
Professor and Chair
Biochemistry and Biophysics
+1 415 476-0156
Jeremy Reiter, MD, PhD focuses on identifying novel intercellular signals that direct the differentiation of embryonic stem cells along defined lineages.
Publications
Smoothened inhibition of PKA at cilia transduces Hedgehog signals.
bioRxiv : the preprint server for biology
Multicilia dynamically transduce Sonic Hedgehog signaling to regulate choroid plexus functions.
Cell reports
Multicilia dynamically transduce Shh signaling to regulate choroid plexus functions.
bioRxiv : the preprint server for biology
ADPKD-Causing Missense Variants in Polycystin-1 Disrupt Cell Surface Localization or Polycystin Channel Function.
bioRxiv : the preprint server for biology
The human ciliopathy protein RSG1 links the CPLANE complex to transition zone architecture.
bioRxiv : the preprint server for biology
Variants in tubule epithelial regulatory elements mediate most heritable differences in human kidney function.
Nature genetics
Cilia-enriched oxysterol 7β,27-DHC is required for polycystin ion channel activation.
Nature communications
Variants in tubule epithelial regulatory elements mediate most heritable differences in human kidney function.
bioRxiv : the preprint server for biology
Rab35 Is Required for Embryonic Development and Kidney and Ureter Homeostasis through Regulation of Epithelial Cell Junctions.
Journal of the American Society of Nephrology : JASN
Emerging mechanistic understanding of cilia function in cellular signalling.
Nature reviews. Molecular cell biology
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway.
Nature structural & molecular biology
Polycystin-2-dependent transcriptome reveals early response of autosomal dominant polycystic kidney disease.
Physiological genomics
Rab35 is required for embryonic development and kidney and ureter homeostasis through regulation of epithelial cell junctions.
bioRxiv : the preprint server for biology
An RFX transcription factor regulates ciliogenesis in the closest living relatives of animals.
Current biology : CB
Hedgehog target genes regulate lipid metabolism to drive basal cell carcinoma and medulloblastoma.
Research square
Seriously cilia: A tiny organelle illuminates evolution, disease, and intercellular communication.
Developmental cell
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway.
bioRxiv : the preprint server for biology
A kinesin mimics DNA.
Nature cell biology
The Intimate Connection Between Lipids and Hedgehog Signaling.
Frontiers in cell and developmental biology
The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans.
Science (New York, N.Y.)
Endoderm development requires centrioles to restrain p53-mediated apoptosis in the absence of ERK activity.
Developmental cell
ATXN10 Is Required for Embryonic Heart Development and Maintenance of Epithelial Cell Phenotypes in the Adult Kidney and Pancreas.
Frontiers in cell and developmental biology
Ciliary Hedgehog signaling patterns the digestive system to generate mechanical forces driving elongation.
Nature communications
A ciliopathy complex builds distal appendages to initiate ciliogenesis.
The Journal of cell biology
Label-retention expansion microscopy.
The Journal of cell biology
Melanocortin 4 receptor signals at the neuronal primary cilium to control food intake and body weight.
The Journal of clinical investigation
Smoothened-activating lipids drive resistance to CDK4/6 inhibition in Hedgehog-associated medulloblastoma cells and preclinical models.
The Journal of clinical investigation
Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway.
The Journal of cell biology
How the centriole builds its cilium: of mothers, daughters, and the acquisition of appendages.
Current opinion in structural biology
SFI1 promotes centriole duplication by recruiting USP9X to stabilize the microcephaly protein STIL.
The Journal of cell biology
Hedgehog Pathway Activation Alters Ciliary Signaling in Primary Hypothalamic Cultures.
Frontiers in cellular neuroscience
Misactivation of Hedgehog signaling causes inherited and sporadic cancers.
The Journal of clinical investigation
Cilia-Associated Oxysterols Activate Smoothened.
Molecular cell
How the Ciliary Membrane Is Organized Inside-Out to Communicate Outside-In.
Current biology : CB
Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity.
Nature genetics
Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways.
Developmental cell
Hedgehog signaling drives medulloblastoma growth via CDK6.
The Journal of clinical investigation
Erratum: Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome.
Nature cell biology
Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome.
Nature cell biology
Genes and molecular pathways underpinning ciliopathies.
Nature reviews. Molecular cell biology
Cilia and Obesity.
Cold Spring Harbor perspectives in biology
Open Sesame: How Transition Fibers and the Transition Zone Control Ciliary Composition.
Cold Spring Harbor perspectives in biology
Endothelial primary cilia inhibit atherosclerosis.
EMBO reports
Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling.
PLoS genetics
Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling.
Developmental cell
TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone.
The Journal of cell biology
Ciliary vesicle formation: a prelude to ciliogenesis.
Developmental cell
Hair follicle and interfollicular epidermal stem cells make varying contributions to wound regeneration.
Cell cycle (Georgetown, Tex.)
C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals.
Proceedings of the National Academy of Sciences of the United States of America
A central region of Gli2 regulates its localization to the primary cilium and transcriptional activity.
Journal of cell science
Hedgehog signaling controls T cell killing at the immunological synapse.
Science (New York, N.Y.)
Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration.
Development (Cambridge, England)
Thyroid-specific inactivation of KIF3A alters the TSH signaling pathway and leads to hypothyroidism.
Journal of molecular endocrinology
Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages.
The EMBO journal
Trask loss enhances tumorigenic growth by liberating integrin signaling and growth factor receptor cross-talk in unanchored cells.
Cancer research
Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis.
Proceedings of the National Academy of Sciences of the United States of America
Scoring a backstage pass: mechanisms of ciliogenesis and ciliary access.
The Journal of cell biology
A high-fat diet regulates gastrin and acid secretion through primary cilia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal.
PLoS genetics
Disruption of a ciliary B9 protein complex causes Meckel syndrome.
American journal of human genetics
A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.
Nature genetics
Role of epidermal primary cilia in the homeostasis of skin and hair follicles.
Development (Cambridge, England)
Wounding mobilizes hair follicle stem cells to form tumors.
Proceedings of the National Academy of Sciences of the United States of America
Crippling SWI-SNF makes tumors GLI-ful.
Nature medicine
The ciliogenic protein Oral-Facial-Digital 1 regulates the neuronal differentiation of embryonic stem cells.
Stem cells and development
Tilting at nodal windmills: planar cell polarity positions cilia to tell left from right.
Developmental cell
Vive la science! Vive le hérisson!
EMBO reports
Ofd1, a human disease gene, regulates the length and distal structure of centrioles.
Developmental cell
Floxin, a resource for genetically engineering mouse ESCs.
Nature methods
Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis.
Nature medicine
The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signaling.
Current biology : CB
Building it up and taking it down: the regulation of vertebrate ciliogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists
A cilium is not a cilium is not a cilium: signaling contributes to ciliary morphological diversity.
Developmental cell
Neur-ons and neur-offs: regulators of neural induction in vertebrate embryos and embryonic stem cells.
Human molecular genetics
The primary cilium at the crossroads of mammalian hedgehog signaling.
Current topics in developmental biology
Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms.
Nature cell biology
Vesicle transport, cilium formation, and membrane specialization: the origins of a sensory organelle.
Proceedings of the National Academy of Sciences of the United States of America
The primary cilium as the cell's antenna: signaling at a sensory organelle.
Science (New York, N.Y.)
Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition.
Genes & development
Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli.
Developmental biology
Notch signaling can regulate endoderm formation in zebrafish.
Developmental dynamics : an official publication of the American Association of Anatomists
Bmp2b and Oep promote early myocardial differentiation through their regulation of gata5.
Developmental biology
Multiple roles for Gata5 in zebrafish endoderm formation.
Development (Cambridge, England)
The zebrafish bonnie and clyde gene encodes a Mix family homeodomain protein that regulates the generation of endodermal precursors.
Genes & development
Gata5 is required for the development of the heart and endoderm in zebrafish.
Genes & development