Daniel Mordes, MD, PhD

Assistant Professor
Institute for Neurodegenerative Diseases

Daniel Mordes, MD, PhD investigates the molecular mechanisms of neurodegenerative diseases, including ALS and dementia, using stem cell-based models and single-cell analyses of brain areas.

Publications: 

C9ORF72 poly-PR disrupts expression of ALS/FTD-implicated STMN2 through SRSF7.

Acta neuropathologica communications

Wang KS, Smeyers J, Eggan K, Budnik B, Mordes DA

Cryo-EM structure of a novel a-synuclein filament subtype from multiple system atrophy.

FEBS letters

Yan NL, Candido F, Tse E, Melo AA, Prusiner SB, Mordes DA, Southworth DR, Paras NA, Merz GE

Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP.

Nature communications

Nadel CM, Pokhrel S, Wucherer K, Oehler A, Thwin AC, Basu K, Callahan MD, Southworth DR, Mordes DA, Craik CS, Gestwicki JE

Methods for high throughput discovery of fluoroprobes that recognize tau fibril polymorphs.

bioRxiv : the preprint server for biology

Carroll EC, Yang H, Jones JG, Oehler A, Charvat AF, Montgomery KM, Yung A, Millbern Z, Vinueza NR, DeGrado WF, Mordes DA, Condello C, Gestwicki JE

Single-nucleus sequencing reveals enriched expression of genetic risk factors in extratelencephalic neurons sensitive to degeneration in ALS.

Nature aging

Limone F, Mordes DA, Couto A, Joseph BJ, Mitchell JM, Therrien M, Ghosh SD, Meyer D, Zhang Y, Goldman M, Bortolin L, Cobos I, Stevens B, McCarroll SA, Kadiu I, Burberry A, Pietiläinen O, Eggan K

Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP.

bioRxiv : the preprint server for biology

Nadel CM, Wucherer K, Oehler A, Thwin AC, Basu K, Callahan MD, Southworth DR, Mordes DA, Craik CS, Gestwicki JE

Running up that pill for amyotrophic lateral sclerosis.

Brain : a journal of neurology

Smeyers J, Mordes DA

The E46K mutation modulates α-synuclein prion replication in transgenic mice.

PLoS pathogens

Holec SAM, Lee J, Oehler A, Batia L, Wiggins-Gamble A, Lau J, Ooi FK, Merz GE, Wang M, Mordes DA, Olson SH, Woerman AL

Pluripotent stem cell strategies for rebuilding the human brain.

Frontiers in aging neuroscience

Limone F, Klim JR, Mordes DA

Multiple system atrophy prions transmit neurological disease to mice expressing wild-type human α-synuclein.

Acta neuropathologica

Holec SAM, Lee J, Oehler A, Ooi FK, Mordes DA, Olson SH, Prusiner SB, Woerman AL

Absence of Survival and Motor Deficits in 500 Repeat C9ORF72 BAC Mice.

Neuron

Mordes DA, Morrison BM, Ament XH, Cantrell C, Mok J, Eggan P, Xue C, Wang JY, Eggan K, Rothstein JD

Kinetics of α-synuclein prions preceding neuropathological inclusions in multiple system atrophy.

PLoS pathogens

Woerman AL, Patel S, Kazmi SA, Oehler A, Lee J, Mordes DA, Olson SH, Prusiner SB

Publisher Correction: Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein.

Nature neuroscience

Farhan SMK, Howrigan DP, Abbott LE, Klim JR, Topp SD, Byrnes AE, Churchhouse C, Phatnani H, Smith BN, Rampersaud E, Wu G, Wuu J, Shatunov A, Iacoangeli A, Khleifat AA, Mordes DA, Ghosh S, ALSGENS Consortium, FALS Consortium, Project MinE Consortium, CReATe Consortium, Eggan K, Rademakers R, McCauley JL, Schüle R, Züchner S, Benatar M, Taylor JP, Nalls M, Gotkine M, Shaw PJ, Morrison KE, Al-Chalabi A, Traynor B, Shaw CE, Goldstein DB, Harms MB, Daly MJ, Neale BM

Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein.

Nature neuroscience

Farhan SMK, Howrigan DP, Abbott LE, Klim JR, Topp SD, Byrnes AE, Churchhouse C, Phatnani H, Smith BN, Rampersaud E, Wu G, Wuu J, Shatunov A, Iacoangeli A, Al Khleifat A, Mordes DA, Ghosh S, ALSGENS Consortium, FALS Consortium, Project MinE Consortium, CReATe Consortium, Eggan K, Rademakers R, McCauley JL, Schüle R, Züchner S, Benatar M, Taylor JP, Nalls M, Gotkine M, Shaw PJ, Morrison KE, Al-Chalabi A, Traynor B, Shaw CE, Goldstein DB, Harms MB, Daly MJ, Neale BM

Multiple system atrophy prions retain strain specificity after serial propagation in two different Tg(SNCA*A53T) mouse lines.

Acta neuropathologica

Woerman AL, Oehler A, Kazmi SA, Lee J, Halliday GM, Middleton LT, Gentleman SM, Mordes DA, Spina S, Grinberg LT, Olson SH, Prusiner SB

ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair.

Nature neuroscience

Klim JR, Williams LA, Limone F, Guerra San Juan I, Davis-Dusenbery BN, Mordes DA, Burberry A, Steinbaugh MJ, Gamage KK, Kirchner R, Moccia R, Cassel SH, Chen K, Wainger BJ, Woolf CJ, Eggan K

Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients.

Acta neuropathologica communications

Mordes DA, Prudencio M, Goodman LD, Klim JR, Moccia R, Limone F, Pietilainen O, Chowdhary K, Dickson DW, Rademakers R, Bonini NM, Petrucelli L, Eggan K

The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis.

Genes & development

Zhang Y, Burberry A, Wang JY, Sandoe J, Ghosh S, Udeshi ND, Svinkina T, Mordes DA, Mok J, Charlton M, Li QZ, Carr SA, Eggan K

Familial Parkinson's point mutation abolishes multiple system atrophy prion replication.

Proceedings of the National Academy of Sciences of the United States of America

Woerman AL, Kazmi SA, Patel S, Aoyagi A, Oehler A, Widjaja K, Mordes DA, Olson SH, Prusiner SB

MSA prions exhibit remarkable stability and resistance to inactivation.

Acta neuropathologica

Woerman AL, Kazmi SA, Patel S, Freyman Y, Oehler A, Aoyagi A, Mordes DA, Halliday GM, Middleton LT, Gentleman SM, Olson SH, Prusiner SB

Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage.

Proceedings of the National Academy of Sciences of the United States of America

Hill SJ, Mordes DA, Cameron LA, Neuberg DS, Landini S, Eggan K, Livingston DM

Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging.

Nature communications

Tian F, Yang W, Mordes DA, Wang JY, Salameh JS, Mok J, Chew J, Sharma A, Leno-Duran E, Suzuki-Uematsu S, Suzuki N, Han SS, Lu FK, Ji M, Zhang R, Liu Y, Strominger J, Shneider NA, Petrucelli L, Xie XS, Eggan K

Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease.

Science translational medicine

Burberry A, Suzuki N, Wang JY, Moccia R, Mordes DA, Stewart MH, Suzuki-Uematsu S, Ghosh S, Singh A, Merkle FT, Koszka K, Li QZ, Zon L, Rossi DJ, Trowbridge JJ, Notarangelo LD, Eggan K

A 34-Year-Old Male with An Intracranial Mass.

Brain pathology (Zurich, Switzerland)

LaBuzetta JN, Mordes D, Arrillaga I, Chi A, Dietrich J

Pigmented Lesions of the Nervous System and the Neural Crest: Lessons From Embryology.

Neurosurgery

Agarwalla PK, Koch MJ, Mordes DA, Codd PJ, Coumans JV

Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening.

Scientific reports

Wood LB, Winslow AR, Proctor EA, McGuone D, Mordes DA, Frosch MP, Hyman BT, Lauffenburger DA, Haigis KM

Case Records of the Massachusetts General Hospital. Case 30-2015: A 50-Year-Old Man with Cardiogenic Shock.

The New England journal of medicine

Wheeler TM, Baker JN, Chad DA, Zilinski JL, Verzosa S, Mordes DA

Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism.

Proceedings of the National Academy of Sciences of the United States of America

Prusiner SB, Woerman AL, Mordes DA, Watts JC, Rampersaud R, Berry DB, Patel S, Oehler A, Lowe JK, Kravitz SN, Geschwind DH, Glidden DV, Halliday GM, Middleton LT, Gentleman SM, Grinberg LT, Giles K

Propagation of prions causing synucleinopathies in cultured cells.

Proceedings of the National Academy of Sciences of the United States of America

Woerman AL, Stöhr J, Aoyagi A, Rampersaud R, Krejciova Z, Watts JC, Ohyama T, Patel S, Widjaja K, Oehler A, Sanders DW, Diamond MI, Seeley WW, Middleton LT, Gentleman SM, Mordes DA, Südhof TC, Giles K, Prusiner SB

Case records of the Massachusetts General Hospital. Case 12-2015. A newborn boy with respiratory distress, lethargy, and hypernatremia.

The New England journal of medicine

Lin TY, Ebb DH, Boepple PA, Thiele EA, Rincon SP, Mordes DA

VE1 antibody immunoreactivity in normal anterior pituitary and adrenal cortex without detectable BRAF V600E mutations.

American journal of clinical pathology

Mordes DA, Lynch K, Campbell S, Dias-Santagata D, Nose V, Louis DN, Hoang MP

Glioblastoma mimicking an arteriovenous malformation.

Frontiers in neurology

Khanna A, Venteicher AS, Walcott BP, Kahle KT, Mordes DA, William CM, Ghogawala Z, Ogilvy CS

Cytopathology of subacute thyroiditis.

Diagnostic cytopathology

Mordes DA, Brachtel EF

A workshop on leadership for MD/PhD students.

Medical education online

Ciampa EJ, Hunt AA, Arneson KO, Mordes DA, Oldham WM, Vin Woo K, Owens DA, Cannon MD, Dermody TS

In vitro fluid dynamics of the Ahmed glaucoma valve modified with expanded polytetrafluoroethylene.

Current eye research

DeCroos FC, Kondo Y, Mordes D, Lee MR, Ahmad S, Asrani S, Allingham RR, Olbrich KC, Klitzman B

Expanded polytetrafluoroethylene membrane alters tissue response to implanted Ahmed glaucoma valve.

Current eye research

DeCroos FC, Ahmad S, Kondo Y, Chow J, Mordes D, Lee MR, Asrani S, Allingham RR, Olbrich KC, Klitzman B

Dpb11 activates the Mec1-Ddc2 complex.

Proceedings of the National Academy of Sciences of the United States of America

Mordes DA, Nam EA, Cortez D

The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling.

Molecular and cellular biology

Xu X, Vaithiyalingam S, Glick GG, Mordes DA, Chazin WJ, Cortez D

Activation of ATR and related PIKKs.

Cell cycle (Georgetown, Tex.)

Mordes DA, Cortez D

TopBP1 activates ATR through ATRIP and a PIKK regulatory domain.

Genes & development

Mordes DA, Glick GG, Zhao R, Cortez D

Function of a conserved checkpoint recruitment domain in ATRIP proteins.

Molecular and cellular biology

Ball HL, Ehrhardt MR, Mordes DA, Glick GG, Chazin WJ, Cortez D

Pre-mRNA splicing and retinitis pigmentosa.

Molecular vision

Mordes D, Luo X, Kar A, Kuo D, Xu L, Fushimi K, Yu G, Sternberg P, Wu JY