Mercedes Paredes, MD, PhD

Associate Professor
Neurology

Mercedes Paredes, MD, PhD studies the source and diversity of postnatally migrating inhibitory neurons in the human frontal lobe.

Publications: 

Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1.

bioRxiv : the preprint server for biology

Yu D, Jain S, Wangzhou A, De Florencio S, Zhu B, Kim JY, Choi JJ, Paredes MF, Nowakowski TJ, Huang EJ, Piao X

Temporally distinct 3D multi-omic dynamics in the developing human brain.

Nature

Heffel MG, Zhou J, Zhang Y, Lee DS, Hou K, Pastor-Alonso O, Abuhanna KD, Galasso J, Kern C, Tai CY, Garcia-Padilla C, Nafisi M, Zhou Y, Schmitt AD, Li T, Haeussler M, Wick B, Zhang MJ, Xie F, Ziffra RS, Mukamel EA, Eskin E, Nowakowski TJ, Dixon JR, Pasaniuc B, Ecker JR, Zhu Q, Bintu B, Paredes MF, Luo C

Molecular and cellular dynamics of the developing human neocortex at single-cell resolution.

bioRxiv : the preprint server for biology

Wang L, Wang C, Moriano JA, Chen S, Zuo G, Cebrián-Silla A, Zhang S, Mukhtar T, Wang S, Song M, de Oliveira LG, Bi Q, Augustin JJ, Ge X, Paredes MF, Huang EJ, Alvarez-Buylla A, Duan X, Li J, Kriegstein AR

Conservation, alteration, and redistribution of mammalian striatal interneurons.

bioRxiv : the preprint server for biology

Corrigan EK, DeBerardine M, Poddar A, Turrero García M, Schmitz MT, Harwell CC, Paredes MF, Krienen FM, Pollen AA

Large-scale neurophysiology and single-cell profiling in human neuroscience.

Nature

Lee AT, Chang EF, Paredes MF, Nowakowski TJ

Cell-Type Specificity of Mosaic Chromosome 1q Gain Resolved by snRNA-seq in a Case of Epilepsy With Hyaline Protoplasmic Astrocytopathy.

Neurology. Genetics

Leng K, Cadwell CR, Devine WP, Tihan T, Qi Z, Singhal NS, Glenn OA, Kamiya S, Wiita AP, Berger AC, Shieh JT, Titus EW, Paredes MF, Upadhyay V

Cell type specificity of mosaic chromosome 1q gain resolved by snRNA-seq in a case of epilepsy with hyaline protoplasmic astrocytopathy.

bioRxiv : the preprint server for biology

Leng K, Cadwell CR, Patrick Devine W, Tihan T, Qi Z, Singhal N, Glenn O, Kamiya S, Wiita A, Berger A, Shieh JT, Titus EW, Paredes MF, Upadhyay V

β-Adrenergic Signaling Promotes Morphological Maturation of Astrocytes in Female Mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Rosenberg MF, Godoy MI, Wade SD, Paredes MF, Zhang Y, Molofsky AV

Single-cell analysis of prenatal and postnatal human cortical development.

Science (New York, N.Y.)

Velmeshev D, Perez Y, Yan Z, Valencia JE, Castaneda-Castellanos DR, Wang L, Schirmer L, Mayer S, Wick B, Wang S, Nowakowski TJ, Paredes M, Huang EJ, Kriegstein AR

A cross-species proteomic map reveals neoteny of human synapse development.

Nature

Wang L, Pang K, Zhou L, Cebrián-Silla A, González-Granero S, Wang S, Bi Q, White ML, Ho B, Li J, Li T, Perez Y, Huang EJ, Winkler EA, Paredes MF, Kovner R, Sestan N, Pollen AA, Liu P, Li J, Piao X, García-Verdugo JM, Alvarez-Buylla A, Liu Z, Kriegstein AR

A CRISPR-engineered isogenic model of the 22q11.2 A-B syndromic deletion.

Scientific reports

Paranjape N, Lin YT, Flores-Ramirez Q, Sarin V, Johnson AB, Chu J, Paredes M, Wiita AP

Cell Migration in the Mammalian Cortex.

Jae Yeon Kim, Samuel J. Pleasure, Mercedes F. Paredes

Ensembles of endothelial and mural cells promote angiogenesis in prenatal human brain.

Cell

Crouch EE, Bhaduri A, Andrews MG, Cebrian-Silla A, Diafos LN, Birrueta JO, Wedderburn-Pugh K, Valenzuela EJ, Bennett NK, Eze UC, Sandoval-Espinosa C, Chen J, Mora C, Ross JM, Howard CE, Gonzalez-Granero S, Lozano JF, Vento M, Haeussler M, Paredes MF, Nakamura K, Garcia-Verdugo JM, Alvarez-Buylla A, Kriegstein AR, Huang EJ

Cell Migration in the Mammalian Cortex.

Jae Yeon Kim, Samuel J. Pleasure, Mercedes F. Paredes

Comment on "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis".

Science (New York, N.Y.)

Alvarez-Buylla A, Cebrian-Silla A, Sorrells SF, Nascimento MA, Paredes MF, Garcia-Verdugo JM, Yang Z, Huang EJ

The development and evolution of inhibitory neurons in primate cerebrum.

Nature

Schmitz MT, Sandoval K, Chen CP, Mostajo-Radji MA, Seeley WW, Nowakowski TJ, Ye CJ, Paredes MF, Pollen AA

Amplification of human interneuron progenitors promotes brain tumors and neurological defects.

Science (New York, N.Y.)

Eichmüller OL, Corsini NS, Vértesy Á, Morassut I, Scholl T, Gruber VE, Peer AM, Chu J, Novatchkova M, Hainfellner JA, Paredes MF, Feucht M, Knoblich JA

Nests of dividing neuroblasts sustain interneuron production for the developing human brain.

Science (New York, N.Y.)

Paredes MF, Mora C, Flores-Ramirez Q, Cebrian-Silla A, Del Dosso A, Larimer P, Chen J, Kang G, Gonzalez Granero S, Garcia E, Chu J, Delgado R, Cotter JA, Tang V, Spatazza J, Obernier K, Ferrer Lozano J, Vento M, Scott J, Studholme C, Nowakowski TJ, Kriegstein AR, Oldham MC, Hasenstaub A, Garcia-Verdugo JM, Alvarez-Buylla A, Huang EJ

Simplified risk-prediction for benchmarking and quality improvement in emergency general surgery. Prospective, multicenter, observational cohort study.

International journal of surgery (London, England)

Villodre C, Taccogna L, Zapater P, Cantó M, Mena L, Ramia JM, Lluís F, Afonso N, Aguilella V, Aguiló J, Alados JC, Alberich M, Apio AB, Balongo R, Bra E, Bravo-Gutiérrez A, Briceño FJ, Cabañas J, Cánovas G, Caravaca I, Carbonell S, Carrera-Dacosta E, Castro EE, Caula C, Choolani-Bhojwani E, Codina A, Corral S, Cuenca C, Curbelo-Peña Y, Delgado-Morales MM, Delgado-Plasencia L, Doménech E, Estévez AM, Feria AM, Gascón-Domínguez MA, Gianchandani R, González C, Hevia RJ, González MA, Hidalgo JM, Lainez M, Lluís N, López F, López-Fernández J, López-Ruíz JA, Lora-Cumplido P, Madrazo Z, Marchena J, de la Cuadra MB, Martín S, Casas MI, Martínez P, Mena-Mateos A, Morales-García D, Mulas C, Muñoz-Forner E, Naranjo A, Navarro-Sánchez A, Oliver I, Ortega I, Ortega-Higueruelo R, Ortega-Ruiz S, Osorio J, Padín MH, Pamies JJ, Paredes M, Pareja-Ciuró F, Parra J, Pérez-Guarinós CV, Pérez-Saborido B, Pintor-Tortolero J, Plua-Muñiz K, Rey M, Rodríguez I, Ruiz C, Ruíz R, Ruiz S, Sánchez A, Sánchez D, Sánchez R, Sánchez-Cabezudo F, Sánchez-Santos R, Santos J, Serrano-Paz MP, Soria-Aledo V, Tallón-Aguilar L, Valdivia-Risco JH, Vallverdú-Cartié H, Varela C, Villar-Del-Moral J, Zambudio N, LUCENTUM Project Researchers

Implications of Extended Inhibitory Neuron Development.

International journal of molecular sciences

Kim JY, Paredes MF

Positive Controls in Adults and Children Support That Very Few, If Any, New Neurons Are Born in the Adult Human Hippocampus.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Sorrells SF, Paredes MF, Zhang Z, Kang G, Pastor-Alonso O, Biagiotti S, Page CE, Sandoval K, Knox A, Connolly A, Huang EJ, Garcia-Verdugo JM, Oldham MC, Yang Z, Alvarez-Buylla A

Interneuron Origins in the Embryonic Porcine Medial Ganglionic Eminence.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Casalia ML, Li T, Ramsay H, Ross PJ, Paredes MF, Baraban SC

Reciprocal Interaction between Vascular Filopodia and Neural Stem Cells Shapes Neurogenesis in the Ventral Telencephalon.

Cell reports

Di Marco B, Crouch EE, Shah B, Duman C, Paredes MF, Ruiz de Almodovar C, Huang EJ, Alfonso J

Maf and Mafb control mouse pallial interneuron fate and maturation through neuropsychiatric disease gene regulation.

eLife

Pai EL, Chen J, Fazel Darbandi S, Cho FS, Chen J, Lindtner S, Chu JS, Paz JT, Vogt D, Paredes MF, Rubenstein JL

Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map.

Nature neuroscience

Bayraktar OA, Bartels T, Holmqvist S, Kleshchevnikov V, Martirosyan A, Polioudakis D, Ben Haim L, Young AMH, Batiuk MY, Prakash K, Brown A, Roberts K, Paredes MF, Kawaguchi R, Stockley JH, Sabeur K, Chang SM, Huang E, Hutchinson P, Ullian EM, Hemberg M, Coppola G, Holt MG, Geschwind DH, Rowitch DH

Cortical Malformations: Lessons in Human Brain Development.

Frontiers in cellular neuroscience

Subramanian L, Calcagnotto ME, Paredes MF

Cortical developmental abnormalities in logopenic variant primary progressive aphasia with dyslexia.

Brain communications

Miller ZA, Spina S, Pakvasa M, Rosenberg L, Watson C, Mandelli ML, Paredes MF, Joie R, Rabinovici GD, Rosen HJ, Grinberg LT, Huang EJ, Miller BL, Seeley WW, Gorno-Tempini ML

Building Bridges Between the Clinic and the Laboratory: A Meeting Review - Brain Malformations: A Roadmap for Future Research.

Frontiers in cellular neuroscience

Sapir T, Barakat TS, Paredes MF, Lerman-Sagie T, Aronica E, Klonowski W, Nguyen L, Ben Zeev B, Bahi-Buisson N, Leventer R, Rachmian N, Reiner O

Immature excitatory neurons develop during adolescence in the human amygdala.

Nature communications

Sorrells SF, Paredes MF, Velmeshev D, Herranz-P?rez V, Sandoval K, Mayer S, Chang EF, Insausti R, Kriegstein AR, Rubenstein JL, Manuel Garcia-Verdugo J, Huang EJ, Alvarez-Buylla A

Multimodal Single-Cell Analysis Reveals Physiological Maturation in the Developing Human Neocortex.

Neuron

Mayer S, Chen J, Velmeshev D, Mayer A, Eze UC, Bhaduri A, Cunha CE, Jung D, Arjun A, Li E, Alvarado B, Wang S, Lovegren N, Gonzales ML, Szpankowski L, Leyrat A, West JAA, Panagiotakos G, Alvarez-Buylla A, Paredes MF, Nowakowski TJ, Pollen AA, Kriegstein AR

Does Adult Neurogenesis Persist in the Human Hippocampus?

Cell stem cell

Paredes MF, Sorrells SF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez Martin AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A

Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity.

Cerebral cortex (New York, N.Y. : 1991)

Raju CS, Spatazza J, Stanco A, Larimer P, Sorrells SF, Kelley KW, Nicholas CR, Paredes MF, Lui JH, Hasenstaub AR, Kriegstein AR, Alvarez-Buylla A, Rubenstein JL, Oldham MC

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults.

Nature

Sorrells SF, Paredes MF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A

Activity Regulates Cell Death within Cortical Interneurons through a Calcineurin-Dependent Mechanism.

Cell reports

Priya R, Paredes MF, Karayannis T, Yusuf N, Liu X, Jaglin X, Graef I, Alvarez-Buylla A, Fishell G

No Evidence For New Adult Neurons.

American Scientist

Shawn Sorrells, Arturo Alvarez-Buylla, Mercedes Paredes

Dynamic behaviour of human neuroepithelial cells in the developing forebrain.

Nature communications

Subramanian L, Bershteyn M, Paredes MF, Kriegstein AR

Extensive migration of young neurons into the infant human frontal lobe.

Science (New York, N.Y.)

Paredes MF, James D, Gil-Perotin S, Kim H, Cotter JA, Ng C, Sandoval K, Rowitch DH, Xu D, McQuillen PS, Garcia-Verdugo JM, Huang EJ, Alvarez-Buylla A

Brain size and limits to adult neurogenesis.

The Journal of comparative neurology

Paredes MF, Sorrells SF, Garcia-Verdugo JM, Alvarez-Buylla A

Encephalitis and AMPA receptor antibodies: Novel findings in a case series of 22 patients.

Neurology

Höftberger R, van Sonderen A, Leypoldt F, Houghton D, Geschwind M, Gelfand J, Paredes M, Sabater L, Saiz A, Titulaer MJ, Graus F, Dalmau J

DISTINCT AND SEPARABLE ROLES FOR HISTONE METHYLTRANSFERASE EZH2 IN NEUROGENIC ASTROCYTES.

Neuro-oncology

D. A. Lim, W. W. Hwang, R. D. Salinas, J. J. Siu, K. W. Kelley, R. N. Delgado, M. F. Paredes, A. Alvarez-Buylla, M. C. Oldham, D. A. Lim

Distinct and separable roles for EZH2 in neurogenic astroglia.

eLife

Hwang WW, Salinas RD, Siu JJ, Kelley KW, Delgado RN, Paredes MF, Alvarez-Buylla A, Oldham MC, Lim DA

Persistent abdominal symptoms in US adults after short-term stay in Mexico.

Journal of travel medicine

Nair P, Okhuysen PC, Jiang ZD, Carlin LG, Belkind-Gerson J, Flores J, Paredes M, DuPont HL

Axons take a dive: Specialized contacts of serotonergic axons with cells in the walls of the lateral ventricles in mice and humans.

Neurogenesis (Austin, Tex.)

Tong CK, Cebri?n-Silla A, Paredes MF, Huang EJ, Garc?a-Verdugo JM, Alvarez-Buylla A

Intrinsically determined cell death of developing cortical interneurons.

Nature

Southwell DG, Paredes MF, Galvao RP, Jones DL, Froemke RC, Sebe JY, Alfaro-Cervello C, Tang Y, Garcia-Verdugo JM, Rubenstein JL, Baraban SC, Alvarez-Buylla A

Campylobacter jejuni is not an important pathogen as a cause of diarrhea in US travelers to Mexico.

Journal of travel medicine

Villa NA, Okhuysen PC, Flores-Figueroa J, Jiang ZD, Belkind-Gerson J, Paredes M, Mohamed JA, Nair P, Carlin L, DuPont HL

Hilar mossy cells share developmental influences with dentate granule neurons.

Developmental neuroscience

Li G, Berger O, Han SM, Paredes M, Wu NC, Pleasure SJ

Expression of SDF-1 and CXCR4 during reorganization of the postnatal dentate gyrus.

Developmental neuroscience

Berger O, Li G, Han SM, Paredes M, Pleasure SJ

Stromal-derived factor-1 (CXCL12) regulates laminar position of Cajal-Retzius cells in normal and dysplastic brains.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Paredes MF, Li G, Berger O, Baraban SC, Pleasure SJ

Dysfunction of synaptic inhibition in epilepsy associated with focal cortical dysplasia.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Calcagnotto ME, Paredes MF, Tihan T, Barbaro NM, Baraban SC

Heterotopic neurons with altered inhibitory synaptic function in an animal model of malformation-associated epilepsy.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Calcagnotto ME, Paredes MF, Baraban SC

A review of gene expression patterns in the malformed brain.

Molecular neurobiology

Paredes MF, Baraban SC