
Professor
Neurological Surgery
+1 415 476-8138
Daniel Lim, MD, PhD studies the role of chromatin remodeling factors in the regulation of neural stem cell fate. By defining the genetic programs and molecular mechanisms of neurogenesis, he hopes to develop therapies for neurodegenerative diseases and injury.
Publications
Neural stem cell relay from B1 to B2 cells in the adult mouse ventricular-subventricular zone.
Cell reports
In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy responses in glioblastoma.
Genome biology
Sex-specific role for the long noncoding RNA Pnky in mouse behavior.
Nature communications
Spatial 3D genome organization controls the activity of bivalent chromatin during human neurogenesis.
bioRxiv : the preprint server for biology
Neural Stem Cell Relay from B1 to B2 cells in the adult mouse Ventricular-Subventricular Zone.
bioRxiv : the preprint server for biology
Deconstructing Intratumoral Heterogeneity through Multiomic and Multiscale Analysis of Serial Sections.
bioRxiv : the preprint server for biology
Epigenetic reprogramming shapes the cellular landscape of schwannoma.
Nature communications
Sex-specific role for the long noncoding RNA Pnky in mouse behavior.
bioRxiv : the preprint server for biology
EPCO-39. CLARIFYING THE MOLECULAR CONSEQUENCES OF ONCOGENIC MUTATIONS THROUGH MULTISCALE AND MULTIOMIC ANALYSIS OF INDIVIDUAL TUMORS.
Neuro-oncology
Identifying Gene-Treatment Interactions and Targetable Radiation Vulnerabilities in Glioblastoma through Coupling of In Vivo CRISPR Perturbation and Single Cell Transcriptomics.
International Journal of Radiation Oncology • Biology • Physics
TMIC-43. HEDGEHOG LIGANDS FROM GLIOBLASTOMA CELLS INDUCE ASTROCYTES INHIBITION OF CANCER STEM CELLS.
Neuro-oncology
Conserved and Distinct Functions of the Autism-Related Chromatin Remodeler CHD8 in Embryonic and Adult Forebrain Neurogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Dual genome-wide coding and lncRNA screens in neural induction of induced pluripotent stem cells.
Cell genomics
A single-cell atlas of the normal and malformed human brain vasculature.
Science (New York, N.Y.)
Distinct nuclear compartment-associated genome architecture in the developing mammalian brain.
Nature neuroscience
Long noncoding RNAs in cancer metastasis.
Nature reviews. Cancer
miRNA-independent function of long noncoding pri-miRNA loci.
Proceedings of the National Academy of Sciences of the United States of America
CT and MRI Image Fusion Error: An Analysis of Co-Registration Error Using Commercially Available Deep Brain Stimulation Surgical Planning Software.
Stereotactic and functional neurosurgery
Genome-Scale Perturbation of Long Noncoding RNA Expression Using CRISPR Interference.
Methods in molecular biology (Clifton, N.J.)
Endoluminal Biopsy for Molecular Classification of Human Brain Arteriovenous Malformations.
Neurosurgery
Multiplatform Genomic Profiling and Magnetic Resonance Imaging Identify Molecular and Radiologic Determinants of Intratumor Heterogeneity Underlying Aggressive Behavior in Meningioma.
International Journal of Radiation Oncology • Biology • Physics
Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma.
Nature communications
Maintenance of neural stem cell positional identity by mixed-lineage leukemia 1.
Science (New York, N.Y.)
CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma.
Genome biology
Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes.
Nature biotechnology
Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma.
Cell stem cell
Long-Term Safety, Immunologic Response, and Imaging Outcomes following Neural Stem Cell Transplantation for Pelizaeus-Merzbacher Disease.
Stem cell reports
The Long Noncoding RNA Pnky Is a Trans-acting Regulator of Cortical Development In Vivo.
Developmental cell
Chapter 17 Stem Cell Transplantation for Neurological Disease: Technical Considerations and Delivery Devices.
Nervous System Drug Delivery
CONICS integrates scRNA-seq with DNA sequencing to map gene expression to tumor sub-clones.
Bioinformatics (Oxford, England)
Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex.
Science (New York, N.Y.)
Maintenance of Positional Identity of Neural Progenitors in the Embryonic and Postnatal Telencephalon.
Frontiers in molecular neuroscience
Forging our understanding of lncRNAs in the brain.
Cell and tissue research
Unique Organization of the Nuclear Envelope in the Post-natal Quiescent Neural Stem Cells.
Stem cell reports
CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells.
Science (New York, N.Y.)
Single-cell sequencing maps gene expression to mutational phylogenies in PDGF- and EGF-driven gliomas.
Molecular systems biology
Maintenance of neural stem cell regional identity in culture.
Neurogenesis (Austin, Tex.)
The Adult Ventricular-Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis.
Cold Spring Harbor perspectives in biology
SCell: integrated analysis of single-cell RNA-seq data.
Bioinformatics (Oxford, England)
Merging DBS with viral vector or stem cell implantation: "hybrid" stereotactic surgery as an evolution in the surgical treatment of Parkinson's disease.
Molecular therapy. Methods & clinical development
Uncovering the roles of long noncoding RNAs in neural development and glioma progression.
Neuroscience letters
Embryonic Nkx2.1-expressing neural precursor cells contribute to the regional heterogeneity of adult V-SVZ neural stem cells.
Developmental biology
Transcriptional and epigenetic insights from stem cells and developing tissues.
Development (Cambridge, England)
The long noncoding RNA Pnky regulates neuronal differentiation of embryonic and postnatal neural stem cells.
Cell stem cell
Combining cell transplants or gene therapy with deep brain stimulation for Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society
Adult neural stem cells stake their ground.
Trends in neurosciences
The Ink4a/Arf locus is a barrier to direct neuronal transdifferentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Interventional magnetic resonance imaging-guided cell transplantation into the brain with radially branched deployment.
Molecular therapy : the journal of the American Society of Gene Therapy
An ingredient for the elixir of youth.
Cell research
Stem cell epigenetics: looking forward.
Cell stem cell
Chromatin-based epigenetics of adult subventricular zone neural stem cells.
Frontiers in genetics
Integration of genome-wide approaches identifies lncRNAs of adult neural stem cells and their progeny in vivo.
Cell stem cell
Devices for cell transplantation into the central nervous system: Design considerations and emerging technologies.
Surgical neurology international
Radially branched deployment for more efficient cell transplantation at the scale of the human brain.
Stereotactic and functional neurosurgery
Surrogate consent for critical care research: exploratory study on public perception and influences on recruitment.
Critical care (London, England)
Neural stem cell engraftment and myelination in the human brain.
Science translational medicine
An old drug for new ideas: metformin promotes adult neurogenesis and spatial memory formation.
Cell stem cell
Normalization, bias correction, and peak calling for ChIP-seq.
Statistical applications in genetics and molecular biology
Oscillations in sensorimotor cortex in movement disorders: an electrocorticography study.
Brain : a journal of neurology
Glial Nature of Adult Neural Stem Cells: Neurogenic Competence in Adult Astrocytes.
Neural Development and Stem Cells
Novel treatment strategies for malignant gliomas using neural stem cells.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Future directions: use of interventional MRI for cell-based therapy of Parkinson disease.
Neurosurgery clinics of North America
Intraoperative MRI in functional neurosurgery. Preface.
Neurosurgery clinics of North America
Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells.
Nature
Safety and feasibility of switching from phenytoin to levetiracetam monotherapy for glioma-related seizure control following craniotomy: a randomized phase II pilot study.
Journal of neuro-oncology
Chapter 1 Structure and Function of the Brain and Spinal Cord.
Essentials of Neuroanesthesia and Neurointensive Care
Lumbar Spine Coccidioidomycosis Osteomyelitis Requiring Lumbo-Pelvic Reconstruction.
Neurosurgery Quarterly
Relationship of glioblastoma multiforme to neural stem cell regions predicts invasive and multifocal tumor phenotype.
Neuro-oncology
Multiple target deep brain stimulation for multiple sclerosis related and poststroke Holmes' tremor.
Stereotactic and functional neurosurgery
The adult neural stem cell niche: lessons for future neural cell replacement strategies.
Neurosurgery clinics of North America
In vivo transcriptional profile analysis reveals RNA splicing and chromatin remodeling as prominent processes for adult neurogenesis.
Molecular and cellular neurosciences
Sonic hedgehog controls stem cell behavior in the postnatal and adult brain.
Development (Cambridge, England)
Telomerase activity in the subventricular zone of adult mice.
Molecular and cellular neurosciences
Postnatal development of radial glia and the ventricular zone (VZ): a continuum of the neural stem cell compartment.
Cerebral cortex (New York, N.Y. : 1991)
DNA hybridization to mismatched templates: a chip study.
Physical review. E, Statistical, nonlinear, and soft matter physics
Investigating the use of primary adult subventricular zone neural precursor cells for neuronal replacement therapies.
Brain research bulletin
Multipotent neural stem cells reside into the rostral extension and olfactory bulb of adult rodents.
The Journal of neuroscience : the official journal of the Society for Neuroscience
A relationship between behavior, neurotrophin expression, and new neuron survival.
Proceedings of the National Academy of Sciences of the United States of America
Interaction between astrocytes and adult subventricular zone precursors stimulates neurogenesis.
Proceedings of the National Academy of Sciences of the United States of America
Condensation-free X-ray diffraction data collection with capillaries at 277 K.
Journal of Applied Crystallography
Architecture and cell types of the adult subventricular zone: in search of the stem cells.
Journal of neurobiology
Competition for DNA binding sites between the short and long forms of E2 dimers underlies repression in bovine papillomavirus type 1 DNA replication control.
Journal of virology
Postnatal mouse subventricular zone neuronal precursors can migrate and differentiate within multiple levels of the developing neuraxis.
Proceedings of the National Academy of Sciences of the United States of America
DNA-binding domain of bovine papillomavirus type 1 E1 helicase: structural and functional aspects.
Journal of virology
The E1 protein of bovine papilloma virus 1 is an ATP-dependent DNA helicase.
Proceedings of the National Academy of Sciences of the United States of America