Jason Cyster, PhD

Professor
Microbiology and Immunology
+1 415 502-6427

Jason Cyster, PhD studies lymphocyte trafficking and homeostasis.

Publications: 

Phosphatidylserine phospholipase A1 enables GPR34-dependent immune cell accumulation in the peritoneal cavity.

The Journal of experimental medicine

Tam H, Xu Y, An J, Schöneberg T, Schulz A, Muppidi JR, Cyster JG

Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer.

bioRxiv : the preprint server for biology

Cleary SJ, Qiu L, Seo Y, Baluk P, Liu D, Serwas NK, Cyster JG, McDonald DM, Krummel MF, Looney MR

LB869 Single-cell RNA-seq analysis of circulating immune cells in dermatomyositis in patients with and without a history of cancer.

Journal of Investigative Dermatology

M.A. Mintz, M. Kazmi, A. Almonte Loya, E. Flynn, L. Maliskova, W. Eckalbar, A.J. Combes, G.K. Fragiadakis, J.G. Cyster, A. Haemel

Participant-derived cell line transcriptomic analyses and mouse studies reveal a role for ZNF335 in plasma cholesterol statin response.

Genome medicine

Theusch E, Ting FY, Qin Y, Stevens K, Naidoo D, King SM, Yang NV, Orr J, Han BY, Cyster JG, Chen YI, Rotter JI, Krauss RM, Medina MW

Plasma membrane abundance dictates phagocytic capacity and functional cross-talk in myeloid cells.

Science immunology

Winer BY, Settle AH, Yakimov AM, Jeronimo C, Lazarov T, Tipping M, Saoi M, Sawh A, Sepp AL, Galiano M, Perry JSA, Wong YY, Geissmann F, Cross J, Zhou T, Kam LC, Pasolli HA, Hohl T, Cyster JG, Weiner OD, Huse M

Dermal TRPV1 innervations engage a macrophage- and fibroblast-containing pathway to activate hair growth in mice.

Developmental cell

Ben-Shaanan TL, Knöpper K, Duan L, Liu R, Taglinao H, Xu Y, An J, Plikus MV, Cyster JG

Lymphoid tissue on the mind.

Trends in immunology

Kirthivasan N, Cyster JG

Mast cells help organize the Peyer's patch niche for induction of IgA responses.

Science immunology

De Giovanni M, Vykunta VS, Biram A, Chen KY, Taglinao H, An J, Sheppard D, Paidassi H, Cyster JG

Dynamic encounters with red blood cells trigger splenic marginal zone B cell retention and function.

Nature immunology

Liu D, Winer BY, Chou MY, Tam H, Xu Y, An J, Gardner JM, Cyster JG

Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive Gs signaling.

Nature communications

Nie Y, Qiu Z, Chen S, Chen Z, Song X, Ma Y, Huang N, Cyster JG, Zheng S

Plasma membrane abundance dictates phagocytic capacity and functional crosstalk in myeloid cells.

bioRxiv : the preprint server for biology

Winer BY, Settle AH, Yakimov AM, Jeronimo C, Lazarov T, Tipping M, Saoi M, Sawh A, Sepp AL, Galiano M, Wong YY, Perry JSA, Geissmann F, Cross J, Zhou T, Kam LC, Pasoli HA, Hohl T, Cyster JG, Weiner OD, Huse M

Participant-derived cell line transcriptomic analyses and mouse studies reveal a role for ZNF335 in plasma cholesterol statin response.

bioRxiv : the preprint server for biology

Theusch E, Ting FY, Qin Y, Stevens K, Naidoo D, King SM, Yang N, Orr J, Han BY, Cyster JG, Chen YI, Rotter JI, Krauss RM, Medina MW

B cell peripheral tolerance is promoted by cathepsin B protease.

Proceedings of the National Academy of Sciences of the United States of America

Chou MY, Liu D, An J, Xu Y, Cyster JG

Transmembrane protein CD69 acts as an S1PR1 agonist.

eLife

Chen H, Qin Y, Chou M, Cyster JG, Li X

GPR35 and mediators from platelets and mast cells in neutrophil migration and inflammation.

Immunological reviews

De Giovanni M, Chen H, Li X, Cyster JG

Skin ?d T�cell inflammatory responses are hardwired in the thymus by oxysterol sensing via GPR183 and calibrated by dietary cholesterol.

Immunity

Frascoli M, Ferraj E, Miu B, Malin J, Spidale NA, Cowan J, Shissler SC, Brink R, Xu Y, Cyster JG, Bhandoola A, Kang J, Reboldi A

Transmembrane protein CD69 acts as an S1PR1 agonist.

bioRxiv : the preprint server for biology

Chen H, Qin Y, Chou M, Cyster JG, Li X

An epithelial cell-derived metabolite tunes immunoglobulin A secretion by gut-resident plasma cells.

Nature immunology

Ceglia S, Berthelette A, Howley K, Li Y, Mortzfeld B, Bhattarai SK, Yiew NKH, Xu Y, Brink R, Cyster JG, Hooper LV, Randolph GJ, Bucci V, Reboldi A

LT�R overexpression promotes plasma cell accumulation.

PloS one

Kotov JA, Xu Y, Carey ND, Cyster JG

GPR174 signals via Gas to control a CD86-containing gene expression program in B cells.

Proceedings of the National Academy of Sciences of the United States of America

Wolf EW, Howard ZP, Duan L, Tam H, Xu Y, Cyster JG

Epithelial-derived oxysterol production tunes intestinal IgA secretion against commensals and enteric pathogen in tissue.

The Journal of Immunology

Simona Ceglia, Alyssa Berthelette, Kelsey Howley, Yun Li, Nicole K. H. Yiew, Ying Xu, Robert Adrian Brink, Jason G. Cyster, Lora V. Hooper, Gwendalyn J. Randolph, Andrea Reboldi

Structure of S1PR2-heterotrimeric G13 signaling complex.

Science advances

Chen H, Chen K, Huang W, Staudt LM, Cyster JG, Li X

GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA.

Cell

De Giovanni M, Tam H, Valet C, Xu Y, Looney MR, Cyster JG

CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells.

Science (New York, N.Y.)

Liu D, Duan L, Rodda LB, Lu E, Xu Y, An J, Qiu L, Liu F, Looney MR, Yang Z, Allen CDC, Li Z, Marson A, Cyster JG

GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA.

Cell

De Giovanni M, Tam H, Valet C, Xu Y, Looney MR, Cyster JG

P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance.

The Journal of experimental medicine

He Y, Gallman AE, Xie C, Shen Q, Ma J, Wolfreys FD, Sandy M, Arsov T, Wu X, Qin Y, Zhang P, Jiang S, Stanley M, Wu P, Tan J, Ding H, Xue H, Chen W, Xu J, Criswell LA, Nititham J, Adamski M, Kitching AR, Cook MC, Cao L, Shen N, Cyster JG, Vinuesa CG

Lymph node-resident dendritic cells drive TH2 cell development involving MARCH1.

Science immunology

Castellanos CA, Ren X, Gonzalez SL, Li HK, Schroeder AW, Liang HE, Laidlaw BJ, Hu D, Mak ACY, Eng C, Rodr?guez-Santana JR, LeNoir M, Yan Q, Celed?n JC, Burchard EG, Zamvil SS, Ishido S, Locksley RM, Cyster JG, Huang X, Shin JS

Follicular dendritic cells restrict interleukin-4 availability in germinal centers and foster memory B cell generation.

Immunity

Duan L, Liu D, Chen H, Mintz MA, Chou MY, Kotov DI, Xu Y, An J, Laidlaw BJ, Cyster JG

Abcc1 and Ggt5 support lymphocyte guidance through export and catabolism of S-geranylgeranyl-l-glutathione.

Science immunology

Gallman AE, Wolfreys FD, Nguyen DN, Sandy M, Xu Y, An J, Li Z, Marson A, Lu E, Cyster JG

ILC3s control splenic cDC homeostasis via lymphotoxin signaling.

The Journal of experimental medicine

Vanderkerken M, Baptista AP, De Giovanni M, Fukuyama S, Browaeys R, Scott CL, Norris PS, Eberl G, Di Santo JP, Vivier E, Saeys Y, Hammad H, Cyster JG, Ware CF, Tumanov AV, De Trez C, Lambrecht BN

Long COVID in the skin: a registry analysis of COVID-19 dermatological duration.

The Lancet. Infectious diseases

McMahon DE, Gallman AE, Hruza GJ, Rosenbach M, Lipoff JB, Desai SR, French LE, Lim H, Cyster JG, Fox LP, Fassett MS, Freeman EE

Requirements for cDC2 positioning in blood-exposed regions of the neonatal and adult spleen.

The Journal of experimental medicine

Liu D, Wu J, An J, Cyster JG

Transcriptional regulation of memory B cell differentiation.

Nature reviews. Immunology

Laidlaw BJ, Cyster JG

Evaluation of SARS-CoV-2 serology assays reveals a range of test performance.

Nature biotechnology

Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong AW, Gillis-Buck EM, Steinhart ZB, Lee Y, Apathy R, Lipke MJ, Smith JA, Zheng T, Boothby IC, Isaza E, Chan J, Acenas DD, Lee J, Macrae TA, Kyaw TS, Wu D, Ng DL, Gu W, York VA, Eskandarian HA, Callaway PC, Warrier L, Moreno ME, Levan J, Torres L, Farrington LA, Loudermilk RP, Koshal K, Zorn KC, Garcia-Beltran WF, Yang D, Astudillo MG, Bernstein BE, Gelfand JA, Ryan ET, Charles RC, Iafrate AJ, Lennerz JK, Miller S, Chiu CY, Stramer SL, Wilson MR, Manglik A, Ye CJ, Krogan NJ, Anderson MS, Cyster JG, Ernst JD, Wu AHB, Lynch KL, Bern C, Hsu PD, Marson A

Marginal zone SIGN-R1+ macrophages are essential for the maturation of germinal center B cells in the spleen.

Proceedings of the National Academy of Sciences of the United States of America

Pirgova G, Chauveau A, MacLean AJ, Cyster JG, Arnon TI

Test performance evaluation of SARS-CoV-2 serological assays.

medRxiv : the preprint server for health sciences

Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong AW, Gillis-Buck EM, Steinhart ZB, Lee Y, Apathy R, Lipke MJ, Smith JA, Zheng T, Boothby IC, Isaza E, Chan J, Acenas DD, Lee J, Macrae TA, Kyaw TS, Wu D, Ng DL, Gu W, York VA, Eskandarian HA, Callaway PC, Warrier L, Moreno ME, Levan J, Torres L, Farrington LA, Loudermilk R, Koshal K, Zorn KC, Garcia-Beltran WF, Yang D, Astudillo MG, Bernstein BE, Gelfand JA, Ryan ET, Charles RC, Iafrate AJ, Lennerz JK, Miller S, Chiu CY, Stramer SL, Wilson MR, Manglik A, Ye CJ, Krogan NJ, Anderson MS, Cyster JG, Ernst JD, Wu AHB, Lynch KL, Bern C, Hsu PD, Marson A

Development of allergic airway immunity depends on MARCH1-mediated ubiquitination of MHCII and CD86 in dendritic cells.

The Journal of Immunology

Carlos A Castellanos, Xin Ren, Hong-Erh Liang, Brian J Laidlaw, Andrea Barczak, Joshua Rudolph, Walter L Eckalbar, Xiaozhu Huang, Jason G Cyster, Richard M Locksley, David J Erle, Satoshi Ishido, Jeoung-Sook Shin

GRK2 suppresses lymphomagenesis by inhibiting the MALT1 proto-oncoprotein.

The Journal of clinical investigation

Cheng J, Klei LR, Hubel NE, Zhang M, Schairer R, Maurer LM, Klei HB, Kang H, Concel VJ, Delekta PC, Dang EV, Mintz MA, Baens M, Cyster JG, Parameswaran N, Thome M, Lucas PC, McAllister-Lucas LM

The HVEM-BTLA Axis Restrains T Cell Help to Germinal Center B Cells and Functions as a Cell-Extrinsic Suppressor in Lymphomagenesis.

Immunity

Mintz MA, Felce JH, Chou MY, Mayya V, Xu Y, Shui JW, An J, Li Z, Marson A, Okada T, Ware CF, Kronenberg M, Dustin ML, Cyster JG

Sphingosine-1-phosphate receptor 2 restrains egress of ?d T cells from the skin.

The Journal of experimental medicine

Laidlaw BJ, Gray EE, Zhang Y, Ram?rez-Valle F, Cyster JG

Loss of sterol metabolic homeostasis triggers inflammasomes?-?how and why.

Current opinion in immunology

Dang EV, Cyster JG

Critical role of integrin CD11c in splenic dendritic cell capture of missing-self CD47 cells to induce adaptive immunity.

Proceedings of the National Academy of Sciences of the United States of America

Wu J, Wu H, An J, Ballantyne CM, Cyster JG

Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity.

Immunity

Rodda LB, Lu E, Bennett ML, Sokol CL, Wang X, Luther SA, Barres BA, Luster AD, Ye CJ, Cyster JG

Atypical chemokine receptor 4 shapes activated B cell fate.

The Journal of experimental medicine

Kara EE, Bastow CR, McKenzie DR, Gregor CE, Fenix KA, Babb R, Norton TS, Zotos D, Rodda LB, Hermes JR, Bourne K, Gilchrist DS, Nibbs RJ, Alsharifi M, Vinuesa CG, Tarlinton DM, Brink R, Hill GR, Cyster JG, Comerford I, McColl SR

GPR55 regulates intraepithelial lymphocyte migration dynamics and susceptibility to intestinal damage.

Science immunology

Sumida H, Lu E, Chen H, Yang Q, Mackie K, Cyster JG

Perivascular Fibroblasts of the Developing Spleen Act as LTα1β2-Dependent Precursors of Both T and B Zone Organizer Cells.

Cell reports

Schaeuble K, Britschgi MR, Scarpellino L, Favre S, Xu Y, Koroleva E, Lissandrin TKA, Link A, Matloubian M, Ware CF, Nedospasov SA, Tumanov AV, Cyster JG, Luther SA

The Eph-related tyrosine kinase ligand Ephrin-B1 marks germinal center and memory precursor B cells.

The Journal of experimental medicine

Laidlaw BJ, Schmidt TH, Green JA, Allen CD, Okada T, Cyster JG

Abstract A065: Oscillatory genes in lymphocyte retention and egress.

Other Topics

Hsin Chen, Timothy Schmidt, Ying Xu, Erick Lu, Jason G. Cyster

Interfer'n with antibody responses.

Science immunology

Laidlaw BJ, Cyster JG

Clathrin light chains' role in selective endocytosis influences antibody isotype switching.

Proceedings of the National Academy of Sciences of the United States of America

Wu S, Majeed SR, Evans TM, Camus MD, Wong NM, Schollmeier Y, Park M, Muppidi JR, Reboldi A, Parham P, Cyster JG, Brodsky FM

Migratory and adhesive cues controlling innate-like lymphocyte surveillance of the pathogen-exposed surface of the lymph node.

eLife

Zhang Y, Roth TL, Gray EE, Chen H, Rodda LB, Liang Y, Ventura P, Villeda S, Crocker PR, Cyster JG

IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches.

Science (New York, N.Y.)

Reboldi A, Arnon TI, Rodda LB, Atakilit A, Sheppard D, Cyster JG

Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses.

The Journal of experimental medicine

Bannard O, McGowan SJ, Ersching J, Ishido S, Victora GD, Shin JS, Cyster JG

Phenotypic and Morphological Properties of Germinal Center Dark Zone Cxcl12-Expressing Reticular Cells.

Journal of immunology (Baltimore, Md. : 1950)

Rodda LB, Bannard O, Ludewig B, Nagasawa T, Cyster JG

Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses.

Immunity

Yi T, Li J, Chen H, Wu J, An J, Xu Y, Hu Y, Lowell CA, Cyster JG

Getting close to the action elicits better memories.

The Journal of experimental medicine

Cyster JG

Inflammation induces dermal V?4+ ?dT17 memory-like cells that travel to distant skin and accelerate secondary IL-17-driven responses.

Proceedings of the National Academy of Sciences of the United States of America

Ram?rez-Valle F, Gray EE, Cyster JG

The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function.

The Journal of experimental medicine

Barnes MJ, Li CM, Xu Y, An J, Huang Y, Cyster JG

CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow.

The Journal of cell biology

Thomas C. Beck, Ana Cordeiro Gomes, Jason G. Cyster, João P. Pereira

CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow.

The Journal of experimental medicine

Beck TC, Gomes AC, Cyster JG, Pereira JP

GPR18 is required for a normal CD8aa intestinal intraepithelial lymphocyte compartment.

The Journal of experimental medicine

Wang X, Sumida H, Cyster JG

Zinc finger protein Zfp335 is required for the formation of the na�ve T cell compartment.

eLife

Han BY, Wu S, Foo CS, Horton RM, Jenne CN, Watson SR, Whittle B, Goodnow CC, Cyster JG

25-Hydroxycholesterols in innate and adaptive immunity.

Nature reviews. Immunology

Cyster JG, Dang EV, Reboldi A, Yi T

Loss of signalling via Ga13 in germinal centre B-cell-derived lymphoma.

Nature

Muppidi JR, Schmitz R, Green JA, Xiao W, Larsen AB, Braun SE, An J, Xu Y, Rosenwald A, Ott G, Gascoyne RD, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Vaidehi N, Staudt LM, Cyster JG

Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon.

Science (New York, N.Y.)

Reboldi A, Dang EV, McDonald JG, Liang G, Russell DW, Cyster JG

Sphingosine-1-phosphate receptor 2 is critical for follicular helper T cell retention in germinal centers.

The Journal of experimental medicine

Moriyama S, Takahashi N, Green JA, Hori S, Kubo M, Cyster JG, Okada T

Integrin-mediated interactions between B cells and follicular dendritic cells influence germinal center B cell fitness.

Journal of immunology (Baltimore, Md. : 1950)

Wang X, Rodda LB, Bannard O, Cyster JG

Blown away: the unexpected role of lymphotoxin in lymphoid organ development.

Journal of immunology (Baltimore, Md. : 1950)

Cyster JG

Blood, sphingosine-1-phosphate and lymphocyte migration dynamics in the spleen.

Current topics in microbiology and immunology

Arnon TI, Cyster JG

Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios? T cells and autoantibodies.

eLife

Daley SR, Coakley KM, Hu DY, Randall KL, Jenne CN, Limnander A, Myers DR, Polakos NK, Enders A, Roots C, Balakishnan B, Miosge LA, Sjollema G, Bertram EM, Field MA, Shao Y, Andrews TD, Whittle B, Barnes SW, Walker JR, Cyster JG, Goodnow CC, Roose JP

Germinal Center Centroblasts Transition to a Centrocyte Phenotype According to a Timed Program and Depend on the Dark Zone for Effective Selection.

Immunity

Oliver Bannard, Robert M. Horton, Christopher D.C. Allen, Jinping An, Takashi Nagasawa, Jason G. Cyster

S-3 Age-dependent hepatic lymphoid organization directs immune priming, cytokine production, and successful immunity to Hepatitis B virus.

Cytokine

Jean Publicover, Anuj Gaggar, Stephen Nishimura, Christine M. Van Horn, Amanda Goodsell, Marcus O. Muench, R. Lee Reinhardt, Nico van Rooijen, Adil E. Wakil Marion Peters, Jason G. Cyster, David J. Erle, Philip Rosenthal, Lia Avanesyan, Rosanne Spolski, Warren J. Leonard, Stewart Cooper, Jody L. Baron

Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B.

The Journal of clinical investigation

Publicover J, Gaggar A, Nishimura S, Van Horn CM, Goodsell A, Muench MO, Reinhardt RL, van Rooijen N, Wakil AE, Peters M, Cyster JG, Erle DJ, Rosenthal P, Cooper S, Baron JL

CXCR4 promotes B cell egress from Peyer's patches.

The Journal of experimental medicine

Schmidt TH, Bannard O, Gray EE, Cyster JG

CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma.

Blood

Rubenstein JL, Wong VS, Kadoch C, Gao HX, Barajas R, Chen L, Josephson SA, Scott B, Douglas V, Maiti M, Kaplan LD, Treseler PA, Cha S, Hwang JH, Cinque P, Cyster JG, Lowell C

Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses.

Immunity

Yi T, Wang X, Kelly LM, An J, Xu Y, Sailer AW, Gustafsson JA, Russell DW, Cyster JG

Immunology. When less signaling is more.

Science (New York, N.Y.)

Bannard OM, Cyster JG

S1PR2 links germinal center confinement and growth regulation.

Immunological reviews

Green JA, Cyster JG

Lymph node macrophages.

Journal of innate immunity

Gray EE, Cyster JG

Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs.

Annual review of immunology

Cyster JG, Schwab SR

How T cells earn the follicular rite of passage.

Immunity

Vinuesa CG, Cyster JG

DOCK8 is essential for T-cell survival and the maintenance of CD8+ T-cell memory.

European journal of immunology

Lambe T, Crawford G, Johnson AL, Crockford TL, Bouriez-Jones T, Smyth AM, Pham TH, Zhang Q, Freeman AF, Cyster JG, Su HC, Cornall RJ

Follicular dendritic cells help establish follicle identity and promote B cell retention in germinal centers.

The Journal of experimental medicine

Wang X, Cho B, Suzuki K, Xu Y, Green JA, An J, Cyster JG

GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood.

Science (New York, N.Y.)

Arnon TI, Xu Y, Lo C, Pham T, An J, Coughlin S, Dorn GW, Cyster JG

Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone.

The Journal of experimental medicine

Muppidi JR, Arnon TI, Bronevetsky Y, Veerapen N, Tanaka M, Besra GS, Cyster JG

EBI2 guides serial movements of activated B cells and ligand activity is detectable in lymphoid and nonlymphoid tissues.

Journal of immunology (Baltimore, Md. : 1950)

Kelly LM, Pereira JP, Yi T, Xu Y, Cyster JG

Oxysterols direct immune cell migration via EBI2.

Nature

Hannedouche S, Zhang J, Yi T, Shen W, Nguyen D, Pereira JP, Guerini D, Baumgarten BU, Roggo S, Wen B, Knochenmuss R, No?l S, Gessier F, Kelly LM, Vanek M, Laurent S, Preuss I, Miault C, Christen I, Karuna R, Li W, Koo DI, Suply T, Schmedt C, Peters EC, Falchetto R, Katopodis A, Spanka C, Roy MO, Detheux M, Chen YA, Schultz PG, Cho CY, Seuwen K, Cyster JG, Sailer AW

FTY720 blocks egress of T cells in part by abrogation of their adhesion on the lymph node sinus.

Journal of immunology (Baltimore, Md. : 1950)

Zhi L, Kim P, Thompson BD, Pitsillides C, Bankovich AJ, Yun SH, Lin CP, Cyster JG, Wu MX

The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement.

Nature immunology

Green JA, Suzuki K, Cho B, Willison LD, Palmer D, Allen CD, Schmidt TH, Xu Y, Proia RL, Coughlin SR, Cyster JG

B cells within germinal centers migrate preferentially from dark to light zone.

Proceedings of the National Academy of Sciences of the United States of America

Beltman JB, Allen CD, Cyster JG, de Boer RJ

Cutting edge: Identification of a motile IL-17-producing gammadelta T cell population in the dermis.

Journal of immunology (Baltimore, Md. : 1950)

Gray EE, Suzuki K, Cyster JG

Association of T-zone reticular networks and conduits with ectopic lymphoid tissues in mice and humans.

The American journal of pathology

Link A, Hardie DL, Favre S, Britschgi MR, Adams DH, Sixt M, Cyster JG, Buckley CD, Luther SA

Lymph node cortical sinus organization and relationship to lymphocyte egress dynamics and antigen exposure.

Proceedings of the National Academy of Sciences of the United States of America

Grigorova IL, Panteleev M, Cyster JG

A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk.

Nature

Heinig M, Petretto E, Wallace C, Bottolo L, Rotival M, Lu H, Li Y, Sarwar R, Langley SR, Bauerfeind A, Hummel O, Lee YA, Paskas S, Rintisch C, Saar K, Cooper J, Buchan R, Gray EE, Cyster JG, Cardiogenics Consortium, Erdmann J, Hengstenberg C, Maouche S, Ouwehand WH, Rice CM, Samani NJ, Schunkert H, Goodall AH, Schulz H, Roider HG, Vingron M, Blankenberg S, M?nzel T, Zeller T, Szymczak S, Ziegler A, Tiret L, Smyth DJ, Pravenec M, Aitman TJ, Cambien F, Clayton D, Todd JA, Hubner N, Cook SA

Erratum: Corrigendum: Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.

Nature immunology

Katrina L Randall, Teresa Lambe, Andy Johnson, Bebhinn Treanor, Edyta Kucharska, Heather Domaschenz, Belinda Whittle, Lina E Tze, Anselm Enders, Tanya L Crockford, Tiphaine Bouriez-Jones, Duncan Alston, Jason G Cyster, Michael J Lenardo, Fabienne Mackay, Elissa K Deenick, Stuart G Tangye, Tyani D Chan, Tahra Camidge, Robert Brink, Carola G Vinuesa, Facundo D Batista, Richard J Cornall, Christopher C Goodnow

Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice.

The Journal of clinical investigation

Tomura M, Honda T, Tanizaki H, Otsuka A, Egawa G, Tokura Y, Waldmann H, Hori S, Cyster JG, Watanabe T, Miyachi Y, Kanagawa O, Kabashima K

Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning.

The Journal of cell biology

Trung H.M. Pham, Peter Baluk, Ying Xu, Irina Grigorova, Alex J. Bankovich, Rajita Pappu, Shaun R. Coughlin, Donald M. McDonald, Susan R. Schwab, Jason G. Cyster

Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning.

The Journal of experimental medicine

Pham TH, Baluk P, Xu Y, Grigorova I, Bankovich AJ, Pappu R, Coughlin SR, McDonald DM, Schwab SR, Cyster JG

Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.

Nature immunology

Randall KL, Lambe T, Johnson AL, Johnson A, Treanor B, Kucharska E, Domaschenz H, Whittle B, Tze LE, Enders A, Crockford TL, Bouriez-Jones T, Alston D, Cyster JG, Lenardo MJ, Mackay F, Deenick EK, Tangye SG, Chan TD, Camidge T, Brink R, Vinuesa CG, Batista FD, Cornall RJ, Goodnow CC

T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow.

The Journal of experimental medicine

Jenne CN, Enders A, Rivera R, Watson SR, Bankovich AJ, Pereira JP, Xu Y, Roots CM, Beilke JN, Banerjee A, Reiner SL, Miller SA, Weinmann AS, Goodnow CC, Lanier LL, Cyster JG, Chun J

Thymic egress: S1P of 1000.

F1000 biology reports

Zachariah MA, Cyster JG

Visualizing B cell capture of cognate antigen from follicular dendritic cells.

The Journal of experimental medicine

Suzuki K, Grigorova I, Phan TG, Kelly LM, Cyster JG

The microanatomy of B cell activation.

Current opinion in immunology

Phan TG, Gray EE, Cyster JG

Settling the thymus: immigration requirements.

The Journal of experimental medicine

Cyster JG

Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids.

Nature immunology

Pereira JP, An J, Xu Y, Huang Y, Cyster JG

Erratum: Cortical sinus probing, S1P1-dependent entry and flow-based capture of egressing T cells.

Nature immunology

Irina L Grigorova, Susan R Schwab, Tri Giang Phan, Trung H M Pham, Takaharu Okada, Jason G Cyster

Cortical sinus probing, S1P1-dependent entry and flow-based capture of egressing T cells.

Nature immunology

Grigorova IL, Schwab SR, Phan TG, Pham TH, Okada T, Cyster JG

A p38 MAPK-MEF2C pathway regulates B-cell proliferation.

Proceedings of the National Academy of Sciences of the United States of America

Khiem D, Cyster JG, Schwarz JJ, Black BL

The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency.

Nature immunology

Shiow LR, Roadcap DW, Paris K, Watson SR, Grigorova IL, Lebet T, An J, Xu Y, Jenne CN, Föger N, Sorensen RU, Goodnow CC, Bear JE, Puck JM, Cyster JG

Finding a way out: lymphocyte egress from lymphoid organs.

Nature immunology

Schwab SR, Cyster JG

Follicular shuttling of marginal zone B cells facilitates antigen transport.

Nature immunology

Cinamon G, Zachariah MA, Lam OM, Foss FW, Cyster JG

Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation.

Journal of immunology (Baltimore, Md. : 1950)

Haynes NM, Allen CD, Lesley R, Ansel KM, Killeen N, Cyster JG

Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells.

Nature immunology

Link A, Vogt TK, Favre S, Britschgi MR, Acha-Orbea H, Hinz B, Cyster JG, Luther SA

Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces.

Nature immunology

Woolf E, Grigorova I, Sagiv A, Grabovsky V, Feigelson SW, Shulman Z, Hartmann T, Sixt M, Cyster JG, Alon R

Germinal-center organization and cellular dynamics.

Immunity

Allen CD, Okada T, Cyster JG

Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate.

Science (New York, N.Y.)

Pappu R, Schwab SR, Cornelissen I, Pereira JP, Regard JB, Xu Y, Camerer E, Zheng YW, Huang Y, Cyster JG, Coughlin SR

CC chemokine receptor 7 contributes to Gi-dependent T cell motility in the lymph node.

Journal of immunology (Baltimore, Md. : 1950)

Okada T, Cyster JG

Specifying the patterns of immune cell migration.

Novartis Foundation symposium

Cyster JG

Imaging of germinal center selection events during affinity maturation.

Science (New York, N.Y.)

Allen CD, Okada T, Tang HL, Cyster JG

Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism.

The Journal of experimental medicine

Kabashima K, Haynes NM, Xu Y, Nutt SL, Allende ML, Proia RL, Cyster JG

Spontaneous class switching and B cell hyperactivity increase autoimmunity against intracellular self antigen in Lyn-deficient mice.

European journal of immunology

Silver K, Bouriez-Jones T, Crockford T, Ferry H, Tang HL, Cyster JG, Cornall RJ

Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival.

Proceedings of the National Academy of Sciences of the United States of America

Lesley R, Kelly LM, Xu Y, Cyster JG

CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs.

Nature

Shiow LR, Rosen DB, Brdicková N, Xu Y, An J, Lanier LL, Cyster JG, Matloubian M

B cell migration and interactions in the early phase of antibody responses.

Current opinion in immunology

Okada T, Cyster JG

TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis.

The Journal of experimental medicine

Chen TT, Li L, Chung DH, Allen CD, Torti SV, Torti FM, Cyster JG, Chen CY, Brodsky FM, Niemi EC, Nakamura MC, Seaman WE, Daws MR

Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients.

Science (New York, N.Y.)

Schwab SR, Pereira JP, Matloubian M, Xu Y, Huang Y, Cyster JG

Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells.

PLoS biology

Okada T, Miller MJ, Parker I, Krummel MF, Neighbors M, Hartley SB, O'Garra A, Cahalan MD, Cyster JG

Intrinsic lymphotoxin-beta receptor requirement for homeostasis of lymphoid tissue dendritic cells.

Immunity

Kabashima K, Banks TA, Ansel KM, Lu TT, Ware CF, Cyster JG

Initiation of cellular organization in lymph nodes is regulated by non-B cell-derived signals and is not dependent on CXC chemokine ligand 13.

Journal of immunology (Baltimore, Md. : 1950)

Cupedo T, Lund FE, Ngo VN, Randall TD, Jansen W, Greuter MJ, de Waal-Malefyt R, Kraal G, Cyster JG, Mebius RE

Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing.

Journal of immunology (Baltimore, Md. : 1950)

Reif K, Okkenhaug K, Sasaki T, Penninger JM, Vanhaesebroeck B, Cyster JG

Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5.

Nature immunology

Allen CD, Ansel KM, Low C, Lesley R, Tamamura H, Fujii N, Cyster JG

FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Brinkmann V, Cyster JG, Hla T

CCR2-dependent trafficking of F4/80dim macrophages and CD11cdim/intermediate dendritic cells is crucial for T cell recruitment to lungs infected with Mycobacterium tuberculosis.

Journal of immunology (Baltimore, Md. : 1950)

Peters W, Cyster JG, Mack M, Schlöndorff D, Wolf AJ, Ernst JD, Charo IF

Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone.

Nature immunology

Cinamon G, Matloubian M, Lesneski MJ, Xu Y, Low C, Lu T, Proia RL, Cyster JG

Requirements for follicular exclusion and competitive elimination of autoantigen-binding B cells.

Journal of immunology (Baltimore, Md. : 1950)

Ekland EH, Forster R, Lipp M, Cyster JG

Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF.

Immunity

Lesley R, Xu Y, Kalled SL, Hess DM, Schwab SR, Shu HB, Cyster JG

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1.

Nature

Matloubian M, Lo CG, Cinamon G, Lesneski MJ, Xu Y, Brinkmann V, Allende ML, Proia RL, Cyster JG

Chapter 14 Dynamics of B Cell Migration to and within Secondary Lymphoid Organs.

Molecular Biology of B Cells

Jason G. Cyster, Ulrich H. Von Andrian

Lymphoid organ development and cell migration.

Immunological reviews

Cyster JG

Homing of antibody secreting cells.

Immunological reviews

Cyster JG

Visualization of the genesis and fate of isotype-switched B cells during a primary immune response.

The Journal of experimental medicine

Pape KA, Kouskoff V, Nemazee D, Tang HL, Cyster JG, Tze LE, Hippen KL, Behrens TW, Jenkins MK

Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development.

The Journal of experimental medicine

Luther SA, Ansel KM, Cyster JG

Integrin-dependence of lymphocyte entry into the splenic white pulp.

The Journal of experimental medicine

Lo CG, Lu TT, Cyster JG

Erratum: Langerhans cells renew in the skin throughout life under steady-state conditions.

Nature immunology

Miriam Merad, Markus G. Manz, Holger Karsunky, Amy Wagers, Wendy Peters, Israel Charo, Irving L. Weissman, Jason G. Cyster, Edgar G. Engleman

Overview of the Alliance for Cellular Signaling.

Nature

Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR, Participating investigators and scientists of the Alliance for Cellular Signaling

Langerhans cells renew in the skin throughout life under steady-state conditions.

Nature immunology

Merad M, Manz MG, Karsunky H, Wagers A, Peters W, Charo I, Weissman IL, Cyster JG, Engleman EG

The CDM protein DOCK2 in lymphocyte migration.

Trends in cell biology

Reif K, Cyster J

Chemokine requirements for B cell entry to lymph nodes and Peyer's patches.

The Journal of experimental medicine

Okada T, Ngo VN, Ekland EH, Förster R, Lipp M, Littman DR, Cyster JG

Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis.

Journal of immunology (Baltimore, Md. : 1950)

Luther SA, Bidgol A, Hargreaves DC, Schmidt A, Xu Y, Paniyadi J, Matloubian M, Cyster JG

B cells control the migration of a subset of dendritic cells into B cell follicles via CXC chemokine ligand 13 in a lymphotoxin-dependent fashion.

Journal of immunology (Baltimore, Md. : 1950)

Yu P, Wang Y, Chin RK, Martinez-Pomares L, Gordon S, Kosco-Vibois MH, Cyster J, Fu YX

Chemorepulsion and thymocyte emigration.

The Journal of clinical investigation

Cyster JG

Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position.

Nature

Reif K, Ekland EH, Ohl L, Nakano H, Lipp M, Förster R, Cyster JG

Traffic patterns of B cells and plasma cells.

Advances in experimental medicine and biology

Cyster JG, Ansel KM, Ngo VN, Hargreaves DC, Lu TT

Splenic T zone development is B cell dependent.

The Journal of experimental medicine

Ngo VN, Cornall RJ, Cyster JG

Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation.

Immunity

Ruuls SR, Hoek RM, Ngo VN, McNeil T, Lucian LA, Janatpour MJ, Körner H, Scheerens H, Hessel EM, Cyster JG, McEvoy LM, Sedgwick JD

A coordinated change in chemokine responsiveness guides plasma cell movements.

The Journal of experimental medicine

Hargreaves DC, Hyman PL, Lu TT, Ngo VN, Bidgol A, Suzuki G, Zou YR, Littman DR, Cyster JG

Chemokines in lymphopoiesis and lymphoid organ development.

Current opinion in immunology

Ansel KM, Cyster JG

Chemokines as regulators of T cell differentiation.

Nature immunology

Luther SA, Cyster JG

Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse.

Proceedings of the National Academy of Sciences of the United States of America

Luther SA, Tang HL, Hyman PL, Farr AG, Cyster JG

A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo.

Nature immunology

Matloubian M, David A, Engel S, Ryan JE, Cyster JG

Follicular stromal cells and lymphocyte homing to follicles.

Immunological reviews

Cyster JG, Ansel KM, Reif K, Ekland EH, Hyman PL, Tang HL, Luther SA, Ngo VN

A chemokine-driven positive feedback loop organizes lymphoid follicles.

Nature

Ansel KM, Ngo VN, Hyman PL, Luther SA, Förster R, Sedgwick JD, Browning JL, Lipp M, Cyster JG

B cells on the front line.

Nature immunology

Cyster JG

Tumor necrosis factor: a master-regulator of leukocyte movement.

Immunology today

Sedgwick JD, Riminton DS, Cyster JG, Körner H

Leukocyte migration: scent of the T zone.

Current biology : CB

Cyster JG

In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines.

The Journal of experimental medicine

Ansel KM, McHeyzer-Williams LJ, Ngo VN, McHeyzer-Williams MG, Cyster JG

Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen.

The Journal of experimental medicine

Ngo VN, Korner H, Gunn MD, Schmidt KN, Riminton DS, Cooper MD, Browning JL, Sedgwick JD, Cyster JG

Chemokines and B-cell homing to follicles.

Current topics in microbiology and immunology

Cyster JG, Ngo VN, Ekland EH, Gunn MD, Sedgwick JD, Ansel KM

Regulation of B cell antigen receptor signaling by the Lyn/CD22/SHP1 pathway.

Current topics in microbiology and immunology

Cornall RJ, Goodnow CC, Cyster JG

Generation of splenic follicular structure and B cell movement in tumor necrosis factor-deficient mice.

The Journal of experimental medicine

Cook MC, Körner H, Riminton DS, Lemckert FA, Hasbold J, Amesbury M, Hodgkin PD, Cyster JG, Sedgwick JD, Basten A

Spontaneous follicular exclusion of SHP1-deficient B cells is conditional on the presence of competitor wild-type B cells.

The Journal of experimental medicine

Schmidt KN, Hsu CW, Griffin CT, Goodnow CC, Cyster JG

A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1.

Nature

Gunn MD, Ngo VN, Ansel KM, Ekland EH, Cyster JG, Williams LT

A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes.

Proceedings of the National Academy of Sciences of the United States of America

Gunn MD, Tangemann K, Tam C, Cyster JG, Rosen SD, Williams LT

Different nuclear signals are activated by the B cell receptor during positive versus negative signaling.

Immunity

Healy JI, Dolmetsch RE, Timmerman LA, Cyster JG, Thomas ML, Crabtree GR, Lewis RS, Goodnow CC

Lymphocyte homing: the scent of a follicle.

Current biology : CB

Goodnow CC, Cyster JG

Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45.

Nature

Cyster JG, Healy JI, Kishihara K, Mak TW, Thomas ML, Goodnow CC

The regulation of self-reactive B cells.

Current opinion in immunology

Cornall RJ, Goodnow CC, Cyster JG

Pertussis toxin inhibits migration of B and T lymphocytes into splenic white pulp cords.

The Journal of experimental medicine

Cyster JG, Goodnow CC

Self-tolerance checkpoints in B lymphocyte development.

Advances in immunology

Goodnow CC, Cyster JG, Hartley SB, Bell SE, Cooke MP, Healy JI, Akkaraju S, Rathmell JC, Pogue SL, Shokat KP

Structure-function studies of CD2 by n.m.r. and mutagenesis.

Biochemical Society Transactions

Driscoll PC, Cyster JG, Somoza C, Crawford DA, Howe P, Harvey TS, Kieffer B, Campbell ID, Williams AF

Mutational analysis of the CD2/CD58 interaction: the binding site for CD58 lies on one face of the first domain of human CD2.

The Journal of experimental medicine

Somoza C, Driscoll PC, Cyster JG, Williams AF

The NH2-terminal domain of rat CD2 binds rat CD48 with a low affinity and binding does not require glycosylation of CD2.

European journal of immunology

van der Merwe PA, McPherson DC, Brown MH, Barclay AN, Cyster JG, Williams AF, Davis SJ

IgE and IgG binding of peptides expressed from fragments of cDNA encoding the major house dust mite allergen Der p I.

Journal of immunology (Baltimore, Md. : 1950)

Greene WK, Cyster JG, Chua KY, O'Brien RM, Thomas WR

Structure of domain 1 of rat T lymphocyte CD2 antigen.

Nature

Driscoll PC, Cyster JG, Campbell ID, Williams AF