
Professor
Medicine
+1 415 750-2089
Daniel Bikle, MD, PhD studies the hormonal regulation of calcium metabolism in the formation, differentiation and repair of bone and skin tissue, as well as in skin cancer development.
Publications
Consensus Statement on Vitamin D Status Assessment and Supplementation: Whys, Whens, and Hows.
Endocrine reviews
Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline.
The Journal of clinical endocrinology and metabolism
Vitamin D and Long Covid: Is there a role in prevention or treatment?
The Journal of clinical endocrinology and metabolism
Validation of Biomechanical Computed Tomography for Fracture Risk Classification in Metastatic Hormone-sensitive Prostate Cancer.
European urology oncology
Mediator 1 ablation induces enamel-to-hair lineage conversion in mice through enhancer dynamics.
Communications biology
Vitamin D receptor cross-talk with p63 signaling promotes epidermal cell fate.
The Journal of steroid biochemistry and molecular biology
Vitamin D and malabsorptive gastrointestinal conditions: A bidirectional relationship?
Reviews in endocrine & metabolic disorders
Highlights from the 24th workshop on vitamin D in Austin, September 2022.
The Journal of steroid biochemistry and molecular biology
Prevalence of osteoporosis in older male veterans receiving hip-containing computed tomography scans: opportunistic use of biomechanical computed tomography analysis (BCT).
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Skin and bone crosstalk during aging.
Nature aging
Role of vitamin D and calcium signaling in epidermal wound healing.
Journal of endocrinological investigation
Response to Letters to the Editor RE: Association of Vitamin D Status and COVID-19-Related Hospitalization and Mortality.
Journal of general internal medicine
Vitamin D Regulation of Immune Function.
Current osteoporosis reports
Vitamin D regulation of immune function during covid-19.
Reviews in endocrine & metabolic disorders
Association of Vitamin D Status and COVID-19-Related Hospitalization and Mortality.
Journal of general internal medicine
Hypercalcemia in non-Hodgkin's lymphoma due to cosecretion of PTHrP and 1,25-dihydroxyvitamin D.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Vitamin D regulation of and by long non coding RNAs.
Molecular and cellular endocrinology
Decreased Calcium-Sensing Receptor Expression Controls Calcium Signaling and Cell-To-Cell Adhesion Defects in Aged Skin.
The Journal of investigative dermatology
Transcriptional Regulation of Dental Epithelial Cell Fate.
International journal of molecular sciences
MECHANISMS IN ENDOCRINOLOGY: Vitamin D and COVID-19.
European journal of endocrinology
Vitamin D and calcium signaling in epidermal stem cells and their regeneration.
World journal of stem cells
p120-catenin suppresses proliferation and tumor growth of oral squamous cell carcinoma via inhibiting nuclear phospholipase C-?1 signaling.
Journal of cellular physiology
Editorial: Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions.
Frontiers in endocrinology
New aspects of vitamin D metabolism and action - addressing the skin as source and target.
Nature reviews. Endocrinology
Vitamin D: Newer Concepts of Its Metabolism and Function at the Basic and Clinical Level.
Journal of the Endocrine Society
The Vitamin D Receptor as Tumor Suppressor in Skin.
Advances in experimental medicine and biology
Vitamin D Metabolism Revised: Fall of Dogmas.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Myosin 1a Regulates Osteoblast Differentiation Independent of Intestinal Calcium Transport.
Journal of the Endocrine Society
Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions.
Endocrine reviews
Do sunscreens block vitamin D production? A critical review by an international panel of experts.
The British journal of dermatology
New developments in our understanding of vitamin metabolism, action and treatment.
Metabolism: clinical and experimental
Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions.
Frontiers in endocrinology
Determination of Free 25(OH)D Concentrations and Their Relationships to Total 25(OH)D in Multiple Clinical Populations.
The Journal of clinical endocrinology and metabolism
Vitamin D assays and the definition of hypovitaminosis D: results from the First International Conference on Controversies in Vitamin D.
British journal of clinical pharmacology
Vitamin D and bone and beyond.
Bone reports
p120-catenin is required for regulating epidermal proliferation, differentiation, and barrier function.
Journal of cellular physiology
Vitamin D Receptor Is Required for Proliferation, Migration, and Differentiation of Epidermal Stem Cells and Progeny during�Cutaneous Wound Repair.
The Journal of investigative dermatology
Vitamin D Assays.
Frontiers of hormone research
Current Controversies: Are Free Vitamin Metabolite Levels a More Accurate Assessment of Vitamin D Status than Total Levels?
Endocrinology and metabolism clinics of North America
IGF-1 signaling mediated cell-specific skeletal mechano-transduction.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Vitamin D Prevents Sunburn: Tips for the Summer?
The Journal of investigative dermatology
Vitamin D: Mechanisms of Action and Clinical Applications.
Endocrinology and metabolism clinics of North America
Mediator 1 contributes to enamel mineralization as a coactivator for Notch1 signaling and stimulates transcription of the alkaline phosphatase gene.
The Journal of biological chemistry
Combined Deletion of the Vitamin D Receptor and Calcium-Sensing Receptor Delays Wound Re-epithelialization.
Endocrinology
Current Assays to Determine Free 25-Hydroxyvitamin D in Serum.
Journal of AOAC International
VITAMIN D BINDING PROTEIN AND 25-HYDROXYVITAMIN D LEVELS: EMERGING CLINICAL APPLICATIONS.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Vitamin D metabolites in captivity? Should we measure free or total 25(OH)D to assess vitamin D status?
The Journal of steroid biochemistry and molecular biology
p120-Catenin Is Required for Dietary Calcium Suppression of Oral Carcinogenesis in Mice.
Journal of cellular physiology
Osteogenic Differentiation of Periosteal Cells During Fracture Healing.
Journal of cellular physiology
The vitamin D hypothesis: Dead or alive?: Response to Dr. William Grant's "The UVB-vitamin D3-pigment hypothesis is alive and well-AJPA-2016-00237".
American journal of physical anthropology
Disruption of Vitamin D and Calcium Signaling in Keratinocytes Predisposes to Skin Cancer.
Frontiers in physiology
Extraskeletal actions of vitamin D.
Annals of the New York Academy of Sciences
Phosphoprotein Phosphatase 1 Is Required for Extracellular Calcium-Induced Keratinocyte Differentiation.
BioMed research international
The Endocrine Society Centennial: Extrarenal Production of 1,25 Dihyroxyvitamin D Is Now Proven.
Endocrinology
The Transient Role for Calcium and Vitamin�D during the Developmental Hair�Follicle Cycle.
The Journal of investigative dermatology
Regulation of Ligand and Shear Stress-induced Insulin-like Growth Factor 1 (IGF1) Signaling by the Integrin Pathway.
The Journal of biological chemistry
Synthesis and evaluation of vitamin D receptor-mediated activities of cholesterol and vitamin D metabolites.
European journal of medicinal chemistry
Response of Vitamin D Concentration to Vitamin D3 Administration in Older Adults without Sun Exposure: A Randomized Double-Blind Trial.
Journal of the American Geriatrics Society
Antitumor Activity of 3-Indolylmethanamines 31B and PS121912.
Anticancer research
Pregnane X receptor expression in skin: the good and the bad.
Experimental dermatology
Osteoblast-Specific Loss of IGF1R Signaling Results in Impaired Endochondral Bone Formation During Fracture Healing.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Vitamin D and calcium regulation of epidermal wound healing.
The Journal of steroid biochemistry and molecular biology
A Case of Hypercalcemia and Overexpression of CYP27B1 in Skeletal Muscle Lesions in a Patient with HIV Infection After Cosmetic Injections with Polymethylmethacrylate (PMMA) for Wasting.
Calcified tissue international
IGF-I Signaling in Osterix-Expressing Cells Regulates Secondary Ossification Center Formation, Growth Plate Maturation, and Metaphyseal Formation During Postnatal Bone Development.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Maternal Hypercalcemia Due to Failure of 1,25-Dihydroxyvitamin-D3 Catabolism in a Patient With CYP24A1 Mutations.
The Journal of clinical endocrinology and metabolism
Gender-Specific Differences in the Skeletal Response to Continuous PTH in Mice Lacking the IGF1 Receptor in Mature Osteoblasts.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Selective Hyaluronan-CD44 Signaling Promotes miRNA-21 Expression and Interacts with Vitamin D Function during Cutaneous Squamous Cell Carcinomas Progression Following UV Irradiation.
Frontiers in immunology
UVB induces epidermal 11�-hydroxysteroid dehydrogenase type 1 activity in vivo.
Experimental dermatology
Total 25(OH) vitamin D, free 25(OH) vitamin D and markers of bone turnover in cirrhotics with and without synthetic dysfunction.
Liver international : official journal of the International Association for the Study of the Liver
Highlights from the 17th workshop on vitamin D, Chicago, IL, June 17-21, 2014.
The Journal of steroid biochemistry and molecular biology
Vitamin D receptor, a tumor suppressor in skin.
Canadian journal of physiology and pharmacology
Novel mechanisms for the vitamin D receptor (VDR) in the skin and in skin cancer.
The Journal of steroid biochemistry and molecular biology
Evidence That Loss-of-Function Filaggrin Gene Mutations Evolved in Northern Europeans to Favor Intracutaneous Vitamin D3 Production.
Evolutionary biology
Anticancer activity of VDR-coregulator inhibitor PS121912.
Cancer chemotherapy and pharmacology
Ephrin B2/EphB4 mediates the actions of IGF-I signaling in regulating endochondral bone formation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Ablation of coactivator Med1 switches the cell fate of dental epithelia to that generating hair.
PloS one
Calcium, Orai1, and epidermal proliferation.
The Journal of investigative dermatology
Highlights from the 16th Vitamin D Workshop, San Francisco, CA, June 11-14, 2013.
The Journal of steroid biochemistry and molecular biology
LncRNA: a new player in 1a, 25(OH)(2) vitamin D(3) /VDR protection against skin cancer formation.
Experimental dermatology
Vitamin D-binding protein and vitamin D in blacks and whites.
The New England journal of medicine
Development of novel Vitamin D Receptor-Coactivator Inhibitors.
ACS medicinal chemistry letters
Vitamin D metabolism, mechanism of action, and clinical applications.
Chemistry & biology
A comparison of measured and calculated free 25(OH) vitamin D levels in clinical populations.
The Journal of clinical endocrinology and metabolism
IDENTIFICATION OF VDR ANTAGONISTS AMONG NUCLEAR RECEPTOR LIGANDS USING VIRTUAL SCREENING.
Nuclear receptor research
The vitamin D receptor: a tumor suppressor in skin.
Advances in experimental medicine and biology
LncRNA profiling reveals new mechanism for VDR protection against skin cancer formation.
The Journal of steroid biochemistry and molecular biology
Reprint of: policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich, et al.
Frontiers in neuroendocrinology
Variability in free 25(OH) vitamin D levels in clinical populations.
The Journal of steroid biochemistry and molecular biology
Reciprocal role of vitamin D receptor on �-catenin regulated keratinocyte proliferation and differentiation.
The Journal of steroid biochemistry and molecular biology
Insulin-like growth factor-1 receptor in mature osteoblasts is required for periosteal bone formation induced by reloading.
Acta astronautica
Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al.
European journal of endocrinology
Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al.
Endocrinology
Vitamin D3 effects on lipids differ in statin and non-statin-treated humans: superiority of free 25-OH D levels in detecting relationships.
The Journal of clinical endocrinology and metabolism
Fifteenth vitamin D workshop.
The Journal of steroid biochemistry and molecular biology
Vitamin D: beyond bone.
Annals of the New York Academy of Sciences
Sex and age modify biochemical and skeletal manifestations of chronic hyperparathyroidism by altering target organ responses to Ca2+ and parathyroid hormone in mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Role of the calcium-sensing receptor in calcium regulation of epidermal differentiation and function.
Best practice & research. Clinical endocrinology & metabolism
Anabolic effects of IGF-1 signaling on the skeleton.
Frontiers in endocrinology
Ceramides stimulate caspase-14 expression in human keratinocytes.
Experimental dermatology
Protective actions of vitamin D in UVB induced skin cancer.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
Vitamin D in cutaneous carcinogenesis: part I.
Journal of the American Academy of Dermatology
Vitamin D in cutaneous carcinogenesis: part II.
Journal of the American Academy of Dermatology
Simulated spaceflight produces a rapid and sustained loss of osteoprogenitors and an acute but transitory rise of osteoclast precursors in two genetic strains of mice.
American journal of physiology. Endocrinology and metabolism
Protective role of vitamin D signaling in skin cancer formation.
The Journal of steroid biochemistry and molecular biology
1a,25(OH)2-dihydroxyvitamin D3/VDR protects the skin from UVB-induced tumor formation by interacting with the �-catenin pathway.
The Journal of steroid biochemistry and molecular biology
Calcium regulation of keratinocyte differentiation.
Expert review of endocrinology & metabolism
Insulin like growth factor-I: a critical mediator of the skeletal response to parathyroid hormone.
Current molecular pharmacology
Vitamin D and bone.
Current osteoporosis reports
Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function.
The Journal of investigative dermatology
PTH/PTHrP and vitamin D control antimicrobial peptide expression and susceptibility to bacterial skin infection.
Science translational medicine
Discovery of the first irreversible small molecule inhibitors of the interaction between the vitamin D receptor and coactivators.
Journal of medicinal chemistry
Vitamin D receptor mediates DNA repair and is UV inducible in intact epidermis but not in cultured keratinocytes.
The Journal of investigative dermatology
Vitamin D and the skin: Physiology and pathophysiology.
Reviews in endocrine & metabolic disorders
SERCA2-controlled Ca�+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease.
The Journal of investigative dermatology
Coactivator MED1 ablation in keratinocytes results in hair-cycling defects and epidermal alterations.
The Journal of investigative dermatology
Osteoblast extracellular Ca2+ -sensing receptor regulates bone development, mineralization, and turnover.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Skeletal unloading-induced insulin-like growth factor 1 (IGF-1) nonresponsiveness is not shared by platelet-derived growth factor: the selective role of integrins in IGF-1 signaling.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Negative cross-talk between calcium-sensing receptor and �-catenin signaling systems in colonic epithelium.
The Journal of biological chemistry
Overexpression of hedgehog signaling is associated with epidermal tumor formation in vitamin D receptor-null mice.
The Journal of investigative dermatology
IGF-1R signaling in chondrocytes modulates growth plate development by interacting with the PTHrP/Ihh pathway.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Vitamin D metabolism and function in the skin.
Molecular and cellular endocrinology
Vitamin D3 inhibits hedgehog signaling and proliferation in murine Basal cell carcinomas.
Cancer prevention research (Philadelphia, Pa.)
The calcium-sensing receptor-dependent regulation of cell-cell adhesion and keratinocyte differentiation requires Rho and filamin A.
The Journal of investigative dermatology
The vitamin D receptor: a tumor suppressor in skin.
Discovery medicine
Vitamin D regulation of immune function.
Vitamins and hormones
Vitamin D: an ancient hormone.
Experimental dermatology
Endoplasmic reticulum Ca2+ depletion activates XBP1 and controls terminal differentiation in keratinocytes and epidermis.
The British journal of dermatology
Lineage-specific effects of 1,25-dihydroxyvitamin D(3) on the development of effector CD4 T cells.
The Journal of biological chemistry
Disruption of the hedgehog signaling pathway contributes to the hair follicle cycling deficiency in Vdr knockout mice.
Journal of cellular physiology
The transcriptional coactivator DRIP/mediator complex is involved in vitamin D receptor function and regulates keratinocyte proliferation and differentiation.
The Journal of investigative dermatology
Differential regulation of epidermal function by VDR coactivators.
The Journal of steroid biochemistry and molecular biology
Vitamin D: newly discovered actions require reconsideration of physiologic requirements.
Trends in endocrinology and metabolism: TEM
Vitamin D and the skin.
Journal of bone and mineral metabolism
Association of prediagnostic serum vitamin D levels with the development of basal cell carcinoma.
The Journal of investigative dermatology
Vitamin D and immune function: understanding common pathways.
Current osteoporosis reports
Hypercalcemia and overexpression of CYP27B1 in a patient with nephrogenic systemic fibrosis: clinical vignette and literature review.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Phosphatidylinositol-4-phosphate 5-kinase 1alpha mediates extracellular calcium-induced keratinocyte differentiation.
Molecular biology of the cell
Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formation.
The Journal of investigative dermatology
Nonclassic actions of vitamin D.
The Journal of clinical endocrinology and metabolism
Vitamin D receptor, UVR, and skin cancer: a potential protective mechanism.
The Journal of investigative dermatology
The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development.
Science signaling
Vitamin D and the immune system: role in protection against bacterial infection.
Current opinion in nephrology and hypertension
Growth hormone/insulin-like growth factor-1/PTH axis in bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Integrins, insulin like growth factors, and the skeletal response to load.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes.
The Journal of biological chemistry
Vitamin D insufficiency/deficiency in gastrointestinal disorders.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3.
The Journal of investigative dermatology
IGF-I receptor is required for the anabolic actions of parathyroid hormone on bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
What is new in vitamin D: 2006-2007.
Current opinion in rheumatology
Constitutive activity of the osteoblast Ca2+-sensing receptor promotes loss of cancellous bone.
Endocrinology
Insulin-like growth factor I stimulates recovery of bone lost after a period of skeletal unloading.
Journal of applied physiology (Bethesda, Md. : 1985)
Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism.
The Journal of clinical investigation
The recruitment of phosphatidylinositol 3-kinase to the E-cadherin-catenin complex at the plasma membrane is required for calcium-induced phospholipase C-gamma1 activation and human keratinocyte differentiation.
The Journal of biological chemistry
Differential role of two VDR coactivators, DRIP205 and SRC-3, in keratinocyte proliferation and differentiation.
The Journal of steroid biochemistry and molecular biology
Sequential regulation of keratinocyte differentiation by 1,25(OH)2D3, VDR, and its coregulators.
The Journal of steroid biochemistry and molecular biology
The role of the calcium sensing receptor in regulating intracellular calcium handling in human epidermal keratinocytes.
The Journal of investigative dermatology
Regulation of human epidermal keratinocyte differentiation by the vitamin D receptor and its coactivators DRIP205, SRC2, and SRC3.
The Journal of investigative dermatology
Role of IGF-I signaling in regulating osteoclastogenesis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Development and progression of alopecia in the vitamin D receptor null mouse.
Journal of cellular physiology
Gender differences in the response of CD-1 mouse bone to parathyroid hormone: potential role of IGF-I.
The Journal of endocrinology
Vitamin D and skin cancer: a problem in gene regulation.
The Journal of steroid biochemistry and molecular biology
Calcium-induced human keratinocyte differentiation requires src- and fyn-mediated phosphatidylinositol 3-kinase-dependent activation of phospholipase C-gamma1.
Molecular biology of the cell
Phospholipase cgamma1 is required for activation of store-operated channels in human keratinocytes.
The Journal of investigative dermatology
Vitamin D and skin cancer.
The Journal of nutrition
The effect of LXR activators on AP-1 proteins in keratinocytes.
The Journal of investigative dermatology
Vitamin D regulated keratinocyte differentiation.
Journal of cellular biochemistry
Calcium and 1,25(OH)2D: interacting drivers of epidermal differentiation.
The Journal of steroid biochemistry and molecular biology
Mice lacking 25OHD 1alpha-hydroxylase demonstrate decreased epidermal differentiation and barrier function.
The Journal of steroid biochemistry and molecular biology
Two distinct coactivators, DRIP/mediator and SRC/p160, are differentially involved in VDR transactivation during keratinocyte differentiation.
The Journal of steroid biochemistry and molecular biology
25 Hydroxyvitamin D 1 alpha-hydroxylase is required for optimal epidermal differentiation and permeability barrier homeostasis.
The Journal of investigative dermatology
Skeletal unloading induces resistance to insulin-like growth factor-I (IGF-I) by inhibiting activation of the IGF-I signaling pathways.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
PTH differentially regulates expression of RANKL and OPG.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Human keratinocyte ATP2C1 localizes to the Golgi and controls Golgi Ca2+ stores.
The Journal of investigative dermatology
bFGF administration lowers the phosphate threshold for mineralization in bone marrow stromal cells.
Calcified tissue international
Two distinct coactivators, DRIP/mediator and SRC/p160, are differentially involved in vitamin D receptor transactivation during keratinocyte differentiation.
Molecular endocrinology (Baltimore, Md.)
The impact of skeletal unloading on bone formation.
Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology
Role of protein kinase C alpha in calcium induced keratinocyte differentiation: defective regulation in squamous cell carcinoma.
Journal of cellular physiology
Biochemical regulation of breast cancer cell expression of S1P2 (Edg-5) and S1P3 (Edg-3) G protein-coupled receptors for sphingosine 1-phosphate.
Journal of cellular biochemistry
Vitamin D regulated keratinocyte differentiation: role of coactivators.
Journal of cellular biochemistry
Squamous cell carcinomas fail to respond to the prodifferentiating actions of 1,25(OH)2D: why?
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
Mechanical and chemical characteristics of mineral produced by basic fibroblast growth factor-treated bone marrow stromal cells in vitro.
Tissue engineering
The vitamin D response element of the involucrin gene mediates its regulation by 1,25-dihydroxyvitamin D3.
The Journal of investigative dermatology
Insulin-like growth factor I is required for the anabolic actions of parathyroid hormone on mouse bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Epidermal expression of the full-length extracellular calcium-sensing receptor is required for normal keratinocyte differentiation.
Journal of cellular physiology
The mechanism of 1,25-dihydroxyvitamin D(3) autoregulation in keratinocytes.
The Journal of biological chemistry
Lack of the vitamin D receptor is associated with reduced epidermal differentiation and hair follicle growth.
The Journal of investigative dermatology
The skeletal structure of insulin-like growth factor I-deficient mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Inhibition of 1,25-dihydroxyvitamin-D-induced keratinocyte differentiation by blocking the expression of phospholipase C-gamma1.
The Journal of investigative dermatology
The extracellular calcium-sensing receptor is required for calcium-induced differentiation in human keratinocytes.
The Journal of biological chemistry
Calcium- and vitamin D-regulated keratinocyte differentiation.
Molecular and cellular endocrinology
Osteoblasts respond to pulsatile fluid flow with short-term increases in PGE(2) but no change in mineralization.
Journal of applied physiology (Bethesda, Md. : 1985)
Cholesterol sulfate stimulates involucrin transcription in keratinocytes by increasing Fra-1, Fra-2, and Jun D.
Journal of lipid research
Stimulation of PPARalpha promotes epidermal keratinocyte differentiation in vivo.
The Journal of investigative dermatology
Requirement of an AP-1 site in the calcium response region of the involucrin promoter.
The Journal of biological chemistry
Farnesol stimulates differentiation in epidermal keratinocytes via PPARalpha.
The Journal of biological chemistry
Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription.
The Journal of investigative dermatology
The calcium sensing receptor and its alternatively spliced form in murine epidermal differentiation.
The Journal of biological chemistry
Effects of a calcium receptor activator on the cellular response to calcium in human keratinocytes.
The Journal of investigative dermatology
Phospholipase C-gamma1 is required for calcium-induced keratinocyte differentiation.
The Journal of biological chemistry
Differences in calcium metabolism between black and white men and women.
Mineral and electrolyte metabolism
1,25 dihydroxyvitamin D3 enhances the calcium response of keratinocytes.
Journal of cellular physiology
Bone and hormonal changes induced by skeletal unloading in the mature male rat.
The American journal of physiology
Six putative IQ motifs of the recombinant chicken intestinal brush border myosin I are involved in calmodulin binding.
Archives of biochemistry and biophysics
Skeletal unloading causes resistance of osteoprogenitor cells to parathyroid hormone and to insulin-like growth factor-I.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
The response of bone to unloading.
Journal of bone and mineral metabolism
The calcium sensing receptor and its alternatively spliced form in keratinocyte differentiation.
The Journal of biological chemistry
Differential regulation of vitamin D responsive elements in normal and transformed keratinocytes.
The Journal of investigative dermatology
Keratinocyte differentiation is stimulated by activators of the nuclear hormone receptor PPARalpha.
The Journal of investigative dermatology
All-trans retinoic acid blocks the antiproliferative prodifferentiating actions of 1,25-dihydroxyvitamin D3 in normal human keratinocytes.
Journal of cellular physiology
Cloning of human 25-hydroxyvitamin D-1 alpha-hydroxylase and mutations causing vitamin D-dependent rickets type 1.
Molecular endocrinology (Baltimore, Md.)
Skeletal unloading inhibits the in vitro proliferation and differentiation of rat osteoprogenitor cells.
The American journal of physiology
Biochemical markers in the assessment of bone disease.
The American journal of medicine
Vitamin D: a calciotropic hormone regulating calcium-induced keratinocyte differentiation.
Journal of the American Academy of Dermatology
Decrease of Ca(2+)-ATPase activity in human keratinocytes during calcium-induced differentiation.
Journal of cellular physiology
The expression of the gap junctional protein Cx43 is restricted to proliferating and non differentiated normal and transformed keratinocytes.
Experimental dermatology
Regional responsiveness of the tibia to intermittent administration of parathyroid hormone as affected by skeletal unloading.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Spaceflight and the skeleton: lessons for the earthbound.
Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology
Cloning of the human phospholipase C-gamma1 promoter and identification of a DR6-type vitamin D-responsive element.
The Journal of biological chemistry
Racial differences in bone density between young adult black and white subjects persist after adjustment for anthropometric, lifestyle, and biochemical differences.
The Journal of clinical endocrinology and metabolism
Space flight and the skeleton: lessons for the earthbound.
The Endocrinologist
Antiestrogen potentiation of antiproliferative effects of vitamin D3 analogues in breast cancer cells.
Cancer research
Zipper protein, a B-G protein with the ability to regulate actin/myosin 1 interactions in the intestinal brush border.
The Journal of biological chemistry
1,25(OH)2D3-modulated calcium induced keratinocyte differentiation.
The journal of investigative dermatology. Symposium proceedings
Squamous carcinoma cell lines fail to respond to 1,25-Dihydroxyvitamin D despite normal levels of the vitamin D receptor.
The Journal of investigative dermatology
Changes in calcium responsiveness and handling during keratinocyte differentiation. Potential role of the calcium receptor.
The Journal of clinical investigation
Evidence for separate control mechanisms at the message, protein, and enzyme activation levels for transglutaminase during calcium-induced differentiation of normal and transformed human keratinocytes.
The Journal of investigative dermatology
Regulation of involucrin gene expression by calcium in normal human keratinocytes.
Frontiers in bioscience : a journal and virtual library
22-Oxa calcitriol is a less potent regulator of keratinocyte proliferation and differentiation due to decreased cellular uptake and enhanced catabolism.
The Journal of investigative dermatology
Skeletal unloading induces selective resistance to the anabolic actions of growth hormone on bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
1,25-Dihydroxyvitamin D3 upregulates the phosphatidylinositol signaling pathway in human keratinocytes by increasing phospholipase C levels.
The Journal of clinical investigation
1,25(OH)2D3-regulated human keratinocyte proliferation and differentiation: basic studies and their clinical application.
The Journal of nutrition
The molecular response of bone to growth hormone during skeletal unloading: regional differences.
Endocrinology
Serum levels of free 1,25-dihydroxyvitamin D in vitamin D toxicity.
Annals of internal medicine
Altered skeletal pattern of gene expression in response to spaceflight and hindlimb elevation.
The American journal of physiology
Alendronate increases skeletal mass of growing rats during unloading by inhibiting resorption of calcified cartilage.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Skeletal unloading induces resistance to insulin-like growth factor I.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Expression of the genes for insulin-like growth factors and their receptors in bone during skeletal growth.
The American journal of physiology
Role of vitamin D, its metabolites, and analogs in the management of osteoporosis.
Rheumatic diseases clinics of North America
Impact of skeletal unloading on bone formation: role of systemic and local factors.
Acta astronautica
1,25-Dihydroxyvitamin D3 potentiates the keratinocyte response to calcium.
The Journal of biological chemistry
Production of 1,25 dihydroxyvitamin D3 by perfused pig skin.
The Journal of investigative dermatology
Regulation of calmodulin binding to the ATP extractable 110 kDa protein (myosin I) from chicken duodenal brush border by 1,25-(OH)2D3.
Biochimica et biophysica acta
Regulation of keratinocyte growth, differentiation, and vitamin D metabolism by analogs of 1,25-dihydroxyvitamin D.
The Journal of investigative dermatology
Alcohol-induced bone disease: relationship to age and parathyroid hormone levels.
Alcoholism, clinical and experimental research
Skeletal unloading decreases production of 1,25-dihydroxyvitamin D.
The American journal of physiology
Elevated 1,25-dihydroxyvitamin D levels in patients with chronic obstructive pulmonary disease treated with prednisone.
The Journal of clinical endocrinology and metabolism
Vitamin D, calcium, and epidermal differentiation.
Endocrine reviews
Zipper protein, a newly described tropomyosin-like protein of the intestinal brush border.
The Journal of biological chemistry
Alcohol-induced bone disease.
World review of nutrition and dietetics
Localization and quantitation of calcium pools and calcium binding sites in cultured human keratinocytes.
Journal of cellular physiology
Metabolic acidosis reverses the increase in serum 1,25(OH)2D in phosphorus-restricted normal men.
The American journal of physiology
Clinical counterpoint: vitamin D: new actions, new analogs, new therapeutic potential.
Endocrine reviews
Effects of dietary protein deficiency on mineral metabolism and bone mineral density.
The American journal of clinical nutrition
Progestin antagonism of estrogen stimulated 1,25-dihydroxyvitamin D levels.
The Journal of clinical endocrinology and metabolism
Adenosine triphosphate stimulates phosphoinositide metabolism, mobilizes intracellular calcium, and inhibits terminal differentiation of human epidermal keratinocytes.
The Journal of clinical investigation
Lanthanum influx into cultured human keratinocytes: effect on calcium flux and terminal differentiation.
Journal of cellular physiology
Squamous carcinoma cell lines produce 1,25 dihydroxyvitamin D, but fail to respond to its prodifferentiating effect.
The Journal of investigative dermatology
Tumor necrosis factor-alpha regulation of 1,25-dihydroxyvitamin D production by human keratinocytes.
Endocrinology
Uncoupling of the calcium-sensing mechanism and differentiation in squamous carcinoma cell lines.
Experimental cell research
Epidermal vitamin D metabolism, function, and regulation.
Advances in lipid research
Role of intracellular-free calcium in the cornified envelope formation of keratinocytes: differences in the mode of action of extracellular calcium and 1,25 dihydroxyvitamin D3.
Journal of cellular physiology
Different responses of trabecular and cortical bone to 1,25(OH)2D3 infusion.
The American journal of physiology
Calcium regulation of growth and differentiation of normal human keratinocytes: modulation of differentiation competence by stages of growth and extracellular calcium.
Journal of cellular physiology
Serum vitamin D metabolites are not responsible for low turnover osteoporosis in chronic liver disease.
The Journal of clinical endocrinology and metabolism
Effects of simulated weightlessness on rat osteocalcin and bone calcium.
The American journal of physiology
Bone response to normal weight bearing after a period of skeletal unloading.
The American journal of physiology
Transpleural gradient of 1,25-dihydroxyvitamin D in tuberculous pleuritis.
The Journal of clinical investigation
Binding and biological effects of tumor necrosis factor alpha on cultured human neonatal foreskin keratinocytes.
The Journal of clinical investigation
Free, and not total, 1,25-dihydroxyvitamin D regulates 25-hydroxyvitamin D metabolism by keratinocytes.
Endocrinology
Regulation of 1,25-dihydroxyvitamin D production in human keratinocytes by interferon-gamma.
Endocrinology
Calmodulin binding to the intestinal brush-border membrane: comparison to other calcium-binding proteins.
Biochimica et biophysica acta
Glucocorticoids and inhibition of bone formation induced by skeletal unloading.
The American journal of physiology
Serum dihydrotachysterol levels and biological action in normal man.
The Journal of clinical endocrinology and metabolism
1,25-Dihydroxyvitamin D production and receptor binding in human keratinocytes varies with differentiation.
The Journal of biological chemistry
Biochemical and morphological characterization of growth and differentiation of normal human neonatal keratinocytes in a serum-free medium.
Journal of cellular physiology
Effects of alcohol abuse on bone.
Comprehensive therapy
Vitamin D and epidermal differentiation: evidence for a role of endogenously produced vitamin D metabolites in keratinocyte differentiation.
Skin pharmacology : the official journal of the Skin Pharmacology Society
Vitamin D metabolite production and function in keratinocytes.
Annals of the New York Academy of Sciences
The effect of vitamin D status on cutaneous sterologenesis in vivo and in vitro.
Biochimica et biophysica acta
Effect of dietary acid and calcium on 25-hydroxyvitamin D metabolism by chick kidney.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Chronic administration of 1,25-dihydroxyvitamin D3: increased bone but impaired mineralization.
Endocrinology
Stimulation by 1,25-dihydroxyvitamin D3 of adenylate cyclase along the villus of chick duodenum.
Endocrinology
Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein.
The Journal of clinical endocrinology and metabolism
Effect of ethanol on intestinal calcium transport in chicks.
Gastroenterology
Chronic 1,25-dihydroxyvitamin D3 administration in the rat reduces the serum concentration of 25-hydroxyvitamin D by increasing metabolic clearance rate.
The Journal of clinical investigation
Free 25-hydroxyvitamin D levels are normal in subjects with liver disease and reduced total 25-hydroxyvitamin D levels.
The Journal of clinical investigation
1,25-Dihydroxyvitamin D3 production by human keratinocytes. Kinetics and regulation.
The Journal of clinical investigation
Skeletal response to dietary calcium in a rat model simulating weightlessness.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
The role of 1,25-dihydroxyvitamin D in the inhibition of bone formation induced by skeletal unloading.
Endocrinology
The temporal response of bone to unloading.
Endocrinology
1,25-Dihydroxyvitamin D increases calmodulin binding to specific proteins in the chick duodenal brush border membrane.
The Journal of clinical investigation
Effect of simulated weightlessness and chronic 1,25-dihydroxyvitamin D administration on bone metabolism.
The Physiologist
Serum protein binding of 1,25-dihydroxyvitamin D: a reevaluation by direct measurement of free metabolite levels.
The Journal of clinical endocrinology and metabolism
Bone disease in alcohol abuse.
Annals of internal medicine
Measurement of 25,26-dihydroxyvitamin D: importance of the configuration of the C-25 hydroxyl group.
Biochemistry
Free 1,25-dihydroxyvitamin D levels in serum from normal subjects, pregnant subjects, and subjects with liver disease.
The Journal of clinical investigation
Separation of isotopically labeled vitamin D metabolites by high-performance liquid chromatography.
Journal of chromatography
Calmodulin may mediate 1,25-dihydroxyvitamin D-stimulated intestinal calcium transport.
FEBS letters
Acute, but not chronic, metabolic acidosis disturbs 25-hydroxyvitamin D3 metabolism.
Kidney international
The relationship of membrane fluidity to calcium flux in chick intestinal brush border membranes.
Endocrinology
The role of calmodulin in 1,25-dihydroxyvitamin D regulation of calcium transport across the intestinal brush border membrane.
Progress in clinical and biological research
Calcium flux across chick duodenal brush border membrane vesicles: regulation by 1,25-dihydroxyvitamin D.
Endocrinology
Simulating certain aspects of hypogravity: effects on bone maturation in the non-weight bearing skeleton.
Aviation, space, and environmental medicine
Fluoride treatment of osteoporosis: a new look at an old drug.
Annals of internal medicine
Calcium absorption and vitamin D metabolism.
Clinics in gastroenterology
Calcium potentiates the cyclic nucleotide and phosphaturic response to parathyroid hormone infusion.
The Journal of clinical endocrinology and metabolism
The vitamin D endocrine system.
Advances in internal medicine
Action of vitamin D on intestinal calcium transport.
Annals of the New York Academy of Sciences
The intestinal response to vitamin D.
Reviews of physiology, biochemistry and pharmacology
Studies of the chick renal mitochondrial 25-hydroxyvitamin D-3 24-hydroxylase.
Biochimica et biophysica acta
Prolactin but not growth hormone stimulates 1,25-dihydroxyvitamin D3 production by chick renal preparations in vitro.
Endocrinology
Calcium accumulation by chick intestinal mitochondria. Regulation by vitamin D-3 and 1,25-dihydroxyvitamin D-3.
Biochimica et biophysica acta
Effects of 1 alpha-hydroxy vitamin D3 on the rachitic chick intestine: a comparison to the effects of 1,25-dihydroxyvitamin D3.
Calcified tissue international
The mechanism of action of vitamin D in the intestine.
The American journal of clinical nutrition
Stimulation of chick gut alkaline phosphatase activity by actinomycin D and 1,25-dihydroxyvitamin D3: evidence for independent mechanisms.
The Journal of laboratory and clinical medicine
Work-induced muscle hypertrophy in vitamin D-deficient rats.
The American journal of clinical nutrition
Immunoperoxidase localization of vitamin D dependent calcium binding protein.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
A biochemical model for the ionic control of 25-hydroxyvitamin D3 1alpha-hydroxylase.
The Journal of biological chemistry
Independence of 1,25-dihydroxyvitamin D3-mediated calcium transport from de novo RNA and protein synthesis.
The Journal of biological chemistry
Intestinal response to 1 alpha, 25-dihydroxycholecalciferol. I. RNA polymerase, alkaline phosphatase, calcium and phosphorus uptake in vitro, and in vivo calcium transport and accumulation.
Biochimica et biophysica acta
Intestinal response to 1alpha,25-dihydroxycholecalciferol. II. A timed study of the intracellular localization of calcium binding protein.
Biochimica et biophysica acta
Ionic control of 1,25-dihydroxy vitamin D-3 production by isolated chick renal mitochondria. Influence of anions and sucrose.
Biochimica et biophysica acta
The effect of 1,25-dihydroxyvitamin D-3 on the distribution of alkaline phosphatase activity along the chick intestinal villus.
Biochimica et biophysica acta
The ionic control of 1,25-dihydroxyvitamin D-3 synthesis in isolated chick renal mitochondria. The role of potassium.
Biochimica et biophysica acta
The ionic control of 1,25-dihydroxyvitamin D3 production in isolated chick renal tubules.
The Journal of clinical investigation
The ionic control of 1,25-dihydroxyvitamin D3 synthesis in isolated chick renal mitochondria. The role of calcium as influenced by inorganic phosphate and hydrogen-ion.
The Journal of clinical investigation
A comparison of the metabolism of 25-hydroxyvitamin D3 by chick renal tubules, homogenates and mitochondria.
Biochimica et biophysica acta
The metabolism of 25-hydroxycholecalciferol by isolated renal tubules in vitro as studied by a new chromatographic technique.
Biochimica et biophysica acta
Hormonal control of the renal conversion of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol.
The Journal of clinical investigation