
Professor
Pathology
+1 415 476-8525
Eric Huang, MD, PhD studies the transcriptional control of neural development.
Publications
Pathogenesis of Germinal Matrix Hemorrhage: Insights from Single-Cell Transcriptomics.
Annual review of pathology
Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1.
bioRxiv : the preprint server for biology
Proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage in prenatal human brain.
Nature neuroscience
CHCHD2 mutant mice display mitochondrial protein accumulation and disrupted energy metabolism.
bioRxiv : the preprint server for biology
Molecular and cellular dynamics of the developing human neocortex at single-cell resolution.
bioRxiv : the preprint server for biology
Comorbid neuropathology and atypical presentation of Alzheimer's disease.
Alzheimer's & dementia (Amsterdam, Netherlands)
TMEM16F exacerbates tau pathology and mediates phosphatidylserine exposure in phospho-tau-burdened neurons.
Proceedings of the National Academy of Sciences of the United States of America
Deconstructing Intratumoral Heterogeneity through Multiomic and Multiscale Analysis of Serial Sections.
bioRxiv : the preprint server for biology
NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62.
Nature communications
Profiling human brain vascular cells using single-cell transcriptomics and organoids.
Nature protocols
Non-synaptic function of the autism spectrum disorder-associated gene SYNGAP1 in cortical neurogenesis.
Nature neuroscience
Single-cell analysis of prenatal and postnatal human cortical development.
Science (New York, N.Y.)
Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains.
bioRxiv : the preprint server for biology
Disentangling brain vasculature in neurogenesis and neurodegeneration using single-cell transcriptomics.
Trends in neurosciences
Astroglial toxicity promotes synaptic degeneration in the thalamocortical circuit in frontotemporal dementia with GRN mutations.
The Journal of clinical investigation
Granulin loss of function in human mature brain organoids implicates astrocytes in TDP-43 pathology.
Stem cell reports
Plastin 3 rescues BDNF-TrkB signaling in spinal muscular atrophy.
The Journal of cell biology
Meta-Analysis of the Test-Retest Repeatability of [18F]-Fluorodeoxyglucose Standardized Uptake Values: Implications for Assessment of Tumor Response.
Clinical cancer research : an official journal of the American Association for Cancer Research
Developmental dynamics of RNA translation in the human brain.
Nature neuroscience
Endosomal recycling defects link Huntington's disease with McLeod syndrome.
The Journal of cell biology
Neuroimmune dysfunction in frontotemporal dementia: Insights from progranulin and C9orf72 deficiency.
Current opinion in neurobiology
Secretory autophagy maintains proteostasis upon lysosome inhibition.
The Journal of cell biology
Comment on "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis".
Science (New York, N.Y.)
Nests of dividing neuroblasts sustain interneuron production for the developing human brain.
Science (New York, N.Y.)
Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.
The Journal of clinical investigation
Atypical Young-onset Dementia in Cerebral Thromboangiitis Obliterans: A Case Report.
Alzheimer disease and associated disorders
Comorbid neuropathological diagnoses in early versus late-onset Alzheimer's disease.
Brain : a journal of neurology
Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration.
Molecular neurodegeneration
Label-retention expansion microscopy.
The Journal of cell biology
ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects.
The Journal of clinical investigation
Positive Controls in Adults and Children Support That Very Few, If Any, New Neurons Are Born in the Adult Human Hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
A Developmental Analysis of Juxtavascular Microglia Dynamics and Interactions with the Vasculature.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant wobbler mice, a model of motor neuron degeneration.
Proceedings of the National Academy of Sciences of the United States of America
Frontotemporal dementia non-sense mutation of progranulin rescued by aminoglycosides.
Human molecular genetics
The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles.
Nature cell biology
Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma.
Cell stem cell
Loss of HIPK2 Protects Neurons from Mitochondrial Toxins by Regulating Parkin Protein Turnover.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Cortical developmental abnormalities in logopenic variant primary progressive aphasia with dyslexia.
Brain communications
C9orf72-specific phenomena associated with frontotemporal dementia and gastrointestinal symptoms in the absence of TDP-43 aggregation.
Acta neuropathologica
Novel and lethal case of cardiac involvement in DNM1L mitochondrial encephalopathy.
American journal of medical genetics. Part A
Neuropathological correlates of structural and functional imaging biomarkers in 4-repeat tauopathies.
Brain : a journal of neurology
Immature excitatory neurons develop during adolescence in the human amygdala.
Nature communications
Impaired aV�8 and TGF� signaling lead to microglial dysmaturation and neuromotor dysfunction.
The Journal of experimental medicine
Does Adult Neurogenesis Persist in the Human Hippocampus?
Cell stem cell
Neurons selectively targeted in frontotemporal dementia reveal early stage TDP-43 pathobiology.
Acta neuropathologica
RNA Binding Proteins and the Pathogenesis of Frontotemporal Lobar Degeneration.
Annual review of pathology
HIPK2-Mediated Transcriptional Control of NMDA Receptor Subunit Expression Regulates Neuronal Survival and Cell Death.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay.
Proceedings of the National Academy of Sciences of the United States of America
Clinicopathological correlations in behavioural variant frontotemporal dementia.
Brain : a journal of neurology
An RNA interference screen identifies druggable regulators of MeCP2 stability.
Science translational medicine
Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease.
Science translational medicine
Afadin controls cell polarization and mitotic spindle orientation in developing cortical radial glia.
Neural development
Progranulin, lysosomal regulation and neurodegenerative disease.
Nature reviews. Neuroscience
Long-term oral kinetin does not protect against a-synuclein-induced neurodegeneration in rodent models of Parkinson's disease.
Neurochemistry international
Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.
Science translational medicine
Typical and atypical pathology in primary progressive aphasia variants.
Annals of neurology
Extensive migration of young neurons into the infant human frontal lobe.
Science (New York, N.Y.)
Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis.
Neuron
Quantitative MRI radiomics in the prediction of molecular classifications of breast cancer subtypes in the TCGA/TCIA data set.
NPJ breast cancer
Selective Frontoinsular von Economo Neuron and Fork Cell Loss in Early Behavioral Variant Frontotemporal Dementia.
Cerebral cortex (New York, N.Y. : 1991)
Dopaminergic Neurons and Brain Reward Pathways: From Neurogenesis to Circuit Assembly.
The American journal of pathology
Modeling ALS and FTD with iPSC-derived neurons.
Brain research
Aldehyde dehydrogenase 1a1 mediates a GABA synthesis pathway in midbrain dopaminergic neurons.
Science (New York, N.Y.)
Myeloid expression of the AP-1 transcription factor JUNB modulates outcomes of type 1 and type 2 parasitic infections.
Parasite immunology
Evaluating and treating neurobehavioral symptoms in professional American football players: Lessons from a case series.
Neurology. Clinical practice
The behavioural/dysexecutive variant of Alzheimer's disease: clinical, neuroimaging and pathological features.
Brain : a journal of neurology
Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1.
Proceedings of the National Academy of Sciences of the United States of America
Dysregulation of locus coeruleus development in congenital central hypoventilation syndrome.
Acta neuropathologica
Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation.
Brain : a journal of neurology
ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP.
Nature communications
Postnatal growth of the human pons: a morphometric and immunohistochemical analysis.
The Journal of comparative neurology
Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Activity-dependent FUS dysregulation disrupts synaptic homeostasis.
Proceedings of the National Academy of Sciences of the United States of America
Massive CNS monocytic infiltration at autopsy in an alemtuzumab-treated patient with NMO.
Neurology(R) neuroimmunology & neuroinflammation
Deletion of Rbpj from postnatal endothelium leads to abnormal arteriovenous shunting in mice.
Development (Cambridge, England)
CCR2 deficiency impairs macrophage infiltration and improves cognitive function after traumatic brain injury.
Journal of neurotrauma
Parallel states of pathological Wnt signaling in neonatal brain injury and colon cancer.
Nature neuroscience
ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects.
The Journal of clinical investigation
Axons take a dive: Specialized contacts of serotonergic axons with cells in the walls of the lateral ventricles in mice and humans.
Neurogenesis (Austin, Tex.)
In vivo signatures of nonfluent/agrammatic primary progressive aphasia caused by FTLD pathology.
Neurology
Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons.
Nature neuroscience
A dramatic increase of C1q protein in the CNS during normal aging.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Overexpression of vascular endothelial growth factor in the germinal matrix induces neurovascular proteases and intraventricular hemorrhage.
Science translational medicine
Lamin B1 mediates cell-autonomous neuropathology in a leukodystrophy mouse model.
The Journal of clinical investigation
Temporal and spatial requirements of Smoothened in ventral midbrain neuronal development.
Neural development
Systematic analysis of challenge-driven improvements in molecular prognostic models for breast cancer.
Science translational medicine
Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-�-TAK1-dependent mechanism.
PLoS biology
Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Conceptual developments in the causes of Cockayne syndrome.
Mechanisms of ageing and development
Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation.
Acta neuropathologica
Nonfluent/agrammatic PPA with in-vivo cortical amyloidosis and Pick's disease pathology.
Behavioural neurology
Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.
The Journal of clinical investigation
STAT3-mediated astrogliosis protects myelin development in neonatal brain injury.
Annals of neurology
Species-dependent posttranscriptional regulation of NOS1 by FMRP in the developing cerebral cortex.
Cell
Replication of hepatitis C virus RNA on autophagosomal membranes.
The Journal of biological chemistry
Dysmyelination not demyelination causes neurological symptoms in preweaned mice in a murine model of Cockayne syndrome.
Proceedings of the National Academy of Sciences of the United States of America
Defective retinal vascular endothelial cell development as a consequence of impaired integrin aV�8-mediated activation of transforming growth factor-�.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis.
Nature immunology
Homeodomain interacting protein kinase 2 regulates postnatal development of enteric dopaminergic neurons and glia via BMP signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Clinicopathological correlations in corticobasal degeneration.
Annals of neurology
Comparative healing of human cutaneous surgical incisions created by the PEAK PlasmaBlade, conventional electrosurgery, and a standard scalpel.
Plastic and reconstructive surgery
Kr�ppel-like factor 15 activates hepatitis B virus gene expression and replication.
Hepatology (Baltimore, Md.)
Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination.
Nature neuroscience
Selective frontoinsular von Economo neuron and fork cell loss in early behavioral variant frontotemporal dementia.
Cerebral cortex (New York, N.Y. : 1991)
Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration.
Proceedings of the National Academy of Sciences of the United States of America
Comparative healing of rat fascia following incision with three surgical instruments.
The Journal of surgical research
Towards improved animal models of neonatal white matter injury associated with cerebral palsy.
Disease models & mechanisms
Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis.
The Journal of clinical investigation
Interactions of Wnt/beta-catenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Extensive FUS-immunoreactive pathology in juvenile amyotrophic lateral sclerosis with basophilic inclusions.
Brain pathology (Zurich, Switzerland)
Two genetic variants of CD38 in subjects with autism spectrum disorder and controls.
Neuroscience research
Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeys.
Human gene therapy
Sporadic corticobasal syndrome due to FTLD-TDP.
Acta neuropathologica
Multiple roles of beta-catenin in controlling the neurogenic niche for midbrain dopamine neurons.
Development (Cambridge, England)
A gamma-secretase inhibitor and quinacrine reduce prions and prevent dendritic degeneration in murine brains.
Proceedings of the National Academy of Sciences of the United States of America
HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America
Increased apoptosis, p53 up-regulation, and cerebellar neuronal degeneration in repair-deficient Cockayne syndrome mice.
Proceedings of the National Academy of Sciences of the United States of America
Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons.
Nature neuroscience
Dynamic expression of neurotrophic factor receptors in postnatal spinal motoneurons and in mouse model of ALS.
Journal of neurobiology
Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2.
Proceedings of the National Academy of Sciences of the United States of America
Selective neuronal vulnerability and inadequate stress response in superoxide dismutase mutant mice.
Free radical biology & medicine
Notch-1 activation and dendritic atrophy in prion disease.
Proceedings of the National Academy of Sciences of the United States of America
Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization.
Genes & development
Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival.
The Journal of cell biology
Homeodomain-interacting protein kinase-2 regulates apoptosis in developing sensory and sympathetic neurons.
Current biology : CB
Trk receptors: roles in neuronal signal transduction.
Annual review of biochemistry
Brn3a is a transcriptional regulator of soma size, target field innervation and axon pathfinding of inner ear sensory neurons.
Development (Cambridge, England)
NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development.
Development (Cambridge, England)
Neurotrophins: roles in neuronal development and function.
Annual review of neuroscience
Formation of a full complement of cranial proprioceptors requires multiple neurotrophins.
Developmental dynamics : an official publication of the American Association of Anatomists
POU domain factor Brn-3a controls the differentiation and survival of trigeminal neurons by regulating Trk receptor expression.
Development (Cambridge, England)
Expression of Trk receptors in the developing mouse trigeminal ganglion: in vivo evidence for NT-3 activation of TrkA and TrkB in addition to TrkC.
Development (Cambridge, England)
Role of dimerization of the membrane-associated growth factor kit ligand in juxtacrine signaling: the Sl17H mutation affects dimerization and stability-phenotypes in hematopoiesis.
The Journal of experimental medicine
Hepatitis B and C coinfections and persistent hepatitis B infections: clinical outcome and liver pathology after transplantation.
Hepatology (Baltimore, Md.)
The expression pattern of the c-kit ligand in gonads of mice supports a role for the c-kit receptor in oocyte growth and in proliferation of spermatogonia.
Developmental biology
The murine steel panda mutation affects kit ligand expression and growth of early ovarian follicles.
Developmental biology
The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis.
Development (Cambridge, England). Supplement
c-kit receptor and ligand expression in postnatal development of the mouse cerebellum suggests a function for c-kit in inhibitory interneurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Cleavage of membrane-anchored growth factors involves distinct protease activities regulated through common mechanisms.
The Journal of biological chemistry
Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2.
Molecular biology of the cell