Guo Huang, PhD

Associate Professor
CVRI
[email protected]
+1 415 502-2873

Guo Huang, PhD studies the cellular and molecular basis of heart regeneration from both evolutionary and developmental perspectives.

Publications: 

Ophthalmic acid is a bloodborne metabolite that contributes to age-induced cardiomyocyte hypertrophy.

bioRxiv : the preprint server for biology

Mehdipour M, Park S, Wei W, Long JZ, Huang GN

PD-1-PD-L1 immunomodulatory pathway regulates cardiac regeneration.

Nature Cardiovascular Research

Qin J, Huang GN, Moslehi J

An injury-responsive mmp14b enhancer is required for heart regeneration.

Science advances

Zlatanova I, Sun F, Wu RS, Chen X, Lau BH, Colombier P, Sinha T, Celona B, Xu SM, Materna SC, Huang GN, Black BL

Quantitative Three-dimensional Label-free Digital Holographic Imaging of Cardiomyocyte Size, Ploidy, and Cell Division.

bioRxiv : the preprint server for biology

Park S, Huang H, Ross I, Moreno J, Khyeam S, Simmons J, Huang GN, Payumo AY

Two decades of heart regeneration research: Cardiomyocyte proliferation and beyond.

WIREs mechanisms of disease

Huang H, Huang GN, Payumo AY

Unlocking cardiomyocyte renewal potential for myocardial regeneration therapy.

Journal of molecular and cellular cardiology

Mehdipour M, Park S, Huang GN

Visualization of regenerating and repairing hearts.

Clinical science (London, England : 1979)

Powers N, Huang GN

Mending a broken heart with novel cardiogenic small molecules.

Cell regeneration (London, England)

Powers N, Huang GN

Adrenergic-Thyroid Hormone Interactions Drive Postnatal Thermogenesis and Loss of Mammalian Heart Regenerative Capacity.

Circulation

Payumo AY, Chen X, Hirose K, Chen X, Hoang A, Khyeam S, Yu H, Wang J, Chen Q, Powers N, Chen L, Bigley RB, Lovas J, Hu G, Huang GN

Vertebrate cardiac regeneration: evolutionary and developmental perspectives.

Cell regeneration (London, England)

Cutie S, Huang GN

Hormonal control of cardiac regenerative potential.

Endocrine connections

Amram AV, Cutie S, Huang GN

KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice.

JCI insight

Wong JC, Perez-Mancera PA, Huang TQ, Kim J, Grego-Bessa J, Del Pilar Alzamora M, Kogan SC, Sharir A, Keefe SH, Morales CE, Schanze D, Castel P, Hirose K, Huang GN, Zenker M, Sheppard D, Klein OD, Tuveson DA, Braun BS, Shannon K

The coevolutionary process of restaurant CSR in the time of mega disruption.

International journal of hospitality management

Ou J, Wong IA, Huang GI

Lamin B2, Guardian of Cardiomyocyte Nuclear Division.

Developmental cell

Payumo AY, Huang GN

Evidence for hormonal control of heart regenerative capacity during endothermy acquisition.

Science (New York, N.Y.)

Hirose K, Payumo AY, Cutie S, Hoang A, Zhang H, Guyot R, Lunn D, Bigley RB, Yu H, Wang J, Smith M, Gillett E, Muroy SE, Schmid T, Wilson E, Field KA, Reeder DM, Maden M, Yartsev MM, Wolfgang MJ, Grützner F, Scanlan TS, Szweda LI, Buffenstein R, Hu G, Flamant F, Olgin JE, Huang GN

Unconventional Functions of Muscles in Planarian Regeneration.

Developmental cell

Cutie S, Hoang AT, Payumo AY, Huang GN

Insights into nuclear dynamics using live-cell imaging approaches.

Wiley interdisciplinary reviews. Systems biology and medicine

Bigley RB, Payumo AY, Alexander JM, Huang GN

Isolation, Culture and Transduction of Adult Mouse Cardiomyocytes.

Journal of visualized experiments : JoVE

Judd J, Lovas J, Huang GN

C/EBP transcription factors mediate epicardial activation during heart development and injury.

Science (New York, N.Y.)

Huang GN, Thatcher JE, McAnally J, Kong Y, Qi X, Tan W, DiMaio JM, Amatruda JF, Gerard RD, Hill JA, Bassel-Duby R, Olson EN

Heart repair by reprogramming non-myocytes with cardiac transcription factors.

Nature

Song K, Nam YJ, Luo X, Qi X, Tan W, Huang GN, Acharya A, Smith CL, Tallquist MD, Neilson EG, Hill JA, Bassel-Duby R, Olson EN

Peptidyl-prolyl isomerase FKBP52 controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel opening.

Neuron

Shim S, Yuan JP, Kim JY, Zeng W, Huang G, Milshteyn A, Kern D, Muallem S, Ming GL, Worley PF

STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction.

Molecular cell

Zeng W, Yuan JP, Kim MS, Choi YJ, Huang GN, Worley PF, Muallem S

NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins.

Science (New York, N.Y.)

Huang GN, Huso DL, Bouyain S, Tu J, McCorkell KA, May MJ, Zhu Y, Lutz M, Collins S, Dehoff M, Kang S, Whartenby K, Powell J, Leahy D, Worley PF

STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels.

Nature cell biology

Yuan JP, Zeng W, Huang GN, Worley PF, Muallem S

STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels.

Nature cell biology

Huang GN, Zeng W, Kim JY, Yuan JP, Han L, Muallem S, Worley PF