Grae Davis, PhD

Professor
Biochemistry and Biophysics
+1 415 476-2699

Graeme Davis, PhD studies the cellular and molecular mechanisms of neuronal development and plasticity.

Publications: 

NMDAR-dependent presynaptic homeostasis in adult hippocampus: Synapse growth and cross-modal inhibitory plasticity.

Neuron

Chipman PH, Fetter RD, Panzera LC, Bergerson SJ, Karmelic D, Yokoyama S, Hoppa MB, Davis GW

SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan.

Nature communications

Johnson AE, Orr BO, Fetter RD, Moughamian AJ, Primeaux LA, Geier EG, Yokoyama JS, Miller BL, Davis GW

Presynaptic Homeostasis Opposes Disease Progression in Mouse Models of ALS-Like Degeneration: Evidence for Homeostatic Neuroprotection.

Neuron

Orr BO, Hauswirth AG, Celona B, Fetter RD, Zunino G, Kvon EZ, Zhu Y, Pennacchio LA, Black BL, Davis GW

Evolution of Mechanisms that Control Mating in Drosophila Males.

Cell reports

Ahmed OM, Avila-Herrera A, Tun KM, Serpa PH, Peng J, Parthasarathy S, Knapp JM, Stern DL, Davis GW, Pollard KS, Shah NM

Dual separable feedback systems govern firing rate homeostasis.

eLife

Kulik Y, Jones R, Moughamian AJ, Whippen J, Davis GW

Dystrobrevin is required postsynaptically for homeostatic potentiation at the Drosophila NMJ.

Biochimica et biophysica acta. Molecular basis of disease

Jantrapirom S, Nimlamool W, Temviriyanukul P, Ahmadian S, Locke CJ, Davis GW, Yamaguchi M, Noordermeer JN, Fradkin LG, Potikanond S

The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.

Cell

Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, Shoichet B, von Zastrow M, Mucke L, Finkbeiner S, Gan L, Sestan N, Ward ME, Huttenhain R, Nowakowski TJ, Bellen HJ, Frank LM, Khokha MK, Lifton RP, Kampmann M, Ideker T, State MW, Krogan NJ

A postsynaptic PI3K-cII dependent signaling controller for presynaptic homeostatic plasticity.

eLife

Hauswirth AG, Ford KJ, Wang T, Fetter RD, Tong A, Davis GW

Engineering a light-activated caspase-3 for precise ablation of neurons in vivo.

Proceedings of the National Academy of Sciences of the United States of America

Smart AD, Pache RA, Thomsen ND, Kortemme T, Davis GW, Wells JA

Composition and Control of a Deg/ENaC Channel during Presynaptic Homeostatic Plasticity.

Cell reports

Orr BO, Gorczyca D, Younger MA, Jan LY, Jan YN, Davis GW

The Global Challenge in Neuroscience Education and Training: The MBL Perspective.

Neuron

Nishi R, Casta?eda E, Davis GW, Fenton AA, Hofmann HA, King J, Ryan TA, Trujillo KA

a2d-3 Is Required for Rapid Transsynaptic Homeostatic Signaling.

Cell reports

Wang T, Jones RT, Whippen JM, Davis GW

The Innate Immune Receptor PGRP-LC Controls Presynaptic Homeostatic Plasticity.

Neuron

Harris N, Braiser DJ, Dickman DK, Fetter RD, Tong A, Davis GW

Homeostatic control of presynaptic neurotransmitter release.

Annual review of physiology

Davis GW, M?ller M

Archaerhodopsin voltage imaging: synaptic calcium and BK channels stabilize action potential repolarization at the Drosophila neuromuscular junction.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Ford KJ, Davis GW

Endostatin is a trans-synaptic signal for homeostatic synaptic plasticity.

Neuron

Wang T, Hauswirth AG, Tong A, Dickman DK, Davis GW

Kr�ppel mediates the selective rebalancing of ion channel expression.

Neuron

Parrish JZ, Kim CC, Tang L, Bergquist S, Wang T, Derisi JL, Jan LY, Jan YN, Davis GW

A presynaptic ENaC channel drives homeostatic plasticity.

Neuron

Younger MA, M?ller M, Tong A, Pym EC, Davis GW

RIM controls homeostatic plasticity through modulation of the readily-releasable vesicle pool.

The Journal of neuroscience : the official journal of the Society for Neuroscience

M?ller M, Liu KS, Sigrist SJ, Davis GW

Snapin is critical for presynaptic homeostatic plasticity.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Dickman DK, Tong A, Davis GW

RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release.

Science (New York, N.Y.)

Liu KS, Siebert M, Mertel S, Knoche E, Wegener S, Wichmann C, Matkovic T, Muhammad K, Depner H, Mettke C, B?ckers J, Hell SW, M?ller M, Davis GW, Schmitz D, Sigrist SJ

Glial-derived prodegenerative signaling in the Drosophila neuromuscular system.

Neuron

Keller LC, Cheng L, Locke CJ, M?ller M, Fetter RD, Davis GW

Stathmin is required for stability of the Drosophila neuromuscular junction.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Graf ER, Heerssen HM, Wright CM, Davis GW, DiAntonio A

arouser reveals a role for synapse number in the regulation of ethanol sensitivity.

Neuron

Eddison M, Guarnieri DJ, Cheng L, Liu CH, Moffat KG, Davis G, Heberlein U

Hts/Adducin controls synaptic elaboration and elimination.

Neuron

Pielage J, Bulat V, Zuchero JB, Fetter RD, Davis GW

Vesicle priming in a SNAP.

Neuron

M?ller M, Davis GW

Synaptic homeostasis is consolidated by the cell fate gene gooseberry, a Drosophila pax3/7 homolog.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Marie B, Pym E, Bergquist S, Davis GW

Formin-dependent synaptic growth: evidence that Dlar signals via Diaphanous to modulate synaptic actin and dynamic pioneer microtubules.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Pawson C, Eaton BA, Davis GW

NF-kappaB, IkappaB, and IRAK control glutamate receptor density at the Drosophila NMJ.

Neuron

Heckscher ES, Fetter RD, Marek KW, Albin SD, Davis GW

Presynaptic spectrin is essential for synapse stabilization.

Current biology : CB

Pielage J, Fetter RD, Davis GW

Controlling the active properties of excitable cells.

Current opinion in neurobiology

Marek KW, Davis GW

Synapse disassembly.

Genes & development

Eaton BA, Davis GW

Dynactin is necessary for synapse stabilization.

Neuron

Eaton BA, Fetter RD, Davis GW

Synapse formation revisited.

Nature neuroscience

Davis GW, Eaton B, Paradis S

Maintaining the stability of neural function: a homeostatic hypothesis.

Annual review of physiology

Davis GW, Bezprozvanny I

A neural tetraspanin, encoded by late bloomer, that facilitates synapse formation.

Science (New York, N.Y.)

Kopczynski CC, Davis GW, Goodman CS

A role for postsynaptic neurons in determining presynaptic release properties in the cricket CNS: evidence for retrograde control of facilitation.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Davis GW, Murphey RK