Professor Emeritus
Radiation Oncology
+1 415 476-9083
John Murnane, PhD studies the relationship between DNA repair and telomere loss, and the role of telomere loss in the extensive chromosome instability in cancer cells.
Publications
The relationship between Rose Anna Shedlock (c1850-1878) and Emile Roux (1853-1933).
Journal of medical biography
Telomeric Double Strand Breaks in G1 Human Cells Facilitate Formation of 5' C-Rich Overhangs and Recruitment of TERRA.
Frontiers in genetics
Loss of TGFβ signaling increases alternative end-joining DNA repair that sensitizes to genotoxic therapies across cancer types.
Science translational medicine
Misrepair in Context: TGFβ Regulation of DNA Repair.
Frontiers in oncology
Subjugation of TGFβ Signaling by Human Papilloma Virus in Head and Neck Squamous Cell Carcinoma Shifts DNA Repair from Homologous Recombination to Alternative End Joining.
Clinical cancer research : an official journal of the American Association for Cancer Research
The DNA damage response at dysfunctional telomeres, and at interstitial and subtelomeric DNA double-strand breaks.
Genes & genetic systems
Replication Stress and Telomere Dysfunction Are Present in Cultured Human Embryonic Stem Cells.
Cytogenetic and genome research
Processing by MRE11 is involved in the sensitivity of subtelomeric regions to DNA double-strand breaks.
Nucleic acids research
In memoriam: Robert Blair Painter.
Radiation research
Numerical chromosomal instability mediates susceptibility to radiation treatment.
Nature communications
Analysis of dose distribution and risk of pneumonitis in stereotactic body radiation therapy for centrally located lung tumors: a comparison of robotic radiosurgery, helical tomotherapy and volumetric modulated arc therapy.
Technology in cancer research & treatment
Effect of radiation quality on mutagenic joining of enzymatically-induced DNA double-strand breaks in previously irradiated human cells.
Radiation research
Increased mutagenic joining of enzymatically-induced DNA double-strand breaks in high-charge and energy particle irradiated human cells.
Radiation research
The role of ATM in the deficiency in nonhomologous end-joining near telomeres in a human cancer cell line.
PLoS genetics
Mechanisms of telomere loss and their consequences for chromosome instability.
Frontiers in oncology
Telomere dysfunction and chromosome instability.
Mutation research
Effect of telomere proximity on telomere position effect, chromosome healing, and sensitivity to DNA double-strand breaks in a human tumor cell line.
Molecular and cellular biology
Telomeres acquire distinct heterochromatin characteristics during siRNA-induced RNA interference in mouse cells.
Current biology : CB
Telomeric transgenes are silenced in adult mouse tissues and embryo fibroblasts but are expressed in embryonic stem cells.
Stem cells (Dayton, Ohio)
Suppression of anchorage-independent growth by expression of the ataxia-telangiectasia group D complementing gene, ATDC.
Biochemical and biophysical research communications
Telomeres and chromosome instability.
DNA repair
Telomeres, chromosome instability and cancer.
Nucleic acids research
Telomere position effect and silencing of transgenes near telomeres in the mouse.
Molecular and cellular biology
The loss of a single telomere can result in instability of multiple chromosomes in a human tumor cell line.
Molecular cancer research : MCR
Chromosome rearrangements resulting from telomere dysfunction and their role in cancer.
BioEssays : news and reviews in molecular, cellular and developmental biology
Applications and technical challenges of fluorescence in situ hybridization in stem cell research.
Blood cells, molecules & diseases
Human fibroblasts expressing hTERT show remarkable karyotype stability even after exposure to ionizing radiation.
Cytogenetic and genome research
Interstitial telomeric repeats are not preferentially involved in radiation-induced chromosome aberrations in human cells.
Cytogenetic and genome research
Telomere instability in a human tumor cell line expressing NBS1 with mutations at sites phosphorylated by ATM.
Molecular cancer research : MCR
Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein.
Human genetics
Environmental factors affecting transcription of the human L1 retrotransposon. II. Stressors.
Mutagenesis
DNA amplification by breakage/fusion/bridge cycles initiated by spontaneous telomere loss in a human cancer cell line.
Neoplasia (New York, N.Y.)
Chromosome instability as a result of double-strand breaks near telomeres in mouse embryonic stem cells.
Molecular and cellular biology
TP53-dependent chromosome instability is associated with transient reductions in telomere length in immortal telomerase-positive cell lines.
Genes, chromosomes & cancer
The relationship between spontaneous telomere loss and chromosome instability in a human tumor cell line.
Neoplasia (New York, N.Y.)
Telomere instability in a human cancer cell line.
Mutation research
Chromosome healing in mouse embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America
Telomere dynamics in a human cancer cell line.
Experimental cell research
The contribution of DNA ploidy to radiation sensitivity in human tumour cell lines.
British journal of cancer
The influence of interstitial telomeric sequences on chromosome instability in human cells.
Cytogenetics and cell genetics
Effect of telomere length on telomeric gene expression.
Nucleic acids research
Role of induced genetic instability in the mutagenic effects of chemicals and radiation.
Mutation research
The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor.
Proceedings of the National Academy of Sciences of the United States of America
Use of a mammalian interspersed repetitive (MIR) element in the coding and processing sequences of mammalian genes.
Nucleic acids research
Simian virus 40 transformation alters the actin cytoskeleton, expression of matrix metalloproteinases and inhibitors of metalloproteinases, and invasive behavior of normal and ataxia-telangiectasia human skin fibroblasts.
Biochemistry and cell biology = Biochimie et biologie cellulaire
A role for genomic instability in cellular radioresistance?
Cancer metastasis reviews
Cell cycle regulation in response to DNA damage in mammalian cells: a historical perspective.
Cancer metastasis reviews
Expression of the candidate A-T gene ATDC is not detectable in a human cell line with a normal response to ionizing radiation.
International journal of radiation biology
Telomere dynamics in an immortal human cell line.
The EMBO journal
Formation of extrachromosomal circular DNA in HeLa cells by nonhomologous recombination.
Nucleic acids research
A critical look at the association of human genetic syndromes with sensitivity to ionizing radiation.
Seminars in cancer biology
Acquisition of telomere repeat sequences by transfected DNA integrated at the site of a chromosome break.
Molecular and cellular biology
Cloning of a candidate gene for ataxia-telangiectasia group D.
American journal of human genetics
The role of recombinational hotspots in genome instability in mammalian cells.
BioEssays : news and reviews in molecular, cellular and developmental biology
Enhanced expression of procollagenase in ataxia-telangiectasia and xeroderma pigmentosum fibroblasts.
In vitro cellular & developmental biology : journal of the Tissue Culture Association
Recombination events during integration of transfected DNA into normal human cells.
Nucleic acids research
Influence of cellular sequences on instability of plasmid integration sites in human cells.
Somatic cell and molecular genetics
Nucleotide sequence analysis of novel junctions near an unstable integrated plasmid in human cells.
Gene
Association of high rate of recombination with amplification of dominant selectable gene in human cells.
Somatic cell and molecular genetics
Inducible gene expression by DNA rearrangements in human cells.
Molecular and cellular biology
Establishment and characterization of a permanent pSV ori--transformed ataxia-telangiectasia cell line.
Experimental cell research
Effect of heat shock on the intracellular distribution of proteins.
Radiation research
Effect of 3-aminobenzamide on sister chromatid exchange frequency in X-irradiated cells.
Radiation research
Complementation of the defects of DNA synthesis in irradiated and unirradiated ataxia-telangiectasia cells.
Proceedings of the National Academy of Sciences of the United States of America
Irreparable DNA cross-links and mammalian cell lethality with bifunctional alkylating agents.
Chemico-biological interactions
The structure of methylated xanthines in relation to their effects on DNA synthesis and cell lethality in nitrogen mustard-treated cells.
Biophysical journal
Mice, men, mustard and methylated xanthines: the potential role of caffeine and related drugs in the sensitization of human tumours to alkylating agents.
British journal of cancer
Effects of methylated xanthines on mammalian cells treated with bifunctional alkylating agents.
Nature
Cytomegalovirus proteins: II. Polypeptide composition of cytomegalovirus complement-fixing antigen.
Journal of medical virology
Cytomegalovirus proteins. I. Polypeptides of virions and dense bodies.
Journal of virology