
Professor
Medicine
+1 415 502-8404
Matthew Springer, PhD studies cell and gene therapies for ischemic diseases to aid in tissue revascularization, preservation and potentially regeneration. He also researches vascular endothelial function and its response to diet and cigarette smoke exposure.
Publications
Association of Endothelial Dysfunction With Chronic Marijuana Smoking and THC-Edible Use.
JAMA cardiology
Impairment of Endothelial Function by Aerosol From Marijuana Leaf Vaporizers.
Journal of the American Heart Association
Inhibition of galectin-3 post-infarction impedes progressive fibrosis by regulating inflammatory profibrotic cascades.
Cardiovascular research
Local decorin delivery via hyaluronic acid microrods improves cardiac performance, ventricular remodeling after myocardial infarction.
NPJ Regenerative medicine
Impairment of Endothelial Function by Cigarette Smoke and e-Cigarette Aerosol Requires RAGE.
Arteriosclerosis, thrombosis, and vascular biology
Chronic E-Cigarette Use Impairs Endothelial Function on the Physiological and Cellular Levels.
Arteriosclerosis, thrombosis, and vascular biology
Impairment of Endothelial Function by Cigarette Smoke Is Not Caused by a Specific Smoke Constituent, but by Vagal Input From the Airway.
Arteriosclerosis, thrombosis, and vascular biology
Comparable Impairment of Vascular Endothelial Function by a Wide Range of Electronic Nicotine Delivery Devices.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
Letter to the Editor.
American journal of infection control
JUUL and Combusted Cigarettes Comparably Impair Endothelial Function.
Tobacco regulatory science
Modeling Cardiovascular Risks of E-Cigarettes With Human-Induced Pluripotent Stem Cell-Derived Endothelial Cells.
Journal of the American College of Cardiology
Vascular endothelial function is impaired by aerosol from a single IQOS HeatStick to the same extent as by cigarette smoke.
Tobacco control
Age-Related Impaired Efficacy of Bone Marrow Cell Therapy for Myocardial Infarction Reflects a Decrease in B Lymphocytes.
Molecular therapy : the journal of the American Society of Gene Therapy
Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice.
American journal of physiology. Lung cellular and molecular physiology
Marijuana, Secondhand Smoke, and Social Acceptability.
JAMA internal medicine
One Minute of Marijuana Secondhand Smoke Exposure Substantially Impairs Vascular Endothelial Function.
Journal of the American Heart Association
San Francisco Medicine
CANNABIS: Clearing some smoke?
Circulating angiogenic cell function is inhibited by cortisol in vitro and associated with psychological stress and cortisol in vivo.
Psychoneuroendocrinology
Overexpression of Nitric Oxide Synthase Restores Circulating Angiogenic Cell Function in Patients With Coronary Artery Disease: Implications for Autologous Cell Therapy for Myocardial Infarction.
Journal of the American Heart Association
Impairment of Endothelial Function by Little Cigar Secondhand Smoke.
Tobacco regulatory science
Brief exposure to secondhand smoke reversibly impairs endothelial vasodilatory function.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
Dietary flavanol intervention lowers the levels of endothelial microparticles in coronary artery disease patients.
The British journal of nutrition
Pharmacological inhibition of S-nitrosoglutathione reductase improves endothelial vasodilatory function in rats in vivo.
Journal of applied physiology (Bethesda, Md. : 1985)
Gene therapy and angiogenesis
Cardiology: An Illustrated Textbook. K. Chatterjee et al., eds.
Earthquake safety at work: An important topic to review with patients
San Francisco Medicine
Instructive nanofiber scaffolds with VEGF create a microenvironment for arteriogenesis and cardiac repair.
Science translational medicine
Advanced Donor Age Impairs Bone Marrow Cell Therapeutic Efficacy for Cardiac Disease.
Journal of tissue science & engineering
Blunting half of the double-edged sword: potential use of interleukin-10 to protect bone marrow-derived cells after myocardial infarction.
Circulation research
Higher fasting glucose levels are associated with reduced circulating angiogenic cell migratory capacity among healthy individuals.
American journal of cardiovascular disease
Donor myocardial infarction impairs the therapeutic potential of bone marrow cells by an interleukin-1-mediated inflammatory response.
Science translational medicine
Nitric oxide counters the inhibitory effects of uremic toxin indoxyl sulfate on endothelial cells by governing ERK MAP kinase and myosin light chain activation.
Biochemical and biophysical research communications
The launch of American Journal of Cardiovascular Disease
Am J Cardiovasc Dis
Timing of bone marrow cell therapy is more important than repeated injections after myocardial infarction
Cardiovasc Pathol
Nitric oxide synthase expression and functional response to nitric oxide are both important modulators of circulating angiogenic cell response to angiogenic stimuli.
Arteriosclerosis, thrombosis, and vascular biology
Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease.
Journal of the American College of Cardiology
Assessment of myocardial angiogenesis and vascularity in small animal models.
Methods in molecular biology (Clifton, N.J.)
Injection of bone marrow cell extract into infarcted hearts results in functional improvement comparable to intact cell therapy.
Molecular therapy : the journal of the American Society of Gene Therapy
Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium.
Arteriosclerosis, thrombosis, and vascular biology
Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function: sustained vascular injury and blunted nitric oxide production.
Journal of the American College of Cardiology
Pleiotrophin induces nitric oxide dependent migration of endothelial progenitor cells.
Journal of cellular physiology
Living both music and medicine: Where the two practices intersect. (One of several sections.)
San Francisco Medicine
In vivo measurement of flow-mediated vasodilation in living rats using high-resolution ultrasound.
American journal of physiology. Heart and circulatory physiology
Myocardial infarct size measurement in the mouse chronic infarction model: comparison of area- and length-based approaches.
Journal of applied physiology (Bethesda, Md. : 1985)
Localization of vascular response to VEGF is not dependent on heparin binding.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Validation of the wall motion score and myocardial performance indexes as novel techniques to assess cardiac function in mice after myocardial infarction.
American journal of physiology. Heart and circulatory physiology
A balancing act: therapeutic approaches for the modulation of angiogenesis.
Current opinion in investigational drugs (London, England : 2000)
Microenvironmental VEGF distribution is critical for stable and functional vessel growth in ischemia
FASEBJ
VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature.
American journal of physiology. Heart and circulatory physiology
Closed-chest cell injections into mouse myocardium guided by high-resolution echocardiography.
American journal of physiology. Heart and circulatory physiology
Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis.
The Journal of clinical investigation
Myoblast-mediated gene transfer for therapeutic angiogenesis and arteriogenesis.
British journal of pharmacology
Localized arteriole formation directly adjacent to the site of VEGF-induced angiogenesis in muscle.
Molecular therapy : the journal of the American Society of Gene Therapy
RIP2, a checkpoint in myogenic differentiation.
Molecular and cellular biology
Transient production of alpha-smooth muscle actin by skeletal myoblasts during differentiation in culture and following intramuscular implantation.
Cell motility and the cytoskeleton
VEGF therapy in heart disease: for better or for worse?
Drug discovery today
Gene delivery to muscle.
Current protocols in human genetics
Myoblast-mediated gene transfer for therapeutic angiogenesis.
Methods in enzymology
Not the usual suspects: the unexpected sources of tissue regeneration.
The Journal of clinical investigation
Induction of angiogenesis by implantation of encapsulated primary myoblasts expressing vascular endothelial growth factor.
The journal of gene medicine
A novel means of drug delivery: myoblast-mediated gene therapy and regulatable retroviral vectors.
Annual review of pharmacology and toxicology
Angiogenesis monitored by perfusion with a space-filling microbead suspension.
Molecular therapy : the journal of the American Society of Gene Therapy
Ex vivo gene therapy using myoblasts and regulatable retroviral vectors
In Gene Therapy: Therapeutic Mechanisms and Strategies, NS Templeton and DD Lasic, eds.
Analysis of immune responses to varicella zoster viral proteins induced by DNA vaccination.
Antiviral research
Inhibition of solid tumor growth by Fas ligand-expressing myoblasts.
Somatic cell and molecular genetics
Immune response and myoblasts that express Fas ligand.
Science (New York, N.Y.)
High-efficiency retroviral infection of primary myoblasts.
Somatic cell and molecular genetics
Towards a treatment for Tay-Sachs disease
Molec. Med. Today
Muscle-mediated gene therapy.
The New England journal of medicine
Gene therapy--a novel form of drug delivery.
The New England journal of medicine
Cell implantation treatment for MPS VII
Molec. Med. Today
Gene therapy for restenosis: retinoblastoma to the rescue
Molec. Med. Today
Stage-specific requirement for myosin II during Dictyostelium development.
Development (Cambridge, England)
Genetic control of fungal differentiation: the three sporulation pathways of Neurospora crassa.
BioEssays : news and reviews in molecular, cellular and developmental biology
Timing of synthesis and cellular localization of two conidiation-specific proteins of Neurospora crassa.
Developmental biology
Expression of con genes along the three sporulation pathways of Neurospora crassa.
Genes & development
Tergitol-induced colonial growth without inhibition of conidiation
Fungal Genet. Newsl.