John Murnane, PhD

Professor Emeritus
Radiation Oncology
+1 415 476-9083

John Murnane, PhD studies the relationship between DNA repair and telomere loss, and the role of telomere loss in the extensive chromosome instability in cancer cells. 

Publications: 

Telomeric Double Strand Breaks in G1 Human Cells Facilitate Formation of 5' C-Rich Overhangs and Recruitment of TERRA.

Frontiers in genetics

Nelson CB, Alturki TM, Luxton JJ, Taylor LE, Maranon DG, Muraki K, Murnane JP, Bailey SM

Loss of TGFβ signaling increases alternative end-joining DNA repair that sensitizes to genotoxic therapies across cancer types.

Science translational medicine

Liu Q, Palomero L, Moore J, Guix I, Espín R, Aytés A, Mao JH, Paulovich AG, Whiteaker JR, Ivey RG, Iliakis G, Luo D, Chalmers AJ, Murnane J, Pujana MA, Barcellos-Hoff MH

Defining the mutation signatures of DNA polymerase θ in cancer genomes.

NAR cancer

Hwang T, Reh S, Dunbayev Y, Zhong Y, Takata Y, Shen J, McBride KM, Murnane JP, Bhak J, Lee S, Wood RD, Takata KI

Misrepair in Context: TGFβ Regulation of DNA Repair.

Frontiers in oncology

Liu Q, Lopez K, Murnane J, Humphrey T, Barcellos-Hoff MH

Subjugation of TGFβ Signaling by Human Papilloma Virus in Head and Neck Squamous Cell Carcinoma Shifts DNA Repair from Homologous Recombination to Alternative End Joining.

Clinical cancer research : an official journal of the American Association for Cancer Research

Liu Q, Ma L, Jones T, Palomero L, Pujana MA, Martinez-Ruiz H, Ha PK, Murnane J, Cuartas I, Seoane J, Baumann M, Linge A, Barcellos-Hoff MH

In memoriam: Robert Blair Painter.

Radiation research

Murnane JP

Numerical chromosomal instability mediates susceptibility to radiation treatment.

Nature communications

Bakhoum SF, Kabeche L, Wood MD, Laucius CD, Qu D, Laughney AM, Reynolds GE, Louie RJ, Phillips J, Chan DA, Zaki BI, Murnane JP, Petritsch C, Compton DA

Analysis of dose distribution and risk of pneumonitis in stereotactic body radiation therapy for centrally located lung tumors: a comparison of robotic radiosurgery, helical tomotherapy and volumetric modulated arc therapy.

Technology in cancer research & treatment

Kannarunimit D, Descovich M, Garcia A, Chen J, Weinberg V, Mcguinness C, Pinnaduwage D, Murnane J, Gottschalk AR, Yom SS

DNA-damage response during mitosis induces whole-chromosome missegregation.

Cancer discovery

Bakhoum SF, Kabeche L, Murnane JP, Zaki BI, Compton DA

Mechanisms of telomere loss and their consequences for chromosome instability.

Frontiers in oncology

Muraki K, Nyhan K, Han L, Murnane JP

Subtelomeric regions in mammalian cells are deficient in DNA double-strand break repair.

DNA repair

Miller D, Reynolds GE, Mejia R, Stark JM, Murnane JP

Increased sensitivity of subtelomeric regions to DNA double-strand breaks in a human cancer cell line.

DNA repair

Zschenker O, Kulkarni A, Miller D, Reynolds GE, Granger-Locatelli M, Pottier G, Sabatier L, Murnane JP

Telomerase-dependent and -independent chromosome healing in mouse embryonic stem cells.

DNA repair

Gao Q, Reynolds GE, Wilcox A, Miller D, Cheung P, Artandi SE, Murnane JP

Telomeric transgenes are silenced in adult mouse tissues and embryo fibroblasts but are expressed in embryonic stem cells.

Stem cells (Dayton, Ohio)

Gao Q, Reynolds GE, Innes L, Pedram M, Jones E, Junabi M, Gao DW, Ricoul M, Sabatier L, Van Brocklin H, Franc BL, Murnane JP

Suppression of anchorage-independent growth by expression of the ataxia-telangiectasia group D complementing gene, ATDC.

Biochemical and biophysical research communications

Hosoi Y, Kapp LN, Murnane JP, Matsumoto Y, Enomoto A, Ono T, Miyagawa K

Telomeres, chromosome instability and cancer.

Nucleic acids research

Bailey SM, Murnane JP

Telomere position effect and silencing of transgenes near telomeres in the mouse.

Molecular and cellular biology

Pedram M, Sprung CN, Gao Q, Lo AW, Reynolds GE, Murnane JP

Decoding the fine-scale structure of a breast cancer genome and transcriptome.

Genome research

Volik S, Raphael BJ, Huang G, Stratton MR, Bignel G, Murnane J, Brebner JH, Bajsarowicz K, Paris PL, Tao Q, Kowbel D, Lapuk A, Shagin DA, Shagina IA, Gray JW, Cheng JF, de Jong PJ, Pevzner P, Collins C

The loss of a single telomere can result in instability of multiple chromosomes in a human tumor cell line.

Molecular cancer research : MCR

Sabatier L, Ricoul M, Pottier G, Murnane JP

Chromosome rearrangements resulting from telomere dysfunction and their role in cancer.

BioEssays : news and reviews in molecular, cellular and developmental biology

Murnane JP, Sabatier L

Applications and technical challenges of fluorescence in situ hybridization in stem cell research.

Blood cells, molecules & diseases

Weier HU, Chu LW, Murnane JP, Weier JF

Human fibroblasts expressing hTERT show remarkable karyotype stability even after exposure to ionizing radiation.

Cytogenetic and genome research

Pirzio LM, Freulet-Marrière MA, Bai Y, Fouladi B, Murnane JP, Sabatier L, Desmaze C

Interstitial telomeric repeats are not preferentially involved in radiation-induced chromosome aberrations in human cells.

Cytogenetic and genome research

Desmaze C, Pirzio LM, Blaise R, Mondello C, Giulotto E, Murnane JP, Sabatier L

DNA amplification by breakage/fusion/bridge cycles initiated by spontaneous telomere loss in a human cancer cell line.

Neoplasia (New York, N.Y.)

Lo AW, Sabatier L, Fouladi B, Pottier G, Ricoul M, Murnane JP

Chromosome instability as a result of double-strand breaks near telomeres in mouse embryonic stem cells.

Molecular and cellular biology

Lo AW, Sprung CN, Fouladi B, Pedram M, Sabatier L, Ricoul M, Reynolds GE, Murnane JP

The relationship between spontaneous telomere loss and chromosome instability in a human tumor cell line.

Neoplasia (New York, N.Y.)

Fouladi B, Sabatier L, Miller D, Pottier G, Murnane JP

Telomere instability in a human cancer cell line.

Mutation research

Sprung CN, Afshar G, Chavez EA, Lansdorp P, Sabatier L, Murnane JP

Chromosome healing in mouse embryonic stem cells.

Proceedings of the National Academy of Sciences of the United States of America

Sprung CN, Reynolds GE, Jasin M, Murnane JP

Telomere dynamics in a human cancer cell line.

Experimental cell research

Sprung CN, Sabatier L, Murnane JP

The contribution of DNA ploidy to radiation sensitivity in human tumour cell lines.

British journal of cancer

Schwartz JL, Murnane J, Weichselbaum RR

The influence of interstitial telomeric sequences on chromosome instability in human cells.

Cytogenetics and cell genetics

Desmaze C, Alberti C, Martins L, Pottier G, Sprung CN, Murnane JP, Sabatier L

Normal telomere maintenance in immortal ataxia telangiectasia cell lines.

Mutation research

Sprung CN, Bryan TM, Reddel RR, Murnane JP

Effect of telomere length on telomeric gene expression.

Nucleic acids research

Sprung CN, Sabatier L, Murnane JP

The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor.

Proceedings of the National Academy of Sciences of the United States of America

Brzoska PM, Chen H, Zhu Y, Levin NA, Disatnik MH, Mochly-Rosen D, Murnane JP, Christman MF

A role for genomic instability in cellular radioresistance?

Cancer metastasis reviews

Morgan WF, Murnane JP

Expression of the candidate A-T gene ATDC is not detectable in a human cell line with a normal response to ionizing radiation.

International journal of radiation biology

Murnane JP, Zhu Y, Young BR, Christman MF

Telomere dynamics in an immortal human cell line.

The EMBO journal

Murnane JP, Sabatier L, Marder BA, Morgan WF

Cell checkpoint and radiosensitivity.

Nature

Murnane JP, Schwartz JL

A radiation hybrid map of human chromosome 11q22-q23 containing the ataxia-telangiectasia disease locus.

Genomics

Richard CW, Cox DR, Kapp L, Murnane J, Cornelis F, Julier C, Lathrop GM, James MR

Cloning of a candidate gene for ataxia-telangiectasia group D.

American journal of human genetics

Kapp LN, Painter RB, Yu LC, van Loon N, Richard CW, James MR, Cox DR, Murnane JP

The role of recombinational hotspots in genome instability in mammalian cells.

BioEssays : news and reviews in molecular, cellular and developmental biology

Murnane JP

Enhanced expression of procollagenase in ataxia-telangiectasia and xeroderma pigmentosum fibroblasts.

In vitro cellular & developmental biology : journal of the Tissue Culture Association

Aggeler J, Murnane JP

Inducible gene expression by DNA rearrangements in human cells.

Molecular and cellular biology

Murnane JP

Effect of 3-aminobenzamide on sister chromatid exchange frequency in X-irradiated cells.

Radiation research

Morgan WF, Schwartz JL, Murnane JP, Wolff S

Complementation of the defects of DNA synthesis in irradiated and unirradiated ataxia-telangiectasia cells.

Proceedings of the National Academy of Sciences of the United States of America

Murnane JP, Painter RB

Cytomegalovirus proteins: II. Polypeptide composition of cytomegalovirus complement-fixing antigen.

Journal of medical virology

Fiala M, Heiner DC, Murnane J, Guze LB

Cytomegalovirus proteins. I. Polypeptides of virions and dense bodies.

Journal of virology

Fiala M, Honess RW, Heiner DC, Heine JW, Murnane J, Wallace R, Guze LB