
Professor
Surgery
+1 415 476-2417
Holger Willenbring, MD explores the way liver cells differentiate and regenerate with the goal of correcting liver diseases using cells derived from stem cells or by reprogramming hematopoietic cells.
Publications
Identification of a robust promoter in mouse and human hepatocytes by in vivo biopanning of a barcoded AAV library.
Molecular therapy : the journal of the American Society of Gene Therapy
AAV capsid prioritization in normal and steatotic human livers maintained by machine perfusion.
Nature biotechnology
Pervasive and programmed nucleosome distortion patterns on single mammalian chromatin fibers.
bioRxiv : the preprint server for biology
Adipocyte inflammation is the primary driver of hepatic insulin resistance in a human iPSC-based microphysiological system.
Nature communications
Human Hepatocytes Can Give Rise to Intrahepatic Cholangiocarcinomas.
Gastroenterology
Modeling and therapeutic targeting of inflammation-induced hepatic insulin resistance using human iPSC-derived hepatocytes and macrophages.
Nature communications
Human iPSC-Derived Proinflammatory Macrophages cause Insulin Resistance in an Isogenic White Adipose Tissue Microphysiological System.
Small (Weinheim an der Bergstrasse, Germany)
Reply.
Hepatology (Baltimore, Md.)
Aquaporin 9 induction in human iPSC-derived hepatocytes facilitates modeling of ornithine transcarbamylase deficiency.
Hepatology (Baltimore, Md.)
Integrated Isogenic Human Induced Pluripotent Stem Cell-Based Liver and Heart Microphysiological Systems Predict Unsafe Drug-Drug Interaction.
Frontiers in pharmacology
Induced Pluripotent Stem Cell-derived Hepatocytes From Patients With Nonalcoholic Fatty Liver Disease Display a Disease-specific Gene Expression Profile.
Gastroenterology
Emerging cell therapy for biliary diseases.
Science (New York, N.Y.)
Transcriptomic Traces of Adult Human Liver Progenitor Cells.
Hepatology (Baltimore, Md.)
Broad Distribution of Hepatocyte Proliferation in Liver Homeostasis and Regeneration.
Cell stem cell
Hepatocyte Nuclear Factor 4 Alpha Activation Is Essential for Termination of Liver Regeneration in Mice.
Hepatology (Baltimore, Md.)
Postnatal Organogenesis by Transdifferentiation.
The FASEB Journal
Advances in cholangiocarcinoma research: report from the third Cholangiocarcinoma Foundation Annual Conference.
Journal of gastrointestinal oncology
In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis.
Cell stem cell
Assessing the therapeutic potential of lab-made hepatocytes.
Hepatology (Baltimore, Md.)
Physiological ranges of matrix rigidity modulate primary mouse hepatocyte function in part through hepatocyte nuclear factor 4 alpha.
Hepatology (Baltimore, Md.)
A screen in mice uncovers repression of lipoprotein lipase by microRNA-29a as a mechanism for lipid distribution away from the liver.
Hepatology (Baltimore, Md.)
AAV8-mediated in vivo overexpression of miR-155 enhances the protective capacity of genetically attenuated malarial parasites.
Molecular therapy : the journal of the American Society of Gene Therapy
Evidence against a Stem Cell Origin of New Hepatocytes in a Common Mouse Model of Chronic Liver Injury.
Cell reports
Evidence against a stem cell origin of new hepatocytes in a common mouse model of chronic liver injury.
Cell reports
Brief report: Parthenogenetic embryonic stem cells are an effective cell source for therapeutic liver repopulation.
Stem cells (Dayton, Ohio)
Failure to achieve normal metabolic response in non-obese diabetic mice and streptozotocin-induced diabetic mice after transplantation of primary murine hepatocytes electroporated with the human proinsulin gene (p3MTChins).
Transplantation proceedings
Inhibition of microRNA-24 expression in liver prevents hepatic lipid accumulation and hyperlipidemia.
Hepatology (Baltimore, Md.)
Addendum: A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice.
Nature protocols
Human induced pluripotent stem cell-based microphysiological tissue models of myocardium and liver for drug development.
Stem cell research & therapy
MicroRNA-494 within an oncogenic microRNA megacluster regulates G1/S transition in liver tumorigenesis through suppression of mutated in colorectal cancer.
Hepatology (Baltimore, Md.)
Highly efficient differentiation of functional hepatocytes from human induced pluripotent stem cells.
Stem cells translational medicine
Akt/Notch activation drives rapid cholangiocarcinoma development originating from mature hepatocytes in the mouse.
Zeitschrift für Gastroenterologie
Cholangiocarcinomas can originate from hepatocytes in mice.
The Journal of clinical investigation
A ZFN/piggyBac step closer to autologous liver cell therapy.
Hepatology (Baltimore, Md.)
A microRNA-21 surge facilitates rapid cyclin D1 translation and cell cycle progression in mouse liver regeneration.
The Journal of clinical investigation
Stem cells in liver diseases and cancer: recent advances on the path to new therapies.
Hepatology (Baltimore, Md.)
Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration.
The Journal of clinical investigation
A simple code for installing hepatocyte function.
Cell stem cell
Mouse chimeras as a system to investigate development, cell and tissue function, disease mechanisms and organ regeneration.
Cell cycle (Georgetown, Tex.)
Core promoter recognition complex changes accompany liver development.
Proceedings of the National Academy of Sciences of the United States of America
The MAP3K TAK1: a chock block to liver cancer formation.
Hepatology (Baltimore, Md.)
Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice.
The Journal of clinical investigation
Transplanted nonviable human hepatocytes produce appreciable serum albumin levels in mice.
Stem cell research
MicroRNAs control hepatocyte proliferation during liver regeneration.
Hepatology (Baltimore, Md.)
On the origin of the term "stem cell".
Cell stem cell
Myeloid lineage progenitors give rise to vascular endothelium.
Proceedings of the National Academy of Sciences of the United States of America
Bone marrow-derived cells fuse with normal and transformed intestinal stem cells.
Proceedings of the National Academy of Sciences of the United States of America
Sustained phosphorylation of Bid is a marker for resistance to Fas-induced apoptosis during chronic liver diseases.
Gastroenterology
In vivo genetic selection of renal proximal tubules.
Molecular therapy : the journal of the American Society of Gene Therapy
Therapeutic cell fusion.
The British journal of surgery
Delineating the hepatocyte's hematopoietic fusion partner.
Cell cycle (Georgetown, Tex.)
Embryonic versus adult stem cell pluripotency: in liver only fusion matters.
Journal of assisted reproduction and genetics
Argininosuccinate lyase (ASL) deficiency: mutation analysis in 27 patients and a completed structure of the human ASL gene.
Human genetics
Genomic structure and transcript variants of the human methylenetetrahydrofolate reductase gene.
European journal of human genetics : EJHG
Telomerase activity distinguishes between neuroblastomas with good and poor prognosis.
Annals of oncology : official journal of the European Society for Medical Oncology
Telomerase activity in human proliferative breast lesions.
International journal of oncology
Nonisotopic single strand conformation analysis of the 5 alpha-reductase type 2 gene for the diagnosis of 5 alpha-reductase deficiency.
The Journal of clinical endocrinology and metabolism