Professor
      
      Urology
          +1 415 476-2838
      Robert Blelloch, MD, PhD studies gene regulation of pluripotent stem cells, early development, and cancer.
Publications
Protocol for genome-wide DNA replication timing analysis using click chemistry-based biotinylation.
STAR protocols
      
            
      
      The miR-290 and miR-302 clusters are essential for reprogramming of fibroblasts to induced pluripotent stem cells.
Stem cells (Dayton, Ohio)
      
            
      
      The miR-290 and miR-302 clusters are essential for reprogramming of fibroblasts to induced pluripotent stem cells.
bioRxiv : the preprint server for biology
      
            
      
      PVRL2 Suppresses Antitumor Immunity through PVRIG- and TIGIT-independent Pathways.
Cancer immunology research
      
            
      
      MLL3/MLL4 enzymatic activity shapes DNA replication timing.
bioRxiv : the preprint server for biology
      
            
      
      Transcriptional repression upon S phase entry protects genome integrity in pluripotent cells.
Nature structural & molecular biology
      
            
      
      G1/S restriction point coordinates phasic gene expression and cell differentiation.
Nature communications
      
            
      
      Beyond Maternal Tolerance: Education of Uterine Natural Killer Cells by Maternal MHC Drives Fetal Growth.
Frontiers in immunology
      
            
      
      The roles of microRNAs in mouse development.
Nature reviews. Genetics
      
            
      
      MicroRNA-dependent inhibition of PFN2 orchestrates ERK activation and pluripotent state transitions by regulating endocytosis.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      LIN28B Impairs the Transition of hESC-Derived � Cells from the Juvenile to Adult State.
Stem cell reports
      
            
      
      Epigenetic control of transcriptional regulation in pluripotency and early differentiation.
Development (Cambridge, England)
      
            
      
      High-throughput, Efficient, and Unbiased Capture of Small RNAs from Low-input Samples for Sequencing.
Scientific reports
      
            
      
      FOXD3 Regulates Pluripotent Stem Cell Potential by Simultaneously Initiating and Repressing Enhancer Activity.
Cell stem cell
      
            
      
      GRHL2-Dependent Enhancer Switching Maintains a Pluripotent Stem Cell Transcriptional Subnetwork after Exit from Naive Pluripotency.
Cell stem cell
      
            
      
      Expression of Alternative Ago2 Isoform Associated with Loss of microRNA-Driven Translational Repression in Mouse Oocytes.
Current biology : CB
      
            
      
      The eutheria-specific miR-290 cluster modulates placental growth and maternal-fetal transport.
Development (Cambridge, England)
      
            
      
      NF45 and NF90/NF110 coordinately regulate ESC pluripotency and differentiation.
RNA (New York, N.Y.)
      
            
      
      Patterning of sharp cellular interfaces with a reconfigurable elastic substrate.
Integrative biology : quantitative biosciences from nano to macro
      
            
      
      The impact of microRNAs on transcriptional heterogeneity and gene co-expression across single embryonic stem cells.
Nature communications
      
            
      
      Vitamin C and l-Proline Antagonistic Effects Capture Alternative States in the Pluripotency Continuum.
Stem cell reports
      
            
      
      miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B�Cell Maturation.
Cell reports
      
            
      
      A miR-372/let-7 Axis Regulates Human Germ Versus Somatic Cell Fates.
Stem cells (Dayton, Ohio)
      
            
      
      FOXD3 Regulates Pluripotent Stem Cell Potential by Simultaneously Initiating and Repressing Enhancer Activity.
Cell stem cell
      
            
      
      Fas-Activated Mitochondrial Apoptosis Culls Stalled Embryonic Stem Cells to Promote Differentiation.
Current biology : CB
      
            
      
      Biogenesis, delivery, and function of extracellular RNA.
Journal of extracellular vesicles
      
            
      
      miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability.
Cell reports
      
            
      
      Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro.
The EMBO journal
      
            
      
      CDK1 inhibition targets the p53-NOXA-MCL1 axis, selectively kills embryonic stem cells, and prevents teratoma formation.
Stem cell reports
      
            
      
      Early postnatal ablation of the microRNA-processing enzyme, Drosha, causes chondrocyte death and impairs the structural integrity of the articular cartilage.
Osteoarthritis and Cartilage
      
            
      
      Suppression of epithelial-mesenchymal transition and apoptotic pathways by miR-294/302 family synergistically blocks let-7-induced silencing of self-renewal in embryonic stem cells.
Cell death and differentiation
      
            
      
      Regulation of pluripotency by RNA binding proteins.
Cell stem cell
      
            
      
      Regulation of microRNA function in somatic stem cell proliferation and differentiation.
Nature reviews. Molecular cell biology
      
            
      
      MicroRNA-based discovery of barriers to dedifferentiation of fibroblasts to pluripotent stem cells.
Nature structural & molecular biology
      
            
      
      Epigenetics of cellular reprogramming.
Current opinion in genetics & development
      
            
      
      microRNA control of mouse and human pluripotent stem cell behavior.
Annual review of cell and developmental biology
      
            
      
      Epigenetics, noncoding RNAs, and cell signaling--crossroads in the regulation of cell fate decisions.
Current opinion in cell biology
      
            
      
      Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs.
Current opinion in cell biology
      
            
      
      Small RNAs in germline development.
Current topics in developmental biology
      
            
      
      An integrated nano-scale approach to profile miRNAs in limited clinical samples.
American journal of clinical and experimental immunology
      
            
      
      Sox1 marks an activated neural stem/progenitor cell in the hippocampus.
Development (Cambridge, England)
      
            
      
      Loss of microRNAs in pyramidal neurons leads to specific changes in inhibitory synaptic transmission in the prefrontal cortex.
Molecular and cellular neurosciences
      
            
      
      Efficiency and specificity in microRNA biogenesis.
Nature structural & molecular biology
      
            
      
      microRNA induced transdifferentiation.
F1000 biology reports
      
            
      
      Dgcr8 controls neural crest cells survival in cardiovascular development.
Developmental biology
      
            
      
      MicroRNA-29 regulates T-box transcription factors and interferon-? production in helper T cells.
Immunity
      
            
      
      High throughput microRNA profiling: optimized multiplex qRT-PCR at nanoliter scale on the fluidigm dynamic arrayTM IFCs.
Journal of visualized experiments : JoVE
      
            
      
      A role for noncanonical microRNAs in the mammalian brain revealed by phenotypic differences in Dgcr8 versus Dicer1 knockouts and small RNA sequencing.
RNA (New York, N.Y.)
      
            
      
      From microRNAs to targets: pathway discovery in cell fate transitions.
Current opinion in genetics & development
      
            
      
      Small RNAs in early mammalian development: from gametes to gastrulation.
Development (Cambridge, England)
      
            
      
      Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells.
Nature biotechnology
      
            
      
      Monoallelic deletion of the microRNA biogenesis gene Dgcr8 produces deficits in the development of excitatory synaptic transmission in the prefrontal cortex.
Neural development
      
            
      
      Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition.
Genes & development
      
            
      
      Cell cycle regulation by microRNAs in stem cells.
Results and problems in cell differentiation
      
            
      
      Microfluidic-based multiplex qRT-PCR identifies diagnostic and prognostic microRNA signatures in the sera of prostate cancer patients.
Cancer research
      
            
      
      miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma.
Nature medicine
      
            
      
      PML-RAR{alpha} and Dnmt3a1 cooperate in vivo to promote acute promyelocytic leukemia.
Cancer research
      
            
      
      Distinct requirements of microRNAs in NK cell activation, survival, and function.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      MicroRNAs control hepatocyte proliferation during liver regeneration.
Hepatology (Baltimore, Md.)
      
            
      
      Mammalian microRNAs: experimental evaluation of novel and previously annotated genes.
Genes & development
      
            
      
      MicroRNA function is globally suppressed in mouse oocytes and early embryos.
Current biology : CB
      
            
      
      MicroRNA Regulation of Embryonic Stem Cell Self-Renewal and Differentiation.
Advances in experimental medicine and biology
      
            
      
      Watching reprogramming in real time.
Nature biotechnology
      
            
      
      Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure.
Circulation research
      
            
      
      Cell cycle regulation by MicroRNAs in embryonic stem cells.
Cancer research
      
            
      
      Embryonic stem cell-specific microRNAs promote induced pluripotency.
Nature biotechnology
      
            
      
      Embryonic stem cell-specific microRNAs regulate the G1-S transition and promote rapid proliferation.
Nature genetics
      
            
      
      CompMoby: comparative MobyDick for detection of cis-regulatory motifs.
BMC bioinformatics
      
            
      
      Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs.
Genes & development
      
            
      
      DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal.
Nature genetics
      
            
      
      Reprogramming efficiency following somatic cell nuclear transfer is influenced by the differentiation and methylation state of the donor nucleus.
Stem cells (Dayton, Ohio)
      
            
      
      Nuclear cloning of embryonal carcinoma cells.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      TRA-1/GLI controls development of somatic gonadal precursors in C. elegans.
Development (Cambridge, England)
      
            
      
      Reprogramming of a melanoma genome by nuclear transplantation.
Genes & development
      
            
      
      Nuclear cloning, epigenetic reprogramming, and cellular differentiation.
Cold Spring Harbor symposia on quantitative biology
      
            
      
      Nuclear transplantation, embryonic stem cells and the potential for cell therapy.
The hematology journal : the official journal of the European Haematology Association
      
            
      
      The gon-1 gene is required for gonadal morphogenesis in Caenorhabditis elegans.
Developmental biology
      
            
      
      Control of cell migration during Caenorhabditis elegans development.
Current opinion in cell biology
      
            
      
      A molecular genetic model of human bladder cancer pathogenesis.
Seminars in oncology