Hubert Kim, MD, PhD

Professor
Orthopaedic Surgery
+1 415 476-0561

Hubert Kim, MD studies the modulation of secondary injury cascades and the application of stem cells to treat traumatic injuries, particularly in tissues that have poor intrinsic healing.

Publications: 

Defining Endogenous Mitochondrial Transfer in Muscle After Rotator Cuff Injury.

The American journal of sports medicine

Chi HM, Davies MR, Garcia SM, Montenegro C, Sharma S, Lizarraga M, Wang Z, Nuthalapati P, Kim HT, Liu X, Feeley BT

Polarized macrophages regulate fibro/adipogenic progenitor (FAP) adipogenesis through exosomes.

Stem cell research & therapy

Liu M, Ng M, Phu T, Bouchareychas L, Feeley BT, Kim HT, Raffai RL, Liu X

The Role of Matrix Metalloproteinase-13 (MMP13) in TGF�/BMP Pathway Regulation of Fibro-Adipogenic Progenitor (FAP) Differentiation.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Liu M, Feeley BT, Kim HT, Liu X

Rotator Cuff Tear Size Regulates Fibroadipogenic Progenitor Number and Gene Expression Profile in the Supraspinatus Independent of Patient Age.

The American journal of sports medicine

Davies MR, Chi H, Kaur G, Liu M, Ma CB, Kim HT, Liu X, Feeley BT

Microenergy acoustic pulses promotes muscle regeneration through in situ activation of muscle stem cells.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Zhang H, Kim HT, Feeley BT, Lin G, Lue TF, Liu M, Banie L, Liu X

Preconditioning improves muscle regeneration after ischemia-reperfusion injury.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Zhang H, Liu M, Kim HT, Feeley BT, Liu X

Rotator cuff tear degeneration and the role of fibro-adipogenic progenitors.

Annals of the New York Academy of Sciences

Agha O, Diaz A, Davies M, Kim HT, Liu X, Feeley BT

Intervertebral disc herniation effects on multifidus muscle composition and resident stem cell populations.

JOR spine

Agha O, Mueller-Immergluck A, Liu M, Zhang H, Theologis AA, Clark A, Kim HT, Liu X, Feeley BT, Bailey JF

Beige FAPs Transplantation Improves Muscle Quality and Shoulder Function After Massive Rotator Cuff Tears.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Lee C, Liu M, Agha O, Kim HT, Feeley BT, Liu X

Rotator Cuff Fibro-Adipogenic Progenitors Demonstrate Highest Concentration, Proliferative Capacity, and Adipogenic Potential Across Muscle Groups.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Lee C, Agha O, Liu M, Davies M, Bertoy L, Kim HT, Liu X, Feeley BT

Knocking-out matrix metalloproteinase-13 exacerbates rotator cuff muscle fatty infiltration.

Muscles, ligaments and tendons journal

Liu X, Ravishankar B, Ning A, Liu M, Kim HT, Feeley BT

Lysophosphatidic acid-induced RhoA signaling and prolonged macrophage infiltration worsens fibrosis and fatty infiltration following rotator cuff tears.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Davies MR, Lee L, Feeley BT, Kim HT, Liu X

Promoting Endochondral Bone Repair Using Human Osteoarthritic Articular Chondrocytes.

Tissue engineering. Part A

Bahney CS, Jacobs L, Tamai R, Hu D, Luan TF, Wang M, Reddy S, Park M, Limburg S, Kim HT, Marcucio R, Kuo AC

Novel intracellular N-terminal truncated matrix metalloproteinase-2 isoform in skeletal muscle ischemia-reperfusion injury.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Joshi SK, Lee L, Lovett DH, Kang H, Kim HT, Delgado C, Liu X

Bone morphogenetic protein signaling in rotator cuff muscle atrophy and fatty infiltration.

Muscles, ligaments and tendons journal

Liu X, Joshi S, Ravishankar B, Laron D, Kim HT, Feeley BT

Rat rotator cuff muscle responds differently from hindlimb muscle to a combined tendon-nerve injury.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Davies MR, Ravishankar B, Laron D, Kim HT, Liu X, Feeley BT

Matrix metalloproteinase-2 plays a critical role in overload induced skeletal muscle hypertrophy.

Muscles, ligaments and tendons journal

Zhang Q, Joshi SK, Lovett DH, Zhang B, Bodine S, Kim HT, Liu X

Upregulation of transforming growth factor-� signaling in a rat model of rotator cuff tears.

Journal of shoulder and elbow surgery

Liu X, Joshi SK, Ravishankar B, Laron D, Kim HT, Feeley BT

Novel mouse model of spinal cord injury-induced heterotopic ossification.

Journal of rehabilitation research and development

Kang H, Dang AB, Joshi SK, Halloran B, Nissenson R, Zhang X, Li J, Kim HT, Liu X

Joint instability and cartilage compression in a mouse model of posttraumatic osteoarthritis.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Onur TS, Wu R, Chu S, Chang W, Kim HT, Dang AB

Differential ubiquitin-proteasome and autophagy signaling following rotator cuff tears and suprascapular nerve injury.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Joshi SK, Kim HT, Feeley BT, Liu X

Trophic stimulation of articular chondrocytes by late-passage mesenchymal stem cells in coculture.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Wang M, Rahnama R, Cheng T, Grotkopp E, Jacobs L, Limburg S, Kim HT, Kuo AC

Original article Muscle extracellular matrix degradation and contractibility following tendon rupture and disuse.

Muscles, ligaments and tendons journal

Zhang Q, Joshi SK, Manzano G, Lovett DH, Kim HT, Liu X

Evaluation of cartilage degeneration in a rat model of rotator cuff tear arthropathy.

Journal of shoulder and elbow surgery

Kramer EJ, Bodendorfer BM, Laron D, Wong J, Kim HT, Liu X, Feeley BT

Cytotoxicity of local anesthetics on human mesenchymal stem cells.

The Journal of bone and joint surgery. American volume

Rahnama R, Wang M, Dang AC, Kim HT, Kuo AC

mTOR regulates fatty infiltration through SREBP-1 and PPAR? after a combined massive rotator cuff tear and suprascapular nerve injury in rats.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Joshi SK, Liu X, Samagh SP, Lovett DH, Bodine SC, Kim HT, Feeley BT

Functional motor recovery after peripheral nerve repair with an aligned nanofiber tubular conduit in a rat model.

Regenerative medicine

Jin J, Park M, Rengarajan A, Zhang Q, Limburg S, Joshi SK, Patel S, Kim HT, Kuo AC

MRI quantification of fatty infiltration and muscle atrophy in a mouse model of rotator cuff tears.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Samagh SP, Kramer EJ, Melkus G, Laron D, Bodendorfer BM, Natsuhara K, Kim HT, Liu X, Feeley BT

Fibroblast growth factor 2 enhances the kinetics of mesenchymal stem cell chondrogenesis.

Biochemical and biophysical research communications

Cheng T, Yang C, Weber N, Kim HT, Kuo AC

Inducible immortality in hTERT-human mesenchymal stem cells.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Piper SL, Wang M, Yamamoto A, Malek F, Luu A, Kuo AC, Kim HT

Thermal stress potentiates bupivacaine chondrotoxicity.

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

Piper SL, Kim HT

A mouse model of massive rotator cuff tears.

The Journal of bone and joint surgery. American volume

Liu X, Laron D, Natsuhara K, Manzano G, Kim HT, Feeley BT

Evaluation of Akt/mTOR activity in muscle atrophy after rotator cuff tears in a rat model.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Liu X, Joshi SK, Samagh SP, Dang YX, Laron D, Lovett DH, Bodine SC, Kim HT, Feeley BT

Muscle degeneration in rotator cuff tears.

Journal of shoulder and elbow surgery

Laron D, Samagh SP, Liu X, Kim HT, Feeley BT

Effects of local anesthetics on articular cartilage.

The American journal of sports medicine

Piper SL, Kramer JD, Kim HT, Feeley BT

Effects of mixing techniques on vancomycin-impregnated polymethylmethacrylate.

The Journal of arthroplasty

Laine JC, Nguyen TQ, Buckley JM, Kim HT

A rat model of massive rotator cuff tears.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Liu X, Manzano G, Kim HT, Feeley BT

Role of AP-1 and RE-1 binding sites in matrix metalloproteinase-2 transcriptional regulation in skeletal muscle atrophy.

Biochemical and biophysical research communications

Liu X, Manzano G, Lovett DH, Kim HT

Role of gelatinases in disuse-induced skeletal muscle atrophy.

Muscle & nerve

Liu X, Lee DJ, Skittone LK, Natsuhara K, Kim HT

Inhibition of MMP2/MMP9 after spinal cord trauma reduces apoptosis.

Spine

Dang AB, Tay BK, Kim HT, Nauth A, Alfonso-Jaume MA, Lovett DH

Chondrocyte apoptosis: implications for osteochondral allograft transplantation.

Clinical orthopaedics and related research

Kim HT, Teng MS, Dang AC

Enhancing osteochondral allograft viability: effects of storage media composition.

Clinical orthopaedics and related research

Teng MS, Yuen AS, Kim HT

Matrix metalloproteinase-2 expression and promoter/enhancer activity in skeletal muscle atrophy.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Skittone LK, Liu X, Tseng A, Kim HT

A peek into the possible future of management of articular cartilage injuries: gene therapy and scaffolds for cartilage repair.

The Journal of orthopaedic and sports physical therapy

Kim HT, Zaffagnini S, Mizuno S, Abelow S, Safran MR

Chondrocyte apoptosis induced by hydrogen peroxide requires caspase activation but not mitochondrial pore transition.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Lo MY, Kim HT

Comparison of chondrocyte apoptosis in vivo and in vitro following acute osteochondral injury.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Costouros JG, Dang AC, Kim HT

Chondrocyte apoptosis induced by collagen degradation: inhibition by caspase inhibitors and IGF-1.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Lo MY, Kim HT