Robert Blelloch, MD, PhD

Professor
Urology
+1 415 476-2838

Robert Blelloch, MD, PhD studies gene regulation of pluripotent stem cells, early development, and cancer.

Publications: 

KMT2C/KMT2D-dependent H3K4me1 mediates changes in DNA replication timing and origin activity during a cell fate transition.

Cell reports

Gökbuget D, Goehring L, Boileau RM, Lenshoek K, Huang TT, Blelloch R

The miR-290 and miR-302 clusters are essential for reprogramming of fibroblasts to induced pluripotent stem cells.

bioRxiv : the preprint server for biology

Ye J, Boileau RM, Parchem RJ, Judson-Torres RL, Blelloch R

PVRL2 Suppresses Antitumor Immunity through PVRIG- and TIGIT-independent Pathways.

Cancer immunology research

Yang J, Wang L, Byrnes JR, Kirkemo LL, Driks H, Belair CD, Aguilar OA, Lanier LL, Wells JA, Fong L, Blelloch R

MLL3/MLL4 enzymatic activity shapes DNA replication timing.

bioRxiv : the preprint server for biology

Gökbuget D, Boileau RM, Lenshoek K, Blelloch R

Transcriptional repression upon S phase entry protects genome integrity in pluripotent cells.

Nature structural & molecular biology

Gökbuget D, Lenshoek K, Boileau RM, Bayerl J, Huang H, Wiita AP, Laird DJ, Blelloch R

G1/S restriction point coordinates phasic gene expression and cell differentiation.

Nature communications

DeVeale B, Liu L, Boileau R, Swindlehurst-Chan J, Marsh B, Freimer JW, Abate A, Blelloch R

Beyond Maternal Tolerance: Education of Uterine Natural Killer Cells by Maternal MHC Drives Fetal Growth.

Frontiers in immunology

Depierreux DM, Kieckbusch J, Shreeve N, Hawkes DA, Marsh B, Blelloch R, Sharkey A, Colucci F

The roles of microRNAs in mouse development.

Nature reviews. Genetics

DeVeale B, Swindlehurst-Chan J, Blelloch R

MicroRNA-dependent inhibition of PFN2 orchestrates ERK activation and pluripotent state transitions by regulating endocytosis.

Proceedings of the National Academy of Sciences of the United States of America

Sangokoya C, Blelloch R

LIN28B Impairs the Transition of hESC-Derived � Cells from the Juvenile to Adult State.

Stem cell reports

Zhou X, Nair GG, Russ HA, Belair CD, Li ML, Shveygert M, Hebrok M, Blelloch R

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory.

Cell

Poggio M, Hu T, Pai CC, Chu B, Belair CD, Chang A, Montabana E, Lang UE, Fu Q, Fong L, Blelloch R

High-throughput, Efficient, and Unbiased Capture of Small RNAs from Low-input Samples for Sequencing.

Scientific reports

Belair CD, Hu T, Chu B, Freimer JW, Cooperberg MR, Blelloch RH

FOXD3 Regulates Pluripotent Stem Cell Potential by Simultaneously Initiating and Repressing Enhancer Activity.

Cell stem cell

Krishnakumar R, Chen AF, Pantovich MG, Danial M, Parchem RJ, Labosky PA, Blelloch R

The eutheria-specific miR-290 cluster modulates placental growth and maternal-fetal transport.

Development (Cambridge, England)

Paikari A, D Belair C, Saw D, Blelloch R

NF45 and NF90/NF110 coordinately regulate ESC pluripotency and differentiation.

RNA (New York, N.Y.)

Ye J, Jin H, Pankov A, Song JS, Blelloch R

Patterning of sharp cellular interfaces with a reconfigurable elastic substrate.

Integrative biology : quantitative biosciences from nano to macro

Curtis A, Li DJ, DeVeale B, Onishi K, Kim MY, Blelloch R, Laird DJ, Hui EE

The impact of microRNAs on transcriptional heterogeneity and gene co-expression across single embryonic stem cells.

Nature communications

Gambardella G, Carissimo A, Chen A, Cutillo L, Nowakowski TJ, di Bernardo D, Blelloch R

Vitamin C and l-Proline Antagonistic Effects Capture Alternative States in the Pluripotency Continuum.

Stem cell reports

D'Aniello C, Habibi E, Cermola F, Paris D, Russo F, Fiorenzano A, Di Napoli G, Melck DJ, Cobellis G, Angelini C, Fico A, Blelloch R, Motta A, Stunnenberg HG, De Cesare D, Patriarca EJ, Minchiotti G

miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B�Cell Maturation.

Cell reports

Coffre M, Benhamou D, Rie? D, Blumenberg L, Snetkova V, Hines MJ, Chakraborty T, Bajwa S, Jensen K, Chong MMW, Getu L, Silverman GJ, Blelloch R, Littman DR, Calado D, Melamed D, Skok JA, Rajewsky K, Koralov SB

A miR-372/let-7 Axis Regulates Human Germ Versus Somatic Cell Fates.

Stem cells (Dayton, Ohio)

Tran ND, Kissner M, Subramanyam D, Parchem RJ, Laird DJ, Blelloch RH

FOXD3 Regulates Pluripotent Stem Cell Potential by Simultaneously Initiating and Repressing Enhancer Activity.

Cell stem cell

Krishnakumar R, Chen AF, Pantovich MG, Danial M, Parchem RJ, Labosky PA, Blelloch R

Fas-Activated Mitochondrial Apoptosis Culls Stalled Embryonic Stem Cells to Promote Differentiation.

Current biology : CB

Wang ES, Reyes NA, Melton C, Huskey NE, Momcilovic O, Goga A, Blelloch R, Oakes SA

Biogenesis, delivery, and function of extracellular RNA.

Journal of extracellular vesicles

Patton JG, Franklin JL, Weaver AM, Vickers K, Zhang B, Coffey RJ, Ansel KM, Blelloch R, Goga A, Huang B, L'Etoille N, Raffai RL, Lai CP, Krichevsky AM, Mateescu B, Greiner VJ, Hunter C, Voinnet O, McManus MT

DGCR8 is essential for tumor progression following PTEN loss in the prostate.

EMBO reports

Belair CD, Paikari A, Moltzahn F, Shenoy A, Yau C, Dall'Era M, Simko J, Benz C, Blelloch R

miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability.

Cell reports

Parchem RJ, Moore N, Fish JL, Parchem JG, Braga TT, Shenoy A, Oldham MC, Rubenstein JL, Schneider RA, Blelloch R

Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro.

The EMBO journal

Russ HA, Parent AV, Ringler JJ, Hennings TG, Nair GG, Shveygert M, Guo T, Puri S, Haataja L, Cirulli V, Blelloch R, Szot GL, Arvan P, Hebrok M

CDK1 inhibition targets the p53-NOXA-MCL1 axis, selectively kills embryonic stem cells, and prevents teratoma formation.

Stem cell reports

Huskey NE, Guo T, Evason KJ, Momcilovic O, Pardo D, Creasman KJ, Judson RL, Blelloch R, Oakes SA, Hebrok M, Goga A

Let-7 and miR-125 cooperate to prime progenitors for astrogliogenesis.

The EMBO journal

Shenoy A, Danial M, Blelloch RH

Early postnatal ablation of the microRNA-processing enzyme, Drosha, causes chondrocyte death and impairs the structural integrity of the articular cartilage.

Osteoarthritis and Cartilage

Kobayashi T, Papaioannou G, Mirzamohammadi F, Kozhemyakina E, Zhang M, Blelloch R, Chong MW

Suppression of epithelial-mesenchymal transition and apoptotic pathways by miR-294/302 family synergistically blocks let-7-induced silencing of self-renewal in embryonic stem cells.

Cell death and differentiation

Guo WT, Wang XW, Yan YL, Li YP, Yin X, Zhang Q, Melton C, Shenoy A, Reyes NA, Oakes SA, Blelloch R, Wang Y

Regulation of microRNA function in somatic stem cell proliferation and differentiation.

Nature reviews. Molecular cell biology

Shenoy A, Blelloch RH

miR-19, miR-345, miR-519c-5p serum levels predict adverse pathology in prostate cancer patients eligible for active surveillance.

PloS one

Wang SY, Shiboski S, Belair CD, Cooperberg MR, Simko JP, Stoppler H, Cowan J, Carroll PR, Blelloch R

Two miRNA clusters reveal alternative paths in late-stage reprogramming.

Cell stem cell

Parchem RJ, Ye J, Judson RL, LaRussa MF, Krishnakumar R, Blelloch A, Oldham MC, Blelloch R

MicroRNA-based discovery of barriers to dedifferentiation of fibroblasts to pluripotent stem cells.

Nature structural & molecular biology

Judson RL, Greve TS, Parchem RJ, Blelloch R

Epigenetics of cellular reprogramming.

Current opinion in genetics & development

Krishnakumar R, Blelloch RH

microRNA control of mouse and human pluripotent stem cell behavior.

Annual review of cell and developmental biology

Greve TS, Judson RL, Blelloch R

Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs.

Current opinion in cell biology

Lamouille S, Subramanyam D, Blelloch R, Derynck R

Small RNAs in germline development.

Current topics in developmental biology

Cook MS, Blelloch R

An integrated nano-scale approach to profile miRNAs in limited clinical samples.

American journal of clinical and experimental immunology

Seumois G, Vijayanand P, Eisley CJ, Omran N, Kalinke L, North M, Ganesan AP, Simpson LJ, Hunkapiller N, Moltzahn F, Woodruff PG, Fahy JV, Erle DJ, Djukanovic R, Blelloch R, Ansel KM

Sox1 marks an activated neural stem/progenitor cell in the hippocampus.

Development (Cambridge, England)

Venere M, Han YG, Bell R, Song JS, Alvarez-Buylla A, Blelloch R

Loss of microRNAs in pyramidal neurons leads to specific changes in inhibitory synaptic transmission in the prefrontal cortex.

Molecular and cellular neurosciences

Hsu R, Schofield CM, Dela Cruz CG, Jones-Davis DM, Blelloch R, Ullian EM

Generation of induced pluripotent stem cells from the prairie vole.

PloS one

Manoli DS, Subramanyam D, Carey C, Sudin E, Van Westerhuyzen JA, Bales KL, Blelloch R, Shah NM

Efficiency and specificity in microRNA biogenesis.

Nature structural & molecular biology

Barad O, Mann M, Chapnik E, Shenoy A, Blelloch R, Barkai N, Hornstein E

microRNA induced transdifferentiation.

F1000 biology reports

Shenoy A, Blelloch R

Dgcr8 controls neural crest cells survival in cardiovascular development.

Developmental biology

Chapnik E, Sasson V, Blelloch R, Hornstein E

MicroRNA-29 regulates T-box transcription factors and interferon-? production in helper T cells.

Immunity

Steiner DF, Thomas MF, Hu JK, Yang Z, Babiarz JE, Allen CD, Matloubian M, Blelloch R, Ansel KM

High throughput microRNA profiling: optimized multiplex qRT-PCR at nanoliter scale on the fluidigm dynamic arrayTM IFCs.

Journal of visualized experiments : JoVE

Moltzahn F, Hunkapiller N, Mir AA, Imbar T, Blelloch R

From microRNAs to targets: pathway discovery in cell fate transitions.

Current opinion in genetics & development

Subramanyam D, Blelloch R

Small RNAs in early mammalian development: from gametes to gastrulation.

Development (Cambridge, England)

Suh N, Blelloch R

Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells.

Nature biotechnology

Subramanyam D, Lamouille S, Judson RL, Liu JY, Bucay N, Derynck R, Blelloch R

Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition.

Genes & development

Chen J, Melton C, Suh N, Oh JS, Horner K, Xie F, Sette C, Blelloch R, Conti M

Cell cycle regulation by microRNAs in stem cells.

Results and problems in cell differentiation

Wang Y, Blelloch R

Microfluidic-based multiplex qRT-PCR identifies diagnostic and prognostic microRNA signatures in the sera of prostate cancer patients.

Cancer research

Moltzahn F, Olshen AB, Baehner L, Peek A, Fong L, St?ppler H, Simko J, Hilton JF, Carroll P, Blelloch R

On the streets of San Francisco: highlights from the ISSCR Annual Meeting 2010.

Cell stem cell

Elefanty AG, Blelloch R, Passegu? E, Wernig M, Mummery CL

miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma.

Nature medicine

Swarbrick A, Woods SL, Shaw A, Balakrishnan A, Phua Y, Nguyen A, Chanthery Y, Lim L, Ashton LJ, Judson RL, Huskey N, Blelloch R, Haber M, Norris MD, Lengyel P, Hackett CS, Preiss T, Chetcuti A, Sullivan CS, Marcusson EG, Weiss W, L'Etoile N, Goga A

PML-RAR{alpha} and Dnmt3a1 cooperate in vivo to promote acute promyelocytic leukemia.

Cancer research

Subramanyam D, Belair CD, Barry-Holson KQ, Lin H, Kogan SC, Passegu? E, Blelloch R

Distinct requirements of microRNAs in NK cell activation, survival, and function.

Journal of immunology (Baltimore, Md. : 1950)

Bezman NA, Cedars E, Steiner DF, Blelloch R, Hesslein DG, Lanier LL

MicroRNAs control hepatocyte proliferation during liver regeneration.

Hepatology (Baltimore, Md.)

Song G, Sharma AD, Roll GR, Ng R, Lee AY, Blelloch RH, Frandsen NM, Willenbring H

Mammalian microRNAs: experimental evaluation of novel and previously annotated genes.

Genes & development

Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP

MicroRNA function is globally suppressed in mouse oocytes and early embryos.

Current biology : CB

Suh N, Baehner L, Moltzahn F, Melton C, Shenoy A, Chen J, Blelloch R

MicroRNA Regulation of Embryonic Stem Cell Self-Renewal and Differentiation.

Advances in experimental medicine and biology

Melton C, Blelloch R

Watching reprogramming in real time.

Nature biotechnology

Subramanyam D, Blelloch R

Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure.

Circulation research

Rao PK, Toyama Y, Chiang HR, Gupta S, Bauer M, Medvid R, Reinhardt F, Liao R, Krieger M, Jaenisch R, Lodish HF, Blelloch R

Embryonic stem cell-specific microRNAs promote induced pluripotency.

Nature biotechnology

Judson RL, Babiarz JE, Venere M, Blelloch R

Posttranscriptional crossregulation between Drosha and DGCR8.

Cell

Han J, Pedersen JS, Kwon SC, Belair CD, Kim YK, Yeom KH, Yang WY, Haussler D, Blelloch R, Kim VN

Embryonic stem cell-specific microRNAs regulate the G1-S transition and promote rapid proliferation.

Nature genetics

Wang Y, Baskerville S, Shenoy A, Babiarz JE, Baehner L, Blelloch R

CompMoby: comparative MobyDick for detection of cis-regulatory motifs.

BMC bioinformatics

Chaivorapol C, Melton C, Wei G, Yeh RF, Ramalho-Santos M, Blelloch R, Li H

Generation of induced pluripotent stem cells in the absence of drug selection.

Cell stem cell

Blelloch R, Venere M, Yen J, Ramalho-Santos M

DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal.

Nature genetics

Wang Y, Medvid R, Melton C, Jaenisch R, Blelloch R

Nuclear cloning of embryonal carcinoma cells.

Proceedings of the National Academy of Sciences of the United States of America

Blelloch RH, Hochedlinger K, Yamada Y, Brennan C, Kim M, Mintz B, Chin L, Jaenisch R

TRA-1/GLI controls development of somatic gonadal precursors in C. elegans.

Development (Cambridge, England)

Mathies LD, Schvarzstein M, Morphy KM, Blelloch R, Spence AM, Kimble J

Reprogramming of a melanoma genome by nuclear transplantation.

Genes & development

Hochedlinger K, Blelloch R, Brennan C, Yamada Y, Kim M, Chin L, Jaenisch R

Nuclear cloning, epigenetic reprogramming, and cellular differentiation.

Cold Spring Harbor symposia on quantitative biology

Jaenisch R, Hochedlinger K, Blelloch R, Yamada Y, Baldwin K, Eggan K

Nuclear transplantation, embryonic stem cells and the potential for cell therapy.

The hematology journal : the official journal of the European Haematology Association

Hochedlinger K, Rideout WM, Kyba M, Daley GQ, Blelloch R, Jaenisch R

The gon-1 gene is required for gonadal morphogenesis in Caenorhabditis elegans.

Developmental biology

Blelloch R, Anna-Arriola SS, Gao D, Li Y, Hodgkin J, Kimble J

Control of cell migration during Caenorhabditis elegans development.

Current opinion in cell biology

Blelloch R, Newman C, Kimble J

Roles of the RAM and ANK domains in signaling by the C. elegans GLP-1 receptor.

The EMBO journal

Roehl H, Bosenberg M, Blelloch R, Kimble J

A molecular genetic model of human bladder cancer pathogenesis.

Seminars in oncology

Reznikoff CA, Belair CD, Yeager TR, Savelieva E, Blelloch RH, Puthenveettil JA, Cuthill S