Daniel Lim, MD, PhD

Professor
Neurological Surgery
+1 415 476-8138

Daniel Lim, MD, PhD studies the role of chromatin remodeling factors in the regulation of neural stem cell fate. By defining the genetic programs and molecular mechanisms of neurogenesis, he hopes to develop therapies for neurodegenerative diseases and injury.

Publications: 

In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy responses in glioblastoma.

Genome biology

Liu SJ, Zou C, Pak J, Morse A, Pang D, Casey-Clyde T, Borah AA, Wu D, Seo K, O'Loughlin T, Lim DA, Ozawa T, Berger MS, Kamber RA, Weiss WA, Raleigh DR, Gilbert LA

Sex-specific role for the long noncoding RNA Pnky in mouse behavior.

Nature communications

Saha P, Andersen RE, Hong SJ, Gil E, Simms J, Choi H, Lim DA

Spatial 3D genome organization controls the activity of bivalent chromatin during human neurogenesis.

bioRxiv : the preprint server for biology

Ahanger SH, Zhang C, Semenza ER, Gil E, Cole MA, Wang L, Kriegstein AR, Lim DA

Neural Stem Cell Relay from B1 to B2 cells in the adult mouse Ventricular-Subventricular Zone.

bioRxiv : the preprint server for biology

Cebrian-Silla A, Assis Nascimento M, Mancia W, Gonzalez-Granero S, Romero-Rodriguez R, Obernier K, Steffen DM, Lim DA, Garcia-Verdugo JM, Alvarez-Buylla A

Deconstructing Intratumoral Heterogeneity through Multiomic and Multiscale Analysis of Serial Sections.

Cancers

Schupp PG, Shelton SJ, Brody DJ, Eliscu R, Johnson BE, Mazor T, Kelley KW, Potts MB, McDermott MW, Huang EJ, Lim DA, Pieper RO, Berger MS, Costello JF, Phillips JJ, Oldham MC

Deconstructing Intratumoral Heterogeneity through Multiomic and Multiscale Analysis of Serial Sections.

bioRxiv : the preprint server for biology

Schupp PG, Shelton SJ, Brody DJ, Eliscu R, Johnson BE, Mazor T, Kelley KW, Potts MB, McDermott MW, Huang EJ, Lim DA, Pieper RO, Berger MS, Costello JF, Phillips JJ, Oldham MC

Epigenetic reprogramming shapes the cellular landscape of schwannoma.

Nature communications

Liu SJ, Casey-Clyde T, Cho NW, Swinderman J, Pekmezci M, Dougherty MC, Foster K, Chen WC, Villanueva-Meyer JE, Swaney DL, Vasudevan HN, Choudhury A, Pak J, Breshears JD, Lang UE, Eaton CD, Hiam-Galvez KJ, Stevenson E, Chen KH, Lien BV, Wu D, Braunstein SE, Sneed PK, Magill ST, Lim D, McDermott MW, Berger MS, Perry A, Krogan NJ, Hansen MR, Spitzer MH, Gilbert L, Theodosopoulos PV, Raleigh DR

Sex-specific role for the long noncoding RNA Pnky in mouse behavior.

bioRxiv : the preprint server for biology

Saha P, Andersen RE, Hong SJ, Gil E, Simms J, Lim DA

A road map for the treatment of pediatric diffuse midline glioma.

Cancer cell

Koschmann C, Al-Holou WN, Alonso MM, Anastas J, Bandopadhayay P, Barron T, Becher O, Cartaxo R, Castro MG, Chung C, Clausen M, Dang D, Doherty R, Duchatel R, Dun M, Filbin M, Franson A, Galban S, Garcia Moure M, Garton H, Gowda P, Marques JG, Hawkins C, Heath A, Hulleman E, Ji S, Jones C, Kilburn L, Kline C, Koldobskiy MA, Lim D, Lowenstein PR, Lu QR, Lum J, Mack S, Magge S, Marini B, Martin D, Marupudi N, Messinger D, Mody R, Morgan M, Mota M, Muraszko K, Mueller S, Natarajan SK, Nazarian J, Niculcea M, Nuechterlein N, Okada H, Opipari V, Pai MP, Pal S, Peterson E, Phoenix T, Prensner JR, Pun M, Raju GP, Reitman ZJ, Resnick A, Rogawski D, Saratsis A, Sbergio SG, Souweidane M, Stafford JM, Tzaridis T, Venkataraman S, Vittorio O, Wadden J, Wahl D, Wechsler-Reya RJ, Yadav VN, Zhang X, Zhang Q, Venneti S

EPCO-12. IN VIVO PERTURB-SEQ DEFINES BIOLOGICAL DRIVERS AND THERAPEUTIC VULNERABILITIES UNDERLYING RADIOTHERAPY RESISTANCE IN GLIOBLASTOMA.

Neuro-oncology

John Liu, Joanna Pak, Christopher Zou, Sixuan Pan, Emily Payne, Kyla Foster, Katie Lin, Tim Casey-Clyde, Kyounghee Seo, Thomas O'Loughlin, David Wu, Daniel Lim, Harish Vasudevan, Aaron Diaz, Tomoko Ozawa, Mitchel Berger, John de Groot, William Weiss, Luke Gilbert, David Raleigh

EPCO-39. CLARIFYING THE MOLECULAR CONSEQUENCES OF ONCOGENIC MUTATIONS THROUGH MULTISCALE AND MULTIOMIC ANALYSIS OF INDIVIDUAL TUMORS.

Neuro-oncology

Patrick Schupp, Samuel Shelton, Daniel Brody, Rebecca Eliscu, Brett Johnson, Tali Mazor, Kevin Kelley, Matthew Potts, Michael McDermott, Eric Huang, Daniel Lim, Russell Pieper, Mitchel Berger, Joseph Costello, Joanna Phillips, Michael Oldham

Identifying Gene-Treatment Interactions and Targetable Radiation Vulnerabilities in Glioblastoma through Coupling of In Vivo CRISPR Perturbation and Single Cell Transcriptomics.

International Journal of Radiation Oncology • Biology • Physics

S.J. Liu, J. Pak, C. Zou, E. Payne, K. Foster, H. Vasudevan, T. Casey-Clyde, K. Seo, T. O'Loughlin, D. Wu, D. Lim, T. Ozawa, J. de Groot, M.S. Berger, W. Weiss, L.A. Gilbert, D. Raleigh

385 A Cell Resolution Atlas of the Human Cerebrovasculature Reveals Angiogenic and Inflammatory Cell Programs in Arteriovenous Malformations.

Neurosurgery

Ethan A. Winkler, Chang Kim, Jayden Ross, Joseph Garcia, Eugene Gil, Irene Oh, Lindsay Chen, David Wu, Joshua Catapano, Kunal P. Raygor, Kazim Narsinh, Helen Kim, Shantel Weinsheimer, Daniel Cooke, Brian Patrick Walcott, Michael T. Lawton, Nalin Gupta, Berislav Zlokovic, Edward F. Chang, Adib Adnan Abla, Daniel A. Lim, Tomasz Nowakowski

TMIC-43. HEDGEHOG LIGANDS FROM GLIOBLASTOMA CELLS INDUCE ASTROCYTES INHIBITION OF CANCER STEM CELLS.

Neuro-oncology

Kyounghee Seo, S John Liu, Vikas Daggubati, Joanna J Phillips, Jennifer Clarke, Michael Prados, Aparna Bhaduri, Daniel Lim, Erik Ullian, David Raleigh

Conserved and Distinct Functions of the Autism-Related Chromatin Remodeler CHD8 in Embryonic and Adult Forebrain Neurogenesis.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Dong C, Zhao C, Chen X, Berry K, Wang J, Zhang F, Liao Y, Han R, Ogurek S, Xu L, Zhang L, Lin Y, Zhou W, Xin M, Lim DA, Campbell K, Nakafuku M, Waclaw RR, Lu QR

Dual genome-wide coding and lncRNA screens in neural induction of induced pluripotent stem cells.

Cell genomics

Wu D, Poddar A, Ninou E, Hwang E, Cole MA, Liu SJ, Horlbeck MA, Chen J, Replogle JM, Carosso GA, Eng NWL, Chang J, Shen Y, Weissman JS, Lim DA

A single-cell atlas of the normal and malformed human brain vasculature.

Science (New York, N.Y.)

Winkler EA, Kim CN, Ross JM, Garcia JH, Gil E, Oh I, Chen LQ, Wu D, Catapano JS, Raygor K, Narsinh K, Kim H, Weinsheimer S, Cooke DL, Walcott BP, Lawton MT, Gupta N, Zlokovic BV, Chang EF, Abla AA, Lim DA, Nowakowski TJ

Endoluminal Biopsy for Molecular Profiling of Human Brain Vascular Malformations.

Neurology

Winkler E, Wu D, Gil E, McCoy D, Narsinh K, Sun Z, Mueller K, Ross J, Kim H, Weinsheimer S, Berger M, Nowakowski T, Lim D, Abla A, Cooke D

Single-cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenesis.

eLife

Cebrian-Silla A, Nascimento MA, Redmond SA, Mansky B, Wu D, Obernier K, Romero Rodriguez R, Gonzalez-Granero S, García-Verdugo JM, Lim DA, Álvarez-Buylla A

Distinct nuclear compartment-associated genome architecture in the developing mammalian brain.

Nature neuroscience

Ahanger SH, Delgado RN, Gil E, Cole MA, Zhao J, Hong SJ, Kriegstein AR, Nowakowski TJ, Pollen AA, Lim DA

Long noncoding RNAs in cancer metastasis.

Nature reviews. Cancer

Liu SJ, Dang HX, Lim DA, Feng FY, Maher CA

miRNA-independent function of long noncoding pri-miRNA loci.

Proceedings of the National Academy of Sciences of the United States of America

He D, Wu D, Muller S, Wang L, Saha P, Ahanger SH, Liu SJ, Cui M, Hong SJ, Jain M, Olson HE, Akeson M, Costello JF, Diaz A, Lim DA

Genome-Scale Perturbation of Long Noncoding RNA Expression Using CRISPR Interference.

Methods in molecular biology (Clifton, N.J.)

Liu SJ, Horlbeck MA, Weissman JS, Lim DA

Endoluminal Biopsy for Molecular Classification of Human Brain Arteriovenous Malformations.

Neurosurgery

Ethan Winkler, David Wu, Daniel A Lim, Daniel Cooke, Adib A Abla

Multiplatform Genomic Profiling and Magnetic Resonance Imaging Identify Molecular and Radiologic Determinants of Intratumor Heterogeneity Underlying Aggressive Behavior in Meningioma.

International Journal of Radiation Oncology • Biology • Physics

H. Vasudevan, S. Magill, K. Seo, J. Villanueva-Meyer, A. Choudhury, S.J. Liu, M. Pekmezci, S. Findakly, S. Hilz, S. LaStella, S.E. Braunstein, N.A. Oberheim, M.K. Aghi, P.V. Theodosopoulos, P.K. Sneed, M.S. Berger, M.W. McDermott, D. Lim, E. Ulian, J. Costello, D. Raleigh

Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma.

Nature communications

Magill ST, Vasudevan HN, Seo K, Villanueva-Meyer JE, Choudhury A, John Liu S, Pekmezci M, Findakly S, Hilz S, Lastella S, Demaree B, Braunstein SE, Bush NAO, Aghi MK, Theodosopoulos PV, Sneed PK, Abate AR, Berger MS, McDermott MW, Lim DA, Ullian EM, Costello JF, Raleigh DR

Maintenance of neural stem cell positional identity by mixed-lineage leukemia 1.

Science (New York, N.Y.)

Delgado RN, Mansky B, Ahanger SH, Lu C, Andersen RE, Dou Y, Alvarez-Buylla A, Lim DA

CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma.

Genome biology

Liu SJ, Malatesta M, Lien BV, Saha P, Thombare SS, Hong SJ, Pedraza L, Koontz M, Seo K, Horlbeck MA, He D, Birk HS, Jain M, Olsen HE, Akeson M, Weissman JS, Monje M, Gupta N, Raleigh DR, Ullian EM, Lim DA

Prefrontal-Subthalamic Hyperdirect Pathway Modulates Movement Inhibition in Humans.

Neuron

Chen W, de Hemptinne C, Miller AM, Leibbrand M, Little SJ, Lim DA, Larson PS, Starr PA

Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes.

Nature biotechnology

Horlbeck MA, Liu SJ, Chang HY, Lim DA, Weissman JS

Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma.

Cell stem cell

Bhaduri A, Di Lullo E, Jung D, M?ller S, Crouch EE, Espinosa CS, Ozawa T, Alvarado B, Spatazza J, Cadwell CR, Wilkins G, Velmeshev D, Liu SJ, Malatesta M, Andrews MG, Mostajo-Radji MA, Huang EJ, Nowakowski TJ, Lim DA, Diaz A, Raleigh DR, Kriegstein AR

Long-Term Safety, Immunologic Response, and Imaging Outcomes following Neural Stem Cell Transplantation for Pelizaeus-Merzbacher Disease.

Stem cell reports

Gupta N, Henry RG, Kang SM, Strober J, Lim DA, Ryan T, Perry R, Farrell J, Ulman M, Rajalingam R, Gage A, Huhn SL, Barkovich AJ, Rowitch DH

The Long Noncoding RNA Pnky Is a Trans-acting Regulator of Cortical Development In Vivo.

Developmental cell

Andersen RE, Hong SJ, Lim JJ, Cui M, Harpur BA, Hwang E, Delgado RN, Ramos AD, Liu SJ, Blencowe BJ, Lim DA

CONICS integrates scRNA-seq with DNA sequencing to map gene expression to tumor sub-clones.

Bioinformatics (Oxford, England)

Müller S, Cho A, Liu SJ, Lim DA, Diaz A

Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element.

Cell

Cho SW, Xu J, Sun R, Mumbach MR, Carter AC, Chen YG, Yost KE, Kim J, He J, Nevins SA, Chin SF, Caldas C, Liu SJ, Horlbeck MA, Lim DA, Weissman JS, Curtis C, Chang HY

Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment.

Genome biology

Müller S, Kohanbash G, Liu SJ, Alvarado B, Carrera D, Bhaduri A, Watchmaker PB, Yagnik G, Di Lullo E, Malatesta M, Amankulor NM, Kriegstein AR, Lim DA, Aghi M, Okada H, Diaz A

Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex.

Science (New York, N.Y.)

Nowakowski TJ, Bhaduri A, Pollen AA, Alvarado B, Mostajo-Radji MA, Di Lullo E, Haeussler M, Sandoval-Espinosa C, Liu SJ, Velmeshev D, Ounadjela JR, Shuga J, Wang X, Lim DA, West JA, Leyrat AA, Kent WJ, Kriegstein AR

GENE-33. THE 3D EVOLUTION AND IN VIVO GROWTH PATTERNS OF GLIOMA CELL POPULATIONS.

Neuro-oncology

Stephanie Hilz, Samuel J Shelton, Llewellyn Jalbert, Hang K Wong, Tali Mazor, Chibo Hong, Josie Hayes, Tracy Luks, Henrik Bengtsson, Annette Molinaro, Michael McDermott, Mitchel S Berger, Daniel Lim, Aaron Diaz, Joanna J Phillips, Susan Chang, Sarah Nelson, Michael C Oldham, Joseph Costello

Forging our understanding of lncRNAs in the brain.

Cell and tissue research

Andersen RE, Lim DA

Unique Organization of the Nuclear Envelope in the Post-natal Quiescent Neural Stem Cells.

Stem cell reports

Cebri?n-Silla A, Alfaro-Cervell? C, Herranz-P?rez V, Kaneko N, Park DH, Sawamoto K, Alvarez-Buylla A, Lim DA, Garc?a-Verdugo JM

Expert Opinion on the Management of Intracerebroventricular (ICV) Drug Delivery.

Neuropediatrics

I. Slavc, J. Cohen-Pfeffer, S. Gururangan, E. Jurecki, J. Krauser, T. Lester, D. Lim, M. Maldaun, C. Schwering, A. Shaywitz, M. Westphal

CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells.

Science (New York, N.Y.)

Liu SJ, Horlbeck MA, Cho SW, Birk HS, Malatesta M, He D, Attenello FJ, Villalta JE, Cho MY, Chen Y, Mandegar MA, Olvera MP, Gilbert LA, Conklin BR, Chang HY, Weissman JS, Lim DA

Single-cell sequencing maps gene expression to mutational phylogenies in PDGF- and EGF-driven gliomas.

Molecular systems biology

M?ller S, Liu SJ, Di Lullo E, Malatesta M, Pollen AA, Nowakowski TJ, Kohanbash G, Aghi M, Kriegstein AR, Lim DA, Diaz A

Maintenance of neural stem cell regional identity in culture.

Neurogenesis (Austin, Tex.)

Delgado RN, Lu C, Lim DA

The Adult Ventricular-Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis.

Cold Spring Harbor perspectives in biology

Lim DA, Alvarez-Buylla A

SCell: integrated analysis of single-cell RNA-seq data.

Bioinformatics (Oxford, England)

Diaz A, Liu SJ, Sandoval C, Pollen A, Nowakowski TJ, Lim DA, Kriegstein A

Single-cell analysis of long non-coding RNAs in the developing human neocortex.

Genome biology

Liu SJ, Nowakowski TJ, Pollen AA, Lui JH, Horlbeck MA, Attenello FJ, He D, Weissman JS, Kriegstein AR, Diaz AA, Lim DA

Merging DBS with viral vector or stem cell implantation: "hybrid" stereotactic surgery as an evolution in the surgical treatment of Parkinson's disease.

Molecular therapy. Methods & clinical development

Rowland NC, Kalia SK, Kalia LV, Larson PS, Lim DA, Bankiewicz KS

Molecular identity of human outer radial glia during cortical development.

Cell

Pollen AA, Nowakowski TJ, Chen J, Retallack H, Sandoval-Espinosa C, Nicholas CR, Shuga J, Liu SJ, Oldham MC, Diaz A, Lim DA, Leyrat AA, West JA, Kriegstein AR

The long noncoding RNA Pnky regulates neuronal differentiation of embryonic and postnatal neural stem cells.

Cell stem cell

Ramos AD, Andersen RE, Liu SJ, Nowakowski TJ, Hong SJ, Gertz C, Salinas RD, Zarabi H, Kriegstein AR, Lim DA

Combining cell transplants or gene therapy with deep brain stimulation for Parkinson's disease.

Movement disorders : official journal of the Movement Disorder Society

Rowland NC, Starr PA, Larson PS, Ostrem JL, Marks WJ, Lim DA

Analysis of Mll1 deficiency identifies neurogenic transcriptional modules and Brn4 as a factor for direct astrocyte-to-neuron reprogramming.

Neurosurgery

Potts MB, Siu JJ, Price JD, Salinas RD, Cho MJ, Ramos AD, Hahn J, Margeta M, Oldham MC, Lim DA

Adult neural stem cells stake their ground.

Trends in neurosciences

Lim DA, Alvarez-Buylla A

The Ink4a/Arf locus is a barrier to direct neuronal transdifferentiation.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Price JD, Park KY, Chen J, Salinas RD, Cho MJ, Kriegstein AR, Lim DA

Activation of neuronal gene expression by the JMJD3 demethylase is required for postnatal and adult brain neurogenesis.

Cell reports

Park DH, Hong SJ, Salinas RD, Liu SJ, Sun SW, Sgualdino J, Testa G, Matzuk MM, Iwamori N, Lim DA

Interventional magnetic resonance imaging-guided cell transplantation into the brain with radially branched deployment.

Molecular therapy : the journal of the American Society of Gene Therapy

Silvestrini MT, Yin D, Martin AJ, Coppes VG, Mann P, Larson PS, Starr PA, Zeng X, Gupta N, Panter SS, Desai TA, Lim DA

An ingredient for the elixir of youth.

Cell research

Andersen RE, Lim DA

Stem cell epigenetics: looking forward.

Cell stem cell

Benitah SA, Bracken A, Dou Y, Huangfu D, Ivanova N, Koseki H, Laurent L, Lim DA, Meshorer E, Pombo A, Sander M, Xu GL

Distinct and separable roles for EZH2 in neurogenic astroglia.

eLife

Hwang WW, Salinas RD, Siu JJ, Kelley KW, Delgado RN, Paredes MF, Alvarez-Buylla A, Oldham MC, Lim DA

A review of percutaneous treatments for trigeminal neuralgia.

Neurosurgery

Cheng JS, Lim DA, Chang EF, Barbaro NM

A Review of Percutaneous Treatments for Trigeminal Neuralgia.

Neurosurgery

Cheng JS, Lim DA, Chang EF, Barbaro NM

Integration of genome-wide approaches identifies lncRNAs of adult neural stem cells and their progeny in vivo.

Cell stem cell

Ramos AD, Diaz A, Nellore A, Delgado RN, Park KY, Gonzales-Roybal G, Oldham MC, Song JS, Lim DA

Radially branched deployment for more efficient cell transplantation at the scale of the human brain.

Stereotactic and functional neurosurgery

Silvestrini MT, Yin D, Coppes VG, Mann P, Martin AJ, Larson PS, Starr PA, Gupta N, Panter SS, Desai TA, Lim DA

Neural stem cell engraftment and myelination in the human brain.

Science translational medicine

Gupta N, Henry RG, Strober J, Kang SM, Lim DA, Bucci M, Caverzasi E, Gaetano L, Mandelli ML, Ryan T, Perry R, Farrell J, Jeremy RJ, Ulman M, Huhn SL, Barkovich AJ, Rowitch DH

Normalization, bias correction, and peak calling for ChIP-seq.

Statistical applications in genetics and molecular biology

Diaz A, Park K, Lim DA, Song JS

Oscillations in sensorimotor cortex in movement disorders: an electrocorticography study.

Brain : a journal of neurology

Crowell AL, Ryapolova-Webb ES, Ostrem JL, Galifianakis NB, Shimamoto S, Lim DA, Starr PA

Glial Nature of Adult Neural Stem Cells: Neurogenic Competence in Adult Astrocytes.

Neural Development and Stem Cells

William W. Hwang, Arturo Alvarez-Buylla, Daniel A. Lim

Malignant Gliomas: Treatment Using Genetically-Modified Neural Stem Cells.

Michael C. Oh, Mitchel S. Berger, Daniel A. Lim

Asymmetry-defective oligodendrocyte progenitors are glioma precursors.

Cancer cell

Sugiarto S, Persson AI, Munoz EG, Waldhuber M, Lamagna C, Andor N, Hanecker P, Ayers-Ringler J, Phillips J, Siu J, Lim DA, Vandenberg S, Stallcup W, Berger MS, Bergers G, Weiss WA, Petritsch C

Novel treatment strategies for malignant gliomas using neural stem cells.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Oh MC, Lim DA

Future directions: use of interventional MRI for cell-based therapy of Parkinson disease.

Neurosurgery clinics of North America

Roskom J, Swistowski A, Zeng X, Lim DA

Intraoperative MRI in functional neurosurgery. Preface.

Neurosurgery clinics of North America

Lim DA, Larson PS

Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells.

Nature

Lim DA, Huang YC, Swigut T, Mirick AL, Garcia-Verdugo JM, Wysocka J, Ernst P, Alvarez-Buylla A

Safety and feasibility of switching from phenytoin to levetiracetam monotherapy for glioma-related seizure control following craniotomy: a randomized phase II pilot study.

Journal of neuro-oncology

Lim DA, Tarapore P, Chang E, Burt M, Chakalian L, Barbaro N, Chang S, Lamborn KR, McDermott MW

miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells.

BMC medicine

Silber J, Lim DA, Petritsch C, Persson AI, Maunakea AK, Yu M, Vandenberg SR, Ginzinger DG, James CD, Costello JF, Bergers G, Weiss WA, Alvarez-Buylla A, Hodgson JG

Chapter 1 Structure and Function of the Brain and Spinal Cord.

Essentials of Neuroanesthesia and Neurointensive Care

Daniel A. Lim, Michael Sughrue, Michael W. McDermott

Lumbar Spine Coccidioidomycosis Osteomyelitis Requiring Lumbo-Pelvic Reconstruction.

Neurosurgery Quarterly

Daniel C. Lu, Daniel A. Lim, Dean Chou

Relationship of glioblastoma multiforme to neural stem cell regions predicts invasive and multifocal tumor phenotype.

Neuro-oncology

Lim DA, Cha S, Mayo MC, Chen MH, Keles E, VandenBerg S, Berger MS

Multiple target deep brain stimulation for multiple sclerosis related and poststroke Holmes' tremor.

Stereotactic and functional neurosurgery

Lim DA, Khandhar SM, Heath S, Ostrem JL, Ringel N, Starr P

The adult neural stem cell niche: lessons for future neural cell replacement strategies.

Neurosurgery clinics of North America

Lim DA, Huang YC, Alvarez-Buylla A

In vivo transcriptional profile analysis reveals RNA splicing and chromatin remodeling as prominent processes for adult neurogenesis.

Molecular and cellular neurosciences

Lim DA, Suárez-Fariñas M, Naef F, Hacker CR, Menn B, Takebayashi H, Magnasco M, Patil N, Alvarez-Buylla A

Sonic hedgehog controls stem cell behavior in the postnatal and adult brain.

Development (Cambridge, England)

Palma V, Lim DA, Dahmane N, Sánchez P, Brionne TC, Herzberg CD, Gitton Y, Carleton A, Alvarez-Buylla A, Ruiz i Altaba A

Telomerase activity in the subventricular zone of adult mice.

Molecular and cellular neurosciences

Caporaso GL, Lim DA, Alvarez-Buylla A, Chao MV

Postnatal development of radial glia and the ventricular zone (VZ): a continuum of the neural stem cell compartment.

Cerebral cortex (New York, N.Y. : 1991)

Tramontin AD, García-Verdugo JM, Lim DA, Alvarez-Buylla A

DNA hybridization to mismatched templates: a chip study.

Physical review. E, Statistical, nonlinear, and soft matter physics

Naef F, Lim DA, Patil N, Magnasco M

A Ca(2+) switch aligns the active site of calpain.

Cell

Moldoveanu T, Hosfield CM, Lim D, Elce JS, Jia Z, Davies PL

Multipotent neural stem cells reside into the rostral extension and olfactory bulb of adult rodents.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Gritti A, Bonfanti L, Doetsch F, Caille I, Alvarez-Buylla A, Lim DA, Galli R, Verdugo JM, Herrera DG, Vescovi AL

Noggin antagonizes BMP signaling to create a niche for adult neurogenesis.

Neuron

Lim DA, Tramontin AD, Trevejo JM, Herrera DG, García-Verdugo JM, Alvarez-Buylla A

A relationship between behavior, neurotrophin expression, and new neuron survival.

Proceedings of the National Academy of Sciences of the United States of America

Li XC, Jarvis ED, Alvarez-Borda B, Lim DA, Nottebohm F

Interaction between astrocytes and adult subventricular zone precursors stimulates neurogenesis.

Proceedings of the National Academy of Sciences of the United States of America

Lim DA, Alvarez-Buylla A

Subventricular zone astrocytes are neural stem cells in the adult mammalian brain.

Cell

Doetsch F, Caillé I, Lim DA, García-Verdugo JM, Alvarez-Buylla A

Condensation-free X-ray diffraction data collection with capillaries at 277 K.

Journal of Applied Crystallography

D. Lim, Q. Ye, Z. Jia

Architecture and cell types of the adult subventricular zone: in search of the stem cells.

Journal of neurobiology

García-Verdugo JM, Doetsch F, Wichterle H, Lim DA, Alvarez-Buylla A

Postnatal mouse subventricular zone neuronal precursors can migrate and differentiate within multiple levels of the developing neuraxis.

Proceedings of the National Academy of Sciences of the United States of America

Lim DA, Fishell GJ, Alvarez-Buylla A

The E1 protein of bovine papilloma virus 1 is an ATP-dependent DNA helicase.

Proceedings of the National Academy of Sciences of the United States of America

Yang L, Mohr I, Fouts E, Lim DA, Nohaile M, Botchan M