
Professor
Bioengineering and Therapeutic Sciences
+1 415 476-8010
Kathy Giacomini, PhD focuses on membrane transporters, which are of great pharmacological importance as they play a major role in drug disposition and response.
Publications
Leading the Way: Multi-Drug Resistance Protein (MDR1) and Clinical Pharmacology-Commentary on Kim et al.
Clinical pharmacology and therapeutics
Predicting OCT2/MATEs-Mediated Drug Interactions in Healthy Volunteers and Patients with Chronic Kidney Disease: Insights from Extended Clearance Concept, Endogenous Biomarkers, and In Vitro Inhibition Studies (Perspectives from the International Transpor
Clinical pharmacology and therapeutics
Drug Interactions Brewing.
Clinical pharmacology and therapeutics
MRI Provides New Insights Into the Pharmacologic Mechanism of Bisacodyl: A Blueprint for Understanding Intestinal Drug Mechanisms.
Clinical pharmacology and therapeutics
Identification and Clinical Evaluation of Potential Biomarkers for Breast Cancer Resistance Protein (BCRP/ABCG2).
Clinical pharmacology and therapeutics
Therapeutic Orphan No More: Role for Clinical Pharmacology and Translational Science in Developing Therapeutics for Rare and Neglected Diseases.
Clinical pharmacology and therapeutics
Publisher Correction: A genome-wide association analysis reveals new pathogenic pathways in gout.
Nature genetics
Is Pharmacogenetic Testing a Vital Tool for Enhancing Therapeutic Management of Patients Worldwide?
Clinical pharmacology and therapeutics
Rare Diseases Linked to Mutations in Vitamin Transporters Expressed in the Human Blood-Brain Barrier.
Clinical pharmacology and therapeutics
Proteomic Profiling Reveals Age-Related Changes in Transporter Proteins in the Human Blood-Brain Barrier.
bioRxiv : the preprint server for biology
Report of the 2023-24 AACP Research and Graduate Affairs Committee.
American journal of pharmaceutical education
Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates.
Nature communications
Haploinsufficiency underlies the neurodevelopmental consequences of SLC6A1 variants.
American journal of human genetics
The full spectrum of SLC22 OCT1 mutations illuminates the bridge between drug transporter biophysics and pharmacogenomics.
Molecular cell
Progress in Clinical Pharmacology in China: A Randomized Controlled Study to Advance Genotype-Guided Precision Medicine.
Clinical pharmacology and therapeutics
Membrane transporters in drug development and as determinants of precision medicine.
Nature reviews. Drug discovery
Artificial intelligence, ChatGPT, and other large language models for social determinants of health: Current state and future directions.
Cell reports. Medicine
Maximum likelihood estimation of renal transporter ontogeny profiles for pediatric PBPK modeling.
CPT: pharmacometrics & systems pharmacology
Ensuring Transparency and Quality of Clinical Trial Reporting in Clinical Pharmacology & Therapeutics: Prospective Trial Registration and Compliance with Reporting Guidelines Are Required for all Clinical Trials.
Clinical pharmacology and therapeutics
Illuminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates.
Research square
TICBase: Integrated Resource for Data on Drug and Environmental Chemical Interactions with Mammalian Drug Transporters.
Clinical pharmacology and therapeutics
Illuminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates.
bioRxiv : the preprint server for biology
Cardiac contraction and relaxation are regulated by distinct subcellular cAMP pools.
Nature chemical biology
Trends in Clinical Pharmacology and Therapeutics.
Clinical pharmacology and therapeutics
The full spectrum of OCT1 (SLC22A1) mutations bridges transporter biophysics to drug pharmacogenomics.
bioRxiv : the preprint server for biology
The Effect of Trimethoprim on Thiamine Absorption: A Transporter-Mediated Drug-Nutrient Interaction.
Clinical pharmacology and therapeutics
Initial Insights into the Genetic Variation Associated with Metformin Treatment Failure in Youth with Type 2 Diabetes.
Pediatric diabetes
Characterization of P-glycoprotein orthologs from human, sheep, pig, dog, and cat.
Journal of veterinary pharmacology and therapeutics
Biomarkers Come of Age in Clinical Pharmacology.
Clinical pharmacology and therapeutics
Diversity, Equity, and Inclusion: Translating Clinical Pharmacology for All.
Clinical pharmacology and therapeutics
Functional genomics of OCTN2 variants informs protein-specific variant effect predictor for Carnitine Transporter Deficiency.
Proceedings of the National Academy of Sciences of the United States of America
More Than Pharmacokinetics: Transporters in Clinical Pharmacology.
Clinical pharmacology and therapeutics
New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium.
Clinical pharmacology and therapeutics
A Critical Overview of the Biological Effects of Excipients (Part I): Impact on Gastrointestinal Absorption.
The AAPS journal
The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and Statin-Associated Musculoskeletal Symptoms.
Clinical pharmacology and therapeutics
The Pandemic as a Catalyst for Disruptive Innovation in Clinical Pharmacology.
Clinical pharmacology and therapeutics
High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3.
Pharmaceutical research
Emerging Roles of the Human Solute Carrier 22 Family.
Drug metabolism and disposition: the biological fate of chemicals
Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas.
Diabetes care
Advancing Precision Medicine Through the New Pharmacogenomics Global Research Network.
Clinical pharmacology and therapeutics
Drugs in COVID-19 Clinical Trials: Predicting Transporter-Mediated Drug-Drug Interactions Using In Vitro Assays and Real-World Data.
Clinical pharmacology and therapeutics
Oxypurinol pharmacokinetics and pharmacodynamics in healthy volunteers: Influence of BCRP Q141K polymorphism and patient characteristics.
Clinical and translational science
Opportunities and challenges for the computational interpretation of rare variation in clinically important genes.
American journal of human genetics
The Effects of Genetic Mutations and Drugs on the Activity of the Thiamine Transporter, SLC19A2.
The AAPS journal
A New Era in Pharmacovigilance: Toward Real-World Data and Digital Monitoring.
Clinical pharmacology and therapeutics
Characterization of cytochrome P450 (CYP) 2D6 drugs as substrates of human organic cation transporters and multidrug and toxin extrusion proteins.
British journal of pharmacology
Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
A Tribute to Professor Per Artursson - Scientist, Explorer, Mentor, Innovator, and Giant in Pharmaceutical Research.
Journal of pharmaceutical sciences
Drug Metabolites Potently Inhibit Renal Organic Anion Transporters, OAT1 and OAT3.
Journal of pharmaceutical sciences
Scientific considerations for global drug development.
Science translational medicine
The activities of drug inactive ingredients on biological targets.
Science (New York, N.Y.)
Neural production of kynurenic acid in Caenorhabditis elegans requires the AAT-1 transporter.
Genes & development
COVID-19: A Defining Moment for Clinical Pharmacology?
Clinical pharmacology and therapeutics
Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives.
Proceedings of the National Academy of Sciences of the United States of America
Oral Anticoagulants and Precision Medicine: Something Old, Something New.
Clinical pharmacology and therapeutics
Novel Technologies Enable Mechanistic Understanding and Modeling of Drug Exposure and Response.
Clinical pharmacology and therapeutics
GenEpi: gene-based epistasis discovery using machine learning.
BMC bioinformatics
Interactions of Oral Molecular Excipients with Breast Cancer Resistance Protein, BCRP.
Molecular pharmaceutics
Clinical Pharmacology & Therapeutics 2030.
Clinical pharmacology and therapeutics
Drug-nutrient interactions: discovering prescription drug inhibitors of the thiamine transporter ThTR-2 (SLC19A3).
The American journal of clinical nutrition
Expanding Precompetitive Multisector Collaborations to Advance Drug Development and Pharmacogenomics.
Clinical pharmacology and therapeutics
Global Pharmacogenomics Within Precision Medicine: Challenges and Opportunities.
Clinical pharmacology and therapeutics
A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster.
PLoS genetics
A Comprehensive Analysis of Ontogeny of Renal Drug Transporters: mRNA Analyses, Quantitative Proteomics, and Localization.
Clinical pharmacology and therapeutics
l-Type amino acid transporter 1 activity of 1,2,3-triazolyl analogs of l-histidine and l-tryptophan.
Bioorganic & medicinal chemistry letters
Genome-Wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol.
Clinical pharmacology and therapeutics
Functional and structural analysis of rare SLC2A2 variants associated with Fanconi-Bickel syndrome and metabolic traits.
Human mutation
Organic Anion Transporter Polypeptide 1B1 Polymorphism Modulates the Extent of Drug-Drug Interaction and Associated Biomarker Levels in Healthy Volunteers.
Clinical and translational science
Research Projects Supported by the University of California, San Francisco-Stanford Center of Excellence in Regulatory Science and Innovation.
Clinical pharmacology and therapeutics
Impact of Pharmaceutical Excipients on Oral Drug Absorption: A Focus on Intestinal Drug Transporters.
Clinical pharmacology and therapeutics
Clinical Probes and Endogenous Biomarkers as Substrates for Transporter Drug-Drug Interaction Evaluation: Perspectives From the International Transporter Consortium.
Clinical pharmacology and therapeutics
The International Transporter Consortium: Summarizing Advances in the Role of Transporters in Drug Development.
Clinical pharmacology and therapeutics
Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1).
Journal of medicinal chemistry
Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance.
Clinical pharmacology and therapeutics
Influence of Transporter Polymorphisms on Drug Disposition and Response: A Perspective From the International Transporter Consortium.
Clinical pharmacology and therapeutics
ITC Commentary on Metformin Clinical Drug-Drug Interaction Study Design That Enables an Efficacy- and Safety-Based Dose Adjustment Decision.
Clinical pharmacology and therapeutics
Pharmacogenetics of Antidiabetic Drugs.
Advances in pharmacology (San Diego, Calif.)
Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity.
Molecular pharmacology
Emerging Clinical Importance of Hepatic Organic Cation Transporter 1 (OCT1) in Drug Pharmacokinetics, Dynamics, Pharmacogenetic Variability, and Drug Interactions.
Clinical pharmacology and therapeutics
Reverse Translational Research of ABCG2 (BCRP) in Human Disease and Drug Response.
Clinical pharmacology and therapeutics
PharmGKB summary: very important pharmacogene information for ABCG2.
Pharmacogenetics and genomics
New Pharmacogenomics Research Network: An Open Community Catalyzing Research and Translation in Precision Medicine.
Clinical pharmacology and therapeutics
PBPK Modeling of the Effect of Reduced Kidney Function on the Pharmacokinetics of Drugs Excreted Renally by Organic Anion Transporters.
Clinical pharmacology and therapeutics
Human Concentrative Nucleoside Transporter 3 (hCNT3, SLC28A3) Forms a Cyclic Homotrimer.
Biochemistry
Computational Discovery and Experimental Validation of Inhibitors of the Human Intestinal Transporter OATP2B1.
Journal of chemical information and modeling
Transporters Involved in Metformin Pharmacokinetics and Treatment Response.
Journal of pharmaceutical sciences
The Effect of Uremic Solutes on the Organic Cation Transporter 2.
Journal of pharmaceutical sciences
Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1).
Journal of medicinal chemistry
Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin: A Metgen Meta-Analysis.
Clinical pharmacology and therapeutics
Genomic Characterization of Metformin Hepatic Response.
PLoS genetics
Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine.
Nature reviews. Drug discovery
The use of drug transporters as therapeutic targets.
Clinical advances in hematology & oncology : H&O
A Molecular Basis for Innovation in Drug Excipients.
Clinical pharmacology and therapeutics
A Longitudinal HbA1c Model Elucidates Genes Linked to Disease Progression on Metformin.
Clinical pharmacology and therapeutics
Metabolomic and Genome-wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1.
Clinical pharmacology and therapeutics
LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates.
Bioorganic & medicinal chemistry letters
Identification and Quantitative Assessment of Uremic Solutes as Inhibitors of Renal Organic Anion Transporters, OAT1 and OAT3.
Molecular pharmaceutics
Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin.
Nature genetics
Genomewide Association Studies in Pharmacogenomics: Meeting Report of the NIH Pharmacogenomics Research Network-RIKEN (PGRN-RIKEN) Collaboration.
Clinical pharmacology and therapeutics
Erratum to: Vesicular monoamine transporter protein expression correlates with clinical features, tumor biology, and MIBG avidity in neuroblastoma: a report from the Children's Oncology Group.
European journal of nuclear medicine and molecular imaging
Pharmacometabolomic Assessment of Metformin in Non-diabetic, African Americans.
Frontiers in pharmacology
The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin.
Clinical pharmacokinetics
A research roadmap for next-generation sequencing informatics.
Science translational medicine
LAT-1 activity of meta-substituted phenylalanine and tyrosine analogs.
Bioorganic & medicinal chemistry letters
The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Volunteers.
Clinical pharmacokinetics
Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines.
The pharmacogenomics journal
Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1-Transfected Human Embryonic Kidney 293 Cells.
Drug metabolism and disposition: the biological fate of chemicals
Unmet needs: Research helps regulators do their jobs.
Science translational medicine
Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3).
Molecular pharmaceutics
Vesicular monoamine transporter protein expression correlates with clinical features, tumor biology, and MIBG avidity in neuroblastoma: a report from the Children's Oncology Group.
European journal of nuclear medicine and molecular imaging
Prediction and validation of enzyme and transporter off-targets for metformin.
Journal of pharmacokinetics and pharmacodynamics
SLC transporters as therapeutic targets: emerging opportunities.
Nature reviews. Drug discovery
Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin.
Molecular pharmacology
Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response.
Clinical pharmacology and therapeutics
Phase I Study of Vorinostat as a Radiation Sensitizer with 131I-Metaiodobenzylguanidine (131I-MIBG) for Patients with Relapsed or Refractory Neuroblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
A pharmacogenetic candidate gene study of tenofovir-associated Fanconi syndrome.
Pharmacogenetics and genomics
OCT1 in hepatic steatosis and thiamine disposition.
Cell cycle (Georgetown, Tex.)
OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.
Proceedings of the National Academy of Sciences of the United States of America
PharmGKB summary: very important pharmacogene information for SLC22A1.
Pharmacogenetics and genomics
Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin.
Clinical pharmacology and therapeutics
Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for ivacaftor therapy in the context of CFTR genotype.
Clinical pharmacology and therapeutics
Towards quantitation of the effects of renal impairment and probenecid inhibition on kidney uptake and efflux transporters, using physiologically based pharmacokinetic modelling and simulations.
Clinical pharmacokinetics
Profiling solute carrier transporters in the human blood-brain barrier.
Clinical pharmacology and therapeutics
A genome-wide association study of bronchodilator response in Latinos implicates rare variants.
The Journal of allergy and clinical immunology
International Transporter Consortium commentary on clinically important transporter polymorphisms.
Clinical pharmacology and therapeutics
SLC classification: an update.
Clinical pharmacology and therapeutics
Transporters in drug development and clinical pharmacology.
Clinical pharmacology and therapeutics
Special Section on Pharmacogenomics: recent advances and future directions.
Journal of human genetics
Impact of polymorphisms in drug pathway genes on disease-free survival in adults with acute myeloid leukemia.
Journal of human genetics
Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8).
Journal of pharmaceutical sciences
Emerging transporters of clinical importance: an update from the International Transporter Consortium.
Clinical pharmacology and therapeutics
Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1.
Proceedings of the National Academy of Sciences of the United States of America
Gene expression profiling of transporters in the solute carrier and ATP-binding cassette superfamilies in human eye substructures.
Molecular pharmaceutics
Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling.
Journal of medicinal chemistry
Molecular modeling and ligand docking for solute carrier (SLC) transporters.
Current topics in medicinal chemistry
Renal transporters in drug development.
Annual review of pharmacology and toxicology
Highlights from the International Transporter Consortium second workshop.
Clinical pharmacology and therapeutics
Metformin pathways: pharmacokinetics and pharmacodynamics.
Pharmacogenetics and genomics
The UCSF-FDA TransPortal: a public drug transporter database.
Clinical pharmacology and therapeutics
The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin.
Clinical pharmacology and therapeutics
Pharmacogenomics and patient care: one size does not fit all.
Science translational medicine
Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Children's Oncology Group.
International journal of molecular imaging
High selectivity of the ?-aminobutyric acid transporter 2 (GAT-2, SLC6A13) revealed by structure-based approach.
The Journal of biological chemistry
Dedication to professor Leslie Z. Benet: 50 years of scientific excellence and still going strong!
Pharmaceutical research
Genetic and epigenetic regulation of the organic cation transporter 3, SLC22A3.
The pharmacogenomics journal
Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition.
Genome research
A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.
Clinical cancer research : an official journal of the American Association for Cancer Research
PharmGKB summary: methotrexate pathway.
Pharmacogenetics and genomics
A common 5'-UTR variant in MATE2-K is associated with poor response to metformin.
Clinical pharmacology and therapeutics
Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET.
Proceedings of the National Academy of Sciences of the United States of America
Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Journal of medicinal chemistry
Interaction of sirolimus and everolimus with hepatic and intestinal organic anion-transporting polypeptide transporters.
Xenobiotica; the fate of foreign compounds in biological systems
Vorinostat increases expression of functional norepinephrine transporter in neuroblastoma in vitro and in vivo model systems.
Clinical cancer research : an official journal of the American Association for Cancer Research
Discovery of regulatory elements in human ATP-binding cassette transporters through expression quantitative trait mapping.
The pharmacogenomics journal
Functional characterization of liver enhancers that regulate drug-associated transporters.
Clinical pharmacology and therapeutics
Interactions of tyrosine kinase inhibitors with organic cation transporters and multidrug and toxic compound extrusion proteins.
Molecular cancer therapeutics
GABAA receptor open-state conformation determines non-competitive antagonist binding.
Toxicology and applied pharmacology
Role of organic cation transporter 1, OCT1 in the pharmacokinetics and toxicity of cis-diammine(pyridine)chloroplatinum(II) and oxaliplatin in mice.
Pharmaceutical research
Consequences of POR mutations and polymorphisms.
Molecular and cellular endocrinology
Effects of genetic variants of human P450 oxidoreductase on catalysis by CYP2D6 in vitro.
Pharmacogenetics and genomics
Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin.
Pharmacogenetics and genomics
SLC19A1 pharmacogenomics summary.
Pharmacogenetics and genomics
Substrate-specific modulation of CYP3A4 activity by genetic variants of cytochrome P450 oxidoreductase.
Pharmacogenetics and genomics
Genetic variants of human organic anion transporter 4 demonstrate altered transport of endogenous substrates.
American journal of physiology. Renal physiology
Genetic polymorphisms in organic cation transporter 1 (OCT1) in Chinese and Japanese populations exhibit altered function.
The Journal of pharmacology and experimental therapeutics
Role of the copper transporter, CTR1, in platinum-induced ototoxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1: predictions of metformin interactions.
The pharmacogenomics journal
Organic cation transporters modulate the uptake and cytotoxicity of picoplatin, a third-generation platinum analogue.
Molecular cancer therapeutics
Pharmacogenomics of membrane transporters: past, present and future.
Pharmacogenomics
Transport of thyroid hormones is selectively inhibited by 3-iodothyronamine.
Molecular bioSystems
Comparison of human solute carriers.
Protein science : a publication of the Protein Society
Membrane transporters in drug development.
Nature reviews. Drug discovery
The International Transporter Consortium: a collaborative group of scientists from academia, industry, and the FDA.
Clinical pharmacology and therapeutics
The pharmacogenomics of membrane transporters project: research at the interface of genomics and transporter pharmacology.
Clinical pharmacology and therapeutics
Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
The role of organic anion-transporting polypeptides and their common genetic variants in mycophenolic acid pharmacokinetics.
Clinical pharmacology and therapeutics
Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1.
Pharmacogenetics and genomics
Institutional Profile: The University of California Pharmacogenomics Center: at the interface of genomics, biological mechanisms and drug therapy.
Pharmacogenomics
A survey of integral alpha-helical membrane proteins.
Journal of structural and functional genomics
Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin.
Pharmacogenetics and genomics
The organic cation transporter, OCTN1, expressed in the human heart, potentiates antagonism of the HERG potassium channel.
Journal of cardiovascular pharmacology
Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function.
The pharmacogenomics journal
Functional genetic variation in the basal promoter of the organic cation/carnitine transporters OCTN1 (SLC22A4) and OCTN2 (SLC22A5).
The Journal of pharmacology and experimental therapeutics
Identification and characterization of proximal promoter polymorphisms in the human concentrative nucleoside transporter 2 (SLC28A2).
The Journal of pharmacology and experimental therapeutics
Selecting optimum eukaryotic integral membrane proteins for structure determination by rapid expression and solubilization screening.
Journal of molecular biology
Genetic variation in human P450 oxidoreductase.
Molecular and cellular endocrinology
Genetic variation in human aquaporins and effects on phenotypes of water homeostasis.
Human mutation
Pharm. D. pathways to biomedical research: the National Institutes of Health special conference on pharmacy research.
Pharmacotherapy
cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects.
Proceedings of the National Academy of Sciences of the United States of America
Creating and evaluating genetic tests predictive of drug response.
Nature reviews. Drug discovery
Genetic variation in drug transporters in ethnic populations.
Clinical pharmacology and therapeutics
Novel variants in human Aquaporin-4 reduce cellular water permeability.
Human molecular genetics
Characterizing the dose-response relationship between mannitol and intracranial pressure in traumatic brain injury patients using a high-frequency physiological data collection system.
Journal of neurotrauma
The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene.
The Journal of pharmacology and experimental therapeutics
Genetics of P450 oxidoreductase: sequence variation in 842 individuals of four ethnicities and activities of 15 missense mutations.
Proceedings of the National Academy of Sciences of the United States of America
Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP.
Molecular pharmacology
Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges.
Nature reviews. Drug discovery
Functional effects of protein sequence polymorphisms in the organic cation/ergothioneine transporter OCTN1 (SLC22A4).
Pharmacogenetics and genomics
Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics.
Clinical pharmacology and therapeutics
Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin.
Clinical pharmacology and therapeutics
Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family.
The Journal of pharmacology and experimental therapeutics
Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action.
The Journal of clinical investigation
Genetic nondiscrimination legislation: a critical prerequisite for pharmacogenomics data sharing.
Pharmacogenomics
When good drugs go bad.
Nature
The pharmacogenetics research network: from SNP discovery to clinical drug response.
Clinical pharmacology and therapeutics
Pharmacogenomics: challenges and opportunities.
Annals of internal medicine
Functional genetic diversity in the high-affinity carnitine transporter OCTN2 (SLC22A5).
Molecular pharmacology
Molecular determinants of specificity for synthetic nucleoside analogs in the concentrative nucleoside transporter, CNT2.
The Journal of biological chemistry
Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants.
The Journal of pharmacology and experimental therapeutics
PharmGKB submission update: IV. PMT submissions of genetic variations in ATP-Binding cassette transporters to the PharmGKB network.
Pharmacological reviews
PharmGKB submission update: V. PMT submissions of genetic variation in SLC22 family transporters.
Pharmacological reviews
PharmGKB submission update: VI. PMT submissions of genetic variations in neurotransmitter transporters (SLC6, SLC17, and SLC18) to the PharmGKB network.
Pharmacological reviews
Transport of drugs in the kidney by the human organic cation transporter, OCT2 and its genetic variants.
Journal of pharmaceutical sciences
The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics.
American journal of physiology. Renal physiology
Functional characterization and haplotype analysis of polymorphisms in the human equilibrative nucleoside transporter, ENT2.
Drug metabolism and disposition: the biological fate of chemicals
Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1).
Pharmacogenetics and genomics
Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2.
Pharmacogenetics and genomics
Enhancing data sharing in collaborative research projects with DASH.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3; SLC28A3).
The pharmacogenomics journal
Haplotype structure and ethnic-specific allele frequencies at the OCTN locus: implications for the genetics of Crohn's disease.
Inflammatory bowel diseases
PharmGKB update: III. Genetic variants of SLC22A1, solute carrier family 22 (organic cation transporter), member 1.
Pharmacological reviews
Functional and genetic diversity in the concentrative nucleoside transporter, CNT1, in human populations.
Molecular pharmacology
Nucleoside transporters in the disposition and targeting of nucleoside analogs in the kidney.
European journal of pharmacology
Estimating the contribution of genes and environment to variation in renal drug clearance.
Pharmacogenetics
Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene.
Pharmacogenetics
PharmGKB update: I. Genetic variants of the organic cation transporter 2 (OCT2, SLC22A2).
Pharmacological reviews
The concentrative nucleoside transporter family, SLC28.
Pflugers Archiv : European journal of physiology
Functional characterization in yeast of genetic variants in the human equilibrative nucleoside transporter, ENT1.
Pharmacogenetics
Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1.
Proceedings of the National Academy of Sciences of the United States of America
Natural variation in human membrane transporter genes reveals evolutionary and functional constraints.
Proceedings of the National Academy of Sciences of the United States of America
Sorting of rat SPNT in renal epithelium is independent of N-glycosylation.
Pharmaceutical research
Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells.
American journal of physiology. Renal physiology
SNP analysis and presentation in the Pharmacogenetics of Membrane Transporters Project.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Interactions of n-tetraalkylammonium compounds and biguanides with a human renal organic cation transporter (hOCT2).
Pharmaceutical research
Specificity of human and rat orthologs of the concentrative nucleoside transporter, SPNT.
American journal of physiology. Renal physiology
Role of aromatic transmembrane residues of the organic anion transporter, rOAT3, in substrate recognition.
Biochemistry
Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function.
Pharmacogenetics
Functional characteristics and steroid hormone-mediated regulation of an organic cation transporter in Madin-Darby canine kidney cells.
The Journal of pharmacology and experimental therapeutics
Arginine 454 and lysine 370 are essential for the anion specificity of the organic anion transporter, rOAT3.
Biochemistry
Localization of GFP-tagged concentrative nucleoside transporters in a renal polarized epithelial cell line.
American journal of physiology. Renal physiology
Screening a large reference sample to identify very low frequency sequence variants: comparisons between two genes.
Nature genetics
Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters.
Journal of pharmaceutical sciences
A novel proton-dependent nucleoside transporter, CeCNT3, from Caenorhabditis elegans.
Molecular pharmacology
Electrophysiological analysis of the substrate selectivity of a sodium-coupled nucleoside transporter (rCNT1) expressed in Xenopus laevis oocytes.
Drug metabolism and disposition: the biological fate of chemicals
Molecular cloning of a Na+-dependent nucleoside transporter from rabbit intestine.
Pharmaceutical research
Interactions of HIV protease inhibitors with a human organic cation transporter in a mammalian expression system.
Drug metabolism and disposition: the biological fate of chemicals
Kinetic and selectivity differences between rodent, rabbit, and human organic cation transporters (OCT1).
The Journal of pharmacology and experimental therapeutics
Functional characterization of a human purine-selective, Na+-dependent nucleoside transporter (hSPNT1) in a mammalian expression system.
The Journal of pharmacology and experimental therapeutics
The interaction of n-tetraalkylammonium compounds with a human organic cation transporter, hOCT1.
The Journal of pharmacology and experimental therapeutics
Characterization of a bioengineered chimeric Na+-nucleoside transporter.
Molecular pharmacology
Serine 318 is essential for the pyrimidine selectivity of the N2 Na+-nucleoside transporter.
The Journal of biological chemistry
Molecular and functional characteristics of cloned human organic cation transporters.
Pharmaceutical biotechnology
Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa).
The Journal of pharmacology and experimental therapeutics
Nucleoside transport in isolated human and rhesus choroid plexus tissue slices.
Pharmaceutical research
Nicotine transport in a human choriocarcinoma cell line (JAR).
Journal of pharmaceutical sciences
Molecular cloning and functional expression of a rabbit renal organic cation transporter.
Biochimica et biophysica acta
Role of organic cation transporters in drug absorption and elimination.
Annual review of pharmacology and toxicology
Membrane transporters in drug disposition.
Journal of pharmacokinetics and biopharmaceutics
Na(+)-dependent purine nucleoside transporter from human kidney: cloning and functional characterization.
The American journal of physiology
Molecular determinants of substrate selectivity in Na+-dependent nucleoside transporters.
The Journal of biological chemistry
Na+-dependent gamma-aminobutyric acid (GABA) transport in the choroid plexus of rabbit.
Biochimica et biophysica acta
Functional and molecular characteristics of Na(+)-dependent nucleoside transporters.
Pharmaceutical research
Transient expression of a purine-selective nucleoside transporter (SPNTint) in a human cell line (HeLa).
Pharmaceutical research
Characterization of guanidine transport in human renal brush border membranes.
Pharmaceutical research
Cloning and functional characterization of a rat renal organic cation transporter isoform (rOCT1A).
The Journal of biological chemistry
Cloning and functional expression of a human liver organic cation transporter.
Molecular pharmacology
Expression of human polyspecific renal organic cation transport activity in Xenopus laevis oocytes.
Journal of pharmaceutical sciences
Guanidine transport in a human choriocarcinoma cell line (JAR).
Pharmaceutical research
Taurine transport in cultured choroid plexus.
Pharmaceutical research
Mechanisms of 5-fluorouracil (5-FU) transport in isolated rabbit choroid plexus tissue slices.
Pharmaceutical research
Primary cell culture of the rabbit choroid plexus: an experimental system to investigate membrane transport.
Pharmaceutical research
Saturable disposition of taurine in the rat cerebrospinal fluid.
The Journal of pharmacology and experimental therapeutics
Isolated renal brush border and basolateral membrane vesicles and cultured renal cells.
Pharmaceutical biotechnology
Methods of study drug transport in isolated choroid plexus tissue and cultured cells.
Pharmaceutical biotechnology
Mechanisms of nucleobase transport in rabbit choroid plexus. Evidence for a Na(+)-dependent nucleobase transporter with broad substrate selectivity.
The Journal of biological chemistry
The effect of N-ethylmaleimide on the Na(+)-dependent nucleoside transporter (N3) in rabbit choroid plexus.
The Journal of pharmacology and experimental therapeutics
The effects of modulation of calcium influx through the voltage-sensitive calcium channel on cardiomyocyte hypertrophy.
Journal of molecular and cellular cardiology
Expression of a human renal sodium nucleoside cotransporter in Xenopus laevis oocytes.
Biochemical pharmacology
Increased 1,4-dihydropyridine binding sites in serum-stimulated cardiomyocyte hypertrophy.
The Journal of pharmacology and experimental therapeutics
Expression of the choroid plexus sodium-nucleoside cotransporter (N3) in Xenopus laevis oocytes.
Biochemical pharmacology
Characterization of a sodium-dependent taurine transporter in rabbit choroid plexus.
Biochimica et biophysica acta
Expression of a renal Na(+)-nucleoside cotransport system (N2) in Xenopus laevis oocytes.
Pflugers Archiv : European journal of physiology
Further characterization of the sodium-dependent nucleoside transporter (N3) in choroid plexus from rabbit.
Biochimica et biophysica acta
Effect of phenylisothiocyanate on organic cation transport in opossum kidney cells.
The Journal of pharmacology and experimental therapeutics
Stereoselective interactions of organic cations with the organic cation transporter in OK cells.
Pharmaceutical research
Substrate selectivity, potential sensitivity and stoichiometry of Na(+)-nucleoside transport in brush border membrane vesicles from human kidney.
Biochimica et biophysica acta
Chemical, enzymatic, and human enantioselective S-oxygenation of cimetidine.
Drug metabolism and disposition: the biological fate of chemicals
Formycin B elimination from the cerebrospinal fluid of the rat.
Pharmaceutical research
Interaction of nucleoside analogues with the sodium-nucleoside transport system in brush border membrane vesicles from human kidney.
Pharmaceutical research
Caring for the community
Caring.
Beta-adrenergic blockers as cardioprotective agents.
The American journal of cardiology
Intact lung cytochrome P-450 is not required for hypoxic pulmonary vasoconstriction.
The American journal of physiology
Sodium-dependent nucleoside transport in choroid plexus from rabbit. Evidence for a single transporter for purine and pyrimidine nucleosides.
The Journal of biological chemistry
Nucleoside transport in brush border membrane vesicles from human kidney.
Biochimica et biophysica acta
Inhibition of N-linked glycosylation affects organic cation transport across the brush border membrane of opossum kidney (OK) cells.
The Journal of biological chemistry
Organic cation transport in human renal brush-border membrane vesicles.
The American journal of physiology
Transport of organic cations by a renal epithelial cell line (OK).
The Journal of biological chemistry
Effect of probenecid on the pharmacokinetics and pharmacodynamics of procainamide.
Journal of clinical pharmacology
Preparation of brush border membrane vesicles from bovine choroid plexus.
Journal of pharmacological methods
Interactions of quinidine and quinine and (+)- and (-)-pindolol with the organic cation/proton antiporter in renal brush border membrane vesicles.
Biochemical pharmacology
Cimetidine transport in isolated brush border membrane vesicles from bovine choroid plexus.
The Journal of pharmacology and experimental therapeutics
Mechanisms of interactions between organic anions and the organic cation transporter in renal brush border membrane vesicles.
Biochemical pharmacology
Computer-guided laser for neurosurgery.
Annales chirurgiae et gynaecologiae
The pharmacokinetics and pharmacodynamics of diltiazem and its metabolites in healthy adults after a single oral dose.
Clinical pharmacology and therapeutics
High-performance liquid chromatographic determination of the enantiomers of beta-adrenoceptor blocking agents in biological fluids. II. Studies with atenolol.
Journal of chromatography
The effect of probenecid on the renal elimination of cimetidine.
Clinical pharmacology and therapeutics
The pharmacokinetics of the enantiomers of atenolol.
Clinical pharmacology and therapeutics
Species differences in the negative inotropic response of 1,4-dihydropyridine calcium channel blockers in myocardium.
Journal of cardiovascular pharmacology
Cimetidine elimination from the cerebrospinal fluid of the rat.
Pharmaceutical research
Renal transport of drugs: an overview of methodology with application to cimetidine.
Pharmaceutical research
Stereoselective binding of disopyramide to plasma proteins.
Pharmaceutical research
The effect of pindolol on the transport of L-lysine in renal brush border membrane vesicles.
Drug metabolism and disposition: the biological fate of chemicals
Inhibition of cimetidine transport by creatinine in luminal membrane vesicles prepared from rabbit kidney.
Drug metabolism and disposition: the biological fate of chemicals
Interactions of organic anions with the organic cation transporter in renal BBMV.
The American journal of physiology
Comparison of binding affinities and negative inotropic potencies of the 1,4-dihydropyridine calcium channel blockers in rabbit myocardium.
The Journal of pharmacology and experimental therapeutics
Cimetidine transport in isolated luminal membrane vesicles from rabbit kidney.
The American journal of physiology
Essential tyrosine residues in transport of organic cations in renal BBMV.
The American journal of physiology
The pH gradient-dependent transport of organic cations in the renal brush border membrane. Studies with acridine orange.
The Journal of biological chemistry
Studies on Ca2+ channel antagonists. 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2- isopropylpentyl isothiocyanate, a chemoaffinity ligand derived from verapamil.
Journal of medicinal chemistry
The interaction of phenylalkylamine calcium channel blockers with the 1,4-dihydropyridine binding site.
Journal of molecular and cellular cardiology
In vivo interaction of the enantiomers of disopyramide in human subjects.
Journal of pharmacokinetics and biopharmaceutics
Posttraumatic complications and inflammatory mediators.
Archives of surgery (Chicago, Ill. : 1960)
High performance liquid chromatographic determination of the enantiomers of beta-adrenoceptor blocking agents in biological fluids. I: Studies with pindolol.
Journal of pharmaceutical sciences
Stereoselective interactions of 2-[(2',6'-dimethoxyphenoxyethyl)aminomethyl]-1,4-benzodioxane (WB-4101) with the calcium channel.
Biochemical pharmacology
Stereoselective renal clearance of pindolol in humans.
The Journal of clinical investigation
Electrophysiology of the enantiomers of disopyramide in dogs.
Journal of cardiovascular pharmacology
The pharmacokinetics and pharmacodynamics of d- and dl-verapamil in rabbits.
Journal of cardiovascular pharmacology
Verapamil interacts stereoselectively with the muscarinic receptor.
Pharmaceutical research
Decreased binding of verapamil to plasma proteins in patients with liver disease.
Journal of cardiovascular pharmacology
Correction for Volume Shift during Equilibrium Dialysis by Measurement of Protein Concentration.
Pharmaceutical research
High-performance liquid chromatographic analysis of hypoxanthine arabinoside in plasma.
Journal of chromatography
Effect of concentration-dependent binding to plasma proteins on the pharmacokinetics and pharmacodynamics of disopyramide.
Clinical pharmacokinetics
Amitriptyline disposition in young and elderly normal men.
Clinical pharmacology and therapeutics
Effect of heparin on the red blood cell-to-plasma concentration ratio of diphenylhydantoin and prazosin.
Therapeutic drug monitoring
Effect of low doses of heparin on the plasma binding of phenytoin and prazosin in normal man.
European journal of clinical pharmacology
Calculation of drug concentration in plasma after equilibrium dialysis.
British journal of clinical pharmacology
High-pressure liquid chromatographic determination of amitriptyline and its major metabolites in human whole blood.
Journal of pharmaceutical sciences
Measurement of ketoconazole, a new antifungal agent, by high-performance liquid chromatography.
Journal of chromatography
The effect of saturable binding to plasma proteins on the pharmacokinetic properties of disopyramide.
Journal of pharmacokinetics and biopharmaceutics
Synthesis and anticholinergic properties of the enantiomers of 4-(isopropylamino)-2-(2-pyridyl)-2-phenylbutyramide, the mono-N-dealkylated metabolite of disopyramide.
Journal of medicinal chemistry
Evaluation of methods for producing renal dysfunction in rats.
Journal of pharmaceutical sciences
Absence of effect of heparin on the binding of prazosin and phenytoin to plasma proteins.
Biochemical pharmacology
The stereoselective disposition of disopyramide in the dog.
Journal of cardiovascular pharmacology
Comparative anticholinergic potencies of R- and S- disopyramide in longitudinal muscle strips from guinea pig ileum.
Life sciences
Administration of heparin causes in vitro release of non-esterified fatty acids in human plasma.
Life sciences
Propoxyphene and norpropoxyphene plasma concentrations after oral propoxyphene in cirrhotic patients with and without surgically constructed portacaval shunt.
Clinical pharmacology and therapeutics
Pharmacokinetic studies of propoxyphene I:Effect of portacaval shunt on systemic availability in dogs.
Journal of pharmaceutical sciences
Propoxyphene and norpropoxyphene plasma concentrations in the anephric patient.
Clinical pharmacology and therapeutics
Effect of hemodialysis on propoxyphene and norpropoxyphene concentrations in blood of anephric patients.
Clinical pharmacology and therapeutics
Phenylalanine metabolism in uremic and normal man.
Kidney international
Rational aspirin dosage regimens.
Clinical pharmacology and therapeutics
Plasma protein binding of d-propoxyphene in normal subjects and anephric patients.
Journal of clinical pharmacology
A Convenient Method for Repetitive Blood Sampling in the Dog
J. Pharmacol. Meth.
[Diagnosis of toxoplasmosis by indirect hemagglutination. II. Value of mixed total antigen fixation in the presence of glutaraldehyde in the early diagnosis of the disease].
Biomedicine / [publiee pour l'A.A.I.C.I.G.]