
Professor
Diabetes Center
+1 415 514-0820
Matthias Hebrok, PhD studies how undifferentiated epithelial cells develop into functional endocrine cells, specifically insulin-producing beta cells.
Publications
Engineering synthetic suppressor T cells that execute locally targeted immunoprotective programs.
Science (New York, N.Y.)
nSMase2-mediated exosome secretion shapes the tumor microenvironment to immunologically support pancreatic cancer.
bioRxiv : the preprint server for biology
Author Correction: Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.
Nature medicine
KRAS degradation averts PDAC chemoresistance.
Nature cancer
Sox9 regulates alternative splicing and pancreatic beta cell function.
Nature communications
Abstract A046: nSMase2-generated ceramide promotes PDA aggression through exosome reprogramming of the stroma.
Cancer research
Stem cell-derived islet therapy: is this the end of the beginning?
Nature reviews. Endocrinology
Role of Cell-Based Therapies in T2D.
Seminars in nephrology
Species-specific roles for the MAFA and MAFB transcription factors in regulating islet β cell identity.
JCI insight
Replenishable prevascularized cell encapsulation devices increase graft survival and function in the subcutaneous space.
Bioengineering & translational medicine
Minimal SC-ß-Cell Properties for Transplantation in Diabetic Patients.
Pluripotent Stem Cell Therapy for Diabetes
Abstract C051: Ceramide signaling regulates PDA aggression through exosome reprogramming of the stroma.
Cancer research
Pancreatic �-Cell Development and Regeneration.
Cold Spring Harbor perspectives in biology
Development of a Beta Cell-Specific Expression Control Element for Recombinant Adeno-Associated Virus.
Human gene therapy
Development of a scalable method to isolate subsets of stem cell-derived pancreatic islet cells.
Stem cell reports
Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation.
Communications biology
Abstract PR-008: Kdm6 demethylases are critical regulators of pancreatic cancer initiation, progression and subtype specification.
Cancer research
Mutations and variants of ONECUT1 in diabetes.
Nature medicine
Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection.
Cell reports
Superporous agarose scaffolds for encapsulation of adult human islets and human stem-cell-derived � cells for intravascular bioartificial pancreas applications.
Journal of biomedical materials research. Part A
Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree.
eLife
Stem Cell-Based Clinical Trials for Diabetes Mellitus.
Frontiers in endocrinology
Non-xenogeneic expansion and definitive endoderm differentiation of human pluripotent stem cells in an automated bioreactor.
Biotechnology and bioengineering
Emerging routes to the generation of functional �-cells for diabetes mellitus cell therapy.
Nature reviews. Endocrinology
Loss of the transcription factor MAFB limits �-cell derivation from human PSCs.
Nature communications
LIN28B Impairs the Transition of hESC-Derived � Cells from the Juvenile to Adult State.
Stem cell reports
Lipid Droplet Accumulation in Human Pancreatic Islets Is Dependent On Both Donor Age and Health.
Diabetes
Using a barcoded AAV capsid library to select for clinically relevant gene therapy vectors.
JCI insight
Supporting Survival of Transplanted Stem-Cell-Derived Insulin-Producing Cells in an Encapsulation Device Augmented with Controlled Release of Amino Acids.
Advanced biosystems
mTORC1 to AMPK switching underlies �-cell metabolic plasticity during maturation and diabetes.
The Journal of clinical investigation
Author Correction: Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells.
Nature cell biology
Pancreatic pericytes originate from the embryonic pancreatic mesenchyme.
Developmental biology
Rapid generation of functional mature pancreatic islet-beta cells from human pluripotent stem cells.
Protocol Exchange
Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived � cells.
Nature cell biology
The BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis.
The Journal of clinical investigation
Co-Transplant of Parathyroid Gland and Stem Cell-Derived Insulin-Producing Cells Enhances Graft Survival through Release of Pro-Angiogenic and Pro-Survival Factors.
Transplantation Journal
Synaptotagmin 4 Regulates Pancreatic � Cell Maturation by Modulating the Ca2+ Sensitivity of Insulin Secretion Vesicles.
Developmental cell
Replication confers β cell immaturity.
Nature communications
Mitigating Ischemic Injury of Stem Cell-Derived Insulin-Producing Cells after Transplant.
Stem cell reports
Corticotropin-releasing hormone type 2 receptor deficiency impairs pancreatic function in a sex-specific manner.
Pancreatology
Atypical flat lesions derive from pancreatic acinar cells.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
Global Protease Activity Profiling Provides Differential Diagnosis of Pancreatic Cysts.
Clinical cancer research : an official journal of the American Association for Cancer Research
Global Protease Activity Profiling Provides Differential Diagnosis of Cystic Precursor Lesions of Pancreatic Cancer.
The FASEB Journal
Designing � Cells.
Cell metabolism
All mixed up: defining roles for β-cell subtypes in mature islets.
Genes & development
Abstract A50: Genotype tunes PDAC tension to induce matricellular-fibrosis and tumor aggression.
Early Detection
PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance.
Genes & development
Human islets contain four distinct subtypes of � cells.
Nature communications
Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.
Nature medicine
p120 Catenin Suppresses Basal Epithelial Cell Extrusion in Invasive Pancreatic Neoplasia.
Cancer research
Life and death of � cells in Type 1 diabetes: A comprehensive review.
Journal of autoimmunity
A functional circadian clock is required for proper insulin secretion by human pancreatic islet cells.
Diabetes, obesity & metabolism
Human pancreatic beta-like cells converted from fibroblasts.
Nature communications
Chapter 30 Development of the Endocrine Pancreas.
Endocrinology: Adult and Pediatric
Regulation of Cellular Identity in Cancer.
Developmental cell
Dynamic Proteomic Analysis of Pancreatic Mesenchyme Reveals Novel Factors That Enhance Human Embryonic Stem Cell to Pancreatic Cell Differentiation.
Stem cells international
Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification.
Development (Cambridge, England)
DNA methylation directs functional maturation of pancreatic � cells.
The Journal of clinical investigation
Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro.
The EMBO journal
Islet formation in mice and men: lessons for the generation of functional insulin-producing �-cells from human pluripotent stem cells.
Current opinion in genetics & development
Brg1 promotes both tumor-suppressive and oncogenic activities at distinct stages of pancreatic cancer formation.
Genes & development
CDK1 inhibition targets the p53-NOXA-MCL1 axis, selectively kills embryonic stem cells, and prevents teratoma formation.
Stem cell reports
NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas.
Gastroenterology
Antithetical NFATc1-Sox2 and p53-miR200 signaling networks govern pancreatic cancer cell plasticity.
The EMBO journal
Plasticity and dedifferentiation within the pancreas: development, homeostasis, and disease.
Cell stem cell
Taming the young and restless--epigenetic gene regulation in pancreas and beta-cell precursors.
The EMBO journal
Generation of insulin-producing cells from human stem cells (207.3).
The FASEB Journal
Diabetes. Solving human �-cell development--what does the mouse say?
Nature reviews. Endocrinology
The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma.
Nature cell biology
Small molecules facilitate the reprogramming of mouse fibroblasts into pancreatic lineages.
Cell stem cell
Overview.
Metabolism of Human Diseases
VHL-mediated disruption of Sox9 activity compromises �-cell identity and results in diabetes mellitus.
Genes & development
Numb regulates acinar cell dedifferentiation and survival during pancreatic damage and acinar-to-ductal metaplasia.
Gastroenterology
Control of cell identity in pancreas development and regeneration.
Gastroenterology
Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development.
Cell stem cell
Dormant cancer cells contribute to residual disease in a model of reversible pancreatic cancer.
Cancer research
Advances in acute and chronic pancreatitis: from development to inflammation and repair.
Gastroenterology
Generating � cells from stem cells-the story so far.
Cold Spring Harbor perspectives in medicine
Bmi1 is required for regeneration of the exocrine pancreas in mice.
Gastroenterology
Abstract LB-429: Dormant cancer cells contribute to residual disease in a mouse model for reversible pancreatic cancer.
Tumor Biology
Transcriptional analysis of pluripotency reveals the Hippo pathway as a barrier to reprogramming.
Human molecular genetics
Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice.
Proceedings of the National Academy of Sciences of the United States of America
Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells.
Nature cell biology
Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression.
Cancer cell
KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma.
Nature reviews. Cancer
Stat3 and MMP7 mediate multiple aspects of pancreatic ductal adenocarcinoma biology.
Journal of the American College of Surgeons
Primary cilia regulate Gli/Hedgehog activation in pancreas.
Proceedings of the National Academy of Sciences of the United States of America
Cellular plasticity within the pancreas--lessons learned from development.
Developmental cell
Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice.
The Journal of clinical investigation
Hedgehog Signaling Pathways in Pancreatic Cancer Pathogenesis.
Pancreatic Cancer
Dicer is required for proper liver zonation.
The Journal of pathology
Disruption of Dicer1 induces dysregulated fetal gene expression and promotes hepatocarcinogenesis.
Gastroenterology
GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation.
Genes & development
Wnt5a is essential for intestinal elongation in mice.
Developmental biology
Hedgehog spikes pancreas regeneration.
Gastroenterology
Stabilization of beta-catenin induces pancreas tumor formation.
Gastroenterology
Safer, longer-lasting regulatory T cells with beta-catenin.
Nature medicine
Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion.
The Journal of clinical investigation
A non-canonical Wnt pathway mediated by Wnt5a is required for midgut elongation.
Developmental biology
Autonomic and sensory pancreatic nerves are differentially affected by large-scale ß-cell turnover in the RIP-cmycER mouse.
Developmental biology
Wnt signaling regulates pancreatic beta cell proliferation.
Proceedings of the National Academy of Sciences of the United States of America
Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America
Dynamics of embryonic pancreas development using real-time imaging.
Developmental biology
Liver-specific loss of beta-catenin results in delayed hepatocyte proliferation after partial hepatectomy.
Hepatology (Baltimore, Md.)
Pancreatic development and disease.
Gastroenterology
Hedgehog/Ras interactions regulate early stages of pancreatic cancer.
Genes & development
Primary cilia deletion in pancreatic epithelial cells results in cyst formation and pancreatitis.
Gastroenterology
Stabilization of beta-catenin impacts pancreas growth.
Development (Cambridge, England)
Liver-specific loss of beta-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice.
Hepatology (Baltimore, Md.)
Hedgehog signaling in pancreas development and disease.
Cellular and molecular life sciences : CMLS
Hedgehog Signaling in Endodermally Derived Tumors.
Hedgehog-Gli Signaling in Human Disease
Hedgehog signaling regulates expansion of pancreatic epithelial cells.
Developmental biology
Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization.
Development (Cambridge, England)
Brain meets pancreas: netrin, an axon guidance molecule, controls epithelial cell migration.
Trends in cell biology
Development and cancer: lessons learned in the pancreas.
Cell cycle (Georgetown, Tex.)
Hedgehog signalling in cancer formation and maintenance.
Nature reviews. Cancer
Combined activities of hedgehog signaling inhibitors regulate pancreas development.
Development (Cambridge, England)
Hedgehog signaling in pancreas development.
Mechanisms of development
Intercellular signals regulating pancreas development and function.
Genes & development
Regulation of pancreas development by hedgehog signaling.
Development (Cambridge, England)
Activin receptor patterning of foregut organogenesis.
Genes & development
CHAPTER 6 INDUCTIVE PHENOMENA.
Principles of Tissue Engineering
Notochord repression of endodermal Sonic hedgehog permits pancreas development.
Genes & development
Notochord to endoderm signaling is required for pancreas development.
Development (Cambridge, England)
Repression of muscle-specific gene activation by the murine Twist protein.
Experimental cell research
Pancreas development in the chick embryo.
Cold Spring Harbor symposia on quantitative biology
M-twist expression inhibits mouse embryonic stem cell-derived myogenic differentiation in vitro.
Experimental cell research
M-twist is an inhibitor of muscle differentiation.
Developmental biology