
Professor
Anatomy
+1 415 476-3977
Jeroen Roose, PhD studies Ras signaling and its impact on lineage decisions in stem cells and progenitor cells.
Publications
nSMase2-mediated exosome secretion shapes the tumor microenvironment to immunologically support pancreatic cancer.
bioRxiv : the preprint server for biology
Abstract A066: nSMase2-mediated exosome secretion shapes the tumor microenvironment to immunologically support pancreatic cancer.
Cancer research
Immediate myeloid depot for SARS-CoV-2 in the human lung.
Science advances
NF-κB inhibitor alpha controls SARS-CoV-2 infection in ACE2-overexpressing human airway organoids.
Scientific reports
Focal adhesion kinase-YAP signaling axis drives drug-tolerant persister cells and residual disease in lung cancer.
Nature communications
Abstract A046: nSMase2-generated ceramide promotes PDA aggression through exosome reprogramming of the stroma.
Cancer research
Single cell proteomics characterization of bone marrow hematopoiesis with distinct Ras pathway lesions.
bioRxiv : the preprint server for biology
Cutting Edge: Induced Loss of Rasgrp1 in Peripheral CD4+ T Cells of Conditional Rasgrp1-Deficient Mice Reveals an Essential Role for Rasgrp1 in TCR/CD28-Induced Ras-MAPK Signaling.
Journal of immunology (Baltimore, Md. : 1950)
Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression.
Cancer cell
SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants.
Stem cell reports
Abstract IA022: Cell archetypes in human brain metastases: Connecting programs in tumor cells with the microenvironment.
Cancer research
NF-κB inhibitor alpha has a cross-variant role during SARS-CoV-2 infection in ACE2-overexpressing human airway organoids.
bioRxiv : the preprint server for biology
Immediate myeloid depot for SARS-CoV-2 in the human lung.
Research square
Immediate myeloid depot for SARS-CoV-2 in the human lung.
bioRxiv : the preprint server for biology
Editorial overview: Communities in immune cell signaling.
Current opinion in immunology
603 Autoreactivity drives increased metabolism in T cells from SLE patients?.
Lupus Science & Medicine
SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator.
bioRxiv : the preprint server for biology
T cells: a dedicated effector kinase pathways for every trait?
The Biochemical journal
Regulation of the Small GTPase Ras and Its Relevance to Human Disease.
Methods in molecular biology (Clifton, N.J.)
Dysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity.
European journal of immunology
Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo.
Cell stem cell
Protocol for Comprehensive Synthetic Lethality Screens.
STAR protocols
Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases.
Science (New York, N.Y.)
mTOR and other effector kinase signals that impact T cell function and activity.
Immunological reviews
Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation.
Science signaling
RasGRP1 is a potential biomarker to stratify anti-EGFR therapy response in colorectal cancer.
JCI insight
High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions.
Cell reports
Tonic Signals: Why Do Lymphocytes Bother?
Trends in immunology
Lost GRP on cytotoxicity?
Nature immunology
One-way membrane trafficking of SOS in receptor-triggered Ras activation.
Nature structural & molecular biology
Distinct oncogenic Ras signals characterized by profound differences in flux through the RasGDP/RasGTP cycle.
Small GTPases
Abstract B22: Screening and validation of combination therapy in T cell leukemia.
Technologies Used in Basic Cancer Research
Suppressive signals in colorectal cancer: RasGRP1 a new marker for anti-EGFR therapy?.
Journal of Clinical Oncology
Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Kinase and Phosphatase Effector Pathways in T Cells.
Encyclopedia of Immunobiology
Abstract 2138: RasGRP3 mediates MAPK pathway activation in GNAQ mutant uveal melanoma.
Molecular and cellular biology
RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth.
Nature cell biology
Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia.
Journal of immunology (Baltimore, Md. : 1950)
Editorial overview: lymphocyte development and activation: lymphocytes, integrators of information.
Current opinion in immunology
Flavors of EGFR-Ras signals impacting intestinal homeostasis.
Cell cycle (Georgetown, Tex.)
Abstract LB-306: The Ras exchange factor RasGRP1 opposes proliferative EGFR-SOS1 Ras signals and restricts intestinal epithelial cell growth.
Molecular and cellular biology
Protein kinase Cδ promotes transitional B cell-negative selection and limits proximal B cell receptor signaling to enforce tolerance.
Molecular and cellular biology
PLC-γ and PI3K link cytokines to ERK activation in hematopoietic cells with normal and oncogenic Kras.
Science signaling
RasGRP Ras guanine nucleotide exchange factors in cancer.
Frontiers in biology
Regulation of ras exchange factors and cellular localization of ras activation by lipid messengers in T cells.
Frontiers in immunology
Biochemical heterogeneity and developmental varieties in T-cell leukemia.
Cell cycle (Georgetown, Tex.)
Activation of extracellular signal-regulated kinase but not of p38 mitogen-activated protein kinase pathways in lymphocytes requires allosteric activation of SOS.
Molecular and cellular biology
Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis.
Science signaling
A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice.
Journal of immunology (Baltimore, Md. : 1950)
The membrane environment can promote or suppress bistability in cell signaling networks.
The journal of physical chemistry. B
Stim1, PKCd and RasGRP proteins set a threshold for pro-apoptotic Erk signaling during B cell development (109.6).
The Journal of Immunology
STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development.
Nature immunology
Abstract 3837: PI-3 kinase acts upstream of oncogenic Ras in hematopoietic cells through a cytokine-PLC?-RasGRP pathway.
Cellular and Molecular Biology
Molecular origin and functional consequences of digital signaling and hysteresis during Ras activation in lymphocytes.
Science signaling
Origin of the sharp boundary that discriminates positive and negative selection of thymocytes.
Proceedings of the National Academy of Sciences of the United States of America
Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes.
Molecular and cellular biology
Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4.
The Journal of experimental medicine
A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells.
Molecular and cellular biology
Intramolecular regulatory switch in ZAP-70: analogy with receptor tyrosine kinases.
Molecular and cellular biology
T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression.
PLoS biology
All Tcf HMG box transcription factors interact with Groucho-related co-repressors.
Nucleic acids research
T cells: getting a GRP on Ras.
Nature immunology
dTcf antagonises Wingless signalling during the development and patterning of the wing in Drosophila.
The International journal of developmental biology
Differential expression of the Groucho-related genes 4 and 5 during early development of Xenopus laevis.
Mechanisms of development
TCF transcription factors: molecular switches in carcinogenesis.
Biochimica et biophysica acta
Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1.
Science (New York, N.Y.)
Differential expression of the HMG box transcription factors XTcf-3 and XLef-1 during early xenopus development.
Mechanisms of development
Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse.
Molecular and cellular biology
High expression of the HMG box factor sox-13 in arterial walls during embryonic development.
Nucleic acids research
The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization.
Genomics
The winged-helix transcription factor Trident is expressed in actively dividing lymphocytes.
Immunobiology
The winged-helix transcription factor Trident is expressed in cycling cells.
Nucleic acids research
Characterization of the gene encoding the polymorphic immunodominant molecule, a neutralizing antigen of Theileria parva.
Journal of immunology (Baltimore, Md. : 1950)
Synthetic protease inhibitors: promising compounds to arrest pathobiologic processes.
The Journal of laboratory and clinical medicine