Pao-Tien Chuang, MD, PhD

Professor
Cardiovascular Research Inst
[email protected]
+1 415 514-0667

Pao-Tien Chuang, MD, PhD studies Hedgehog signaling in mammalian embryogenesis and postnatal physiology.

Publications: 

The alveolus: Our current knowledge of how the gas exchange unit of the lung is constructed and repaired.

Current topics in developmental biology

Zhang K, Yao E, Aung T, Chuang PT

Monitoring the performance of a dedicated weaning unit using risk-adjusted control charts for the weaning rate in prolonged mechanical ventilation.

Journal of the Formosan Medical Association = Taiwan yi zhi

Huang HF, Jerng JS, Hsu PJ, Lin NH, Lin LM, Hung SM, Kuo YW, Ku SC, Chuang PY, Chen SY

Wnt5a-Vangl1/2 signaling regulates the position and direction of lung branching through the cytoskeleton and focal adhesions.

PLoS biology

Zhang K, Yao E, Chuang E, Chen B, Chuang EY, Volk RF, Hofmann KL, Zaro B, Chuang PT

A functional circuit formed by the autonomic nerves and myofibroblasts controls mammalian alveolar formation for gas exchange.

Developmental cell

Zhang K, Yao E, Wang SA, Chuang E, Wong J, Minichiello L, Schroeder A, Eckalbar W, Wolters PJ, Chuang PT

Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria.

eLife

Zhang K, Yao E, Chen B, Chuang E, Wong J, Seed RI, Nishimura SL, Wolters PJ, Chuang PT

Notch Signaling Controls Transdifferentiation of Pulmonary Neuroendocrine Cells in Response to Lung Injury.

Stem cells (Dayton, Ohio)

Yao E, Lin C, Wu Q, Zhang K, Song H, Chuang PT

Selective Ablation of Tumor Suppressors in Parafollicular C Cells Elicits Medullary Thyroid Carcinoma.

The Journal of biological chemistry

Song H, Lin C, Yao E, Zhang K, Li X, Wu Q, Chuang PT

Hedgehog signaling: From basic research to clinical applications.

Journal of the Formosan Medical Association = Taiwan yi zhi

Yao E, Chuang PT

Regulation of Sufu activity by p66� and Mycbp provides new insight into vertebrate Hedgehog signaling.

Genes & development

Lin C, Yao E, Wang K, Nozawa Y, Shimizu H, Johnson JR, Chen JN, Krogan NJ, Chuang PT

Differential regulation of Gli proteins by Sufu in the lung affects PDGF signaling and myofibroblast development.

Developmental biology

Lin C, Chen MH, Yao E, Song H, Gacayan R, Hui CC, Chuang PT

A switch from low to high Shh activity regulates establishment of limb progenitors and signaling centers.

Developmental cell

Zhulyn O, Li D, Deimling S, Vakili NA, Mo R, Puviindran V, Chen MH, Chuang PT, Hopyan S, Hui CC

Fused (Stk36) is a ciliary protein required for central pair assembly and motile cilia orientation in the mammalian oviduct.

Developmental dynamics : an official publication of the American Association of Anatomists

Nozawa YI, Yao E, Lin C, Yang JH, Wilson CW, Gacayan R, Chuang PT

Alveolar type II cells possess the capability of initiating lung tumor development.

PloS one

Lin C, Song H, Huang C, Yao E, Gacayan R, Xu SM, Chuang PT

Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis.

Proceedings of the National Academy of Sciences of the United States of America

Song H, Yao E, Lin C, Gacayan R, Chen MH, Chuang PT

The path to chemotaxis and transcription is smoothened.

Science signaling

Lin C, Nozawa YI, Chuang PT

A cell-based screen for inhibitors of flagella-driven motility in Chlamydomonas reveals a novel modulator of ciliary length and retrograde actin flow.

Cytoskeleton (Hoboken, N.J.)

Engel BD, Ishikawa H, Feldman JL, Wilson CW, Chuang PT, Snedecor J, Williams J, Sun Z, Marshall WF

Mechanism and evolution of cytosolic Hedgehog signal transduction.

Development (Cambridge, England)

Wilson CW, Chuang PT

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved.

Genes & development

Chen MH, Wilson CW, Li YJ, Law KK, Lu CS, Gacayan R, Zhang X, Hui CC, Chuang PT

Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis.

Nature

Wilson CW, Nguyen CT, Chen MH, Yang JH, Gacayan R, Huang J, Chen JN, Chuang PT

Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy.

Development (Cambridge, England)

Mak KK, Kronenberg HM, Chuang PT, Mackem S, Yang Y

Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms.

Nature cell biology

Corbit KC, Shyer AE, Dowdle WE, Gaulden J, Singla V, Chen MH, Chuang PT, Reiter JF

SnapShot: hedgehog signaling pathway.

Cell

Chen MH, Wilson CW, Chuang PT

Hhip regulates zebrafish muscle development by both sequestering Hedgehog and modulating localization of Smoothened.

Developmental biology

Ochi H, Pearson BJ, Chuang PT, Hammerschmidt M, Westerfield M

GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis.

Development (Cambridge, England)

Hu MC, Mo R, Bhella S, Wilson CW, Chuang PT, Hui CC, Rosenblum ND

N-myristoyltransferase 1 is essential in early mouse development.

The Journal of biological chemistry

Yang SH, Shrivastav A, Kosinski C, Sharma RK, Chen MH, Berthiaume LG, Peters LL, Chuang PT, Young SG, Bergo MO

Immunoprevention of basal cell carcinomas with recombinant hedgehog-interacting protein.

The Journal of experimental medicine

Vogt A, Chuang PT, Hebert J, Hwang J, Lu Y, Kopelovich L, Athar M, Bickers DR, Epstein EH

Continuous lateral rotational therapy in the medical intensive care unit.

Journal of the Formosan Medical Association = Taiwan yi zhi

Wang JY, Chuang PY, Lin CJ, Yu CJ, Yang PC

Combined activities of hedgehog signaling inhibitors regulate pancreas development.

Development (Cambridge, England)

Kawahira H, Ma NH, Tzanakakis ES, McMahon AP, Chuang PT, Hebrok M

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.

Nucleic acids research

Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE

Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling.

Development (Cambridge, England)

Kawakami T, Kawcak T, Li YJ, Zhang W, Hu Y, Chuang PT

Activation of expression of hedgehog target genes in basal cell carcinomas.

The Journal of investigative dermatology

Bonifas JM, Pennypacker S, Chuang PT, McMahon AP, Williams M, Rosenthal A, De Sauvage FJ, Epstein EH

Hedgehog signaling is required for pituitary gland development.

Development (Cambridge, England)

Treier M, O'Connell S, Gleiberman A, Price J, Szeto DP, Burgess R, Chuang PT, McMahon AP, Rosenfeld MG

Determination of the chromosomal location and genomic structure of the Hedgehog-Interacting Protein gene, and analysis of its role in Holoprosencephaly.

International Journal of Genomics

Liang Huo, Erich Roessler, Amalia Dutra, Pao-Tien Chuang, A. P. McMahon, Maximilian Muenke

Determination of the chromosomal location and genomic structure of theHedgehog-Interacting Protein gene, and analysis of its role in Holoprosencephaly.

International Journal of Genomics

Liang Huo, Erich Roessler, Amalia Dutra, Pao-Tien Chuang, A. P. McMahon, Maximilian Muenke

On the range of hedgehog signaling.

Current opinion in genetics & development

Chuang PT, Kornberg TB

Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb.

Development (Cambridge, England)

Yang Y, Drossopoulou G, Chuang PT, Duprez D, Marti E, Bumcrot D, Vargesson N, Clarke J, Niswander L, McMahon A, Tickle C

Hedgehogs in the clinic.

Nature medicine

McMahon AP, Chuang PT