
Professor and Chair
Pathology
+1 415 514-0681
Jayanta Debnath, MD is working to understand the role and regulation of autophagy in epithelial homeostasis and cancer pathogenesis.
Publications
First in-beam experiment in K500 superconducting cyclotron at VECC.
Nuclear Physics A
Magnetic field optimisation and study of beam dynamics in 50 MeV compact H- cyclotron.
Journal of Instrumentation
Characterization of the first beam from the K 500 superconducting cyclotron at VECC.
Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment
Lysosomal lipid peroxidation mediates immunogenic cell death.
The Journal of clinical investigation
Autophagy and autophagy-related pathways in cancer.
Nature reviews. Molecular cell biology
Control of unconventional secretion by the autophagy machinery
Curr Opin Physiology
Control of Unconventional Secretion By The Autophagy Machinery.
Current Opinion in Physiology
Autophagy in PDGFRa+ mesenchymal cells is essential for intestinal stem cell survival.
Proceedings of the National Academy of Sciences of the United States of America
Secretory autophagy maintains proteostasis upon lysosome inhibition.
The Journal of cell biology
A beam dynamics study for efficient extraction from the VECC K500 superconducting cyclotron.
Journal of Instrumentation
Pathology: Hub and Integrator of Modern, Multidisciplinary [Precision] Oncology.
Clinical cancer research : an official journal of the American Association for Cancer Research
GRASP55 restricts early-stage autophagy and regulates spatial organization of the early secretory network.
Biology open
Longitudinal tracking of neuronal mitochondria delineates PINK1/Parkin-dependent mechanisms of mitochondrial recycling and degradation.
Science advances
Autophagy in stromal fibroblasts promotes tumor desmoplasia and mammary tumorigenesis.
Genes & development
Atg32-dependent mitophagy sustains spermidine and nitric oxide required for heat-stress tolerance in Saccharomycescerevisiae.
Journal of cell science
Atg32 dependent mitophagy sustains spermidine and nitric oxide required for heat stress tolerance in S. cerevisiae.
Journal of cell science
Emerging roles for the autophagy machinery in extracellular vesicle biogenesis and secretion.
FASEB bioAdvances
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
Autophagy
Beyond Autophagy: The Expanding Roles of ATG8 Proteins.
Trends in biochemical sciences
The pleiotropic functions of autophagy in metastasis.
Journal of cell science
The pleiotropic functions of autophagy in metastasis.
Journal of cell science
Unconventional secretion: cargo channeling by TMED10.
Cell research
Ribosome profiling reveals a functional role for autophagy in mRNA translational control.
Communications biology
Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression.
Developmental cell
Unraveling the mechanisms that specify molecules for secretion in extracellular vesicles.
Methods (San Diego, Calif.)
The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles.
Nature cell biology
An ATG16L1-dependent pathway promotes plasma membrane repair and limits Listeria monocytogenes cell-to-cell spread.
Nature microbiology
Autophagy and the cell biology of age-related disease.
Nature cell biology
WIPIng the Brakes off Autophagy Induction.
Molecular cell
CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling.
The EMBO journal
Macropinocytosis Fuels Prostate Cancer.
Cancer discovery
Atg12-Atg3 Coordinates Basal Autophagy, Endolysosomal Trafficking, and Exosome Release.
Molecular & cellular oncology
Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins.
The Journal of cell biology
Autophagy-Dependent Shuttling of TBC1D5 Controls Plasma Membrane Translocation of GLUT1 and Glucose Uptake.
Molecular cell
Molecular definitions of autophagy and related processes.
The EMBO journal
The Interconnections between Autophagy and Integrin-Mediated Cell Adhesion.
Journal of molecular biology
A computationally engineered RAS rheostat reveals RAS-ERK signaling dynamics.
Nature chemical biology
Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment.
The Journal of clinical investigation
Autophagy in adhesion and migration.
Journal of cell science
At the crossroads of autophagy and infection: Noncanonical roles for ATG proteins in viral replication.
The Journal of cell biology
Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance.
Cell metabolism
NBR1-dependent selective autophagy is required for efficient cell-matrix adhesion site disassembly.
Autophagy
The Evolving, Multifaceted Roles of Autophagy in Cancer.
Advances in cancer research
NBR1 enables autophagy-dependent focal adhesion turnover.
The Journal of cell biology
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy
Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection.
Nature
Autophagy Devours the Nuclear Lamina to Thwart Oncogenic Stress.
Developmental cell
Autophagy at the crossroads of catabolism and anabolism.
Nature reviews. Molecular cell biology
Atg12–Atg3 Coordinates Basal Autophagy, Endolysosomal Trafficking, and Exosome Release.
Molecular & cellular oncology
Autophagy in malignant transformation and cancer progression.
The EMBO journal
ATG12-ATG3 interacts with Alix to promote basal autophagic flux and late endosome function.
Nature cell biology
A nuclear option that initiates autophagy.
Molecular cell
Autophagy-independent senescence and genome instability driven by targeted telomere dysfunction.
Autophagy
Ironing out VPS34 inhibition.
Nature cell biology
Loss of Atg12, but not Atg5, in pro-opiomelanocortin neurons exacerbates diet-induced obesity.
Autophagy
Cellular and metabolic functions for autophagy in cancer cells.
Trends in cell biology
Mouse models address key concerns regarding autophagy inhibition in cancer therapy.
Cancer discovery
'Doubling down' on the autophagy pathway to suppress tumor growth.
Genes & development
Autophagy-dependent production of secreted factors facilitates oncogenic RAS-driven invasion.
Cancer discovery
Autophagy and cancer metabolism.
Methods in enzymology
Oncogenic targeting of BRM drives malignancy through C/EBP�-dependent induction of a5 integrin.
Oncogene
Abstract 2924: The role of autophagy in telomere damage-induced replicative senescence.
Molecular and cellular biology
Regulation of tumor cell dormancy by tissue microenvironments and autophagy.
Advances in experimental medicine and biology
Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK.
Oncogene
Autophagy as a stress-response and quality-control mechanism: implications for cell injury and human disease.
Annual review of pathology
Cyclic AMP regulates formation of mammary epithelial acini in vitro.
Molecular biology of the cell
cAMP regulates polarization and apoptosis during mammary epithelial acini formation in vitro.
The FASEB Journal
Targeting chaperone-mediated autophagy in cancer.
Science translational medicine
The multifaceted roles of autophagy in tumors-implications for breast cancer.
Journal of mammary gland biology and neoplasia
PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment.
Molecular and cellular biology
Autophagy suppression promotes apoptotic cell death in response to inhibition of the PI3K-mTOR pathway in pancreatic adenocarcinoma.
Journal of molecular medicine (Berlin, Germany)
Ras, autophagy and glycolysis.
Cell cycle (Georgetown, Tex.)
ATG12-ATG3 and mitochondria.
Autophagy
Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation.
Molecular biology of the cell
Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST).
Proceedings of the National Academy of Sciences of the United States of America
Autophagy and tumorigenesis.
Seminars in immunopathology
A computational approach to resolve cell level contributions to early glandular epithelial cancer progression.
BMC systems biology
Autophagy and tumorigenesis.
FEBS letters
Autophagy and metastasis: another double-edged sword.
Current opinion in cell biology
Computational investigation of epithelial cell dynamic phenotype in vitro.
Theoretical biology & medical modelling
Ubiquilins accelerate autophagosome maturation and promote cell survival during nutrient starvation.
Autophagy
PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation.
EMBO reports
Detachment-induced autophagy in three-dimensional epithelial cell cultures.
Methods in enzymology
Extracellular matrix regulation of autophagy.
Current opinion in cell biology
Modeling morphogenesis and oncogenesis in three-dimensional breast epithelial cultures.
Annual review of pathology
Induction of autophagy during extracellular matrix detachment promotes cell survival.
Molecular biology of the cell
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.
Autophagy
The Dual Roles for Autophagy in Cell Death and Survival.
Autophagy in Immunity and Infection
Modelling glandular epithelial cancers in three-dimensional cultures.
Nature reviews. Cancer
Does autophagy contribute to cell death?
Autophagy
Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture.
The Journal of cell biology
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro.
Proceedings of the National Academy of Sciences of the United States of America
Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner.
The Journal of cell biology
Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis.
Nature cell biology
Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures.
Methods (San Diego, Calif.)
Biochemical and genetic analyses of the Tec kinases Itk and Rlk/Txk.
Biochemical Society Transactions
Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk.
BMC immunology
Tec family kinases modulate thresholds for thymocyte development and selection.
The Journal of experimental medicine
Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity.
Science (New York, N.Y.)
rlk/TXK encodes two forms of a novel cysteine string tyrosine kinase activated by Src family kinases.
Molecular and cellular biology
HPLC-based method for determination of absolute configuration of alpha-chiral amines.
Analytical chemistry
Activation of an adrenergic pro-drug through sequential stereoselective action of tandem target enzymes.
Biochemical and biophysical research communications