
Professor
M_MED-CORE-PULM
+1 415 819-2807
Michael Matthay, MD is interested in stem cell treatment for acute lung injury – a major cause of acute respiratory failure characterized by pulmonary edema, inflammation, arterial hypoxemia and the need for mechanical ventilation.
Publications
Awake Prone Positioning in COVID-19-Is There a New Standard of Care?
JAMA internal medicine
Beyond immunosuppression: decoding systemic immune dysregulation in ICU-acquired pneumonia.
The European respiratory journal
A randomized trial of open lung protective ventilation compared to conventional mechanical ventilation in deceased organ donors.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Endothelial ENaC-α Restrains Oxidative Stress in Lung Capillaries in Murine Pneumococcal Pneumonia-associated Acute Lung Injury.
American journal of respiratory cell and molecular biology
Gut bacterial lactate stimulates lung epithelial mitochondria and exacerbates acute lung injury.
bioRxiv : the preprint server for biology
Agreement Between Sepsis-2 and Sepsis-3 Definitions Among Patients Admitted to the Intensive Care Unit.
Annals of the American Thoracic Society
Temporal Transitions of the Hyperinflammatory and Hypoinflammatory Phenotypes in Critical Illness.
American journal of respiratory and critical care medicine
Unlocking the Therapeutic Code of Mesenchymal Stromal Cells.
American journal of respiratory and critical care medicine
Elastance May Determine the Neuromuscular Blockade Effect on Mortality in Acute Respiratory Distress Syndrome.
American journal of respiratory and critical care medicine
Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia.
Nature communications
Acute respiratory distress syndrome.
BMJ (Clinical research ed.)
Biomarkers of Acute Respiratory Distress Syndrome: Current State and Future Prospects.
Clinics in chest medicine
Definitions of Acute Respiratory Distress Syndrome: Present Recommendations and Challenges.
Clinics in chest medicine
Immediate myeloid depot for SARS-CoV-2 in the human lung.
Science advances
Macrophage-fibroblast crosstalk drives Arg1-dependent lung fibrosis via ornithine loading.
bioRxiv : the preprint server for biology
Longitudinal Importance of the Soluble Receptor for Advanced Glycation End-Products in Non-intubated Hospitalized Patients with COVID-19 Pneumonia.
American journal of physiology. Lung cellular and molecular physiology
Use of modified Berlin criteria in identifying patients with acute respiratory distress syndrome: a single-centre retrospective cohort study.
British journal of anaesthesia
Long-term air pollution exposure and the risk of primary graft dysfunction after lung transplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
A fibroblast-dependent TGFß1/sFRP2 noncanonical Wnt signaling axis promotes epithelial metaplasia in idiopathic pulmonary fibrosis.
The Journal of clinical investigation
11β hydroxysteroid dehydrogenase type 1 transgenic mesenchymal stem cells attenuate inflammation in models of sepsis.
Frontiers in bioengineering and biotechnology
NF-κB inhibitor alpha controls SARS-CoV-2 infection in ACE2-overexpressing human airway organoids.
Scientific reports
Vagal-α7 nicotinic acetylcholine receptor signaling exacerbates influenza severity by promoting lung epithelial cell infection.
Journal of medical virology
Incidence of acute kidney injury and attributive mortality in acute respiratory distress syndrome randomized trials.
Intensive care medicine
Biological effects of corticosteroids on pneumococcal pneumonia in Mice-translational significance.
Critical care (London, England)
Early trajectories of virological and immunological biomarkers and clinical outcomes in patients admitted to hospital for COVID-19: an international, prospective cohort study.
The Lancet. Microbe
Neutrophil Reduction Attenuates the Severity of Lung Injury in the Early Phase of Pneumococcal Pneumonia in Mice.
American journal of physiology. Lung cellular and molecular physiology
Elevated Hemoglobin A1c and the Risk of Developing ARDS in Two Cohort Studies.
CHEST critical care
Reply to Du, et al. and Palanidurai, et al.
American journal of respiratory and critical care medicine
Causes and attributable fraction of death from ARDS in inflammatory phenotypes of sepsis.
Critical care (London, England)
Life-saving effect of pulmonary surfactant in premature babies.
The Journal of clinical investigation
Respiratory drive heterogeneity associated with systemic inflammation and vascular permeability in acute respiratory distress syndrome.
Critical care (London, England)
Rapidly improving ARDS differs clinically and biologically from persistent ARDS.
Critical care (London, England)
The Plasma Lipidomic Landscape in Patients with Sepsis due to Community-acquired Pneumonia.
American journal of respiratory and critical care medicine
Timing of antibiotic treatment identifies distinct clinical presentations among patients presenting with suspected septic shock.
Journal of the American College of Emergency Physicians open
Cell-based Therapies for Acute Respiratory Distress Syndrome: Where Are We Now?
American journal of respiratory and critical care medicine
Host and Microbe Blood Metagenomics Reveals Key Pathways Characterizing Critical Illness Phenotypes.
American journal of respiratory and critical care medicine
Molecular Phenotypes of Acute Respiratory Distress Syndrome in the ROSE Trial Have Differential Outcomes and Gene Expression Patterns That Differ at Baseline and Longitudinally over Time.
American journal of respiratory and critical care medicine
Effect of Neutralizing Monoclonal Antibody Treatment on Early Trajectories of Virologic and Immunologic Biomarkers in Patients Hospitalized With COVID-19.
The Journal of infectious diseases
The Translational Value of Rodent Models of Sepsis.
American journal of respiratory and critical care medicine
Novel subtypes of severe COVID-19 respiratory failure based on biological heterogeneity: a secondary analysis of a randomized controlled trial.
Critical care (London, England)
The antibiotic resistance reservoir of the lung microbiome expands with age in a population of critically ill patients.
Nature communications
A New Global Definition of Acute Respiratory Distress Syndrome.
American journal of respiratory and critical care medicine
Unraveling the enigma of genetics and phenotypes in ARDS.
Intensive care medicine
In vivo protein turnover rates in varying oxygen tensions nominate MYBBP1A as a mediator of the hyperoxia response.
Science advances
Corticosteroids in adults with acute respiratory distress syndrome and severe pneumonia.
BJA education
Evidence for lung barrier regeneration by differentiation prior to binucleated and stem cell division.
The Journal of cell biology
Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials.
The Lancet. Respiratory medicine
Exposure to ambient air pollutants and acute respiratory distress syndrome risk in sepsis.
Intensive care medicine
Clinical and biological heterogeneity of multisystem inflammatory syndrome in adults following SARS-CoV-2 infection: a case series.
Frontiers in medicine
Intravenous aviptadil and remdesivir for treatment of COVID-19-associated hypoxaemic respiratory failure in the USA (TESICO): a randomised, placebo-controlled trial.
The Lancet. Respiratory medicine
ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies.
Intensive care medicine
Early plasma angiopoietin-2 is prognostic for ARDS and mortality among critically ill patients with sepsis.
Critical care (London, England)
Should We Add Fludrocortisone to Hydrocortisone for Treatment of Septic Shock?
JAMA internal medicine
Impaired alveolar macrophage 11β-hydroxysteroid dehydrogenase type 1 reductase activity contributes to increased pulmonary inflammation and mortality in sepsis-related ARDS.
Frontiers in immunology
Tight Glycemic Control, Inflammation, and the ICU: Evidence for Heterogeneous Treatment Effects in Two Randomized Controlled Trials.
American journal of respiratory and critical care medicine
Effect of total cholesterol and statin therapy on mortality in ARDS patients: a secondary analysis of the SAILS and HARP-2 trials.
Critical care (London, England)
Association of SARS-CoV-2 nucleocapsid viral antigen and the receptor for advanced glycation end products with development of severe disease in patients presenting to the emergency department with COVID-19.
Frontiers in immunology
Aerosolized nicotine from e-cigarettes alters gene expression, increases lung protein permeability, and impairs viral clearance in murine influenza infection.
Frontiers in immunology
Effects of the circulating environment of COVID-19 on platelet and neutrophil behavior.
Frontiers in immunology
Oxygen toxicity causes cyclic damage by destabilizing specific Fe-S cluster-containing protein complexes.
Molecular cell
SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants.
Stem cell reports
Are circulating endothelial cells the next target for transcriptome-level pathway analysis in ARDS?
American journal of physiology. Lung cellular and molecular physiology
Myeloid Extracellular Vesicles: New Players in Indirect Lung Injury.
American journal of respiratory cell and molecular biology
Understanding the Role of Mesenchymal Stromal Cells in Treating COVID-19 Acute Respiratory Distress Syndrome.
American journal of respiratory and critical care medicine
Mechanisms of impaired alveolar fluid clearance.
Anatomical record (Hoboken, N.J. : 2007)
Plasma metabolic profiling implicates dysregulated lipid metabolism and glycolytic shift in hyperinflammatory ARDS.
American journal of physiology. Lung cellular and molecular physiology
Lessons From a Negative Clinical Trial: Novel Immunological Targets for COVID-19 and Beyond.
Critical care medicine
Chest x-ray imaging score is associated with severity of COVID-19 pneumonia: the MBrixia score.
Scientific reports
Reply to Khatun <i>et al.</i>
American journal of respiratory and critical care medicine
Integrated host-microbe plasma metagenomics for sepsis diagnosis in a prospective cohort of critically ill adults.
Nature microbiology
COVID-19-associated Lung Microvascular Endotheliopathy: A "From the Bench" Perspective.
American journal of respiratory and critical care medicine
Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung.
Science (New York, N.Y.)
The prognostic value of early measures of the ventilatory ratio in the ARDS ROSE trial.
Critical care (London, England)
Plasma SARS-CoV-2 nucleocapsid antigen levels are associated with progression to severe disease in hospitalized COVID-19.
Critical care (London, England)
New Insights into Clinical and Mechanistic Heterogeneity of the Acute Respiratory Distress Syndrome: Summary of the Aspen Lung Conference 2021.
American journal of respiratory cell and molecular biology
Opportunities for improved clinical trial designs in acute respiratory distress syndrome.
The Lancet. Respiratory medicine
The Association of Baseline Plasma SARS-CoV-2 Nucleocapsid Antigen Level and Outcomes in Patients Hospitalized With COVID-19.
Annals of internal medicine
Pulse oximetry for the diagnosis and management of acute respiratory distress syndrome.
The Lancet. Respiratory medicine
Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19 : A Randomized Controlled Trial.
Annals of internal medicine
NF-κB inhibitor alpha has a cross-variant role during SARS-CoV-2 infection in ACE2-overexpressing human airway organoids.
bioRxiv : the preprint server for biology
Upcoming and urgent challenges in critical care research based on COVID-19 pandemic experience.
Anaesthesia, critical care & pain medicine
Use of pragmatic and explanatory trial designs in acute care research: lessons from COVID-19.
The Lancet. Respiratory medicine
Impact of e-cigarette aerosol on primary human alveolar epithelial type 2 cells.
American journal of physiology. Lung cellular and molecular physiology
Ventilatory Ratio Is a Valuable Prognostic Indicator in an Observational Cohort of Patients With ARDS.
Respiratory care
Importance of catecholamine signaling in the development of platelet exhaustion after traumatic injury.
Journal of thrombosis and haemostasis : JTH
Immediate myeloid depot for SARS-CoV-2 in the human lung.
Research square
Mesenchymal Stromal Cell Extracellular Vesicles: A New Approach for Preventing Bronchopulmonary Dysplasia?
American journal of respiratory and critical care medicine
Immediate myeloid depot for SARS-CoV-2 in the human lung.
bioRxiv : the preprint server for biology
RAGE has potential pathogenetic and prognostic value in nonintubated hospitalized patients with COVID-19.
JCI insight
Extracorporeal Membrane Oxygenation for Respiratory Failure Related to COVID-19: A Nationwide Cohort Study.
Anesthesiology
Transfusion-related Acute Lung Injury: 36 Years of Progress (1985-2021).
Annals of the American Thoracic Society
Cigarette Smoke Exposure and Acute Respiratory Distress Syndrome in Sepsis: Epidemiology, Clinical Features, and Biologic Markers.
American journal of respiratory and critical care medicine
Aerosolized vitamin E acetate causes oxidative injury in mice and in alveolar macrophages.
American journal of physiology. Lung cellular and molecular physiology
Pulmonary microbiome and gene expression signatures differentiate lung function in pediatric hematopoietic cell transplant candidates.
Science translational medicine
CD14-positive extracellular vesicles in bronchoalveolar lavage fluid as a new biomarker of acute respiratory distress syndrome.
American journal of physiology. Lung cellular and molecular physiology
Single Nucleotide Variant in FAS Associates With Organ Failure and Soluble Fas Cell Surface Death Receptor in Critical Illness.
Critical care medicine
A decoy mutant ACE2 designed to reduce COVID-19.
Trends in pharmacological sciences
Limited Cross-Variant Immunity after Infection with the SARS-CoV-2 Omicron Variant Without Vaccination.
medRxiv : the preprint server for health sciences
Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report.
American journal of respiratory cell and molecular biology
Functional Transcriptomic Studies of Immune Responses and Endotoxin Tolerance in Early Human Sepsis.
Shock (Augusta, Ga.)
Functional Outcomes and Morbidity in Pediatric Sepsis Survivors: A Tanzanian Experience.
Frontiers in pediatrics
Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis.
The Lancet. Respiratory medicine
Mesenchymal stem/stromal cell-based therapies for severe viral pneumonia: therapeutic potential and challenges.
Intensive care medicine experimental
Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells.
Nature cell biology
Responses to a Neutralizing Monoclonal Antibody for Hospitalized Patients With COVID-19 According to Baseline Antibody and Antigen Levels : A Randomized Controlled Trial.
Annals of internal medicine
Cell Therapy with the Cell or without the Cell for Premature Infants?: Time Will Tell.
American journal of respiratory and critical care medicine
Carbonic Anhydrase IX: Scaring Away the Grim Reaper in Acute Lung Injury?
American journal of respiratory cell and molecular biology
Delayed Presentation and Mortality in Children With Sepsis in a Public Tertiary Care Hospital in Tanzania.
Frontiers in pediatrics
Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
medRxiv : the preprint server for health sciences
Promises and challenges of personalized medicine to guide ARDS therapy.
Critical care (London, England)
Intravenous immunoglobulin therapy for COVID-19 ARDS.
The Lancet. Respiratory medicine
Molecular programs of fibrotic change in aging human lung.
Nature communications
Delayed angiopoietin-2 blockade reduces influenza-induced lung injury and improves survival in mice.
Physiological reports
Healthy versus inflamed lung environments differentially affect mesenchymal stromal cells.
The European respiratory journal
Environmental Factors.
Critical care clinics
Preface.
Critical care clinics
Assessment of Alveolar Macrophage Dysfunction Using an in vitro Model of Acute Respiratory Distress Syndrome.
Frontiers in medicine
Therapeutic effects of high molecular weight hyaluronic acid in severe Pseudomonas aeruginosa pneumonia in ex vivo perfused human lungs.
American journal of physiology. Lung cellular and molecular physiology
Acute respiratory distress syndrome is associated with impaired alveolar macrophage efferocytosis.
The European respiratory journal
Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS.
Nature communications
Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.
The New England journal of medicine
Thrombomodulin is associated with increased mortality and organ failure in mechanically ventilated children with acute respiratory failure: biomarker analysis from a multicenter randomized controlled trial.
Critical care (London, England)
Publisher Correction: Global absence and targeting of protective immune states in severe COVID-19.
Nature
Plasma Metabolites in Early Sepsis Identify Distinct Clusters Defined by Plasma Lipids.
Critical care explorations
Vitamin D Status and Clinical Outcomes in Acute Respiratory Distress Syndrome: A Secondary Analysis From the Assessment of Low Tidal Volume and Elevated End-Expiratory Volume to Obviate Lung Injury (ALVEOLI) Trial.
Journal of intensive care medicine
Readmission following both cardiac and non-cardiac acute dyspnoea is associated with a striking risk of death.
ESC heart failure
SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator.
bioRxiv : the preprint server for biology
Associations of D-Dimer on Admission and Clinical Features of COVID-19 Patients: A Systematic Review, Meta-Analysis, and Meta-Regression.
Frontiers in immunology
The Berlin definition of acute respiratory distress syndrome: should patients receiving high-flow nasal oxygen be included?
The Lancet. Respiratory medicine
Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
Research square
Inhibition of the lipoxin A4 and resolvin D1 receptor impairs host response to acute lung injury caused by pneumococcal pneumonia in mice.
American journal of physiology. Lung cellular and molecular physiology
The ARREST Pneumonia Clinical Trial. Rationale and Design.
Annals of the American Thoracic Society
Fibrinolytic niche is required for alveolar type 2 cell-mediated alveologenesis via a uPA-A6-CD44+-ENaC signal cascade.
Signal transduction and targeted therapy
COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone.
Research square
The ABO histo-blood group, endothelial activation, and acute respiratory distress syndrome risk in critical illness.
The Journal of clinical investigation
A neutrophil subset defined by intracellular olfactomedin 4 is associated with mortality in sepsis.
American journal of physiology. Lung cellular and molecular physiology
A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19.
The New England journal of medicine
Biological Mechanisms of COVID-19 Acute Respiratory Distress Syndrome.
American journal of respiratory and critical care medicine
Corticosteroids, COVID-19 pneumonia, and acute respiratory distress syndrome.
The Journal of clinical investigation
Dose-Dependent Pulmonary Toxicity of Aerosolized Vitamin E Acetate.
American journal of respiratory cell and molecular biology
Alternative Tobacco Product Use in Critically Ill Patients.
International journal of environmental research and public health
Phenotypes and personalized medicine in the acute respiratory distress syndrome.
Intensive care medicine
Designing an ARDS trial for 2020 and beyond: focus on enrichment strategies.
Intensive care medicine
Dexamethasone in hospitalised patients with COVID-19: addressing uncertainties.
The Lancet. Respiratory medicine
Global Absence and Targeting of Protective Immune States in Severe COVID-19.
bioRxiv : the preprint server for biology
Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung.
Nature cell biology
Using best subset regression to identify clinical characteristics and biomarkers associated with sepsis-associated acute kidney injury.
American journal of physiology. Renal physiology
The endogenous capacity to produce proinflammatory mediators by the ex vivo human perfused lung.
Intensive care medicine experimental
Monitoring Research Blood Sampling in Critically Ill Patients: Avoiding Iatrogenic Anemia.
American journal of respiratory and critical care medicine
Insufficient hyperfibrinolysis in COVID-19: a systematic review of thrombolysis based on meta-analysis and meta-regression.
medRxiv : the preprint server for health sciences
Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells.
American journal of physiology. Lung cellular and molecular physiology
NT-proBNP levels in the identification and classification of pulmonary transfusion reactions.
Transfusion
Is a "Cytokine Storm" Relevant to COVID-19?
JAMA internal medicine
Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care. NHLBI Working Group Report.
American journal of respiratory and critical care medicine
Association of patient weight status with plasma surfactant protein D, a biomarker of alveolar epithelial injury, in children with acute respiratory failure.
Pediatric pulmonology
Combined Mesenchymal Stromal Cell Therapy and Extracorporeal Membrane Oxygenation in Acute Respiratory Distress Syndrome. A Randomized Controlled Trial in Sheep.
American journal of respiratory and critical care medicine
Higher plasma cystatin C is associated with mortality after acute respiratory distress syndrome: findings from a Fluid and Catheter Treatment Trial (FACTT) substudy.
Critical care (London, England)
Extracellular Vesicles: A New Frontier for Research in Acute Respiratory Distress Syndrome.
American journal of respiratory cell and molecular biology
The ex vivo perfused human lung is resistant to injury by high-dose S. pneumoniae bacteremia.
American journal of physiology. Lung cellular and molecular physiology
Clinician Recognition of the Acute Respiratory Distress Syndrome: Risk Factors for Under-Recognition and Trends Over Time.
Critical care medicine
Impact of Bilateral Infiltrates on Inflammatory Biomarker Levels and Clinical Outcomes of Children With Oxygenation Defect.
Critical care medicine
Plasmin improves blood-gas barrier function in oedematous lungs by cleaving epithelial sodium channels.
British journal of pharmacology
Patterns and Trends in Advance Care Planning Among Older Adults Who Received Intensive Care at the End of Life.
JAMA internal medicine
The potential of lipid mediator networks as ocular surface therapeutics and biomarkers.
The ocular surface
Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis.
Nature communications
Acute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models: protocol for a systematic review and meta-analysis.
Respiratory research
Gender Differences in Authorship of Critical Care Literature.
American journal of respiratory and critical care medicine
Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility.
Physiological reviews
Acute respiratory distress syndrome-attributable mortality in critically ill patients with sepsis.
Intensive care medicine
Treatment for severe acute respiratory distress syndrome from COVID-19.
The Lancet. Respiratory medicine
Improved survival after lung transplantation for adults requiring preoperative invasive mechanical ventilation: A national cohort study.
The Journal of thoracic and cardiovascular surgery
Potential Value of Biomarker Signatures in Sepsis and Acute Respiratory Distress Syndrome in Children and Adults.
Critical care medicine
Contemporary strategies to improve clinical trial design for critical care research: insights from the First Critical Care Clinical Trialists Workshop.
Intensive care medicine
Peripheral blood leukocyte telomere length is associated with survival of sepsis patients.
The European respiratory journal
Development and validation of parsimonious algorithms to classify acute respiratory distress syndrome phenotypes: a secondary analysis of randomised controlled trials.
The Lancet. Respiratory medicine
Plasma sRAGE Acts as a Genetically Regulated Causal Intermediate in Sepsis-associated Acute Respiratory Distress Syndrome.
American journal of respiratory and critical care medicine
The authors reply.
Critical care medicine
Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study.
Critical care (London, England)
Therapeutic Effects of Hyaluronic Acid in Bacterial Pneumonia in Ex Vivo Perfused Human Lungs.
American journal of respiratory and critical care medicine
Proliferative regulation of alveolar epithelial type 2 progenitor cells by human Scnn1d gene.
Theranostics
Lung inflammatory environments differentially alter mesenchymal stromal cell behavior.
American journal of physiology. Lung cellular and molecular physiology
Clinically relevant model of pneumococcal pneumonia, ARDS, and nonpulmonary organ dysfunction in mice.
American journal of physiology. Lung cellular and molecular physiology
A Multicenter Study of the Causes and Consequences of Optimistic Expectations About Prognosis by Surrogate Decision-Makers in ICUs.
Critical care medicine
Association of Elevated Plasma Interleukin-18 Level With Increased Mortality in a Clinical Trial of Statin Treatment for Acute Respiratory Distress Syndrome.
Critical care medicine
Pulmonary Dead Space Monitoring: Identifying Subjects With ARDS at Risk of Developing Right Ventricular Dysfunction.
Respiratory care
Pathogenesis of Acute Respiratory Distress Syndrome.
Seminars in respiratory and critical care medicine
Clinician-Family Communication About Patients' Values and Preferences in Intensive Care Units.
JAMA internal medicine
Is a Part Better than the Whole for Cell-based Therapy for Acute Respiratory Distress Syndrome?
Anesthesiology
A prospective investigation of interleukin-8 levels in pediatric acute respiratory failure and acute respiratory distress syndrome.
Critical care (London, England)
Could Decisions to Limit Treatment Contribute to Mortality Differences between Patients with Different Presepsis Trajectories?
Annals of the American Thoracic Society
Identification of Acute Kidney Injury Subphenotypes with Differing Molecular Signatures and Responses to Vasopressin Therapy.
American journal of respiratory and critical care medicine
Positive Cumulative Fluid Balance Is Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome in the Setting of Acute Kidney Injury.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Precision medicine for cell therapy in acute respiratory distress syndrome - Authors' reply.
The Lancet. Respiratory medicine
The authors reply.
Critical care medicine
The authors reply.
Critical care medicine
Acute respiratory distress syndrome.
Nature reviews. Disease primers
Heterogeneity in sepsis: new biological evidence with clinical applications.
Critical care (London, England)
AIMing Immunomodulation Therapy at Sepsis.
American journal of respiratory cell and molecular biology
Prospective Assessment of the Feasibility of a Trial of Low-Tidal Volume Ventilation for Patients with Acute Respiratory Failure.
Annals of the American Thoracic Society
Physiologic Analysis and Clinical Performance of the Ventilatory Ratio in Acute Respiratory Distress Syndrome.
American journal of respiratory and critical care medicine
Early Plasma Matrix Metalloproteinase Profiles. A Novel Pathway in Pediatric Acute Respiratory Distress Syndrome.
American journal of respiratory and critical care medicine
ECMO in severe acute respiratory distress syndrome.
The Lancet. Respiratory medicine
Low to Moderate Air Pollutant Exposure and Acute Respiratory Distress Syndrome after Severe Trauma.
American journal of respiratory and critical care medicine
Variability in Pediatric Ideal Body Weight Calculation: Implications for Lung-Protective Mechanical Ventilation Strategies in Pediatric Acute Respiratory Distress Syndrome.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Integrating host response and unbiased microbe detection for lower respiratory tract infection diagnosis in critically ill adults.
Proceedings of the National Academy of Sciences of the United States of America
Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial.
The Lancet. Respiratory medicine
Beyond Low Tidal Volume Ventilation: Treatment Adjuncts for Severe Respiratory Failure in Acute Respiratory Distress Syndrome.
Critical care medicine
Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis.
Intensive care medicine
Latent class analysis of ARDS subphenotypes: a secondary analysis of the statins for acutely injured lungs from sepsis (SAILS) study.
Intensive care medicine
Interleukin-1 Receptor Antagonist Is Associated With Pediatric Acute Respiratory Distress Syndrome and Worse Outcomes in Children With Acute Respiratory Failure.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome.
The New England journal of medicine
Possible hepatotoxicity of IQOS.
Tobacco control
Meta-Analysis of Preclinical Studies of Fibrinolytic Therapy for Acute Lung Injury.
Frontiers in immunology
Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial.
The Lancet. Respiratory medicine
Effect of Rosuvastatin on Acute Kidney Injury in Sepsis-Associated Acute Respiratory Distress Syndrome.
Canadian journal of kidney health and disease
Effects of bone marrow-derived mesenchymal stromal cells on gene expression in human alveolar type II cells exposed to TNF-α, IL-1β, and IFN-γ.
Physiological reports
Pulmonary mechanics and gas exchange characteristics in uncommon etiologies of acute respiratory distress syndrome.
Journal of thoracic disease
Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data.
Intensive care medicine
Human pulmonary endothelial cell permeability after exposure to LPS-stimulated leukocyte supernatants derived from patients with early sepsis.
American journal of physiology. Lung cellular and molecular physiology
Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype.
The Journal of clinical investigation
Influence of Clinical Factors and Exclusion Criteria on Mortality in ARDS Observational Studies and Randomized Controlled Trials.
Respiratory care
A psychometric study of the decisional conflict scale in surrogate decision makers.
Patient education and counseling
Secondary peritonitis: principles of diagnosis and intervention.
BMJ (Clinical research ed.)
Mesenchymal stromal cells and macrophages in sepsis: new insights.
The European respiratory journal
Contemporary Risk Factors and Outcomes of Transfusion-Associated Circulatory Overload.
Critical care medicine
Endothelial biomarkers in human sepsis: pathogenesis and prognosis for ARDS.
Pulmonary circulation
Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice.
American journal of physiology. Lung cellular and molecular physiology
Inhibiting Bruton's tyrosine kinase rescues mice from lethal influenza-induced acute lung injury.
American journal of physiology. Lung cellular and molecular physiology
Assessing Preventable Harms in the Intensive Care Unit: Data From a Tertiary Care Academic Medical Institution.
American journal of medical quality : the official journal of the American College of Medical Quality
Elevated donor plasminogen activator inhibitor-1 levels and the risk of primary graft dysfunction.
Clinical transplantation
The TLR4-PAR1 Axis Regulates Bone Marrow Mesenchymal Stromal Cell Survival and Therapeutic Capacity in Experimental Bacterial Pneumonia.
Stem cells (Dayton, Ohio)
Cell-based Therapy in Sepsis. A Step Closer.
American journal of respiratory and critical care medicine
Mesenchymal stem cell-derived extracellular vesicles attenuate pulmonary vascular permeability and lung injury induced by hemorrhagic shock and trauma.
The journal of trauma and acute care surgery
Exosome-based Therapy for Bronchopulmonary Dysplasia.
American journal of respiratory and critical care medicine
Measurement of Protein Permeability and Fluid Transport of Human Alveolar Epithelial Type II Cells Under Pathological Conditions.
Methods in molecular biology (Clifton, N.J.)
Rectal and Bladder Temperatures vs Forehead Core Temperatures Measured With SpotOn Monitoring System.
American journal of critical care : an official publication, American Association of Critical-Care Nurses
Clinical Presentation and Outcomes among Children with Sepsis Presenting to a Public Tertiary Hospital in Tanzania.
Frontiers in pediatrics
The Epithelial Sodium Channel Is a Modifier of the Long-Term Nonprogressive Phenotype Associated with F508del CFTR Mutations.
American journal of respiratory cell and molecular biology
ENaCs as Both Effectors and Regulators of MiRNAs in Lung Epithelial Development and Regeneration.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Extracellular Vesicle Transfer from Mesenchymal Stromal Cells Modulates Macrophage Function in Acute Lung Injury. Basic Science and Clinical Implications.
American journal of respiratory and critical care medicine
Intratracheal instillation of alveolar type II cells enhances recovery from acute lung injury in rats.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Cytokine Profiles of Severe Influenza Virus-Related Complications in Children.
Frontiers in immunology
Reply to "Letter to the Editor: Pulmonary toxicity of electronic cigarettes: more doubts than certainties".
American journal of physiology. Lung cellular and molecular physiology
Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
Derivation and validation of a two-biomarker panel for diagnosis of ARDS in patients with severe traumatic injuries.
Trauma surgery & acute care open
Fifty Years of Research in ARDS. Cell-based Therapy for Acute Respiratory Distress Syndrome. Biology and Potential Therapeutic Value.
American journal of respiratory and critical care medicine
Local lung hypoxia determines epithelial fate decisions during alveolar regeneration.
Nature cell biology
Epithelial Sodium Channel-α Mediates the Protective Effect of the TNF-Derived TIP Peptide in Pneumolysin-Induced Endothelial Barrier Dysfunction.
Frontiers in immunology
Effects of IV Acetaminophen on Core Body Temperature and Hemodynamic Responses in Febrile Critically Ill Adults: A Randomized Controlled Trial.
Critical care medicine
Inhalation therapies in acute respiratory distress syndrome.
Annals of translational medicine
Lung Injury Etiology and Other Factors Influencing the Relationship Between Dead-Space Fraction and Mortality in ARDS.
Respiratory care
External validation of a biomarker and clinical prediction model for hospital mortality in acute respiratory distress syndrome.
Intensive care medicine
Clinical trials in acute respiratory distress syndrome: challenges and opportunities.
The Lancet. Respiratory medicine
Pulmonary toxicity of e-cigarettes.
American journal of physiology. Lung cellular and molecular physiology
Keratinocyte growth factor for the treatment of the acute respiratory distress syndrome (KARE): a randomised, double-blind, placebo-controlled phase 2 trial.
The Lancet. Respiratory medicine
Understanding blood gas analysis.
Intensive care medicine
Differentiating pulmonary transfusion reactions using recipient and transfusion factors.
Transfusion
Incorporating Inflammation into Mortality Risk in Pediatric Acute Respiratory Distress Syndrome.
Critical care medicine
Randomized Clinical Trial of a Combination of an Inhaled Corticosteroid and Beta Agonist in Patients at Risk of Developing the Acute Respiratory Distress Syndrome.
Critical care medicine
Signals of vagal circuits engaging with AKT1 in α7 nAChR+CD11b+ cells lessen E. coli and LPS-induced acute inflammatory injury.
Cell discovery
Alveolar Fluid Clearance in Pathologically Relevant Conditions: In Vitro and In Vivo Models of Acute Respiratory Distress Syndrome.
Frontiers in immunology
Profiling of ARDS pulmonary edema fluid identifies a metabolically distinct subset.
American journal of physiology. Lung cellular and molecular physiology
Higher mini-BAL total protein concentration in early ARDS predicts faster resolution of lung injury measured by more ventilator-free days.
American journal of physiology. Lung cellular and molecular physiology
Protein biomarkers associated with primary graft dysfunction following lung transplantation.
American journal of physiology. Lung cellular and molecular physiology
Concise Review: Mesenchymal Stem (Stromal) Cells: Biology and Preclinical Evidence for Therapeutic Potential for Organ Dysfunction Following Trauma or Sepsis.
Stem cells (Dayton, Ohio)
Incidence and clinical characteristics of transfusion-associated circulatory overload using an active surveillance algorithm.
Vox sanguinis
Acute kidney injury subphenotypes based on creatinine trajectory identifies patients at increased risk of death.
Critical care (London, England)
Overnight Extubation in Patients With Mechanical Ventilation: Is It Harmful?
JAMA internal medicine
Challenges in predicting which patients will develop ARDS.
The Lancet. Respiratory medicine
A Simple and Robust Bedside Model for Mortality Risk in Pediatric Patients With Acute Respiratory Distress Syndrome.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Poor Adherence to Lung-Protective Mechanical Ventilation in Pediatric Acute Respiratory Distress Syndrome.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
The authors reply.
Critical care medicine
The authors reply.
Critical care medicine
Quantifying unintended exposure to high tidal volumes from breath stacking dyssynchrony in ARDS: the BREATHE criteria.
Intensive care medicine
A new experimental model of acid- and endotoxin-induced acute lung injury in rats.
American journal of physiology. Lung cellular and molecular physiology
The acute respiratory distress syndrome following isolated severe traumatic brain injury.
The journal of trauma and acute care surgery
Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome.
Critical care (London, England)
Sepsis: pathophysiology and clinical management.
BMJ (Clinical research ed.)
Long-Term Ozone Exposure Increases the Risk of Developing the Acute Respiratory Distress Syndrome.
American journal of respiratory and critical care medicine
Mitochondrial Transfer via Tunneling Nanotubes is an Important Mechanism by Which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the In Vitro and In Vivo Models of ARDS.
Stem cells (Dayton, Ohio)
Experts' opinion on management of hemodynamics in ARDS patients: focus on the effects of mechanical ventilation.
Intensive care medicine
Diagnostic workup for ARDS patients.
Intensive care medicine
Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Key stakeholders' perceptions of the acceptability and usefulness of a tablet-based tool to improve communication and shared decision making in ICUs.
Journal of critical care
Acute Hypoxemic Respiratory Failure after Large-Volume Thoracentesis. Mechanisms of Pleural Fluid Formation and Reexpansion Pulmonary Edema.
Annals of the American Thoracic Society
Acute cor pulmonale and the acute respiratory distress syndrome.
Intensive care medicine
Timing of Intubation and Clinical Outcomes in Adults With Acute Respiratory Distress Syndrome.
Critical care medicine
Elevated soluble thrombomodulin is associated with organ failure and mortality in children with acute respiratory distress syndrome (ARDS): a prospective observational cohort study.
Critical care (London, England)
Plasma angiopoietin-2 outperforms other markers of endothelial injury in prognosticating pediatric ARDS mortality.
American journal of physiology. Lung cellular and molecular physiology
Cigarette Smoke Exposure and the Acute Respiratory Distress Syndrome.
Critical care medicine
Therapeutic Effects of Human Mesenchymal Stem Cell-derived Microvesicles in Severe Pneumonia in Mice.
American journal of respiratory and critical care medicine
Resolution of Alveolar Edema in Acute Respiratory Distress Syndrome. Physiology and Biology.
American journal of respiratory and critical care medicine
Human Mesenchymal Stem (Stromal) Cells Promote the Resolution of Acute Lung Injury in Part through Lipoxin A4.
Journal of immunology (Baltimore, Md. : 1950)
Visualization of Fra-1/AP-1 activation during LPS-induced inflammatory lung injury using fluorescence optical imaging.
American journal of physiology. Lung cellular and molecular physiology
Distinct molecular phenotypes of direct vs indirect ARDS in single-center and multicenter studies.
Chest
Unexpected Role for Adaptive αβTh17 Cells in Acute Respiratory Distress Syndrome.
Journal of immunology (Baltimore, Md. : 1950)
Saving lives with high-flow nasal oxygen.
The New England journal of medicine
Estimating dead-space fraction for secondary analyses of acute respiratory distress syndrome clinical trials.
Critical care medicine
Microvesicles Derived From Human Mesenchymal Stem Cells Restore Alveolar Fluid Clearance in Human Lungs Rejected for Transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Mesenchymal stem (stromal) cells for treatment of acute respiratory distress syndrome - authors' reply.
The Lancet. Respiratory medicine
Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS.
American journal of physiology. Lung cellular and molecular physiology
Erratum to: plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome.
Intensive care medicine
Therapeutic potential of mesenchymal stromal cells for acute respiratory distress syndrome.
Annals of the American Thoracic Society
Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome.
Intensive care medicine
A multicenter study of key stakeholders' perspectives on communicating with surrogates about prognosis in intensive care units.
Annals of the American Thoracic Society
Proteolytic regulation of epithelial sodium channels by urokinase plasminogen activator: cutting edge and cleavage sites.
The Journal of biological chemistry
Body temperature and mortality in patients with acute respiratory distress syndrome.
American journal of critical care : an official publication, American Association of Critical-Care Nurses
Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial.
The Lancet. Respiratory medicine
Recipient clinical risk factors predominate in possible transfusion-related acute lung injury.
Transfusion
Biology and pathology of fibroproliferation following the acute respiratory distress syndrome.
Intensive care medicine
Mesenchymal stem cells: mechanisms of potential therapeutic benefit in ARDS and sepsis.
The Lancet. Respiratory medicine
Endogenous and exogenous cell-based pathways for recovery from acute respiratory distress syndrome.
Clinics in chest medicine
A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation.
American journal of respiratory and critical care medicine
Prevalence and impact of active and passive cigarette smoking in acute respiratory distress syndrome.
Critical care medicine
Is there a need for emerging drugs for the acute respiratory distress syndrome?
Expert opinion on emerging drugs
Donor smoking is associated with pulmonary edema, inflammation and epithelial dysfunction in ex vivo human donor lungs.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Silencing Bruton's tyrosine kinase in alveolar neutrophils protects mice from LPS/immune complex-induced acute lung injury.
American journal of physiology. Lung cellular and molecular physiology
Influenza causes prolonged disruption of the alveolar-capillary barrier in mice unresponsive to mesenchymal stem cell therapy.
American journal of physiology. Lung cellular and molecular physiology
Protective effect of Growth Hormone-Releasing Hormone agonist in bacterial toxin-induced pulmonary barrier dysfunction.
Frontiers in physiology
Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome.
Annals of intensive care
Intensive care unit scoring systems outperform emergency department scoring systems for mortality prediction in critically ill patients: a prospective cohort study.
Journal of Intensive Care
Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*.
Critical care medicine
Translational studies in the ex vivo human lung.
Respiratory investigation
Keratinocyte growth factor promotes epithelial survival and resolution in a human model of lung injury.
American journal of respiratory and critical care medicine
Accumulation of BDCA1⁺ dendritic cells in interstitial fibrotic lung diseases and Th2-high asthma.
PloS one
Resolution of pulmonary edema. Thirty years of progress.
American journal of respiratory and critical care medicine
Correspondence to: soliciting strategies for developing cell-based reference materials to advance mesenchymal stem/stromal cell research and clinical translation.
Stem cells and development
Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials.
The Lancet. Respiratory medicine
Rosuvastatin for sepsis-associated acute respiratory distress syndrome.
The New England journal of medicine
Mechanical ventilation in acute hypoxemic respiratory failure: a review of new strategies for the practicing hospitalist.
Journal of hospital medicine
Applying metabolomics to uncover novel biology in ARDS.
American journal of physiology. Lung cellular and molecular physiology
Conditioned media from mesenchymal stromal cells restore sodium transport and preserve epithelial permeability in an in vitro model of acute alveolar injury.
American journal of physiology. Lung cellular and molecular physiology
A randomized trial of the effects of nebulized albuterol on pulmonary edema in brain-dead organ donors.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Is there still a role for the lung injury score in the era of the Berlin definition ARDS?
Annals of intensive care
Clinical grade allogeneic human mesenchymal stem cells restore alveolar fluid clearance in human lungs rejected for transplantation.
American journal of physiology. Lung cellular and molecular physiology
Mesenchymal stromal (stem) cell therapy: an emerging immunomodulatory strategy for the adjunctive treatment of sepsis.
American journal of respiratory and critical care medicine
Reperfusion pulmonary edema in children with tetralogy of Fallot, pulmonary atresia, and major aortopulmonary collateral arteries undergoing unifocalization procedures: A pilot study examining potential pathophysiologic mechanisms and clinical significanc
The Journal of thoracic and cardiovascular surgery
One-year mortality and predictors of death among hospital survivors of acute respiratory distress syndrome.
Intensive care medicine
TGF-β and lung fluid balance in ARDS.
Proceedings of the National Academy of Sciences of the United States of America
Effect of simvastatin on physiological and biological outcomes in patients undergoing esophagectomy: a randomized placebo-controlled trial.
Annals of surgery
Human mesenchymal stem cell microvesicles for treatment of Escherichia coli endotoxin-induced acute lung injury in mice.
Stem cells (Dayton, Ohio)
The association between physiologic dead-space fraction and mortality in subjects with ARDS enrolled in a prospective multi-center clinical trial.
Respiratory care
Treating ARDS: new hope for a tough problem.
The Lancet. Respiratory medicine
Cystic fibrosis epithelial cell and bacterial binding.
American journal of physiology. Lung cellular and molecular physiology
Prognostic and diagnostic value of plasma soluble suppression of tumorigenicity-2 concentrations in acute respiratory distress syndrome.
Critical care medicine
Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome.
Critical care (London, England)
Comparison of thermodilution measured extravascular lung water with chest radiographic assessment of pulmonary oedema in patients with acute lung injury.
Annals of intensive care
Viral pathogens and acute lung injury: investigations inspired by the SARS epidemic and the 2009 H1N1 influenza pandemic.
Seminars in respiratory and critical care medicine
Acute cor pulmonale in ARDS.
Intensive care medicine
Cell therapy for lung diseases. Report from an NIH-NHLBI workshop, November 13-14, 2012.
American journal of respiratory and critical care medicine
Early acute lung injury: criteria for identifying lung injury prior to the need for positive pressure ventilation*.
Critical care medicine
Mesenchymal stem cells and idiopathic pulmonary fibrosis. Potential for clinical testing.
American journal of respiratory and critical care medicine
Reply: idiopathic pulmonary fibrosis: a degenerative disease requiring a regenerative approach.
American journal of respiratory and critical care medicine
Sugar administration is an effective adjunctive therapy in the treatment of Pseudomonas aeruginosa pneumonia.
American journal of physiology. Lung cellular and molecular physiology
The acute respiratory distress syndrome in 2013.
Translational respiratory medicine
Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients.
American journal of respiratory and critical care medicine
The Berlin definition of ARDS versus pathological evidence of diffuse alveolar damage.
American journal of respiratory and critical care medicine
The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases.
The Journal of clinical investigation
Therapeutic effects of human mesenchymal stem cells in ex vivo human lungs injured with live bacteria.
American journal of respiratory and critical care medicine
Noradrenergic neurons regulate monocyte trafficking and mortality during gram-negative peritonitis in mice.
Journal of immunology (Baltimore, Md. : 1950)
Calcium flux and endothelial dysfunction during acute lung injury: a STIMulating target for therapy.
The Journal of clinical investigation
Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome.
Molecular medicine (Cambridge, Mass.)
Activation of the heat shock response attenuates the interleukin 1β-mediated inhibition of the amiloride-sensitive alveolar epithelial ion transport.
Shock (Augusta, Ga.)
Risk factors and outcomes in transfusion-associated circulatory overload.
The American journal of medicine
From protective ventilation to super-protective ventilation for acute respiratory distress syndrome.
Intensive care medicine
Cecal ligation model of sepsis in mice: new insights.
Critical care medicine
Hyperoxic acute lung injury.
Respiratory care
Regulation and repair of the alveolar-capillary barrier in acute lung injury.
Annual review of physiology
IL-8 inhibits cAMP-stimulated alveolar epithelial fluid transport via a GRK2/PI3K-dependent mechanism.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Novel aspects of urokinase function in the injured lung: role of α2-macroglobulin.
American journal of physiology. Lung cellular and molecular physiology
Beta-adrenergic receptor polymorphisms and cardiac graft function in potential organ donors.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials.
American journal of physiology. Lung cellular and molecular physiology
The acute respiratory distress syndrome.
The Journal of clinical investigation
The severity of shock is associated with impaired rates of net alveolar fluid clearance in clinical acute lung injury.
American journal of physiology. Lung cellular and molecular physiology
Clinical evidence of early acute lung injury often precedes the diagnosis of ALI.
Journal of intensive care medicine
Clinical review: Early treatment of acute lung injury--paradigm shift toward prevention and treatment prior to respiratory failure.
Critical care (London, England)
Inflection points in sepsis biology: from local defense to systemic organ injury.
American journal of physiology. Lung cellular and molecular physiology
Cell-based therapy for acute lung injury: are we there yet?
Anesthesiology
Plasma angiopoietin-2 in clinical acute lung injury: prognostic and pathogenetic significance.
Critical care medicine
The adenosine 2A receptor agonist GW328267C improves lung function after acute lung injury in rats.
American journal of physiology. Lung cellular and molecular physiology
Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability.
American journal of respiratory cell and molecular biology
Multipotent stromal stem cells from human placenta demonstrate high therapeutic potential.
Stem cells translational medicine
IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia.
American journal of physiology. Lung cellular and molecular physiology
Progress in modelling acute lung injury in a pre-clinical mouse model.
The European respiratory journal
Mesenchymal stem cells and the stem cell niche: a new chapter.
American journal of physiology. Lung cellular and molecular physiology
Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes.
American journal of physiology. Lung cellular and molecular physiology
Lung mast cell density defines a subpopulation of patients with idiopathic pulmonary fibrosis.
Histopathology
The 4G/4G genotype of the PAI-1 (serpine-1) 4G/5G polymorphism is associated with decreased lung allograft utilization.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Quantifying the severity of acute lung injury using dead-space ventilation: should the lung injury score be updated?
Respiratory care
Comparison of chest radiograph scoring to lung weight as a quantitative index of pulmonary edema in organ donors.
Clinical transplantation
Anti-inflammatory effects of β2 adrenergic receptor agonists in experimental acute lung injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema.
Proceedings of the National Academy of Sciences of the United States of America
Altered lymphatics in an ovine model of congenital heart disease with increased pulmonary blood flow.
American journal of physiology. Lung cellular and molecular physiology
A simple classification model for hospital mortality in patients with acute lung injury managed with lung protective ventilation.
Critical care medicine
Acute kidney injury in patients with acute lung injury: impact of fluid accumulation on classification of acute kidney injury and associated outcomes.
Critical care medicine
Prognostic value of pulmonary dead space in patients with the acute respiratory distress syndrome.
Critical care (London, England)
Acute lung failure.
Seminars in respiratory and critical care medicine
Randomized, placebo-controlled clinical trial of an aerosolized β₂-agonist for treatment of acute lung injury.
American journal of respiratory and critical care medicine
Physiology, reductionism, and translational medicine: the right mix.
American journal of physiology. Lung cellular and molecular physiology
Clinical review: Thinking outside the box--an iconoclastic view of current practice.
Critical care (London, England)
Claudin-4 levels are associated with intact alveolar fluid clearance in human lungs.
The American journal of pathology
Advancing donor management research: design and implementation of a large, randomized, placebo-controlled trial.
Annals of intensive care
Clinical significance of elevated B-type natriuretic peptide in patients with acute lung injury with or without right ventricular dilatation: an observational cohort study.
Annals of intensive care
Concise review: Mesenchymal stem cells for acute lung injury: role of paracrine soluble factors.
Stem cells (Dayton, Ohio)
Positive fluid balance is associated with higher mortality and prolonged mechanical ventilation in pediatric patients with acute lung injury.
Critical care research and practice
Mesenchymal stem cells and acute lung injury.
Critical care clinics
An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals.
American journal of respiratory cell and molecular biology
Con: corticosteroids are not indicated for treatment of acute lung injury from H1N1 viral pneumonia.
American journal of respiratory and critical care medicine
Decreased respiratory system compliance on the sixth day of mechanical ventilation is a predictor of death in patients with established acute lung injury.
Respiratory research
Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis.
American journal of physiology. Lung cellular and molecular physiology
Biomarkers in acute lung injury: insights into the pathogenesis of acute lung injury.
Critical care clinics
Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury.
Critical care medicine
Active and passive cigarette smoking and acute lung injury after severe blunt trauma.
American journal of respiratory and critical care medicine
Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid status.
Critical care (London, England)
Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in mice.
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
Informed consent in research to improve the number and quality of deceased donor organs.
Critical care medicine
Single-nucleotide polymorphisms in the β-adrenergic receptor genes are associated with lung allograft utilization.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Proteolytic release of the receptor for advanced glycation end products from in vitro and in situ alveolar epithelial cells.
American journal of physiology. Lung cellular and molecular physiology
Neuregulin-1-human epidermal receptor-2 signaling is a central regulator of pulmonary epithelial permeability and acute lung injury.
The Journal of biological chemistry
Biomarkers increase detection of active smoking and secondhand smoke exposure in critically ill patients.
Critical care medicine
The acute respiratory distress syndrome: pathogenesis and treatment.
Annual review of pathology
Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37.
Stem cells (Dayton, Ohio)
Stem cells in sepsis and acute lung injury.
Critical care medicine
The utility of clinical predictors of acute lung injury: towards prevention and earlier recognition.
Expert review of respiratory medicine
Priming with endotoxin increases acute lung injury in mice by enhancing the severity of lung endothelial injury.
Anatomical record (Hoboken, N.J. : 2007)
Mesenchymal stem cells for acute lung injury: preclinical evidence.
Critical care medicine
Thinking outside the box: Introduction.
Critical care medicine
The influence of race on the development of acute lung injury in trauma patients.
American journal of surgery
Pathophysiology of transfusion-related acute lung injury.
Current opinion in hematology
Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients.
Critical care medicine
Assessing the quantity of pulmonary edema in critically ill children.
Critical care (London, England)
Advances and challenges in translating stem cell therapies for clinical diseases.
Translational research : the journal of laboratory and clinical medicine
Alveolar fluid clearance is faster in women with acute lung injury compared to men.
Journal of critical care
Acute lung injury: epidemiology, pathogenesis, and treatment.
Journal of aerosol medicine and pulmonary drug delivery
Acute respiratory distress syndrome after surgery: can the risk be decreased?
Anesthesia and analgesia
Therapeutic strategies for severe acute lung injury.
Critical care medicine
Allogeneic human mesenchymal stem cells restore epithelial protein permeability in cultured human alveolar type II cells by secretion of angiopoietin-1.
The Journal of biological chemistry
Age-, sex-, and race-based differences among patients enrolled versus not enrolled in acute lung injury clinical trials.
Critical care medicine
Plasma interleukin-8 is not an effective risk stratification tool for adults with vasopressor-dependent septic shock.
Critical care medicine
Update on acute lung injury and critical care medicine 2009.
American journal of respiratory and critical care medicine
Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis.
The Journal of trauma
Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis.
American journal of physiology. Lung cellular and molecular physiology
Regulated gene expression in cultured type II cells of adult human lung.
American journal of physiology. Lung cellular and molecular physiology
Simulation of lung alveolar epithelial wound healing in vitro.
Journal of the Royal Society, Interface
Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury.
Proceedings of the National Academy of Sciences of the United States of America
Standards and recommendations for quantitative assessment of lung structure in research.
American journal of physiology. Lung cellular and molecular physiology
Measuring the quantity of pulmonary edema in clinical lung injury.
Critical care medicine
Thirty years of critical care medicine.
Critical care (London, England)
Transforming growth factor beta1 inhibits cystic fibrosis transmembrane conductance regulator-dependent cAMP-stimulated alveolar epithelial fluid transport via a phosphatidylinositol 3-kinase-dependent mechanism.
The Journal of biological chemistry
Mesenchymal stem cells for the prevention of bronchopulmonary dysplasia: delivering the secretome.
American journal of respiratory and critical care medicine
Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury.
Journal of immunology (Baltimore, Md. : 1950)
Laminin gamma2 fragments are increased in the circulation of patients with early phase acute lung injury.
Intensive care medicine
Early elevations in B-type natriuretic peptide levels are associated with poor clinical outcomes in pediatric acute lung injury.
Pediatric pulmonology
Elevated PAI-1 is associated with poor clinical outcomes in pediatric patients with acute lung injury.
Intensive care medicine
Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury.
The Journal of clinical investigation
Potential application of mesenchymal stem cells in acute lung injury.
Expert opinion on biological therapy
Determining the aetiology of pulmonary oedema by the oedema fluid-to-plasma protein ratio.
The European respiratory journal
Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung.
Proceedings of the National Academy of Sciences of the United States of America
Serotonin decreases alveolar epithelial fluid transport via a direct inhibition of the epithelial sodium channel.
American journal of respiratory cell and molecular biology
Comparison of two non-bronchoscopic methods for evaluating inflammation in patients with acute hypoxaemic respiratory failure.
Critical care (London, England)
NADPH oxidase-1 plays a crucial role in hyperoxia-induced acute lung injury in mice.
American journal of respiratory and critical care medicine
Measurement of extravascular lung water using the single indicator method in patients: research and potential clinical value.
American journal of physiology. Lung cellular and molecular physiology
Inhaled activated protein C: a novel therapy for acute lung injury?
Critical care (London, England)
Protective mechanisms of activated protein C in severe inflammatory disorders.
British journal of pharmacology
Blood product transfusions and clinical outcomes in pediatric patients with acute lung injury.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Higher pulmonary dead space may predict prolonged mechanical ventilation after cardiac surgery.
Pediatric pulmonology
Recent trends in acute lung injury mortality: 1996-2005.
Critical care medicine
Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury.
American journal of physiology. Lung cellular and molecular physiology
Neutrophil sandwiches injure the microcirculation.
Nature medicine
Role of protease activated receptor 2 in experimental acute lung injury and lung fibrosis.
Anatomical record (Hoboken, N.J. : 2007)
Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers.
American journal of respiratory and critical care medicine
The pathogenetic and prognostic value of biologic markers in acute lung injury.
Journal of intensive care medicine
The role of angiotensin-converting enzyme inhibition in endotoxin-induced lung injury in rats.
Critical care medicine
Racial and ethnic disparities in mortality from acute lung injury.
Critical care medicine
Anti-chemokine autoantibody:chemokine immune complexes activate endothelial cells via IgG receptors.
American journal of respiratory cell and molecular biology
Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid mediates protective effects through regulation of the ERK pathway.
Free radical biology & medicine
Beyond fishing: the role of discovery proteomics in mechanistic lung research.
American journal of physiology. Lung cellular and molecular physiology
Role of coagulation pathways and treatment with activated protein C in hyperoxic lung injury.
Thorax
Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury.
Intensive care medicine
Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury.
Thorax
Randomized clinical trial of activated protein C for the treatment of acute lung injury.
American journal of respiratory and critical care medicine
Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion.
Critical care medicine
CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia.
Journal of immunology (Baltimore, Md. : 1950)
Novel molecular strategy to prevent pulmonary edema.
Critical care medicine
Measurement of extravascular lung water in patients with pulmonary edema.
American journal of physiology. Lung cellular and molecular physiology
Protein C as a surrogate end-point for clinical trials of sepsis.
Critical care (London, England)
Treatment of acute lung injury: clinical and experimental studies.
Proceedings of the American Thoracic Society
Biomarkers of inflammation, coagulation and fibrinolysis predict mortality in acute lung injury.
Critical care (London, England)
A framework and mechanistically focused, in silico method for enabling rational translational research.
Summit on translational bioinformatics
Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activity.
American journal of physiology. Lung cellular and molecular physiology
Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms.
Circulation research
Advances in critical care for the nephrologist: acute lung injury/ARDS.
Clinical journal of the American Society of Nephrology : CJASN
Prostaglandin E2 mediates IL-1beta-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptors.
Journal of immunology (Baltimore, Md. : 1950)
Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury.
Critical care medicine
Lung epithelial cells induce endodermal differentiation in mouse mesenchymal bone marrow stem cells by paracrine mechanism.
Tissue engineering
The role of protein C in sepsis.
Current infectious disease reports
Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders.
Critical care medicine
Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway.
American journal of physiology. Renal physiology
Evidence of temporary airway epithelial repopulation and rare clonal formation by BM-derived cells following naphthalene injury in mice.
Anatomical record (Hoboken, N.J. : 2007)
Surfactant treatment of aspiration-induced lung injury in children.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice.
Journal of immunology (Baltimore, Md. : 1950)
Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome.
Critical care medicine
Workshop summary: phosgene-induced pulmonary toxicity revisited: appraisal of early and late markers of pulmonary injury from animal models with emphasis on human significance.
Inhalation toxicology
Plasma receptor for advanced glycation end-products predicts duration of ICU stay and mechanical ventilation in patients after lung transplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Pulmonary barriers to pneumonia and sepsis.
Nature medicine
Acute lung injury edema fluid decreases net fluid transport across human alveolar epithelial type II cells.
The Journal of biological chemistry
Alveolar edema fluid clearance and acute lung injury.
Respiratory physiology & neurobiology
Anti-IL-8 autoantibody:IL-8 immune complexes suppress spontaneous apoptosis of neutrophils.
American journal of physiology. Lung cellular and molecular physiology
Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway?
Annals of surgery
MAPK pathway mediates EGR-1-HSP70-dependent cigarette smoke-induced chemokine production.
American journal of physiology. Lung cellular and molecular physiology
Genomics and proteomics of lung disease: conference summary.
American journal of physiology. Lung cellular and molecular physiology
Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats.
American journal of respiratory cell and molecular biology
Impact of low and high tidal volumes on the rat alveolar epithelial type II cell proteome.
American journal of respiratory and critical care medicine
Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs.
American journal of physiology. Lung cellular and molecular physiology
Early elevation of plasma von Willebrand factor antigen in pediatric acute lung injury is associated with an increased risk of death and prolonged mechanical ventilation.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis.
Molecular biology of the cell
Pulmonary artery catheter and fluid management in acute lung injury and the acute respiratory distress syndrome.
Clinics in chest medicine
Cigarette smoke stimulates matrix metalloproteinase-2 activity via EGR-1 in human lung fibroblasts.
American journal of respiratory cell and molecular biology
Novel role of the human alveolar epithelium in regulating intra-alveolar coagulation.
American journal of respiratory cell and molecular biology
Higher urine nitric oxide is associated with improved outcomes in patients with acute lung injury.
American journal of respiratory and critical care medicine
Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function.
American journal of respiratory cell and molecular biology
Protein permeability in lung injury: now in real time again?
Journal of applied physiology (Bethesda, Md. : 1985)
Treatment of acute lung injury: historical perspective and potential future therapies.
Seminars in respiratory and critical care medicine
Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury.
American journal of physiology. Lung cellular and molecular physiology
Activation of the stress protein response prevents the development of pulmonary edema by inhibiting VEGF cell signaling in a model of lung ischemia-reperfusion injury in rats.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Acute lung injury and the coagulation pathway: Potential role of gene polymorphisms in the protein C and fibrinolytic pathways.
Intensive care medicine
Beta-2-agonist treatment as a potential therapy for acute inhalational lung injury.
Critical care medicine
Sepsis and stretch: synergistic effects on alveolar epithelial cell death?
Critical care medicine
Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury.
The Journal of clinical investigation
Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury.
The Journal of clinical investigation
Higher urine desmosine levels are associated with mortality in patients with acute lung injury.
American journal of physiology. Lung cellular and molecular physiology
Integrating acute lung injury and regulation of alveolar fluid clearance.
American journal of physiology. Lung cellular and molecular physiology
Evolving practices in critical care and potential implications for management of acute kidney injury.
Clinical journal of the American Society of Nephrology : CJASN
Extracellular heat shock protein 72 is a marker of the stress protein response in acute lung injury.
American journal of physiology. Lung cellular and molecular physiology
Airway epithelium, inflammation, and mechanisms of disease: A tribute to Carol B. Basbaum.
American journal of respiratory cell and molecular biology
Animal models of transfusion-related acute lung injury.
Critical care medicine
Pharmacotherapy of acute lung injury and the acute respiratory distress syndrome.
Journal of intensive care medicine
Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury.
American journal of physiology. Lung cellular and molecular physiology
Perspectives, translational research, and letters to the editor.
American journal of physiology. Lung cellular and molecular physiology
Alveolar epithelial ion and fluid transport: recent progress.
American journal of respiratory cell and molecular biology
Clinical trial design--effect of prone positioning on clinical outcomes in infants and children with acute respiratory distress syndrome.
Journal of critical care
Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine.
Critical care medicine
Warm ischemia-induced alterations in oxidative and inflammatory proteins in hepatic Kupffer cells in rats.
Molecular & cellular proteomics : MCP
Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury.
American journal of respiratory and critical care medicine
Beta-adrenergic agonist therapy as a potential treatment for acute lung injury.
American journal of respiratory and critical care medicine
Bench-to-bedside review: the role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury.
Critical care (London, England)
Biological markers of lung injury before and after the institution of positive pressure ventilation in patients with acute lung injury.
Critical care (London, England)
Clinical practice. Acute pulmonary edema.
The New England journal of medicine
TNFalpha-induced long pentraxin PTX3 expression in human lung epithelial cells via JNK.
Journal of immunology (Baltimore, Md. : 1950)
Protective effect of endogenous beta-adrenergic tone on lung fluid balance in acute bacterial pneumonia in mice.
American journal of physiology. Lung cellular and molecular physiology
Congenital diaphragmatic hernia prevents absorption of distal air space fluid in late-gestation rat fetuses.
American journal of physiology. Lung cellular and molecular physiology
Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management.
American journal of respiratory cell and molecular biology
High prevalence of pulmonary arterial thrombi in donor lungs rejected for transplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells.
American journal of physiology. Lung cellular and molecular physiology
Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms.
Journal of immunology (Baltimore, Md. : 1950)
Leukotrienes in acute lung injury: a potential therapeutic target?
American journal of respiratory and critical care medicine
VEGF levels in the alveolar compartment do not distinguish between ARDS and hydrostatic pulmonary oedema.
The European respiratory journal
Recent advances in mechanical ventilation.
The American journal of medicine
Proteinase-activated receptor-1 mediates elastase-induced apoptosis of human lung epithelial cells.
American journal of respiratory cell and molecular biology
Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance.
American journal of physiology. Lung cellular and molecular physiology
Critical care in AJRCCM 2004.
American journal of respiratory and critical care medicine
Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway.
The Journal of biological chemistry
In vitro and in vivo regulation of transepithelial lung alveolar sodium transport by serine proteases.
American journal of physiology. Lung cellular and molecular physiology
Acute effects of tidal volume strategy on hemodynamics, fluid balance, and sedation in acute lung injury.
Critical care medicine
Alveolar epithelium: role in lung fluid balance and acute lung injury.
Proceedings of the American Thoracic Society
Differential effects of sustained inflation recruitment maneuvers on alveolar epithelial and lung endothelial injury.
Critical care medicine
Is there a role for beta-adrenoceptor agonists in the management of acute lung injury and the acute respiratory distress syndrome?
Treatments in respiratory medicine
Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury.
Critical care medicine
Subglottic secretion drainage for preventing ventilator-associated pneumonia: a meta-analysis.
The American journal of medicine
Pediatric acute lung injury: prospective evaluation of risk factors associated with mortality.
American journal of respiratory and critical care medicine
Integrated control of lung fluid balance.
American journal of physiology. Lung cellular and molecular physiology
HO-1 induction restores c-AMP-dependent lung epithelial fluid transport following severe hemorrhage in rats.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Can nicotine treat sepsis?
Nature medicine
Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injury.
American journal of physiology. Lung cellular and molecular physiology
Acute lung injury and acute respiratory distress syndrome in pregnancy.
Critical care clinics
Direct visual instillation as a method for efficient delivery of fluid into the distal airspaces of anesthetized mice.
Experimental lung research
Prognostic value of the pulmonary dead-space fraction during the first 6 days of acute respiratory distress syndrome.
Respiratory care
Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome.
The New England journal of medicine
Hydrostatic mechanisms may contribute to the pathogenesis of human re-expansion pulmonary edema.
Intensive care medicine
Coagulation-dependent mechanisms and asthma.
The Journal of clinical investigation
Proteomics: current techniques and potential applications to lung disease.
American journal of physiology. Lung cellular and molecular physiology
Bench-to-bedside review: the role of the alveolar epithelium in the resolution of pulmonary edema in acute lung injury.
Critical care (London, England)
Significance of von Willebrand factor in septic and nonseptic patients with acute lung injury.
American journal of respiratory and critical care medicine
Plasma protein C levels in patients with acute lung injury: prognostic significance.
Critical care medicine
H(2)O(2) inhibits alveolar epithelial wound repair in vitro by induction of apoptosis.
American journal of physiology. Lung cellular and molecular physiology
Mechanisms of alveolar protein clearance in the intact lung.
American journal of physiology. Lung cellular and molecular physiology
Diagnostic utility of B-type natriuretic peptide in patients with acute dyspnea or pleural effusions.
The American journal of medicine
Fluid transport across cultured rat alveolar epithelial cells: a novel in vitro system.
American journal of physiology. Lung cellular and molecular physiology
Malnutrition impairs alveolar fluid clearance in rat lungs.
American journal of physiology. Lung cellular and molecular physiology
Pulmonary edema fluid from patients with early lung injury stimulates fibroblast proliferation through IL-1 beta-induced IL-6 expression.
Journal of immunology (Baltimore, Md. : 1950)
Look before you leap: how do intensivists improve care for critically ill patients?
The American journal of medicine
Why does acute lung injury have no impact on mortality in patients with major trauma?
Critical care medicine
Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha.
The Journal of biological chemistry
Proteomic analysis of pulmonary edema fluid and plasma in patients with acute lung injury.
American journal of physiology. Lung cellular and molecular physiology
Proinflammatory activity of anti-IL-8 autoantibody:IL-8 complexes in alveolar edema fluid from patients with acute lung injury.
American journal of physiology. Lung cellular and molecular physiology
Acute cardiopulmonary effects of a dual-endothelin receptor antagonist on oleic acid-induced pulmonary arterial hypertension in dogs.
Experimental lung research
The ADP ribosyltransferase domain of Pseudomonas aeruginosa ExoT contributes to its biological activities.
Infection and immunity
Cytokine-mediated inflammation in acute lung injury.
Cytokine & growth factor reviews
Transforming growth factor-beta 1 regulates lung epithelial barrier function and fluid transport.
American journal of physiology. Lung cellular and molecular physiology
Transgenic overexpression of granulocyte macrophage-colony stimulating factor in the lung prevents hyperoxic lung injury.
The American journal of pathology
Effects of recruitment maneuvers in patients with acute lung injury and acute respiratory distress syndrome ventilated with high positive end-expiratory pressure.
Critical care medicine
Effect of continuous hemofiltration on hemodynamics, lung inflammation and pulmonary edema in a canine model of acute lung injury.
Intensive care medicine
Acute lung injury and the acute respiratory distress syndrome.
Critical care clinics
Elevation of KL-6, a lung epithelial cell marker, in plasma and epithelial lining fluid in acute respiratory distress syndrome.
American journal of physiology. Lung cellular and molecular physiology
Pulmonary edema fluid antioxidants are depressed in acute lung injury.
Critical care medicine
Transforming growth factor-beta induces fibrosis in immune cell-depleted lungs.
American journal of physiology. Lung cellular and molecular physiology
Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism.
The Journal of biological chemistry
Functional identification of the alveolar edema reabsorption activity of murine tumor necrosis factor-alpha.
American journal of respiratory and critical care medicine
Early elevation of plasma soluble intercellular adhesion molecule-1 in pediatric acute lung injury identifies patients at increased risk of death and prolonged mechanical ventilation.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Protein C and thrombomodulin in human acute lung injury.
American journal of physiology. Lung cellular and molecular physiology
Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injury.
American journal of physiology. Lung cellular and molecular physiology
Future research directions in acute lung injury: summary of a National Heart, Lung, and Blood Institute working group.
American journal of respiratory and critical care medicine
Therapeutic strategies to hasten the resolution of pulmonary edema.
Critical care medicine
Prevention of ventilator-associated pneumonia: an evidence-based systematic review.
Annals of internal medicine
Keratinocyte growth factor promotes cell motility during alveolar epithelial repair in vitro.
Experimental cell research
High tidal volume ventilation induces NOS2 and impairs cAMP- dependent air space fluid clearance.
American journal of physiology. Lung cellular and molecular physiology
Prognostic value of surfactant proteins A and D in patients with acute lung injury.
Critical care medicine
Lung edema clearance: 20 years of progress: invited review: alveolar edema fluid clearance in the injured lung.
Journal of applied physiology (Bethesda, Md. : 1985)
Meta-analysis of acute lung injury and acute respiratory distress syndrome trials.
American journal of respiratory and critical care medicine
Alveolar epithelial fluid transport in acute lung injury: new insights.
The European respiratory journal
Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome.
The American journal of pathology
Hypoxia upregulates VEGF expression in alveolar epithelial cells in vitro and in vivo.
American journal of physiology. Lung cellular and molecular physiology
Selected contribution: long-term effects of beta(2)-adrenergic receptor stimulation on alveolar fluid clearance in mice.
Journal of applied physiology (Bethesda, Md. : 1985)
Selected contribution: mechanisms that may stimulate the resolution of alveolar edema in the transplanted human lung.
Journal of applied physiology (Bethesda, Md. : 1985)
Measuring microvascular blood flow in sepsis--a continuing challenge.
Lancet (London, England)
Science review: mechanisms of ventilator-induced injury.
Critical care (London, England)
Hypoxia and beta 2-agonists regulate cell surface expression of the epithelial sodium channel in native alveolar epithelial cells.
The Journal of biological chemistry
Central line infections.
Current opinion in critical care
Invited review: Active fluid clearance from the distal air spaces of the lung.
Journal of applied physiology (Bethesda, Md. : 1985)
Time-dependent effect of pneumonectomy on alveolar epithelial fluid clearance in rat lungs.
The Journal of thoracic and cardiovascular surgery
Ventilator-induced lung injury: in vivo and in vitro mechanisms.
American journal of physiology. Lung cellular and molecular physiology
Pleural surface fluorescence measurement of Na+ and Cl- transport across the air space-capillary barrier.
Journal of applied physiology (Bethesda, Md. : 1985)
Assessment of lungs rejected for transplantation and implications for donor selection.
Lancet (London, England)
The pulmonary epithelium is an important mediator of ventilator-induced lung injury.
Critical care medicine
Evidence against aquaporin-1-dependent CO2 permeability in lung and kidney.
The Journal of physiology
Keratinocyte growth factor can enhance alveolar epithelial repair by nonmitogenic mechanisms.
American journal of physiology. Lung cellular and molecular physiology
Lung epithelial fluid transport and the resolution of pulmonary edema.
Physiological reviews
Enhancing the safety of critically ill patients by reducing urinary and central venous catheter-related infections.
American journal of respiratory and critical care medicine
Aerosolized beta(2)-adrenergic agonists achieve therapeutic levels in the pulmonary edema fluid of ventilated patients with acute respiratory failure.
Intensive care medicine
Activity of pulmonary edema fluid interleukin-8 bound to alpha(2)-macroglobulin in patients with acute lung injury.
American journal of physiology. Lung cellular and molecular physiology
Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair.
American journal of physiology. Lung cellular and molecular physiology
Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome.
The New England journal of medicine
Airway pressures and early barotrauma in patients with acute lung injury and acute respiratory distress syndrome.
American journal of respiratory and critical care medicine
Clinical Acute Lung Injury and Acute Respiratory Distress Syndrome.
Current treatment options in cardiovascular medicine
Distal air space epithelial fluid clearance in near-term rat fetuses is fast and requires endogenous catecholamines.
American journal of physiology. Lung cellular and molecular physiology
Lidocaine induces a reversible decrease in alveolar epithelial fluid clearance in rats.
Anesthesiology
Novel role for CFTR in fluid absorption from the distal airspaces of the lung.
The Journal of general physiology
Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungs.
American journal of respiratory and critical care medicine
Stress preconditioning attenuates oxidative injury to the alveolar epithelium of the lung following haemorrhage in rats.
The Journal of physiology
von Willebrand factor antigen is an independent marker of poor outcome in patients with early acute lung injury.
Critical care medicine
Hypoxia reduces alveolar epithelial sodium and fluid transport in rats: reversal by beta-adrenergic agonist treatment.
American journal of respiratory cell and molecular biology
Keratinocyte growth factor reduces alveolar epithelial susceptibility to in vitro mechanical deformation.
American journal of physiology. Lung cellular and molecular physiology
Targeted transgenic expression of beta(2)-adrenergic receptors to type II cells increases alveolar fluid clearance.
American journal of physiology. Lung cellular and molecular physiology
The Role of Protein C in Sepsis.
Current infectious disease reports
Treatment of ARDS.
Chest
Efficacy of low tidal volume ventilation in patients with different clinical risk factors for acute lung injury and the acute respiratory distress syndrome.
American journal of respiratory and critical care medicine
Beta1-adrenoceptor stimulation by high-dose terbutaline downregulates terbutaline-stimulated alveolar fluid clearance in ex vivo rat lung.
Experimental lung research
Partial restoration of defective chloride conductance in DeltaF508 CF mice by trimethylamine oxide.
American journal of physiology. Lung cellular and molecular physiology
Rapid alveolar epithelial fluid clearance following lung lavage in pulmonary alveolar proteinosis.
Chest
Mechanisms of TNF-alpha stimulation of amiloride-sensitive sodium transport across alveolar epithelium.
American journal of physiology. Lung cellular and molecular physiology
Role of aquaporin water channels in airway fluid transport, humidification, and surface liquid hydration.
The Journal of general physiology
TGF-beta is a critical mediator of acute lung injury.
The Journal of clinical investigation
Reactive nitrogen species inhibit alveolar epithelial fluid transport after hemorrhagic shock in rats.
Journal of immunology (Baltimore, Md. : 1950)
Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome.
American journal of respiratory and critical care medicine
Pulmonary edema fluid from patients with acute lung injury augments in vitro alveolar epithelial repair by an IL-1beta-dependent mechanism.
American journal of respiratory and critical care medicine
Contribution of amiloride-insensitive pathways to alveolar fluid clearance in adult rats.
Journal of applied physiology (Bethesda, Md. : 1985)
Pseudomonas aeruginosa ExoT inhibits in vitro lung epithelial wound repair.
Cellular microbiology
Severe sepsis--a new treatment with both anticoagulant and antiinflammatory properties.
The New England journal of medicine
Alveolar epithelial transport. Basic science to clinical medicine.
American journal of respiratory and critical care medicine
Denopamine, a beta(1)-adrenergic agonist, increases alveolar fluid clearance in ex vivo rat and guinea pig lungs.
Journal of applied physiology (Bethesda, Md. : 1985)
Increased levels of nitrate and surfactant protein a nitration in the pulmonary edema fluid of patients with acute lung injury.
American journal of respiratory and critical care medicine
Transepithelial sodium and water transport in the lung. Major player and novel therapeutic target in pulmonary edema.
Advances in experimental medicine and biology
Interleukin-1beta augments in vitro alveolar epithelial repair.
American journal of physiology. Lung cellular and molecular physiology
Role of aquaporin water channels in pleural fluid dynamics.
American journal of physiology. Cell physiology
Beta-adrenergic agonist therapy accelerates the resolution of hydrostatic pulmonary edema in sheep and rats.
Journal of applied physiology (Bethesda, Md. : 1985)
Alveolar epithelial barrier. Role in lung fluid balance in clinical lung injury.
Clinics in chest medicine
Relationship of interstitial fluid volume to alveolar fluid clearance in mice: ventilated vs. in situ studies.
Journal of applied physiology (Bethesda, Md. : 1985)
Diabetes mellitus: a negative predictor for the development of acute respiratory distress syndrome from septic shock.
Critical care medicine
Role of aquaporins in alveolar fluid clearance in neonatal and adult lung, and in oedema formation following acute lung injury: studies in transgenic aquaporin null mice.
The Journal of physiology
Cost-effectiveness of noninvasive ventilation for acute chronic obstructive pulmonary disease: cashing in too quickly.
Critical care medicine
Lung overexpression of the vascular endothelial growth factor gene induces pulmonary edema.
American journal of respiratory cell and molecular biology
Lung deflation impairs alveolar epithelial fluid transport in ischemic rabbit and rat lungs.
Transplantation
The acute respiratory distress syndrome.
The New England journal of medicine
Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome.
The New England journal of medicine
Aquaporin water channels and lung physiology.
American journal of physiology. Lung cellular and molecular physiology
Hypoxia regulates gene expression of alveolar epithelial transport proteins.
Journal of applied physiology (Bethesda, Md. : 1985)
[Amiloride-sensitive sodium channel in the nephron and its activation by vasopressin].
Annales d'endocrinologie
Increased neutrophil numbers and IL-8 levels in airway secretions in acute severe asthma: Clinical and biologic significance.
American journal of respiratory and critical care medicine
A novel alveolar type I cell-specific biochemical marker of human acute lung injury.
American journal of respiratory and critical care medicine
Dexamethasone and thyroid hormone pretreatment upregulate alveolar epithelial fluid clearance in adult rats.
Journal of applied physiology (Bethesda, Md. : 1985)
Carbon dioxide permeability of aquaporin-1 measured in erythrocytes and lung of aquaporin-1 null mice and in reconstituted proteoliposomes.
The Journal of biological chemistry
Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: time for a reevaluation.
Critical care medicine
Early expression of beta- and gamma-subunits of epithelial sodium channel during human airway development.
American journal of physiology. Lung cellular and molecular physiology
Initial severity of metabolic acidosis predicts the development of acute lung injury in severely traumatized patients.
Critical care medicine
Lung fluid transport in aquaporin-5 knockout mice.
The Journal of clinical investigation
Noninvasive ventilation for acute respiratory failure.
Journal of clinical monitoring and computing
Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method.
The Journal of general physiology
Health-related quality of life after acute lung injury.
Critical care medicine
Acid-induced lung injury. Protective effect of anti-interleukin-8 pretreatment on alveolar epithelial barrier function in rabbits.
American journal of respiratory and critical care medicine
Alveolar epithelial fluid transport can be simultaneously upregulated by both KGF and beta-agonist therapy.
Journal of applied physiology (Bethesda, Md. : 1985)
Interleukin-8 mediates injury from smoke inhalation to both the lung endothelial and the alveolar epithelial barriers in rabbits.
American journal of respiratory and critical care medicine
Alveolar epithelial fluid transport and the resolution of clinically severe hydrostatic pulmonary edema.
Journal of applied physiology (Bethesda, Md. : 1985)
The lectin-like domain of tumor necrosis factor-alpha increases membrane conductance in microvascular endothelial cells and peritoneal macrophages.
European journal of immunology
alpha-adrenergic blockade restores normal fluid transport capacity of alveolar epithelium after hemorrhagic shock.
The American journal of physiology
Indomethacin does not influence alveolar liquid clearance in anesthetized sheep or rats.
Experimental lung research
Oxidant-mediated lung injury in the acute respiratory distress syndrome.
Critical care medicine
Inhibition of beta-adrenergic-dependent alveolar epithelial clearance by oxidant mechanisms after hemorrhagic shock.
The American journal of physiology
Alveolar epithelial fluid transport capacity in reperfusion lung injury after lung transplantation.
American journal of respiratory and critical care medicine
Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice.
The Journal of clinical investigation
The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome.
Critical care medicine
Alveolar epithelial fluid clearance persists in the presence of moderate left atrial hypertension in sheep.
Journal of applied physiology (Bethesda, Md. : 1985)
Ischemia-reperfusion lung injury in rabbits: mechanisms of injury and protection.
The American journal of physiology
Reduced osmotic water permeability of the peritoneal barrier in aquaporin-1 knockout mice.
The American journal of physiology
Role of collagenase in mediating in vitro alveolar epithelial wound repair.
Journal of cell science
Risk reduction in the intensive care unit.
The American journal of medicine
Alveolar epithelial fluid transport: basic mechanisms and clinical relevance.
Proceedings of the Association of American Physicians
Pulmonary edema in obstetric patients is rapidly resolved except in the presence of infection or of nitroglycerin tocolysis after open fetal surgery.
American journal of obstetrics and gynecology
Upregulation of alveolar epithelial fluid transport after subacute lung injury in rats from bleomycin.
The American journal of physiology
Hepatocyte growth factor and keratinocyte growth factor in the pulmonary edema fluid of patients with acute lung injury. Biologic and clinical significance.
American journal of respiratory and critical care medicine
Protective ventilation for the acute respiratory distress syndrome.
The New England journal of medicine
A mouse model to test the in vivo efficacy of chemical chaperones.
Journal of pharmacological and toxicological methods
Effects of ATP-sensitive potassium channel opener on potassium transport and alveolar fluid clearance in the resected human lung.
Pharmacology & toxicology
Evidence against a role of mouse, rat, and two cloned human t1alpha isoforms as a water channel or a regulator of aquaporin-type water channels.
American journal of respiratory cell and molecular biology
New in situ mouse model to quantify alveolar epithelial fluid clearance.
Journal of applied physiology (Bethesda, Md. : 1985)
High microvascular endothelial water permeability in mouse lung measured by a pleural surface fluorescence method.
Biophysical journal
The American-European Consensus Conference on ARDS, part 2. Ventilatory, pharmacologic, supportive therapy, study design strategies and issues related to recovery and remodeling.
Intensive care medicine
The American-European Consensus Conference on ARDS, part 2: Ventilatory, pharmacologic, supportive therapy, study design strategies, and issues related to recovery and remodeling. Acute respiratory distress syndrome.
American journal of respiratory and critical care medicine
Highly water-permeable type I alveolar epithelial cells confer high water permeability between the airspace and vasculature in rat lung.
Proceedings of the National Academy of Sciences of the United States of America
Just say NO to inhaled nitric oxide for the acute respiratory distress syndrome.
Critical care medicine
Developmental changes in water permeability across the alveolar barrier in perinatal rabbit lung.
The Journal of clinical investigation
Early detection of type III procollagen peptide in acute lung injury. Pathogenetic and prognostic significance.
American journal of respiratory and critical care medicine
Dobutamine increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation.
American journal of respiratory and critical care medicine
Upregulation of alveolar liquid clearance after fluid resuscitation for hemorrhagic shock in rats.
The American journal of physiology
Inhibition of CD18 or CD11b attenuates acute lung injury after acid instillation in rabbits.
Journal of applied physiology (Bethesda, Md. : 1985)
Noninvasive positive pressure ventilation for acute respiratory failure: underutilized or overrated?
Chest
Protein tyrosine phosphatases mediate cell readhesion in alveolar epithelial cells mechanically separated from in vitro matrix.
American journal of respiratory cell and molecular biology
Biological markers of acute lung injury: prognostic and pathogenetic significance.
American journal of respiratory and critical care medicine
Beta-adrenergic agonist stimulated alveolar fluid clearance in ex vivo human and rat lungs.
American journal of respiratory and critical care medicine
Acute bacterial pneumonia in rats increases alveolar epithelial fluid clearance by a tumor necrosis factor-alpha-dependent mechanism.
The Journal of clinical investigation
Increased alveolar fluid clearance following thoracotomy: report of a case and results of an analysis.
Surgery today
Sharp increase in rat lung water channel expression in the perinatal period.
American journal of respiratory cell and molecular biology
Soluble and insoluble fibronectin increases alveolar epithelial wound healing in vitro.
The American journal of physiology
Anti-IL-8 autoantibodies in alveolar fluid from patients with the adult respiratory distress syndrome.
Journal of immunology (Baltimore, Md. : 1950)
Increased interleukin-8 concentrations in the pulmonary edema fluid of patients with acute respiratory distress syndrome from sepsis.
Critical care medicine
Transalveolar osmotic and diffusional water permeability in intact mouse lung measured by a novel surface fluorescence method.
The Journal of general physiology
Acid aspiration induced lung injury. New insights and therapeutic options.
American journal of respiratory and critical care medicine
Alveolar liquid clearance is increased by endogenous catecholamines in hemorrhagic shock in rats.
Journal of applied physiology (Bethesda, Md. : 1985)
Transforming growth factor-alpha increases alveolar liquid clearance in anesthetized ventilated rats.
The American journal of physiology
The acute respiratory distress syndrome.
The New England journal of medicine
Alveolar epithelial clearance of protein.
Journal of applied physiology (Bethesda, Md. : 1985)
Preservation of alveolar epithelial fluid transport mechanisms in rewarmed human lung after severe hypothermia.
Journal of applied physiology (Bethesda, Md. : 1985)
Salt and water transport across alveolar and distal airway epithelia in the adult lung.
The American journal of physiology
Transepithelial water permeability in microperfused distal airways. Evidence for channel-mediated water transport.
The Journal of clinical investigation
Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.
The Journal of experimental medicine
Alveolar endotoxin increases alveolar liquid clearance in rats.
Journal of applied physiology (Bethesda, Md. : 1985)
Identification of patients with acute lung injury. Predictors of mortality.
American journal of respiratory and critical care medicine
Cellular uptake of albumin from lungs of anesthetized rabbits.
The American journal of physiology
Acid aspiration-induced lung injury in rabbits is mediated by interleukin-8-dependent mechanisms.
The Journal of clinical investigation
Evaluation of definitions of ARDS.
American journal of respiratory and critical care medicine
Resistance of the alveolar epithelium to injury from septic shock in sheep.
American journal of respiratory and critical care medicine
Frequency and importance of barotrauma in 100 patients with acute lung injury.
Critical care medicine
Fibrosing alveolitis in the adult respiratory distress syndrome.
Annals of internal medicine
The effect of salt water on alveolar epithelial barrier function.
American journal of respiratory and critical care medicine
Transforming growth factor-alpha enhances alveolar epithelial cell repair in a new in vitro model.
The American journal of physiology
Alveolar fluid clearance in the resected human lung.
American journal of respiratory and critical care medicine
Stimulation of lung epithelial liquid clearance by endogenous release of catecholamines in septic shock in anesthetized rats.
The Journal of clinical investigation
Alveolar liquid and protein clearance in anesthetized ventilated rats.
Journal of applied physiology (Bethesda, Md. : 1985)
Transcellular water transport in lung alveolar epithelium through mercury-sensitive water channels.
Proceedings of the National Academy of Sciences of the United States of America
Effect of endocytosis inhibitors on alveolar clearance of albumin, immunoglobulin G, and SP-A in rabbits.
The American journal of physiology
Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues.
The Journal of biological chemistry
Alveolar epithelial barrier and acute lung injury.
New horizons (Baltimore, Md.)
Transient effect of epidermal growth factor on the motility of an immortalized mammary epithelial cell line.
Journal of cell science
Alveolar epithelial injury and pleural empyema in acute P. aeruginosa pneumonia in anesthetized rabbits.
Journal of applied physiology (Bethesda, Md. : 1985)
Pseudomonas aeruginosa-induced lung and pleural injury in sheep. Differential protective effect of circulating versus alveolar immunoglobulin G antibody.
The Journal of clinical investigation
Effect of temperature on alveolar liquid and protein clearance in an in situ perfused goat lung.
Journal of applied physiology (Bethesda, Md. : 1985)
Neutrophil-activating peptide-2 in patients with pulmonary edema from congestive heart failure or ARDS.
The American journal of physiology
Soluble E-selectin is found in supernatants of activated endothelial cells and is elevated in the serum of patients with septic shock.
Journal of immunology (Baltimore, Md. : 1950)
Alveolar liquid and protein clearance in the absence of blood flow or ventilation in sheep.
Journal of applied physiology (Bethesda, Md. : 1985)
Clearance of different-sized proteins from the alveolar space in humans and rabbits.
Journal of applied physiology (Bethesda, Md. : 1985)
Pulmonary edema associated with salt water near-drowning: new insights.
The American review of respiratory disease
Persistent paralysis in critically ill patients after long-term administration of vecuronium.
The New England journal of medicine
Elevated levels of NAP-1/interleukin-8 are present in the airspaces of patients with the adult respiratory distress syndrome and are associated with increased mortality.
The American review of respiratory disease
Effect of epinephrine on the ability of end-tidal carbon dioxide readings to predict initial resuscitation from cardiac arrest.
Critical care medicine
Alveolar and lung liquid clearance in the absence of pulmonary blood flow in sheep.
Journal of applied physiology (Bethesda, Md. : 1985)
Differential responses of the endothelial and epithelial barriers of the lung in sheep to Escherichia coli endotoxin.
The Journal of clinical investigation
Alveolar and lung liquid clearance in anesthetized rabbits.
Journal of applied physiology (Bethesda, Md. : 1985)
Resolution of pulmonary edema. New insights.
The Western journal of medicine
Right-heart catheterization is a diagnostic procedure not a therapeutic intervention.
Journal of intensive care medicine
Intact epithelial barrier function is critical for the resolution of alveolar edema in humans.
The American review of respiratory disease
Pulmonary endothelial cell injury and altered lung metabolic function. Early detection of the adult respiratory distress syndrome and possible functional significance.
Clinics in chest medicine
The adult respiratory distress syndrome. Definition and prognosis.
Clinics in chest medicine
Elevated von Willebrand factor antigen is an early plasma predictor of acute lung injury in nonpulmonary sepsis syndrome.
The Journal of clinical investigation
The adult respiratory distress syndrome: definition and prognosis, pathogenesis and treatment.
British journal of anaesthesia
The case for oxidants in the adult respiratory distress syndrome--"elementary, Dr. Watson".
The Journal of laboratory and clinical medicine
Prolonged neuromuscular blockade after long-term administration of vecuronium in two critically ill patients.
Anesthesiology
Pulmonary manifestations of endocrine and metabolic disorders.
Clinics in chest medicine
Effects of leukotriene B4 in the human lung. Recruitment of neutrophils into the alveolar spaces without a change in protein permeability.
The Journal of clinical investigation
Protein clearance from the air spaces and lungs of unanesthetized sheep over 144 h.
Journal of applied physiology (Bethesda, Md. : 1985)
Ureteral obstruction caused by vasculitis.
The Journal of urology
The adult respiratory distress syndrome. New insights into diagnosis, pathophysiology, and treatment.
The Western journal of medicine
Fate of aerosolized recombinant DNA-produced alpha 1-antitrypsin: use of the epithelial surface of the lower respiratory tract to administer proteins of therapeutic importance.
Proceedings of the National Academy of Sciences of the United States of America
Bedside catheterization of the pulmonary artery: risks compared with benefits.
Annals of internal medicine
Relationship of pleural effusions to increased permeability pulmonary edema in anesthetized sheep.
The Journal of clinical investigation
An expanded definition of the adult respiratory distress syndrome.
The American review of respiratory disease
Alveolar liquid and protein clearance from normal dog lungs.
Journal of applied physiology (Bethesda, Md. : 1985)
Sulfidopeptide-leukotriene peptidases in pulmonary edema fluid from patients with the adult respiratory distress syndrome.
Journal of clinical immunology
Beta-adrenergic agonists increase lung liquid clearance in anesthetized sheep.
The Journal of clinical investigation
The adult respiratory distress syndrome.
The Yale journal of biology and medicine
Central intravascular pressure measurements: when should we believe them?
Journal of thoracic imaging
Pathophysiology of the adult respiratory distress syndrome. What have we learned from human studies?
Critical care clinics
Leukotrienes in pulmonary edema fluid after cardiopulmonary bypass.
Anesthesia and analgesia
Pulmonary embolism. Guide to diagnosis, treatment, and prevention.
Postgraduate medicine
Intensive care unit: how stressful for physicians?
Critical care medicine
Relationship of pleural effusions to pulmonary hemodynamics in patients with congestive heart failure.
The American review of respiratory disease
Cellular basis for injury and repair in the adult respiratory distress syndrome.
The Western journal of medicine
Long-term clearance of liquid and protein from the lungs of unanesthetized sheep.
Journal of applied physiology (Bethesda, Md. : 1985)
Pathophysiology of pulmonary edema.
Clinics in chest medicine
Resolution of pulmonary edema. Mechanisms of liquid, protein, and cellular clearance from the lung.
Clinics in chest medicine
Undrained bloody pericardial effusion in the early postoperative period after coronary bypass surgery: a prospective blood pool study.
American heart journal
Biologically active products of complement and acute lung injury in patients with the sepsis syndrome.
The American review of respiratory disease
Elevated concentrations of leukotriene D4 in pulmonary edema fluid of patients with the adult respiratory distress syndrome.
Journal of clinical immunology
Neurogenic pulmonary edema.
The American review of respiratory disease
Guillain-Barré syndrome: psychosocial aspects of management.
Psychosomatics
Hemodynamic management in the adult respiratory distress syndrome.
Clinics in chest medicine
Invasive hemodynamic monitoring in critically ill patients.
Clinics in chest medicine
Overperfusion, hypoxia, and increased pressure cause only hydrostatic pulmonary edema in anesthetized sheep.
Circulation research
Differential liquid and protein clearance from the alveoli of anesthetized sheep.
Journal of applied physiology: respiratory, environmental and exercise physiology
Adult respiratory distress syndrome complicating diabetic ketoacidosis.
The Western journal of medicine
Anatomic variations of efferent duct from caudal mediastinal lymph node in sheep.
Journal of applied physiology: respiratory, environmental and exercise physiology
Thyrotoxicosis: comparison of effects of thyroid ablation and beta-adrenergic blockade on metabolic rate and ventilatory control.
The Journal of clinical endocrinology and metabolism
Acute pseudogout in the absence of synovial fluid Leukocytes.
The Journal of rheumatology