
Professor
Orofacial Sciences
Pamela Den Besten, DDS studies the development of ameloblasts, the cells that deposit enamel on developing teeth, and explores the development of stem cells derived from tooth pulp in the reconstruction of teeth.
Publications
Fluoride exposure and blood cell markers of inflammation in children and adolescents in the United States: NHANES, 2013-2016.
Environmental health : a global access science source
Three-Dimensional Culture of Ameloblast-Originated HAT-7 Cells for Functional Modeling of Defective Tooth Enamel Formation.
Frontiers in pharmacology
TRPM7-Mediated Calcium Transport in HAT-7 Ameloblasts.
International journal of molecular sciences
Maternal and fetal exposures to fluoride during mid-gestation among pregnant women in northern California.
Environmental health : a global access science source
Fluoride related changes in behavioral outcomes may relate to increased serotonin.
Physiology & behavior
The Importance of Connexin 43 in Enamel Development and Mineralization.
Frontiers in physiology
Oral Sciences PhD Program Enrollment, Graduates, and Placement: 1994 to 2016.
Journal of dental research
No Change in Bicarbonate Transport but Tight-Junction Formation Is Delayed by Fluoride in a Novel Ameloblast Model.
Frontiers in physiology
Meeting report: a hard look at the state of enamel research.
International journal of oral science
The Role of Na:K:2Cl Cotransporter 1 (NKCC1/SLC12A2) in Dental Epithelium during Enamel Formation in Mice.
Frontiers in physiology
Corrigendum to " Mineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisors" [Archives of Oral Biology 29 (July (83)) (2017) 214-221].
Archives of oral biology
Importance of bicarbonate transport in pH control during amelogenesis - need for functional studies.
Oral diseases
Mineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisors.
Archives of oral biology
Mediator 1 contributes to enamel mineralization as a coactivator for Notch1 signaling and stimulates transcription of the alkaline phosphatase gene.
The Journal of biological chemistry
Buffering of protons released by mineral formation during amelogenesis in mice.
European journal of oral sciences
The C-terminus of amelogenin enhances osteogenic differentiation of human cementoblast lineage cells.
Journal of periodontal research
Effects of C-Terminal Amelogenin Peptide on Proliferation of Human Cementoblast Lineage Cells.
Journal of periodontology
Ameloblast Modulation and Transport of Cl?, Na?, and K? during Amelogenesis.
Journal of dental research
Slc26a3/Dra and Slc26a6 in Murine Ameloblasts.
Journal of dental research
Composition of mineralizing incisor enamel in cystic fibrosis transmembrane conductance regulator-deficient mice.
European journal of oral sciences
Amelogenins as potential buffers during secretory-stage amelogenesis.
Journal of dental research
Distinctive genetic activity pattern of the human dental pulp between deciduous and permanent teeth.
PloS one
NBCe1 (SLC4A4) a potential pH regulator in enamel organ cells during enamel development in the mouse.
Cell and tissue research
WDR72 models of structure and function: a stage-specific regulator of enamel mineralization.
Matrix biology : journal of the International Society for Matrix Biology
Barrier formation: potential molecular mechanism of enamel fluorosis.
Journal of dental research
Inductive ability of human developing and differentiated dental mesenchyme.
Cells, tissues, organs
Leucine rich amelogenin peptide alters ameloblast differentiation in vivo.
Matrix biology : journal of the International Society for Matrix Biology
The similarity between human embryonic stem cell-derived epithelial cells and ameloblast-lineage cells.
International journal of oral science
Clinical efficacy and effects of xylitol wipes on bacterial virulence.
Advances in dental research
Enamel pits in hamster molars, formed by a single high fluoride dose, are associated with a perturbation of transitional stage ameloblasts.
Caries research
Effects of xylitol wipes on cariogenic bacteria and caries in young children.
Journal of dental research
Amelogenin exons 8 and 9 encoded peptide enhances leucine rich amelogenin peptide mediated dental pulp repair.
Cells, tissues, organs
Developmental expression of solute carrier family 26A member 4 (SLC26A4/pendrin) during amelogenesis in developing rodent teeth.
European journal of oral sciences
Fluoride incorporation into apatite crystals delays amelogenin hydrolysis.
European journal of oral sciences
Evolutionary story of mammalian-specific amelogenin exons 4, "4b", 8, and 9.
Journal of dental research
Chronic fluoride toxicity: dental fluorosis.
Monographs in oral science
Altered self-assembly and apatite binding of amelogenin induced by N-terminal proline mutation.
Archives of oral biology
NBCe1 in mouse and human ameloblasts may be indirectly regulated by fluoride.
Journal of dental research
Fate of fluoride-induced subameloblastic cysts in developing hamster molar tooth germs.
Archives of oral biology
Ameloblast differentiation in the human developing tooth: effects of extracellular matrices.
Matrix biology : journal of the International Society for Matrix Biology
Horizontal transmission of mutans streptococci in children.
Journal of dental research
The impact of fluoride on ameloblasts and the mechanisms of enamel fluorosis.
Journal of dental research
Calcium-mediated differentiation of ameloblast lineage cells in vitro.
Journal of experimental zoology. Part B, Molecular and developmental evolution
Dentin extracellular matrix molecules implanted into exposed pulps generate reparative dentin: a novel strategy in regenerative dentistry.
Journal of dental research
Functional roles of prolines at amelogenin C terminal during tooth enamel formation.
Cells, tissues, organs
The effect of fluoride on enamel and dentin formation in the uremic rat incisor.
Pediatric nephrology (Berlin, Germany)
Inflammatory and immunological aspects of dental pulp repair.
Pharmacological research
Reduced amelogenin-MMP20 interactions in amelogenesis imperfecta.
Journal of dental research
Comparative properties of recombinant human and bovine matrix metalloproteinase-20.
Archives of oral biology
Effects of fluoride on the interactions between amelogenin and apatite crystals.
Journal of dental research
Matricellular molecules and odontoblast progenitors as tools for dentin repair and regeneration.
Clinical oral investigations
The effect of LRAP on enamel organ epithelial cell differentiation.
Journal of dental research
Dentonin, a MEPE fragment, initiates pulp-healing response to injury.
Journal of dental research
JNK/c-Jun signaling pathway mediates the fluoride-induced down-regulation of MMP-20 in vitro.
Matrix biology : journal of the International Society for Matrix Biology
Micromolar fluoride alters ameloblast lineage cells in vitro.
Journal of dental research
Elevated TGF-beta2 signaling in dentin results in sex related enamel defects.
Archives of oral biology
Comparative calcium binding of leucine-rich amelogenin peptide and full-length amelogenin.
European journal of oral sciences
Differentiation of human ameloblast-lineage cells in vitro.
European journal of oral sciences
Fluoride down-regulates the expression of matrix metalloproteinase-20 in human fetal tooth ameloblast-lineage cells in vitro.
European journal of oral sciences
Growth of ameloblast-lineage cells in a three-dimensional Matrigel environment.
European journal of oral sciences
Self-assembly and effect on crystal growth of the leucine-rich amelogenin peptide.
European journal of oral sciences
The impact of bioactive molecules to stimulate tooth repair and regeneration as part of restorative dentistry.
Dental clinics of North America
On-column activation of bovine recombinant metalloproteinase 20.
Analytical biochemistry
Amelogenin control over apatite crystal growth is affected by the pH and degree of ionic saturation.
Orthodontics & craniofacial research
Mouse amelogenin exons 8 and 9: sequence analysis and protein distribution.
Journal of dental research
MEPE is downregulated as dental pulp stem cells differentiate.
Archives of oral biology
Characterization of human primary enamel organ epithelial cells in vitro.
Archives of oral biology
Effects of sodium fluoride on the actin cytoskeleton of murine ameloblasts.
Archives of oral biology
Amelogenin-guided crystal growth on fluoroapatite glass-ceramics.
Journal of dental research
Dentonin, a fragment of MEPE, enhanced dental pulp stem cell proliferation.
Journal of dental research
X-linked amelogenesis imperfecta may result from decreased formation of tyrosine rich amelogenin peptide (TRAP).
Archives of oral biology
Early childhood caries: an overview with reference to our experience in California.
Journal of the California Dental Association
Effects of fluoride on rat dental enamel matrix proteinases.
Archives of oral biology
Expression of alternatively spliced RNA transcripts of amelogenin gene exons 8 and 9 and its end products in the rat incisor.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Stem cell properties of human dental pulp stem cells.
Journal of dental research
Identification of the calcium-sensing receptor in the developing tooth organ.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
The effect of TGF-beta 2 on dentin apposition and hardness in transgenic mice.
Advances in dental research
Reduced hydrolysis of amelogenin may result in X-linked amelogenesis imperfecta.
Matrix biology : journal of the International Society for Matrix Biology
Increased fluoride content in the femur growth plate and cortical bone of uremic rats.
Pediatric nephrology (Berlin, Germany)
Is teething associated with diarrhea?
The Western journal of medicine
Activation of recombinant bovine matrix metalloproteinase-20 and its hydrolysis of two amelogenin oligopeptides.
European journal of oral sciences
Development and characterization of an SV40 immortalized porcine ameloblast-like cell line.
European journal of oral sciences
Biological mechanisms of dental fluorosis relevant to the use of fluoride supplements.
Community dentistry and oral epidemiology
Canadian Consensus Conference on the appropriate use of fluoride supplements for the prevention of dental caries in children.
Journal (Canadian Dental Association)
Identification of two additional exons at the 3' end of the amelogenin gene.
Archives of oral biology
Fluoride levels in whole saliva of preschool children after brushing with 0.25 g (pea-sized) as compared to 1.0 g (full-brush) of a fluoride dentifrice.
Pediatric dentistry
Alternative splicing of amelogenin mRNA from rat incisor ameloblasts.
Journal of dental research
Purification of nonamelogenin proteins from bovine secretory enamel.
Calcified tissue international
Neurotoxicity of sodium fluoride in rats.
Neurotoxicology and teratology
Effects of chronic fluoride exposure on morphometric parameters defining the stages of amelogenesis and ameloblast modulation in rat incisors.
The Anatomical record
Expression of bone protein mRNA at physiological fluoride concentrations in rat osteoblast culture.
Bone and mineral
Characterization of amelogenin mRNA from secretory- and maturation-stage rat incisor enamel.
Archives of oral biology
Biological mechanisms of fluorosis and level and timing of systemic exposure to fluoride with respect to fluorosis.
Journal of dental research
Fluoride binding by matrix proteins in rat mineralizing tissue.
Archives of oral biology
The presence and possible functions of the matrix metalloproteinase collagenase activator protein in developing enamel matrix.
The Biochemical journal
Enamel proteases in secretory and maturation enamel of rats ingesting 0 and 100 PPM fluoride in drinking water.
Advances in dental research
Separation by polyacrylamide gel electrophoresis of multiple proteases in rat and bovine enamel.
Archives of oral biology
Studies on the changes in developing enamel caused by ingestion of high levels of fluoride in the rat.
Advances in dental research
Changes in the fluoride-induced modulation of maturation stage ameloblasts of rats.
Journal of dental research
Oral self-mutilation in a child with congenital toxoplasmosis: a clinical report.
Pediatric dentistry
The effects of chronic high fluoride levels on forming enamel in the rat.
Archives of oral biology