
Professor
Ophthalmology
+1 415 476-1314
Erik Ullian, PhD studies the cell extrinsic and intrinsic mechanisms that regulate synapse number and function, particularly the role of glial cells in regulating neuronal synapse formation and function.
Publications
C12ORF57: a novel principal regulator of synaptic AMPA currents and excitatory neuronal homeostasis.
bioRxiv : the preprint server for biology
Nemo-like kinase disrupts nuclear import and drives TDP43 mislocalization in ALS.
bioRxiv : the preprint server for biology
CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions.
bioRxiv : the preprint server for biology
Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies.
Science (New York, N.Y.)
Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies.
bioRxiv : the preprint server for biology
Astroglial toxicity promotes synaptic degeneration in the thalamocortical circuit in frontotemporal dementia with GRN mutations.
The Journal of clinical investigation
Granulin loss of function in human mature brain organoids implicates astrocytes in TDP-43 pathology.
Stem cell reports
TMIC-43. HEDGEHOG LIGANDS FROM GLIOBLASTOMA CELLS INDUCE ASTROCYTES INHIBITION OF CANCER STEM CELLS.
Neuro-oncology
CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states.
Nature neuroscience
Tropism of SARS-CoV-2 for human cortical astrocytes.
Proceedings of the National Academy of Sciences of the United States of America
Trans-Seq maps a selective mammalian retinotectal synapse instructed by Nephronectin.
Nature neuroscience
Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma.
Nature communications
CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma.
Genome biology
Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map.
Nature neuroscience
GENE-39. CRISPRi-BASED RADIATION MODIFIER SCREEN IDENTIFIES LONG NON-CODING RNA THERAPEUTIC TARGETS IN GLIOMA.
Neuro-oncology
TMOD-27. A NEURAL CREST CELL SUBPOPULATION UNDERLIES INTRATUMOR HETEROGENEITY IN MENINGIOMA.
Neuro-oncology
COL4A1 Mutations Cause Neuromuscular Disease with Tissue-Specific Mechanistic Heterogeneity.
American journal of human genetics
Proceedings of the fifth international RASopathies symposium: When development and cancer intersect.
American journal of medical genetics. Part A
Clemastine rescues myelination defects and promotes functional recovery in hypoxic brain injury.
Brain : a journal of neurology
Cellular Phenotypes in Human iPSC-Derived Neurons from a Genetic Model of Autism Spectrum Disorder.
Cell reports
Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes.
Stem cell reports
Patient-derived iPSCs show premature neural differentiation and neuron type-specific phenotypes relevant to neurodevelopment.
Molecular psychiatry
Human stem cell-derived astrocytes replicate human prions in a PRNP genotype-dependent manner.
The Journal of experimental medicine
Zika virus cell tropism in the developing human brain and inhibition by azithromycin.
Proceedings of the National Academy of Sciences of the United States of America
Selective Vulnerability of Specific Retinal Ganglion Cell Types and Synapses after Transient Ocular Hypertension.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes.
Stem cell reports
Human astrocytes are distinct contributors to the complexity of synaptic function.
Brain research bulletin
Dynamic Modulation of Myelination in Response to Visual Stimuli Alters Optic Nerve Conduction Velocity.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Dysregulation of astrocyte extracellular signaling in Costello syndrome.
Science translational medicine
Phosphorylation of LKB1/Par-4 establishes Schwann cell polarity to initiate and control myelin extent.
Nature communications
A cellular star atlas: using astrocytes from human pluripotent stem cells for disease studies.
Frontiers in cellular neuroscience
Loss of microRNAs in pyramidal neurons leads to specific changes in inhibitory synaptic transmission in the prefrontal cortex.
Molecular and cellular neurosciences
Astrocytes and disease: a neurodevelopmental perspective.
Genes & development
Afadin, a Ras/Rap effector that controls cadherin function, promotes spine and excitatory synapse density in the hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
A role for noncanonical microRNAs in the mammalian brain revealed by phenotypic differences in Dgcr8 versus Dicer1 knockouts and small RNA sequencing.
RNA (New York, N.Y.)
Monoallelic deletion of the microRNA biogenesis gene Dgcr8 produces deficits in the development of excitatory synaptic transmission in the prefrontal cortex.
Neural development
Chapter 39 Development of Retinogeniculate Projections.
Adler\u0027s Physiology of the Eye
Neuronal pentraxins mediate silent synapse conversion in the developing visual system.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Dact1 is a postsynaptic protein required for dendrite, spine, and excitatory synapse development in the mouse forebrain.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Astrocytes and synaptic plasticity.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
Delta-catenin regulates spine and synapse morphogenesis and function in hippocampal neurons during development.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Functional regulations of p120 catenin at presynaptic site in neuron cultures.
International Journal of Developmental Neuroscience
Neuronal pentraxins mediate silent synapse conversion in the developing visual system.
International Journal of Developmental Neuroscience
Synapses are regulated by the cytoplasmic tyrosine kinase Fer in a pathway mediated by p120catenin, Fer, SHP-2, and beta-catenin.
The Journal of cell biology
Developmental control of synaptic receptivity.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration.
Proceedings of the National Academy of Sciences of the United States of America
New roles for astrocytes in developing synaptic circuits.
Communicative & integrative biology
Neuronal pentraxins mediate synaptic refinement in the developing visual system.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Extracellular Matrix Molecules and Formation of CNS Synapses.
Molecular Mechanisms of Synaptogenesis
Invulnerability of retinal ganglion cells to NMDA excitotoxicity.
Molecular and cellular neurosciences
Schwann cells and astrocytes induce synapse formation by spinal motor neurons in culture.
Molecular and cellular neurosciences
Control of synapse number by glia.
Science (New York, N.Y.)
Rapid synaptic transmission in the avian ciliary ganglion is mediated by two distinct classes of nicotinic receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Pronounced cellular diversity and extrasynaptic location of nicotinic acetylcholine receptor subunit immunoreactivities in the chicken pretectum.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Receptor localization.
International Symposium on Nicotine: The Effects of Nicotine on Biological Systems II