
Professor
Surgery
+1 415 476-1739
Qizhi Tang, PhD is working on developing regulatory T cell therapies to induce immune tolerance so that foreign tissue can be transplanted without the need for life-long immunosuppression.
Publications
Acquired immune tolerance 2.0.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Harnessing regulatory T cells to establish immune tolerance.
Science translational medicine
Epidermal Stem Cell Derived Exosomes Alleviate Excessive Autophagy Induced Endothelial Cell Apoptosis by Delivering miR200b-3p to Diabetic Wounds.
The Journal of investigative dermatology
Feasibility of an implantable bioreactor for renal cell therapy using silicon nanopore membranes.
Nature communications
Regulatory T cells targeting a pathogenic MHC class II: Insulin peptide epitope postpone spontaneous autoimmune diabetes.
Frontiers in immunology
Donor antigen-specific regulatory T cell administration to recipients of live donor kidneys: A ONE Study consortium pilot trial.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Replenishable prevascularized cell encapsulation devices increase graft survival and function in the subcutaneous space.
Bioengineering & translational medicine
Impact of interleukin-6 on T cells in kidney transplant recipients.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
The dichotomous outcomes of TNFα signaling in CD4+ T cells.
Frontiers in immunology
Selective decrease of donor-reactive Tregs after liver transplantation limits Treg therapy for promoting allograft tolerance in humans.
Science translational medicine
A Phase I/IIa study of autologous tolerogenic dendritic cells immunotherapy in kidney transplant recipients.
Kidney international
Anti-HLA-A2-CAR Tregs prolong vascularized mouse heterotopic heart allograft survival.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
IL-6 and TNFα Drive Extensive Proliferation of Human Tregs Without Compromising Their Lineage Stability or Function.
Frontiers in immunology
Lung transplant recipients with idiopathic pulmonary fibrosis have impaired alloreactive immune responses.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Polyclonal Regulatory T Cell Manufacturing Under cGMP: A Decade of Experience.
Frontiers in immunology
The effect of low-dose IL-2 and Treg adoptive cell therapy in patients with type 1 diabetes.
JCI insight
Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance.
Frontiers in immunology
The Role of Regulatory T Cells in Pulmonary Arterial Hypertension.
Frontiers in immunology
Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection.
Cell reports
A Comparison of Ex Vivo Expanded Human Regulatory T Cells Using Allogeneic Stimulated B Cells or Monocyte-Derived Dendritic Cells.
Frontiers in immunology
A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance.
The Journal of experimental medicine
The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28.
Frontiers in immunology
Interleukin-6 blockade with tocilizumab increases Tregs and reduces T effector cytokines in renal graft inflammation: A randomized controlled trial.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Solving the Puzzle of Immune Tolerance for �-Cell Replacement Therapy for Type 1 Diabetes.
Cell stem cell
Functional CRISPR dissection of gene networks controlling human regulatory T cell identity.
Nature immunology
CAR-Tregs as a Strategy for Inducing Graft Tolerance.
Current transplantation reports
Novel In Situ Hybridization and Multiplex Immunofluorescence Technology Combined With Whole-slide Digital Image Analysis in Kidney Transplantation.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials.
Lancet (London, England)
Next-generation regulatory T cell therapy.
Nature reviews. Drug discovery
Supporting Survival of Transplanted Stem-Cell-Derived Insulin-Producing Cells in an Encapsulation Device Augmented with Controlled Release of Amino Acids.
Advanced biosystems
NextGen cell-based immunotherapies in cancer and other immune disorders.
Current opinion in immunology
NKG2C Natural Killer Cells in Bronchoalveolar Lavage Are Associated With Cytomegalovirus Viremia and Poor Outcomes in Lung Allograft Recipients.
Transplantation
Adoptive Treg Cell Therapy in a Patient With Systemic Lupus Erythematosus.
Arthritis & rheumatology (Hoboken, N.J.)
Islet encapsulation therapy - racing towards the finish line?
Nature reviews. Endocrinology
Regulatory T-cell therapy for autoimmune and autoinflammatory diseases: The next frontier.
The Journal of allergy and clinical immunology
Treg cells-the next frontier of cell therapy.
Science (New York, N.Y.)
Suppressed calcineurin-dependent gene expression identifies lung allograft recipients at increased risk of infection.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Revealing the specificity of regulatory T cells in murine autoimmune diabetes.
Proceedings of the National Academy of Sciences of the United States of America
Alloreactive fetal T cells promote uterine contractility in preterm labor via IFN-γ and TNF-α.
Science translational medicine
Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization.
Frontiers in immunology
Mitigating Ischemic Injury of Stem Cell-Derived Insulin-Producing Cells after Transplant.
Stem cell reports
Transplant trials with Tregs: perils and promises.
The Journal of clinical investigation
Cutting Edge: Origins, Recruitment, and Regulation of CD11c+ Cells in Inflamed Islets of Autoimmune Diabetes Mice.
Journal of immunology (Baltimore, Md. : 1950)
Glucose-Stimulated Insulin Response of Silicon Nanopore-Immunoprotected Islets under Convective Transport.
ACS biomaterials science & engineering
Impact of Immune-Modulatory Drugs on Regulatory T Cell.
Transplantation
Restoring Regulatory T Cells in Type 1 Diabetes.
Current diabetes reports
Donor-Reactive Regulatory T Cell Frequency Increases During Acute Cellular Rejection of Lung Allografts.
Transplantation
Virtual Global Transplant Laboratory Standard Operating Procedures for Blood Collection, PBMC Isolation, and Storage.
Transplantation direct
Assessment of Immune Isolation of Allogeneic Mouse Pancreatic Progenitor Cells by a Macroencapsulation Device.
Transplantation
Heightened Immune Activation in Fetuses with Gastroschisis May Be Blocked by Targeting IL-5.
Journal of immunology (Baltimore, Md. : 1950)
Silicon nanopore membrane (SNM) for islet encapsulation and immunoisolation under convective transport.
Scientific reports
Approaching a cure for type 1 diabetes.
Nature medicine
Type 1 diabetes immunotherapy using polyclonal regulatory T cells.
Science translational medicine
Targeting Treg signaling for the treatment of autoimmune diseases.
Current opinion in immunology
Immunotherapy: making the case for precision medicine.
Science translational medicine
Therapeutic regulatory T cells subvert effector T cell function in inflamed islets to halt autoimmune diabetes.
Journal of immunology (Baltimore, Md. : 1950)
Antigen recognition in the islets changes with progression of autoimmune islet infiltration.
Journal of immunology (Baltimore, Md. : 1950)
Interpretation of transplant biopsies and immune responses following Treg cell therapy.
Current opinion in organ transplantation
Fetal intervention increases maternal T cell awareness of the foreign conceptus and can lead to immune-mediated fetal demise.
Journal of immunology (Baltimore, Md. : 1950)
Regulatory T-cell therapy in transplantation: moving to the clinic.
Cold Spring Harbor perspectives in medicine
Altered balance between effector T cells and FOXP3+ HELIOS+ regulatory T cells after thymoglobulin induction in kidney transplant recipients.
Transplant international : official journal of the European Society for Organ Transplantation
IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.
Cell metabolism
Regulatory T-cell therapy for transplantation: how many cells do we need?
Current opinion in organ transplantation
CD4(+)Foxp3(+) regulatory T cell therapy in transplantation.
Journal of molecular cell biology
B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America
Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Requirements for prolongation of allograft survival with regulatory T cell infusion in lymphosufficient hosts.
The Journal of surgical research
The maternal immune response inhibits the success of in utero hematopoietic cell transplantation.
Chimerism
Maternal T cells limit engraftment after in utero hematopoietic cell transplantation in mice.
The Journal of clinical investigation
IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells.
The Journal of experimental medicine
Prevention of diabetes by FTY720-mediated stabilization of peri-islet tertiary lymphoid organs.
Diabetes
Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal.
Nature immunology
Amplification of autoimmune response through induction of dendritic cell maturation in inflamed tissues.
Journal of immunology (Baltimore, Md. : 1950)
T regulatory cells in autoimmune diabetes: past challenges, future prospects.
Journal of clinical immunology
Spontaneous development of a pancreatic exocrine disease in CD28-deficient NOD mice.
Journal of immunology (Baltimore, Md. : 1950)
Mechanisms of PDL1-mediated regulation of autoimmune diabetes.
Clinical immunology (Orlando, Fla.)
Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway.
The Journal of experimental medicine
Regulatory T-cell physiology and application to treat autoimmunity.
Immunological reviews
Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Imaging the function of regulatory T cells in vivo.
Current opinion in immunology
Plasmacytoid DCs and T(reg) cells: casual acquaintance or monogamous relationship?
Nature immunology
Antigen-specific regulatory T cells--ex vivo expansion and therapeutic potential.
Seminars in immunology
Ex vivo-expanded CD4+CD25+ immunoregulatory T cells prevent graft-versus-host-disease by inhibiting activation/differentiation of pathogenic T cells.
Journal of immunology (Baltimore, Md. : 1950)
Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice.
Nature immunology
How do CD4+CD25+ regulatory T cells control autoimmunity?
Current opinion in immunology
Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950)
Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function.
European journal of immunology
Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells.
Proceedings of the National Academy of Sciences of the United States of America
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes.
The Journal of experimental medicine
Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
CD28/B7 regulation of anti-CD3-mediated immunosuppression in vivo.
Journal of immunology (Baltimore, Md. : 1950)
CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment.
Nature immunology
The role of CD28 and CTLA4 in the function and homeostasis of CD4+CD25+ regulatory T cells.
Novartis Foundation symposium
The Src family kinase Fyn mediates signals induced by TCR antagonists.
Journal of immunology (Baltimore, Md. : 1950)
ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse.
Immunity
Antigen-specific blockade of T cells in vivo using dimeric MHC peptide.
Journal of immunology (Baltimore, Md. : 1950)
Development and applications of surface-linked single chain antibodies against T-cell antigens.
Journal of immunological methods
Partial TCR signals delivered by FcR-nonbinding anti-CD3 monoclonal antibodies differentially regulate individual Th subsets.
Journal of immunology (Baltimore, Md. : 1950)
T cell receptor-gamma/delta cells protect mice from herpes simplex virus type 1-induced lethal encephalitis.
The Journal of experimental medicine
Proinflammatory functions of IL-2 in herpes simplex virus corneal infection.
Journal of immunology (Baltimore, Md. : 1950)
Interferon gamma regulates platelet endothelial cell adhesion molecule 1 expression and neutrophil infiltration into herpes simplex virus-infected mouse corneas.
The Journal of experimental medicine
Ex vivo model of leukocyte migration into herpes simplex virus-infected mouse corneas.
Journal of leukocyte biology
Inflammatory infiltration of the trigeminal ganglion after herpes simplex virus type 1 corneal infection.
Journal of virology
Involvement of LFA-1 and ICAM-1 in the herpetic disease resulting from HSV-1 corneal infection.
Current eye research
Herpes simplex virus glycoproteins E and I facilitate cell-to-cell spread in vivo and across junctions of cultured cells.
Journal of virology
IL-8 gene expression in cultures of human corneal epithelial cells and keratocytes.
Investigative ophthalmology & visual science