Jacquelyn Maher, MD

Novel autoantibody targets identified in patients with autoimmune hepatitis (AIH) by PhIP-Seq reveals pathogenic insights.

medRxiv : the preprint server for health sciences

Klepper A, Kung A, Vazquez SE, Mitchell A, Mann S, Zorn K, Avila-Vargas I, Kari S, Tekeste M, Castro J, Lee B, Duarte M, Khalili M, Yang M, Wolters P, Price J, Perito E, Feng S, Maher JJ, Lai J, Weiler-Normann C, Lohse AW, DeRisi J, Tana M

Hyperpolarized [1-13 C] pyruvate MRSI to detect metabolic changes in liver in a methionine and choline-deficient diet rat model of fatty liver disease.

Magnetic resonance in medicine

Piraquive Agudelo J, Kim Y, Agarwal S, Sriram R, Bok R, Kurhanewicz J, Mattis AN, Maher JJ, von Morze C, Ohliger MA

A genetic basis of mitochondrial DNAJA3 in nonalcoholic steatohepatitis-related hepatocellular carcinoma.

Hepatology (Baltimore, Md.)

Chang CW, Chen YS, Huang CH, Lin CH, Ng WV, Chu LJ, Trépo E, Zucman-Rossi J, Siao K, Maher JJ, Chiew MY, Chou CH, Huang HD, Teo WH, Lee IS, Lo JF, Wang XW

Modeling and therapeutic targeting of inflammation-induced hepatic insulin resistance using human iPSC-derived hepatocytes and macrophages.

Nature communications

Groeger M, Matsuo K, Heidary Arash E, Pereira A, Le Guillou D, Pino C, Telles-Silva KA, Maher JJ, Hsiao EC, Willenbring H

The Role of STING in Liver Injury Is Both Stimulus- and Time-Dependent.

Nutrients

Siao K, Le Guillou D, Maher JJ, Duwaerts CC

Mouse liver injury induces hepatic macrophage FGF23 production.

PloS one

Kumar P, Liu Y, Shen Y, Maher JJ, Cingolani F, Czaja MJ

Doxycycline Significantly Enhances Induction of Induced Pluripotent Stem Cells to Endoderm by Enhancing Survival Through Protein Kinase B Phosphorylation.

Hepatology (Baltimore, Md.)

Peaslee C, Esteva-Font C, Su T, Munoz-Howell A, Duwaerts CC, Liu Z, Rao S, Liu K, Medina M, Sneddon JB, Maher JJ, Mattis AN

Visceral Adipose Tissue Inflammation and Radiographic Visceral-to-Subcutaneous Adipose Tissue Ratio in Patients with Cirrhosis.

Digestive diseases and sciences

Ha NB, Cho SJ, Mohamad Y, Kent D, Jun G, Wong R, Swarnakar V, Lin S, Maher JJ, Lai JC

Induced Pluripotent Stem Cell-derived Hepatocytes From Patients With Nonalcoholic Fatty Liver Disease Display a Disease-specific Gene Expression Profile.

Gastroenterology

Duwaerts CC, Le Guillou D, Her CL, Phillips NJ, Willenbring H, Mattis AN, Maher JJ

Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α.

Cell death and differentiation

Duwaerts CC, Siao K, Soon RK, Her C, Iwawaki T, Kohno K, Mattis AN, Maher JJ

Ly6cLo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation.

Scientific reports

Alkhani A, Levy CS, Tsui M, Rosenberg KA, Polovina K, Mattis AN, Mack M, Van Dyken S, Wang BM, Maher JJ, Nijagal A

Nonalcoholic Fatty Liver Disease in 2020.

Gastroenterology

Maher JJ, Schattenberg JM

Macronutrients and the Adipose-Liver Axis in Obesity and Fatty Liver.

Cellular and molecular gastroenterology and hepatology

Duwaerts CC, Maher JJ

Loss of Integrin αvβ8 in Murine Hepatocytes Accelerates Liver Regeneration.

The American journal of pathology

Greenhalgh SN, Matchett KP, Taylor RS, Huang K, Li JT, Saeteurn K, Donnelly MC, Simpson EEM, Pollack JL, Atakilit A, Simpson KJ, Maher JJ, Iredale JP, Sheppard D, Henderson NC

Macrophages Steal STING From the Infectious Disease Playbook to Promote Nonalcoholic Fatty Liver Disease.

Gastroenterology

Maher JJ

Race/ethnicity is an independent risk factor for autoimmune hepatitis among the San Francisco underserved.

Autoimmunity

Lee B, Holt EW, Wong RJ, Sewell JL, Somsouk M, Khalili M, Maher JJ, Tana MM

Hospitalizations for Autoimmune Hepatitis Disproportionately Affect Black and Latino Americans.

The American journal of gastroenterology

Wen JW, Kohn MA, Wong R, Somsouk M, Khalili M, Maher J, Tana MM

CD18 deficiency improves liver injury in the MCD model of steatohepatitis.

PloS one

Pierce AA, Duwaerts CC, Siao K, Mattis AN, Goodsell A, Baron JL, Maher JJ

Specific Macronutrients Exert Unique Influences on the Adipose-Liver Axis to Promote Hepatic Steatosis in Mice.

Cellular and molecular gastroenterology and hepatology

Duwaerts CC, Amin AM, Siao K, Her C, Fitch M, Beysen C, Turner SM, Goodsell A, Baron JL, Grenert JP, Cho SJ, Maher JJ

Modeling fatty liver disease in animals: Is there an optimal approach, and is the effort worthwhile?

Hepatology (Baltimore, Md.)

Maher JJ

Pathogenesis of NAFLD and NASH.

Alcoholic and Non-Alcoholic Fatty Liver Disease

Jacquelyn J. Maher

Nonalcoholic fatty liver disease.

Nature reviews. Disease primers

Brunt EM, Wong VW, Nobili V, Day CP, Sookoian S, Maher JJ, Bugianesi E, Sirlin CB, Neuschwander-Tetri BA, Rinella ME

Isocaloric manipulation of macronutrients within a high-carbohydrate/moderate-fat diet induces unique effects on hepatic lipogenesis, steatosis and liver injury.

The Journal of nutritional biochemistry

Pierce AA, Duwaerts CC, Soon RK, Siao K, Grenert JP, Fitch M, Hellerstein MK, Beysen C, Turner SM, Maher JJ

Differential hepatotoxicity of dietary and DNL-derived palmitate in the methionine-choline-deficient model of steatohepatitis.

BMC gastroenterology

Pierce AA, Pickens MK, Siao K, Grenert JP, Maher JJ

A screen in mice uncovers repression of lipoprotein lipase by microRNA-29a as a mechanism for lipid distribution away from the liver.

Hepatology (Baltimore, Md.)

Mattis AN, Song G, Hitchner K, Kim RY, Lee AY, Sharma AD, Malato Y, McManus MT, Esau CC, Koller E, Koliwad S, Lim LP, Maher JJ, Raffai RL, Willenbring H

Mechanisms of Liver Injury in Non-Alcoholic Steatohepatitis.

Current hepatology reports

Duwaerts CC, Maher JJ

Circulating interleukin-8 levels explain breast cancer osteolysis in mice and humans.

Bone

Kamalakar A, Bendre MS, Washam CL, Fowler TW, Carver A, Dilley JD, Bracey JW, Akel NS, Margulies AG, Skinner RA, Swain FL, Hogue WR, Montgomery CO, Lahiji P, Maher JJ, Leitzel KE, Ali SM, Lipton A, Nicholas RW, Gaddy D, Suva LJ

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs.

Nature medicine

Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH, Sheppard D

A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition.

Nature medicine

Wei K, Piecewicz SM, McGinnis LM, Taniguchi CM, Wiegand SJ, Anderson K, Chan CW, Mulligan KX, Kuo D, Yuan J, Vallon M, Morton L, Lefai E, Simon MC, Maher JJ, Mithieux G, Rajas F, Annes J, McGuinness OP, Thurston G, Giaccia AJ, Kuo CJ

Retinol binding protein 4 and fatty liver: A direct link?

Hepatology (Baltimore, Md.)

Maher JJ

Hepatic fibrosis: evaluation with semiquantitative contrast-enhanced CT.

Radiology

Varenika V, Fu Y, Maher JJ, Gao D, Kakar S, Cabarrus MC, Yeh BM

Insulin sensitivity and variability in hepatitis C virus infection using direct measurement.

Digestive diseases and sciences

Mukhtar NA, Bacchetti P, Ayala CE, Melgar J, Christensen S, Maher JJ, Khalili M

The basic helix-loop-helix transcription factor, heart and neural crest derivatives expressed transcript 2, marks hepatic stellate cells in zebrafish: analysis of stellate cell entry into the developing liver.

Hepatology (Baltimore, Md.)

Yin C, Evason KJ, Maher JJ, Stainier DY

Specific bile acids inhibit hepatic fatty acid uptake in mice.

Hepatology (Baltimore, Md.)

Nie B, Park HM, Kazantzis M, Lin M, Henkin A, Ng S, Song S, Chen Y, Tran H, Lai R, Her C, Maher JJ, Forman BM, Stahl A

Impact of insulin resistance on HCV treatment response and impact of HCV treatment on insulin sensitivity using direct measurements of insulin action.

Diabetes care

Brandman D, Bacchetti P, Ayala CE, Maher JJ, Khalili M

Assessment of factors associated with pre-diabetes in HCV infection including direct and dynamic measurements of insulin action.

Journal of viral hepatitis

Mukhtar NA, Ayala C, Maher JJ, Khalili M

Lipids in liver disease: looking beyond steatosis.

Gastroenterology

Schwabe RF, Maher JJ

New insights from rodent models of fatty liver disease.

Antioxidants & redox signaling

Maher JJ

Stress signaling in the methionine-choline-deficient model of murine fatty liver disease.

Gastroenterology

Soon RK, Yan JS, Grenert JP, Maher JJ

Comparison of surrogate and direct measurement of insulin resistance in chronic hepatitis C virus infection: impact of obesity and ethnicity.

Hepatology (Baltimore, Md.)

Lam KD, Bacchetti P, Abbasi F, Ayala CE, Loeb SM, Shah V, Wen MJ, Reaven GM, Maher JJ, Khalili M

Computational experiments reveal plausible mechanisms for changing patterns of hepatic zonation of xenobiotic clearance and hepatotoxicity.

Journal of theoretical biology

Sheikh-Bahaei S, Maher JJ, Anthony Hunt C

Dietary fructose exacerbates hepatocellular injury when incorporated into a methionine-choline-deficient diet.

Liver international : official journal of the International Association for the Study of the Liver

Pickens MK, Ogata H, Soon RK, Grenert JP, Maher JJ

Trunk fat as a determinant of liver disease.

Gastroenterology

Maher JJ

Short passive cooling protects rats during hepatectomy by inducing heat shock proteins and limiting the induction of pro-inflammatory cytokines.

The Journal of surgical research

Niemann CU, Xu F, Choi S, Behrends M, Park Y, Hirose R, Maher JJ

Dietary sucrose is essential to the development of liver injury in the methionine-choline-deficient model of steatohepatitis.

Journal of lipid research

Pickens MK, Yan JS, Ng RK, Ogata H, Grenert JP, Beysen C, Turner SM, Maher JJ

DAMPs ramp up drug toxicity.

The Journal of clinical investigation

Maher JJ

Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitis.

Hepatology (Baltimore, Md.)

Maher JJ, Leon P, Ryan JC

Impaired dexamethasone-mediated induction of tryptophan 2,3-dioxygenase in heme-deficient rat hepatocytes: translational control by a hepatic eIF2alpha kinase, the heme-regulated inhibitor.

The Journal of pharmacology and experimental therapeutics

Liao M, Pabarcus MK, Wang Y, Hefner C, Maltby DA, Medzihradszky KF, Salas-Castillo SP, Yan J, Maher JJ, Correia MA

Characterization of the physiological turnover of native and inactivated cytochromes P450 3A in cultured rat hepatocytes: a role for the cytosolic AAA ATPase p97?

Biochemistry

Faouzi S, Medzihradszky KF, Hefner C, Maher JJ, Correia MA

Polyunsaturated fat in the methionine-choline-deficient diet influences hepatic inflammation but not hepatocellular injury.

Journal of lipid research

Lee GS, Yan JS, Ng RK, Kakar S, Maher JJ

Alcoholic steatohepatitis: management and prognosis.

Current gastroenterology reports

Maher JJ

Mild hypothermia protects obese rats from fulminant hepatic necrosis induced by ischemia-reperfusion.

Surgery

Niemann CU, Choi S, Behrends M, Hirose R, Noh J, Coatney JL, Roberts JP, Serkova NJ, Maher JJ

Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1.

Journal of lipid research

Rizki G, Arnaboldi L, Gabrielli B, Yan J, Lee GS, Ng RK, Turner SM, Badger TM, Pitas RE, Maher JJ

Heme-reversible impairment of CYP2B1/2 induction in heme-depleted rat hepatocytes in primary culture: translational control by a hepatic alpha-subunit of the eukaryotic initiation factor kinase?

The Journal of pharmacology and experimental therapeutics

Han XM, Lee G, Hefner C, Maher JJ, Correia MA

Blocking the secretion of hepatic very low density lipoproteins renders the liver more susceptible to toxin-induced injury.

The Journal of biological chemistry

Björkegren J, Beigneux A, Bergo MO, Maher JJ, Young SG

The CYP2E1 knockout delivers another punch: first ASH, now NASH. Alcoholic steatohepatitis. Nonalcoholic steatohepatitis.

Hepatology (Baltimore, Md.)

Maher J

Glutathione regulation in rat hepatic stellate cells. Comparative studies in primary culture and in liver injury in vivo.

Biochemical pharmacology

Maher JJ, Saito JM, Neuschwander-Tetri BA

Adenovirus-mediated expression of cytokine-induced neutrophil chemoattractant in rat liver induces a neutrophilic hepatitis.

Hepatology (Baltimore, Md.)

Maher JJ, Scott MK, Saito JM, Burton MC

Acetaldehyde-induced stimulation of collagen synthesis and gene expression is dependent on conditions of cell culture: studies with rat lipocytes and fibroblasts.

Alcoholism, clinical and experimental research

Maher JJ, Zia S, Tzagarakis C

Partial cloning of the M subunit of laminin from adult rat lipocytes: expression of the M subunit by cells isolated from normal and injured liver.

Hepatology (Baltimore, Md.)

Maher JJ, Tzagarakis C

Cell-matrix interactions in liver.

Seminars in cell biology

Maher JJ, Bissell DM

Cell-specific expression of hepatocyte growth factor in liver. Upregulation in sinusoidal endothelial cells after carbon tetrachloride.

The Journal of clinical investigation

Maher JJ

Parenchymal and nonparenchymal cell interactions in the liver.

Seminars in liver disease

Maher JJ, Friedman SL

Inhibition of rat hepatic lipocyte activation in culture by interferon-gamma.

Hepatology (Baltimore, Md.)

Rockey DC, Maher JJ, Jarnagin WR, Gabbiani G, Friedman SL

Isolated hepatic lipocytes and Kupffer cells from normal human liver: morphological and functional characteristics in primary culture.

Hepatology (Baltimore, Md.)

Friedman SL, Rockey DC, McGuire RF, Maher JJ, Boyles JK, Yamasaki G

Yet another role for the "good" matrix protein: laminin in regenerating liver.

Hepatology (Baltimore, Md.)

Maher JJ

Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo.

The Journal of clinical investigation

Maher JJ, McGuire RF

Support of cultured hepatocytes by a laminin-rich gel. Evidence for a functionally significant subendothelial matrix in normal rat liver.

The Journal of clinical investigation

Bissell DM, Arenson DM, Maher JJ, Roll FJ

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Jacquelyn Maher, MD