
Professor
Medicine
+1 415 514-0269
Neil Shah, MD, PhD is an expert in developing molecularly targeted therapies for chronic myeloid leukemia and other hematologic malignancies.
Publications
FOXA2 promotes metastatic competence in small cell lung cancer.
Nature communications
A Phase 1b/2 Study of Talazoparib and Axitinib in Patients with Advanced Clear-cell Renal Cell Carcinoma.
European urology oncology
Baseline colitogenicity and acute perturbations of gut microbiota in immunotherapy-related colitis.
The Journal of experimental medicine
Esophagectomy may have a role in stage IV esophageal adenocarcinoma.
The Journal of thoracic and cardiovascular surgery
Health Care Resource Use for Modern First-Line Treatments in Metastatic Renal Cell Carcinoma.
JAMA network open
Immunologic Profiling of Immune-Related Cutaneous Adverse Events with Checkpoint Inhibitors Reveals Polarized Actionable Pathways.
Clinical cancer research : an official journal of the American Association for Cancer Research
Overcoming Secondary Mutations of Type II Kinase Inhibitors.
Journal of medicinal chemistry
Cabozantinib Plus Nivolumab in Patients with Non-Clear Cell Renal Cell Carcinoma: Updated Results from a Phase 2 Trial.
European urology
Chronic Myeloid Leukemia, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology.
Journal of the National Comprehensive Cancer Network : JNCCN
Treatment-free remission after dasatinib in patients with chronic myeloid leukaemia in chronic phase with deep molecular response: Final 5-year analysis of DASFREE.
British journal of haematology
Patient-Reported Functional Outcomes in Patients With Chronic Myeloid Leukemia After Stopping Tyrosine Kinase Inhibitors.
Journal of the National Cancer Institute
Inflammatory Bowel Disease in Patients with Congenital Chloride Diarrhoea.
Journal of Crohn's & colitis
Recurrent Mutations in Cyclin D3 Confer Clinical Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research
Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease.
Nature communications
Alterations in T and B Cell Receptor Repertoires Patterns in Patients With IL10 Signaling Defects and History of Infantile-Onset IBD.
Frontiers in immunology
Long-term Outcomes of Paediatric Patients Admitted With Acute Severe Colitis- A Multicentre Study From the Paediatric IBD Porto Group of ESPGHAN.
Journal of Crohn's & colitis
Janus kinase inhibition for autoinflammation in patients with DNASE2 deficiency.
The Journal of allergy and clinical immunology
Dasatinib discontinuation in patients with chronic-phase chronic myeloid leukemia and stable deep molecular response: the DASFREE study.
Leukemia & lymphoma
Diagnosis and management of children with Blue Rubber Bleb Nevus Syndrome: A multi-center case series.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
ATP-Competitive Inhibitors Midostaurin and Avapritinib Have Distinct Resistance Profiles in Exon 17-Mutant KIT.
Cancer research
Sub-10-minute High-quality Diagnostic Colonoscopy With Terminal Ileum Intubation in Children Is Feasible and Safe.
Journal of pediatric gastroenterology and nutrition
Corrigendum: Vedolizumab in Paediatric Inflammatory Bowel Disease: A Retrospective Multi-Centre Experience From the Paediatric IBD Porto Group of ESPGHAN.
Journal of Crohn's & colitis
Detecting inflammation in inflammatory bowel disease - how does ultrasound compare to magnetic resonance enterography using standardised scoring systems?
Pediatric radiology
Front-Line Treatment Options for Chronic-Phase Chronic Myeloid Leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Vedolizumab in Paediatric Inflammatory Bowel Disease: A Retrospective Multi-Centre Experience From the Paediatric IBD Porto Group of ESPGHAN.
Journal of Crohn's & colitis
Evaluation of cardiovascular ischemic event rates in dasatinib-treated patients using standardized incidence ratios.
Annals of hematology
Iodine Status and Growth in Cow's Milk Allergy.
Journal of pediatric gastroenterology and nutrition
Paediatric magnetic resonance enteroclysis under general anaesthesia - initial experience.
Pediatric radiology
Establishing the prevalence of low vitamin D in non-immunoglobulin-E mediated gastrointestinal food allergic children in a tertiary centre.
The World Allergy Organization journal
NCCN Guidelines Insights: Chronic Myeloid Leukemia, Version 1.2017.
Journal of the National Comprehensive Cancer Network : JNCCN
The impact of the elimination diet on growth and nutrient intake in children with food protein induced gastrointestinal allergies.
Clinical and translational allergy
Dasatinib in imatinib-resistant or -intolerant chronic-phase, chronic myeloid leukemia patients: 7-year follow-up of study CA180-034.
American journal of hematology
Phenotypic and Genotypic Characterisation of Inflammatory Bowel Disease Presenting Before the Age of 2 years.
Journal of Crohn's & colitis
Final 5-Year Study Results of DASISION: The Dasatinib Versus Imatinib Study in Treatment-Naïve Chronic Myeloid Leukemia Patients Trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Histopathological features of gastrointestinal mucosal biopsies in children with juvenile idiopathic arthritis.
Pediatric research
Detecting inflammation in the unprepared pediatric colon - how reliable is magnetic resonance enterography?
Pediatric radiology
Adalimumab as a second-line biological therapy in children with refractory ulcerative colitis.
European journal of gastroenterology & hepatology
Systematic review of the impact of feed protein type and degree of hydrolysis on gastric emptying in children.
BMC gastroenterology
Clinical features of pulmonary arterial hypertension in patients receiving dasatinib.
American journal of hematology
Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance.
Scientific reports
Time to symptom improvement using elimination diets in non-IgE-mediated gastrointestinal food allergies.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Cow's Milk Protein Allergy from Diagnosis to Management: A Very Different Journey for General Practitioners and Parents.
Children (Basel, Switzerland)
Histological findings in infants with Gastrointestinal food allergy are associated with specific gastrointestinal symptoms; retrospective review from a tertiary centre.
BMC clinical pathology
Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397.
Cancer discovery
A practical approach to vitamin and mineral supplementation in food allergic children.
Clinical and translational allergy
Dietary elimination of children with food protein induced gastrointestinal allergy - micronutrient adequacy with and without a hypoallergenic formula?
Clinical and translational allergy
Feeding difficulties in children with food protein-induced gastrointestinal allergies.
Journal of gastroenterology and hepatology
The use of sirolimus (rapamycin) in the management of refractory inflammatory bowel disease in children.
Journal of Crohn's & colitis
Targeted gene panel sequencing in children with very early onset inflammatory bowel disease--evaluation and prospective analysis.
Journal of medical genetics
Crenolanib is a selective type I pan-FLT3 inhibitor.
Proceedings of the National Academy of Sciences of the United States of America
What does a deep molecular response signify?
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Phenotypic characterization of very early-onset IBD due to mutations in the IL10, IL10 receptor alpha or beta gene: a survey of the Genius Working Group.
Inflammatory bowel diseases
Duodenal haematoma following endoscopy as a marker of coagulopathy.
Pediatric radiology
Chronic Myelogenous Leukemia, Version 1.2014.
Journal of the National Comprehensive Cancer Network : JNCCN
The role of pre- and probiotics in infant nutrition.
The journal of family health care
Manifestations of food protein induced gastrointestinal allergies presenting to a single tertiary paediatric gastroenterology unit.
The World Allergy Organization journal
The role of endoscopy and biopsy in the management of severe gastrointestinal disease in cystic fibrosis patients.
Pediatric pulmonology
Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD.
Blood
The role of kinase inhibitors in the treatment of patients with acute myeloid leukemia.
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
Clinical outcome in IL-10- and IL-10 receptor-deficient patients with or without hematopoietic stem cell transplantation.
The Journal of allergy and clinical immunology
Front-line TKI therapy for chronic-phase CML: the luxury of choice.
Oncology (Williston Park, N.Y.)
Interleukin-10 and interleukin-10-receptor defects in inflammatory bowel disease.
Current allergy and asthma reports
Gastrointestinal endoscopy and mucosal biopsy in the first year of life: indications and outcome.
Journal of pediatric gastroenterology and nutrition
Cow's milk challenge increases weakly acidic reflux in children with cow's milk allergy and gastroesophageal reflux disease.
The Journal of pediatrics
Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia.
Nature
Practical dietary management of protein energy malnutrition in young children with cow's milk protein allergy.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Mechanisms of resistance to targeted therapies in acute myeloid leukemia and chronic myeloid leukemia.
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
IL-10 and IL-10 receptor defects in humans.
Annals of the New York Academy of Sciences
Ponatinib: targeting the T315I mutation in chronic myelogenous leukemia.
Clinical advances in hematology & oncology : H&O
Is it downhill from here? Eliminating leukemic stem cells and curing chronic myeloid leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research
BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia.
The Journal of experimental medicine
Tyrosine kinase inhibitor therapy for chronic myeloid leukemia: approach to patients with treatment-naive or refractory chronic-phase disease.
Hematology. American Society of Hematology. Education Program
Infant colitis--it's in the genes.
Lancet (London, England)
Dasatinib 140 mg once daily versus 70 mg twice daily in patients with Ph-positive acute lymphoblastic leukemia who failed imatinib: Results from a phase 3 study.
American journal of hematology
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.
The New England journal of medicine
Clonal hematopoiesis in Philadelphia chromosome-negative bone marrow cells of chronic myeloid leukemia patients receiving dasatinib.
Leukemia research
Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations.
Cancer research
Intermittent target inhibition with dasatinib 100 mg once daily preserves efficacy and improves tolerability in imatinib-resistant and -intolerant chronic-phase chronic myeloid leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Successful treatment of extensive infantile hemangiomatosis of the small bowel in a 3-month-old with thalidomide and somatostatin analog.
Journal of pediatric gastroenterology and nutrition
Advanced CML: therapeutic options for patients in accelerated and blast phases.
Journal of the National Comprehensive Cancer Network : JNCCN
Treatment of intractable ulcerating enterocolitis of infancy by allogeneic bone marrow transplantation.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Progressive thoughts about progressive disease.
Clinical cancer research : an official journal of the American Association for Cancer Research
Sequential ABL kinase inhibitor therapy selects for compound drug-resistant BCR-ABL mutations with altered oncogenic potency.
The Journal of clinical investigation
Dasatinib.
Drugs of today (Barcelona, Spain : 1998)
Medical management of CML.
Hematology. American Society of Hematology. Education Program
Gene expression changes associated with progression and response in chronic myeloid leukemia.
Proceedings of the National Academy of Sciences of the United States of America
Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680.
Cancer research
Long-term outcome of intractable ulcerating enterocolitis of infancy.
Journal of pediatric gastroenterology and nutrition
Loss of response to imatinib: mechanisms and management.
Hematology. American Society of Hematology. Education Program
Overriding imatinib resistance with a novel ABL kinase inhibitor.
Science (New York, N.Y.)
Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain P-loop.
Proceedings of the National Academy of Sciences of the United States of America