
Professor
Ob/Gyn, Reproductive Sciences
+1 415 476-9214
Marco Conti, MD focuses on signal transduction required for germ cell development.
Publications
Multiple intersecting pathways are involved in CPEB1 phosphorylation and regulation of translation during mouse oocyte meiosis.
Development (Cambridge, England)
Alternative cleavage and polyadenylation of the Ccnb1 mRNA defines accumulation of cyclin protein during the meiotic cell cycle.
Nucleic acids research
Multiple intersecting pathways are involved in the phosphorylation of CPEB1 to activate translation during mouse oocyte meiosis.
bioRxiv : the preprint server for biology
A genome-wide perspective of the maternal mRNA translation program during oocyte development.
Seminars in cell & developmental biology
Author Correction: CPEB1-dependent disruption of the mRNA translation program in oocytes during maternal aging.
Nature communications
CPEB1-dependent disruption of the mRNA translation program in oocytes during maternal aging.
Nature communications
A PI3K? mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases.
Science translational medicine
The H3.3 chaperone Hira complex orchestrates oocyte developmental competence.
Development (Cambridge, England)
Defining the Program of Maternal mRNA Translation during In vitro Maturation using a Single Oocyte Reporter Assay.
Journal of visualized experiments : JoVE
Genome-wide analysis reveals a switch in the translational program upon oocyte meiotic resumption.
Nucleic acids research
The RNA-binding protein DAZL functions as repressor and activator of mRNA translation during oocyte maturation.
Nature communications
Cyclin B2 is required for progression through meiosis in mouse oocytes.
Development (Cambridge, England)
Synergistic effect of phosphodiesterase 4 inhibitor and serum on migration of endotoxin-stimulated macrophages.
Innate immunity
Acquisition of oocyte competence to develop as an embryo: integrated nuclear and cytoplasmic events.
Human reproduction update
Profiling Maternal mRNA Translation During Oocyte Development.
Methods in molecular biology (Clifton, N.J.)
Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4.
Scientific reports
The Translation of Cyclin B1 and B2 is Differentially Regulated during Mouse Oocyte Reentry into the Meiotic Cell Cycle.
Scientific reports
Cyclin A2 modulates kinetochore-microtubule attachment in meiosis II.
The Journal of cell biology
Report from the 2016 University of California, San Francisco, Center for Reproductive Sciences retreat.
Molecular reproduction and development
Maternal mRNAs with distinct 3' UTRs define the temporal pattern of Ccnb1 synthesis during mouse oocyte meiotic maturation.
Genes & development
Functional selectivity of GPCR-directed drug action through location bias.
Nature chemical biology
Phosphodiesterase 4B negatively regulates endotoxin-activated interleukin-1 receptor antagonist responses in macrophages.
Scientific reports
International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases.
Pharmacological reviews
Dynamic secretion during meiotic reentry integrates the function of the oocyte and cumulus cells.
Proceedings of the National Academy of Sciences of the United States of America
DAZL and CPEB1 regulate mRNA translation synergistically during oocyte maturation.
Journal of cell science
FSH Regulates mRNA Translation in Mouse Oocytes and Promotes Developmental Competence.
Endocrinology
PDE4D phosphorylation: A coincidence detector integrating multiple signaling pathways.
Cellular signalling
A CaMKII/PDE4D negative feedback regulates cAMP signaling.
Proceedings of the National Academy of Sciences of the United States of America
Hira-mediated H3.3 incorporation is required for DNA replication and ribosomal RNA transcription in the mouse zygote.
Developmental cell
The upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s).
The Biochemical journal
Multiple pathways mediate luteinizing hormone regulation of cGMP signaling in the mouse ovarian follicle.
Biology of reproduction
Mice deficient in phosphodiesterase-4A display anxiogenic-like behavior.
Psychopharmacology
Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes.
Cardiovascular research
PDE4B mediates local feedback regulation of �1-adrenergic cAMP signaling in a sarcolemmal compartment of cardiac myocytes.
Journal of cell science
Cyclic AMP compartments and signaling specificity: role of cyclic nucleotide phosphodiesterases.
The Journal of general physiology
Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytes.
Nature cell biology
Anchored PDE4 regulates chloride conductance in wild-type and ?F508-CFTR human airway epithelia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Histone variant H3.3 maintains a decondensed chromatin state essential for mouse preimplantation development.
Development (Cambridge, England)
PDE4 as a target for cognition enhancement.
Expert opinion on therapeutic targets
Cdc25A activity is required for the metaphase II arrest in mouse oocytes.
Journal of cell science
Analysis of signaling pathways controlling flagellar movements in mammalian spermatozoa.
Methods in enzymology
A novel loss-of-function mutation in Npr2 clarifies primary role in female reproduction and reveals a potential therapy for acromesomelic dysplasia, Maroteaux type.
Human molecular genetics
Cyclic adenosine monophosphate phosphodiesterase type 4 protects against atrial arrhythmias.
Journal of the American College of Cardiology
Amphiregulin promotes the maturation of oocytes isolated from the small antral follicles of the rhesus macaque.
Human reproduction (Oxford, England)
Novel signaling mechanisms in the ovary during oocyte maturation and ovulation.
Molecular and cellular endocrinology
Phosphodiesterases and regulation of female reproductive function.
Current opinion in pharmacology
Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ current.
Circulation research
When an egg is not an egg: compromised maternal mRNA storage and stabilization.
Biology of reproduction
Phosphodiesterase 4B in the cardiac L-type Ca�? channel complex regulates Ca�? current and protects against ventricular arrhythmias in mice.
The Journal of clinical investigation
Inactivation of multidrug resistance proteins disrupts both cellular extrusion and intracellular degradation of cAMP.
Molecular pharmacology
Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition.
Genes & development
Protein tyrosine kinase Wee1B is essential for metaphase II exit in mouse oocytes.
Science (New York, N.Y.)
PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblasts.
The Journal of biological chemistry
Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Conserved expression and functions of PDE4 in rodent and human heart.
Basic research in cardiology
Phosphodiesterase 4B is essential for T(H)2-cell function and development of airway hyperresponsiveness in allergic asthma.
The Journal of allergy and clinical immunology
Lack of functional pregnancy-associated plasma protein-A (PAPPA) compromises mouse ovarian steroidogenesis and female fertility.
Biology of reproduction
Wee1B, Myt1, and Cdc25 function in distinct compartments of the mouse oocyte to control meiotic resumption.
The Journal of cell biology
Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals.
Circulation research
Cyclic GMP signaling is involved in the luteinizing hormone-dependent meiotic maturation of mouse oocytes.
Biology of reproduction
Epidermal growth factor-like growth factors in the follicular fluid: role in oocyte development and maturation.
Seminars in reproductive medicine
Growth factors and the development and function of the reproductive organs.
Seminars in reproductive medicine
From stem cells to germ cells and back again.
Nature medicine
Critical role of PDE4D in beta2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts.
The Journal of biological chemistry
Soluble adenylyl cyclase is not required for axon guidance to netrin-1.
The Journal of neuroscience : the official journal of the Society for Neuroscience
PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia.
Schizophrenia research
Spatiotemporal dynamics of beta-adrenergic cAMP signals and L-type Ca2+ channel regulation in adult rat ventricular myocytes: role of phosphodiesterases.
Circulation research
Generation of mouse oocytes defective in cAMP synthesis and degradation: endogenous cyclic AMP is essential for meiotic arrest.
Developmental biology
Luteinizing hormone signaling in preovulatory follicles involves early activation of the epidermal growth factor receptor pathway.
Molecular endocrinology (Baltimore, Md.)
Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4.
The EMBO journal
The mouse polyubiquitin gene Ubb is essential for meiotic progression.
Molecular and cellular biology
Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B).
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D.
Journal of immunology (Baltimore, Md. : 1950)
Dynamic regulation of cystic fibrosis transmembrane conductance regulator by competitive interactions of molecular adaptors.
The Journal of biological chemistry
Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling.
Annual review of biochemistry
Luteinizing hormone-dependent activation of the epidermal growth factor network is essential for ovulation.
Molecular and cellular biology
Protein kinase B/Akt phosphorylation of PDE3A and its role in mammalian oocyte maturation.
The EMBO journal
Cellular mechanisms underlying prostaglandin-induced transient cAMP signals near the plasma membrane of HEK-293 cells.
American journal of physiology. Cell physiology
Soluble adenylyl cyclase (sAC) is indispensable for sperm function and fertilization.
Developmental biology
A specific pattern of phosphodiesterases controls the cAMP signals generated by different Gs-coupled receptors in adult rat ventricular myocytes.
Circulation research
New pathways from PKA to the Cdc2/cyclin B complex in oocytes: Wee1B as a potential PKA substrate.
Cell cycle (Georgetown, Tex.)
Signaling pathways for modulation of mouse sperm motility by adenosine and catecholamine agonists.
Biology of reproduction
The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes.
Developmental biology
AKAP3 selectively binds PDE4A isoforms in bovine spermatozoa.
Biology of reproduction
Wee1B is an oocyte-specific kinase involved in the control of meiotic arrest in the mouse.
Current biology : CB
G-protein-coupled receptor signaling and the EGF network in endocrine systems.
Trends in endocrinology and metabolism: TEM
Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Role of the epidermal growth factor network in ovarian follicles.
Molecular endocrinology (Baltimore, Md.)
Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are differentially expressed and regulated in rat tissue.
The Biochemical journal
Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes.
Proceedings of the National Academy of Sciences of the United States of America
Generation of PDE4 knockout mice by gene targeting.
Methods in molecular biology (Clifton, N.J.)
Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Phosphodiesterase 4D forms a cAMP diffusion barrier at the apical membrane of the airway epithelium.
The Journal of biological chemistry
Potential role of protein tyrosine phosphatase nonreceptor type 13 in the control of oocyte meiotic maturation.
Development (Cambridge, England)
A view into the catalytic pocket of cyclic nucleotide phosphodiesterases.
Nature structural & molecular biology
Cyclic nucleotide phosphodiesterase 3A-deficient mice as a model of female infertility.
The Journal of clinical investigation
The oligomerization state determines regulatory properties and inhibitor sensitivity of type 4 cAMP-specific phosphodiesterases.
The Journal of biological chemistry
Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect.
Proceedings of the National Academy of Sciences of the United States of America
EGF-like growth factors as mediators of LH action in the ovulatory follicle.
Science (New York, N.Y.)
Expression of the soluble adenylyl cyclase during rat spermatogenesis: evidence for cytoplasmic sites of cAMP production in germ cells.
Developmental biology
PDE4D plays a critical role in the control of airway smooth muscle contraction.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Calcium regulation of the soluble adenylyl cyclase expressed in mammalian spermatozoa.
Proceedings of the National Academy of Sciences of the United States of America
Lowering cyclic adenosine-3',5'-monophosphate (cAMP) levels by expression of a cAMP-specific phosphodiesterase decreases intrinsic pulsatile gonadotropin-releasing hormone secretion from GT1 cells.
Molecular endocrinology (Baltimore, Md.)
Rodent oocytes express an active adenylyl cyclase required for meiotic arrest.
Developmental biology
IGF-I-induced differentiation of L6 myogenic cells requires the activity of cAMP-phosphodiesterase.
Molecular biology of the cell
Phosphodiesterase regulation is critical for the differentiation and pattern of gene expression in granulosa cells of the ovarian follicle.
Molecular endocrinology (Baltimore, Md.)
Desensitization of Gs-coupled receptor signaling by constitutively active mutants of the human lutropin/choriogonadotropin receptor.
The Journal of clinical endocrinology and metabolism
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
The Biochemical journal
Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signaling.
The Journal of biological chemistry
Phosphodiesterase expression targeted to gonadotropin-releasing hormone neurons inhibits luteinizing hormone pulses in transgenic rats.
Proceedings of the National Academy of Sciences of the United States of America
Specificity of the cyclic adenosine 3',5'-monophosphate signal in granulosa cell function.
Biology of reproduction
Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins.
Science (New York, N.Y.)
Antidepressant-like profile and reduced sensitivity to rolipram in mice deficient in the PDE4D phosphodiesterase enzyme.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis.
The Journal of clinical investigation
Dimerization of the type 4 cAMP-specific phosphodiesterases is mediated by the upstream conserved regions (UCRs).
The Journal of biological chemistry
Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responses.
Proceedings of the National Academy of Sciences of the United States of America
Regulation of cAMP-specific phosphodiesterases type 4B and 4D (PDE4) splice variants by cAMP signaling in primary cortical neurons.
Journal of neurochemistry
Role of cyclic nucleotide signaling in oocyte maturation.
Molecular and cellular endocrinology
Cyclic nucleotide phosphodiesterases and their role in endocrine cell signaling.
Trends in endocrinology and metabolism: TEM
Differential expression of non-muscle myosin heavy chain genes during Xenopus embryogenesis.
Mechanisms of development
Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors.
The Journal of biological chemistry
Phosphorylation of vertebrate nonmuscle myosin heavy chains by protein kinase C.
Advances in second messenger and phosphoprotein research
Phosphorylation by cyclic adenosine 3':5'-monophosphate-dependent protein kinase regulates myosin light chain kinase.
Federation proceedings
Phosphorylation of smooth muscle myosin light chain kinase by the catalytic subunit of adenosine 3': 5'-monophosphate-dependent protein kinase.
The Journal of biological chemistry