Matthias Hebrok, PhD

Engineering synthetic suppressor T cells that execute locally targeted immunoprotective programs.

Science (New York, N.Y.)

Reddy NR, Maachi H, Xiao Y, Simic MS, Yu W, Tonai Y, Cabanillas DA, Serrano-Wu E, Pauerstein PT, Tamaki W, Allen GM, Parent AV, Hebrok M, Lim WA

nSMase2-mediated exosome secretion shapes the tumor microenvironment to immunologically support pancreatic cancer.

bioRxiv : the preprint server for biology

Hendley AM, Ashe S, Urano A, Ng M, Phu TA, Peng XL, Luan C, Finger AM, Jang GH, Kerper NR, Berrios DI, Jin D, Lee J, Riahi IR, Gbenedio OM, Chung C, Roose JP, Yeh JJ, Gallinger S, Biankin AV, O'Kane GM, Ntranos V, Chang DK, Dawson DW, Kim GE, Weaver VM, Raffai RL, Hebrok M

Author Correction: Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.

Nature medicine

Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM

KRAS degradation averts PDAC chemoresistance.

Nature cancer

Leonhardt L, Hebrok M

Sox9 regulates alternative splicing and pancreatic beta cell function.

Nature communications

Puri S, Maachi H, Nair G, Russ HA, Chen R, Pulimeno P, Cutts Z, Ntranos V, Hebrok M

Abstract A046: nSMase2-generated ceramide promotes PDA aggression through exosome reprogramming of the stroma.

Cancer research

Audrey M. Hendley, Atsushi Urano, Xianlu L. Peng, Sudipta Ashe, Tuan A. Phu, Martin Ng, Natanya R. Kerper, David I. Berrios, Jonghyun Lee, David Jin, Gun H. Jang, Oghenekevwe M. Gbenedio, Jeroen P. Roose, Jen J. Yeh, Steven Gallinger, Andrew V. Biankin, Vasilis Ntranos, David K. Chang, David W. Dawson, Grace E. Kim, Valerie M. Weaver, Robert L. Raffai, Matthias Hebrok

Stem cell-derived islet therapy: is this the end of the beginning?

Nature reviews. Endocrinology

Cochrane VA, Hebrok M

Role of Cell-Based Therapies in T2D.

Seminars in nephrology

Ashe S, Hebrok M

Species-specific roles for the MAFA and MAFB transcription factors in regulating islet β cell identity.

JCI insight

Cha J, Tong X, Walker EM, Dahan T, Cochrane VA, Ashe S, Russell R, Osipovich AB, Mawla AM, Guo M, Liu JH, Loyd ZA, Huising MO, Magnuson MA, Hebrok M, Dor Y, Stein R

Loss of ZNF148 enhances insulin secretion in human pancreatic β cells.

JCI insight

de Klerk E, Xiao Y, Emfinger CH, Keller MP, Berrios DI, Loconte V, Ekman AA, White KL, Cardone RL, Kibbey RG, Attie AD, Hebrok M

Replenishable prevascularized cell encapsulation devices increase graft survival and function in the subcutaneous space.

Bioengineering & translational medicine

Chendke GS, Kharbikar BN, Ashe S, Faleo G, Sneddon JB, Tang Q, Hebrok M, Desai TA

Minimal SC-ß-Cell Properties for Transplantation in Diabetic Patients.

Pluripotent Stem Cell Therapy for Diabetes

Veronica Cochrane, Yini Xiao, Hasna Maachi, Matthias Hebrok

Abstract C051: Ceramide signaling regulates PDA aggression through exosome reprogramming of the stroma.

Cancer research

Audrey M. Hendley, Atsushi Urano, Xianlu L. Peng, Sudipta Ashe, Natanya R. Kerper, Tuan A. Phu, Martin Ng, Simone Giacometti, David I. Berrios, Gun H. Jang, Jen J. Yeh, Steven Gallinger, David K. Chang, Andrew V. Biankin, Valerie M. Weaver, Grace E. Kim, David W. Dawson, Robert L. Raffai, Matthias Hebrok

Multiplexed microfluidic platform for stem-cell derived pancreatic islet � cells.

Lab on a chip

Goswami I, de Klerk E, Carnese P, Hebrok M, Healy KE

Pancreatic �-Cell Development and Regeneration.

Cold Spring Harbor perspectives in biology

Kerper N, Ashe S, Hebrok M

� Cell-specific deletion of Zfp148 improves nutrient-stimulated � cell Ca2+ responses.

JCI insight

Emfinger CH, de Klerk E, Schueler KL, Rabaglia ME, Stapleton DS, Simonett SP, Mitok KA, Wang Z, Liu X, Paulo JA, Yu Q, Cardone RL, Foster HR, Lewandowski SL, Perales JC, Kendziorski CM, Gygi SP, Kibbey RG, Keller MP, Hebrok M, Merrins MJ, Attie AD

Development of a Beta Cell-Specific Expression Control Element for Recombinant Adeno-Associated Virus.

Human gene therapy

Chai S, Kim Y, Galivo F, Dorrell C, Wakefield L, Posey J, Ackermann AM, Kaestner KH, Hebrok M, Grompe M

Development of a scalable method to isolate subsets of stem cell-derived pancreatic islet cells.

Stem cell reports

Parent AV, Ashe S, Nair GG, Li ML, Chavez J, Liu JS, Zhong Y, Streeter PR, Hebrok M

Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation.

Communications biology

Heller S, Li Z, Lin Q, Geusz R, Breunig M, Hohwieler M, Zhang X, Nair GG, Seufferlein T, Hebrok M, Sander M, Julier C, Kleger A, Costa IG

Abstract PR-008: Kdm6 demethylases are critical regulators of pancreatic cancer initiation, progression and subtype specification.

Cancer research

Laura Leonhardt, Lucia Y. Li, David I. Berrios, Sudipta Ashe, Audrey M. Hendley, Grace E. Kim, Matthias Hebrok

Mutations and variants of ONECUT1 in diabetes.

Nature medicine

Philippi A, Heller S, Costa IG, Sen?e V, Breunig M, Li Z, Kwon G, Russell R, Illing A, Lin Q, Hohwieler M, Degavre A, Zalloua P, Liebau S, Schuster M, Krumm J, Zhang X, Geusz R, Benthuysen JR, Wang A, Chiou J, Gaulton K, Neubauer H, Simon E, Klein T, Wagner M, Nair G, Besse C, Dandine-Roulland C, Olaso R, Deleuze JF, Kuster B, Hebrok M, Seufferlein T, Sander M, Boehm BO, Oswald F, Nicolino M, Julier C, Kleger A

Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection.

Cell reports

Parent AV, Faleo G, Chavez J, Saxton M, Berrios DI, Kerper NR, Tang Q, Hebrok M

Superporous agarose scaffolds for encapsulation of adult human islets and human stem-cell-derived � cells for intravascular bioartificial pancreas applications.

Journal of biomedical materials research. Part A

Shaheen R, Gurlin RE, Gologorsky R, Blaha C, Munnangi P, Santandreu A, Torres A, Carnese P, Nair GG, Szot G, Fissell WH, Hebrok M, Roy S

Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree.

eLife

Hendley AM, Rao AA, Leonhardt L, Ashe S, Smith JA, Giacometti S, Peng XL, Jiang H, Berrios DI, Pawlak M, Li LY, Lee J, Collisson EA, Anderson MS, Fragiadakis GK, Yeh JJ, Ye CJ, Kim GE, Weaver VM, Hebrok M

Stem Cell-Based Clinical Trials for Diabetes Mellitus.

Frontiers in endocrinology

de Klerk E, Hebrok M

Non-xenogeneic expansion and definitive endoderm differentiation of human pluripotent stem cells in an automated bioreactor.

Biotechnology and bioengineering

Jacobson EF, Chen Z, Stoukides DM, Nair GG, Hebrok M, Tzanakakis ES

Emerging routes to the generation of functional �-cells for diabetes mellitus cell therapy.

Nature reviews. Endocrinology

Nair GG, Tzanakakis ES, Hebrok M

Loss of the transcription factor MAFB limits �-cell derivation from human PSCs.

Nature communications

Russell R, Carnese PP, Hennings TG, Walker EM, Russ HA, Liu JS, Giacometti S, Stein R, Hebrok M

LIN28B Impairs the Transition of hESC-Derived � Cells from the Juvenile to Adult State.

Stem cell reports

Zhou X, Nair GG, Russ HA, Belair CD, Li ML, Shveygert M, Hebrok M, Blelloch R

Abstract C20: Smpd3 augments chemotherapy and thwarts PDA progression.

Cancer research

Audrey M. Hendley, Atsushi Urano, Natanya R. Kerper, Phat Duong, Peter Bailey, David K. Chang, Andrew V. Biankin, David W. Dawson, Grace Kim, Robert L. Raffai, Matthias Hebrok

Lipid Droplet Accumulation in Human Pancreatic Islets Is Dependent On Both Donor Age and Health.

Diabetes

Tong X, Dai C, Walker JT, Nair GG, Kennedy A, Carr RM, Hebrok M, Powers AC, Stein R

Using a barcoded AAV capsid library to select for clinically relevant gene therapy vectors.

JCI insight

Pekrun K, De Alencastro G, Luo QJ, Liu J, Kim Y, Nygaard S, Galivo F, Zhang F, Song R, Tiffany MR, Xu J, Hebrok M, Grompe M, Kay MA

Supporting Survival of Transplanted Stem-Cell-Derived Insulin-Producing Cells in an Encapsulation Device Augmented with Controlled Release of Amino Acids.

Advanced biosystems

Chendke GS, Faleo G, Juang C, Parent AV, Bernards DA, Hebrok M, Tang Q, Desai TA

mTORC1 to AMPK switching underlies �-cell metabolic plasticity during maturation and diabetes.

The Journal of clinical investigation

Jaafar R, Tran S, Shah AN, Sun G, Valdearcos M, Marchetti P, Masini M, Swisa A, Giacometti S, Bernal-Mizrachi E, Matveyenko A, Hebrok M, Dor Y, Rutter GA, Koliwad SK, Bhushan A

The Pdx1-Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet �-Cell Function.

Diabetes

Spaeth JM, Liu JH, Peters D, Guo M, Osipovich AB, Mohammadi F, Roy N, Bhushan A, Magnuson MA, Hebrok M, Wright CVE, Stein R

Author Correction: Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells.

Nature cell biology

Nair GG, Liu JS, Russ HA, Tran S, Saxton MS, Chen R, Juang C, Li ML, Nguyen VQ, Giacometti S, Puri S, Xing Y, Wang Y, Szot GL, Oberholzer J, Bhushan A, Hebrok M

Pancreatic pericytes originate from the embryonic pancreatic mesenchyme.

Developmental biology

Harari N, Sakhneny L, Khalifa-Malka L, Busch A, Hertel KJ, Hebrok M, Landsman L

Rapid generation of functional mature pancreatic islet-beta cells from human pluripotent stem cells.

Protocol Exchange

Gopika Nair, Gopika Nair, Holger Russ, Matthias Hebrok

Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived � cells.

Nature cell biology

Nair GG, Liu JS, Russ HA, Tran S, Saxton MS, Chen R, Juang C, Li ML, Nguyen VQ, Giacometti S, Puri S, Xing Y, Wang Y, Szot GL, Oberholzer J, Bhushan A, Hebrok M

The BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis.

The Journal of clinical investigation

Tsuda M, Fukuda A, Roy N, Hiramatsu Y, Leonhardt L, Kakiuchi N, Hoyer K, Ogawa S, Goto N, Ikuta K, Kimura Y, Matsumoto Y, Takada Y, Yoshioka T, Maruno T, Yamaga Y, Kim GE, Akiyama H, Ogawa S, Wright CV, Saur D, Takaori K, Uemoto S, Hebrok M, Chiba T, Seno H

Co-Transplant of Parathyroid Gland and Stem Cell-Derived Insulin-Producing Cells Enhances Graft Survival through Release of Pro-Angiogenic and Pro-Survival Factors.

Transplantation Journal

Gaetano Faleo, Casey Ward, Audrey Parent, Gopika Nair, Wenhan Chang, Peter Stock, Matthias Hebrok, Qizhi Tang

Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges.

Cell stem cell

Sneddon JB, Tang Q, Stock P, Bluestone JA, Roy S, Desai T, Hebrok M

Synaptotagmin 4 Regulates Pancreatic � Cell Maturation by Modulating the Ca2+ Sensitivity of Insulin Secretion Vesicles.

Developmental cell

Huang C, Walker EM, Dadi PK, Hu R, Xu Y, Zhang W, Sanavia T, Mun J, Liu J, Nair GG, Tan HYA, Wang S, Magnuson MA, Stoeckert CJ, Hebrok M, Gannon M, Han W, Stein R, Jacobson DA, Gu G

Replication confers β cell immaturity.

Nature communications

Puri S, Roy N, Russ HA, Leonhardt L, French EK, Roy R, Bengtsson H, Scott DK, Stewart AF, Hebrok M

Mitigating Ischemic Injury of Stem Cell-Derived Insulin-Producing Cells after Transplant.

Stem cell reports

Faleo G, Russ HA, Wisel S, Parent AV, Nguyen V, Nair GG, Freise JE, Villanueva KE, Szot GL, Hebrok M, Tang Q

Nanoporous Immunoprotective Device for Stem-Cell-Derived �-Cell Replacement Therapy.

ACS nano

Chang R, Faleo G, Russ HA, Parent AV, Elledge SK, Bernards DA, Allen JL, Villanueva K, Hebrok M, Tang Q, Desai TA

Corticotropin-releasing hormone type 2 receptor deficiency impairs pancreatic function in a sex-specific manner.

Pancreatology

Aditi Bhargava, Shinichiro Hagiwara, Sapna Puri, Matthias Hebrok, Gregory Szot, Burcu Hasdemir, Sreenivasan Paruthiyil

Atypical flat lesions derive from pancreatic acinar cells.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]

von Figura G, Fahrenkrog-Petersen L, Hidalgo-Sastre A, Hartmann D, H?ser N, Schmid RM, Hebrok M, Roy N, Esposito I

Global Protease Activity Profiling Provides Differential Diagnosis of Pancreatic Cysts.

Clinical cancer research : an official journal of the American Association for Cancer Research

Ivry SL, Sharib JM, Dominguez DA, Roy N, Hatcher SE, Yip-Schneider MT, Schmidt CM, Brand RE, Park WG, Hebrok M, Kim GE, O'Donoghue AJ, Kirkwood KS, Craik CS

Global Protease Activity Profiling Provides Differential Diagnosis of Cystic Precursor Lesions of Pancreatic Cancer.

The FASEB Journal

Sam Lacey Ivry, Dana Dominguez, Nilotpal Roy, Stacy Hatcher, Matthias Hebrok, Grace Kim, Anthony O'Donoghue, Kim Kirkwood, Charles Craik

Designing � Cells.

Cell metabolism

Hebrok M

All mixed up: defining roles for β-cell subtypes in mature islets.

Genes & development

Liu JS, Hebrok M

Abstract A50: Genotype tunes PDAC tension to induce matricellular-fibrosis and tumor aggression.

Early Detection

Hanane Laklai, Yekaterina Miroshnikova, Michael Pickup, Eric Collisson, Kim Grace, Alex Barrett, Ryan Hill, Johnathon Lakins, David Schlaepfer, Janna Mouw, Valerie LeBleu, Sergey Novitskiy, Julie Johansen, Valeria Poli, Rahgu Kalluri, Laura Wood, Matthias Hebrok, Kirk Hansen, Harold Moses, Valerie Weaver

PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance.

Genes & development

Roy N, Takeuchi KK, Ruggeri JM, Bailey P, Chang D, Li J, Leonhardt L, Puri S, Hoffman MT, Gao S, Halbrook CJ, Song Y, Ljungman M, Malik S, Wright CV, Dawson DW, Biankin AV, Hebrok M, Crawford HC

Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity.

Diabetologia

Bonifacio E, Mathieu C, Nepom GT, Ziegler AG, Anhalt H, Haller MJ, Harrison LC, Hebrok M, Kushner JA, Norris JM, Peakman M, Powers AC, Todd JA, Atkinson MA

Loss of Pancreas upon Activated Wnt Signaling Is Concomitant with Emergence of Gastrointestinal Identity.

PloS one

Mu?oz-Bravo JL, Flores-Mart?nez A, Herrero-Martin G, Puri S, Taketo MM, Rojas A, Hebrok M, Cano DA

Human islets contain four distinct subtypes of � cells.

Nature communications

Dorrell C, Schug J, Canaday PS, Russ HA, Tarlow BD, Grompe MT, Horton T, Hebrok M, Streeter PR, Kaestner KH, Grompe M

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.

Nature medicine

Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM

p120 Catenin Suppresses Basal Epithelial Cell Extrusion in Invasive Pancreatic Neoplasia.

Cancer research

Hendley AM, Wang YJ, Polireddy K, Alsina J, Ahmed I, Lafaro KJ, Zhang H, Roy N, Savidge SG, Cao Y, Hebrok M, Maitra A, Reynolds AB, Goggins M, Younes M, Iacobuzio-Donahue CA, Leach SD, Bailey JM

Life and death of � cells in Type 1 diabetes: A comprehensive review.

Journal of autoimmunity

Wilcox NS, Rui J, Hebrok M, Herold KC

A functional circadian clock is required for proper insulin secretion by human pancreatic islet cells.

Diabetes, obesity & metabolism

Saini C, Petrenko V, Pulimeno P, Giovannoni L, Berney T, Hebrok M, Howald C, Dermitzakis ET, Dibner C

Human pancreatic beta-like cells converted from fibroblasts.

Nature communications

Zhu S, Russ HA, Wang X, Zhang M, Ma T, Xu T, Tang S, Hebrok M, Ding S

Chapter 30 Development of the Endocrine Pancreas.

Endocrinology: Adult and Pediatric

Matthias Hebrok, Michael S. German

Regulation of Cellular Identity in Cancer.

Developmental cell

Roy N, Hebrok M

�-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1.

Cell

Suriben R, Kaihara KA, Paolino M, Reichelt M, Kummerfeld SK, Modrusan Z, Dugger DL, Newton K, Sagolla M, Webster JD, Liu J, Hebrok M, Dixit VM

Dynamic Proteomic Analysis of Pancreatic Mesenchyme Reveals Novel Factors That Enhance Human Embryonic Stem Cell to Pancreatic Cell Differentiation.

Stem cells international

Russ HA, Landsman L, Moss CL, Higdon R, Greer RL, Kaihara K, Salamon R, Kolker E, Hebrok M

Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification.

Development (Cambridge, England)

Zdravkovic T, Nazor KL, Larocque N, Gormley M, Donne M, Hunkapillar N, Giritharan G, Bernstein HS, Wei G, Hebrok M, Zeng X, Genbacev O, Mattis A, McMaster MT, Krtolica A, Valbuena D, Sim?n C, Laurent LC, Loring JF, Fisher SJ

DNA methylation directs functional maturation of pancreatic � cells.

The Journal of clinical investigation

Dhawan S, Tschen SI, Zeng C, Guo T, Hebrok M, Matveyenko A, Bhushan A

Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro.

The EMBO journal

Russ HA, Parent AV, Ringler JJ, Hennings TG, Nair GG, Shveygert M, Guo T, Puri S, Haataja L, Cirulli V, Blelloch R, Szot GL, Arvan P, Hebrok M

Islet formation in mice and men: lessons for the generation of functional insulin-producing �-cells from human pluripotent stem cells.

Current opinion in genetics & development

Nair G, Hebrok M

Brg1 promotes both tumor-suppressive and oncogenic activities at distinct stages of pancreatic cancer formation.

Genes & development

Roy N, Malik S, Villanueva KE, Urano A, Lu X, Von Figura G, Seeley ES, Dawson DW, Collisson EA, Hebrok M

CDK1 inhibition targets the p53-NOXA-MCL1 axis, selectively kills embryonic stem cells, and prevents teratoma formation.

Stem cell reports

Huskey NE, Guo T, Evason KJ, Momcilovic O, Pardo D, Creasman KJ, Judson RL, Blelloch R, Oakes SA, Hebrok M, Goga A

NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas.

Gastroenterology

Chen NM, Singh G, Koenig A, Liou GY, Storz P, Zhang JS, Regul L, Nagarajan S, K?hnemuth B, Johnsen SA, Hebrok M, Siveke J, Billadeau DD, Ellenrieder V, Hessmann E

Antithetical NFATc1-Sox2 and p53-miR200 signaling networks govern pancreatic cancer cell plasticity.

The EMBO journal

Singh SK, Chen NM, Hessmann E, Siveke J, Lahmann M, Singh G, Voelker N, Vogt S, Esposito I, Schmidt A, Brendel C, Stiewe T, Gaedcke J, Mernberger M, Crawford HC, Bamlet WR, Zhang JS, Li XK, Smyrk TC, Billadeau DD, Hebrok M, Neesse A, Koenig A, Ellenrieder V

Plasticity and dedifferentiation within the pancreas: development, homeostasis, and disease.

Cell stem cell

Puri S, Folias AE, Hebrok M

Taming the young and restless--epigenetic gene regulation in pancreas and beta-cell precursors.

The EMBO journal

Russ HA, Hebrok M

Aberrant innate immune activation following tissue injury impairs pancreatic regeneration.

PloS one

Folias AE, Penaranda C, Su AL, Bluestone JA, Hebrok M

Dicer regulates differentiation and viability during mouse pancreatic cancer initiation.

PloS one

Morris JP, Greer R, Russ HA, von Figura G, Kim GE, Busch A, Lee J, Hertel KJ, Kim S, McManus M, Hebrok M

Generation of insulin-producing cells from human stem cells (207.3).

The FASEB Journal

Matthias Hebrok

Analyzing pancreas development with the goal to generate functional ß-cells from stem cells and prevent neoplastic transformation.

Pancreatology

Matthias Hebrok

Diabetes. Solving human �-cell development--what does the mouse say?

Nature reviews. Endocrinology

Folias AE, Hebrok M

The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma.

Nature cell biology

von Figura G, Fukuda A, Roy N, Liku ME, Morris Iv JP, Kim GE, Russ HA, Firpo MA, Mulvihill SJ, Dawson DW, Ferrer J, Mueller WF, Busch A, Hertel KJ, Hebrok M

Small molecules facilitate the reprogramming of mouse fibroblasts into pancreatic lineages.

Cell stem cell

Li K, Zhu S, Russ HA, Xu S, Xu T, Zhang Y, Ma T, Hebrok M, Ding S

Overview.

Metabolism of Human Diseases

Alexandra E. Folias, Matthias Hebrok

VHL-mediated disruption of Sox9 activity compromises �-cell identity and results in diabetes mellitus.

Genes & development

Puri S, Akiyama H, Hebrok M

Elimination of von Hippel-Lindau function perturbs pancreas endocrine homeostasis in mice.

PloS one

Puri S, Garc?a-N??ez A, Hebrok M, Cano DA

Numb regulates acinar cell dedifferentiation and survival during pancreatic damage and acinar-to-ductal metaplasia.

Gastroenterology

Greer RL, Staley BK, Liou A, Hebrok M

Canonical wnt signaling is required for pancreatic carcinogenesis.

Cancer research

Zhang Y, Morris JP, Yan W, Schofield HK, Gurney A, Simeone DM, Millar SE, Hoey T, Hebrok M, Pasca di Magliano M

Control of cell identity in pancreas development and regeneration.

Gastroenterology

Stanger BZ, Hebrok M

Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development.

Cell stem cell

Parent AV, Russ HA, Khan IS, LaFlam TN, Metzger TC, Anderson MS, Hebrok M

Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation.

Gut

von Figura G, Morris JP, Wright CV, Hebrok M

Dormant cancer cells contribute to residual disease in a model of reversible pancreatic cancer.

Cancer research

Lin WC, Rajbhandari N, Liu C, Sakamoto K, Zhang Q, Triplett AA, Batra SK, Opavsky R, Felsher DW, DiMaio DJ, Hollingsworth MA, Morris JP, Hebrok M, Witkiewicz AK, Brody JR, Rui H, Wagner KU

Factors expressed by murine embryonic pancreatic mesenchyme enhance generation of insulin-producing cells from hESCs.

Diabetes

Guo T, Landsman L, Li N, Hebrok M

Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma.

Cancer cell

Kopp JL, von Figura G, Mayes E, Liu FF, Dubois CL, Morris JP, Pan FC, Akiyama H, Wright CV, Jensen K, Hebrok M, Sander M

Advances in acute and chronic pancreatitis: from development to inflammation and repair.

Gastroenterology

Pasca di Magliano M, Forsmark C, Freedman S, Hebrok M, Pasricha PJ, Saluja A, Stanger BZ, Holt J, Serrano J, James SP, Rustgi AK

Diabetic � Cells: To Be or Not To Be?

Cell

Puri S, Hebrok M

Generating � cells from stem cells-the story so far.

Cold Spring Harbor perspectives in medicine

Hebrok M

Bmi1 is required for regeneration of the exocrine pancreas in mice.

Gastroenterology

Fukuda A, Morris JP, Hebrok M

Abstract LB-429: Dormant cancer cells contribute to residual disease in a mouse model for reversible pancreatic cancer.

Tumor Biology

Wan-Chi Lin, Nirakar Rajbhandari, Chengbao Liu, Kazuhito Sakamoto, Surinder Batra, Rene Opavsky, Dean Felsher, Michael Hollingsworth, Matthias Hebrok, Hallgeir Rui, Kay-Uwe Wagner

Transcriptional analysis of pluripotency reveals the Hippo pathway as a barrier to reprogramming.

Human molecular genetics

Qin H, Blaschke K, Wei G, Ohi Y, Blouin L, Qi Z, Yu J, Yeh RF, Hebrok M, Ramalho-Santos M

Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice.

Proceedings of the National Academy of Sciences of the United States of America

Landsman L, Parent A, Hebrok M

Pancreatic mesenchyme regulates epithelial organogenesis throughout development.

PLoS biology

Landsman L, Nijagal A, Whitchurch TJ, Vanderlaan RL, Zimmer WE, Mackenzie TC, Hebrok M

How does type 1 diabetes develop?: the notion of homicide or �-cell suicide revisited.

Diabetes

Atkinson MA, Bluestone JA, Eisenbarth GS, Hebrok M, Herold KC, Accili D, Pietropaolo M, Arvan PR, Von Herrath M, Markel DS, Rhodes CJ

Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells.

Nature cell biology

Ohi Y, Qin H, Hong C, Blouin L, Polo JM, Guo T, Qi Z, Downey SL, Manos PD, Rossi DJ, Yu J, Hebrok M, Hochedlinger K, Costello JF, Song JS, Ramalho-Santos M