Professor
Pediatrics
+1 415 476-9181
Raphael Hirsch, MD studies immune tolerance and inflammatory mediators in autoimmunity.
Publications
Supporting Career Transitions of Senior Faculty: Perspectives of Chairs and Full Professors.
The Journal of pediatrics
Regulation of Pulmonary Bacterial Immunity by Follistatin-Like Protein 1.
Infection and immunity
The Follistatin-like Protein 1 Pathway Is Important for Maintaining Healthy Articular Cartilage.
ACR open rheumatology
FSTL-1 Attenuation Causes Spontaneous Smoke-Resistant Pulmonary Emphysema.
American journal of respiratory and critical care medicine
Expanding the Pipeline for Pediatric Physician-Scientists.
The Journal of pediatrics
Follistatin-like protein 1 modulates IL-17 signaling via IL-17RC regulation in stromal cells.
Immunology and cell biology
Follistatin-like protein 1 and its role in inflammation and inflammatory diseases.
Immunologic research
Follistatin-like protein 1 is a critical mediator of experimental Lyme arthritis and the humoral response to Borrelia burgdorferi infection.
Microbial pathogenesis
Follistatin-like protein 1 regulates chondrocyte proliferation and chondrogenic differentiation of mesenchymal stem cells.
Annals of the Rheumatic Diseases
Follistatin-like protein 1 enhances NLRP3 inflammasome-mediated IL-1ß secretion from monocytes and macrophages.
European journal of immunology
Follistatin-like protein 1 and the ferritin/erythrocyte sedimentation rate ratio are potential biomarkers for dysregulated gene expression and macrophage activation syndrome in systemic juvenile idiopathic arthritis.
The Journal of rheumatology
Do patients with juvenile idiopathic arthritis in clinical remission have evidence of persistent inflammation on 3T magnetic resonance imaging?
Arthritis care & research
The DBA/1 strain is a novel mouse model for experimental Borrelia burgdorferi infection.
Clinical and vaccine immunology : CVI
2011 Pediatric Rheumatology Symposium sponsored by the American College of Rheumatology Miami, FL, USA. 2-5 June 2011. Abstracts.
Pediatric rheumatology online journal
Plasma follistatin-like protein 1 is elevated in Kawasaki disease and may predict coronary artery aneurysm formation.
The Journal of pediatrics
FSTL1 promotes arthritis in mice by enhancing inflammatory cytokine/chemokine expression.
Arthritis and rheumatism
Akt fine-tunes NF-?B-dependent gene expression during T cell activation.
The Journal of biological chemistry
Hypocomplementemia associated with macrophage activation syndrome in systemic juvenile idiopathic arthritis and adult onset still's disease: 3 cases.
The Journal of rheumatology
Follistatin-like protein 1 is a mesenchyme-derived inflammatory protein and may represent a biomarker for systemic-onset juvenile rheumatoid arthritis.
Arthritis and rheumatism
Synovial fluid proteins differentiate between the subtypes of juvenile idiopathic arthritis.
Arthritis and rheumatism
Pediatric pigmented villonodular synovitis mimicking a septic hip.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
Loeys-Dietz syndrome in pregnancy: a case description and report of a novel mutation.
Fetal diagnosis and therapy
Follistatin-like protein 1 promotes arthritis by up-regulating IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950)
Is long-term etanercept therapy safe and effective in patients with juvenile RA?
Nature clinical practice. Rheumatology
Three-dimensional and thermal surface imaging produces reliable measures of joint shape and temperature: a potential tool for quantifying arthritis.
Arthritis research & therapy
Gene therapy for arthritis.
Modern rheumatology
Follistatin-like protein-1 is a novel proinflammatory molecule.
Journal of immunology (Baltimore, Md. : 1950)
Inflammatory cytokine regulation of transgene expression in human fibroblast-like synoviocytes infected with adeno-associated virus.
Arthritis and rheumatism
NOD.c3c4 congenic mice develop autoimmune biliary disease that serologically and pathogenetically models human primary biliary cirrhosis.
The Journal of experimental medicine
A soluble divalent class I MHC/IgG1 fusion protein activates CD8+ T cells in vivo.
Clinical immunology (Orlando, Fla.)
Serum protein profile in systemic-onset juvenile idiopathic arthritis differentiates response versus nonresponse to therapy.
Arthritis research & therapy
Proteasome inhibition enhances AAV-mediated transgene expression in human synoviocytes in vitro and in vivo.
Molecular therapy : the journal of the American Society of Gene Therapy
Recombinant adeno-associated virus preferentially transduces human, compared to mouse, synovium: implications for arthritis therapy.
Modern rheumatology
DNA microarray analysis reveals novel gene expression profiles in collagen-induced arthritis.
Clinical immunology (Orlando, Fla.)
Gene transfer of a fibronectin peptide inhibits leukocyte recruitment and suppresses inflammation in mouse collagen-induced arthritis.
Arthritis and rheumatism
A single-chain class II MHC-IgG3 fusion protein inhibits autoimmune arthritis by induction of antigen-specific hyporesponsiveness.
Journal of immunology (Baltimore, Md. : 1950)