
Assistant Professor
Surgery
Kyle Cromer, PhD focuses on using genome editing to engineer erythropoiesis for clinical applications.
Publications
Engineering synthetic signaling receptors to enable erythropoietin-free erythropoiesis.
Nature communications
Enhancement of erythropoietic output by Cas9-mediated insertion of a natural variant in haematopoietic stem and progenitor cells.
Nature biomedical engineering
Lineage-tracing hematopoietic stem cell origins in vivo to efficiently make human HLF+ HOXA+ hematopoietic progenitors from pluripotent stem cells.
Developmental cell
Transient inhibition of 53BP1 increases the frequency of targeted integration in human hematopoietic stem and progenitor cells.
Nature communications
High-efficiency transgene integration by homology-directed repair in human primary cells using DNA-PKcs inhibition.
Nature biotechnology
Comparative analysis of CRISPR off-target discovery tools following ex vivo editing of CD34+ hematopoietic stem and progenitor cells.
Molecular therapy : the journal of the American Society of Gene Therapy
CRISPR nuclease off-target activity and mitigation strategies.
Frontiers in genome editing
Ultra-deep sequencing validates safety of CRISPR/Cas9 genome editing in human hematopoietic stem and progenitor cells.
Nature communications
Development of β-globin gene correction in human hematopoietic stem cells as a potential durable treatment for sickle cell disease.
Science translational medicine
Gene replacement of α-globin with β-globin restores hemoglobin balance in β-thalassemia-derived hematopoietic stem and progenitor cells.
Nature medicine
Improved Genome Editing through Inhibition of FANCM and Members of the BTR Dissolvase Complex.
Molecular therapy : the journal of the American Society of Gene Therapy
Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards.
Nature communications
Global Transcriptional Response to CRISPR/Cas9-AAV6-Based Genome Editing in CD34+ Hematopoietic Stem and Progenitor Cells.
Molecular therapy : the journal of the American Society of Gene Therapy
Priming Human Repopulating Hematopoietic Stem and Progenitor Cells for Cas9/sgRNA Gene Targeting.
Molecular therapy. Nucleic acids
Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas.
Proceedings of the National Academy of Sciences of the United States of America
Identification of somatic mutations in parathyroid tumors using whole-exome sequencing.
The Journal of clinical endocrinology and metabolism