaction of alpha-synuclein with membranes.

The Journal of biological chemistry

Kubo S, Nemani VM, Chalkley RJ, Anthony MD, Hattori N, Mizuno Y, Edwards RH, Fortin DL

Expression of the vesicular glutamate transporters during development indicates the widespread corelease of multiple neurotransmitters.

The Journal of comparative neurology

Boulland JL, Qureshi T, Seal RP, Rafiki A, Gundersen V, Bergersen LH, Fremeau RT, Edwards RH, Storm-Mathisen J, Chaudhry FA

Normal biogenesis and cycling of empty synaptic vesicles in dopamine neurons of vesicular monoamine transporter 2 knockout mice.

Molecular biology of the cell

Croft BG, Fortin GD, Corera AT, Edwards RH, Beaudet A, Trudeau LE, Fon EA

Vesicular glutamate transporter 3 expression identifies glutamatergic amacrine cells in the rodent retina.

The Journal of comparative neurology

Johnson J, Sherry DM, Liu X, Fremeau RT, Seal RP, Edwards RH, Copenhagen DR

The effect of rare human sequence variants on the function of vesicular monoamine transporter 2.

Pharmacogenetics

Burman J, Tran CH, Glatt C, Freimer NB, Edwards RH

Lipid rafts mediate the synaptic localization of alpha-synuclein.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Fortin DL, Troyer MD, Nakamura K, Kubo S, Anthony MD, Edwards RH

Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites.

Science (New York, N.Y.)

Fremeau RT, Kam K, Qureshi T, Johnson J, Copenhagen DR, Storm-Mathisen J, Chaudhry FA, Nicoll RA, Edwards RH

VGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate.

Trends in neurosciences

Fremeau RT, Voglmaier S, Seal RP, Edwards RH

Plasma membrane and vesicular glutamate transporter mRNAs/proteins in hypothalamic neurons that regulate body weight.

The European journal of neuroscience

Collin M, Bäckberg M, Ovesjö ML, Fisone G, Edwards RH, Fujiyama F, Meister B

Organic anion transport is the primary function of the SLC17/type I phosphate transporter family.

Pflugers Archiv : European journal of physiology

Reimer RJ, Edwards RH

The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Wreden CC, Johnson J, Tran C, Seal RP, Copenhagen DR, Reimer RJ, Edwards RH

Vesicular neurotransmitter transporter expression in developing postnatal rodent retina: GABA and glycine precede glutamate.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Johnson J, Tian N, Caywood MS, Reimer RJ, Edwards RH, Copenhagen DR

The identification of vesicular glutamate transporter 3 suggests novel modes of signaling by glutamate.

Proceedings of the National Academy of Sciences of the United States of America

Fremeau RT, Burman J, Qureshi T, Tran CH, Proctor J, Johnson J, Zhang H, Sulzer D, Copenhagen DR, Storm-Mathisen J, Reimer RJ, Chaudhry FA, Edwards RH

Cell-specific expression of the glutamine transporter SN1 suggests differences in dependence on the glutamine cycle.

The European journal of neuroscience

Boulland JL, Osen KK, Levy LM, Danbolt NC, Edwards RH, Storm-Mathisen J, Chaudhry FA

The glutamine commute: take the N line and transfer to the A.

The Journal of cell biology

Chaudhry FA, Reimer RJ, Edwards RH

Glutamine uptake by neurons: interaction of protons with system a transporters.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Chaudhry FA, Schmitz D, Reimer RJ, Larsson P, Gray AT, Nicoll R, Kavanaugh M, Edwards RH