Daniel Bikle, MD, PhD

Professor
Medicine
[email protected]
+1 415 750-2089

Daniel Bikle, MD, PhD studies the hormonal regulation of calcium metabolism in the formation, differentiation and repair of bone and skin tissue, as well as in skin cancer development.

Publications: 

Consensus Statement on Vitamin D Status Assessment and Supplementation: Whys, Whens, and Hows.

Endocrine reviews

Giustina A, Bilezikian JP, Adler RA, Banfi G, Bikle DD, Binkley NC, Bollerslev J, Bouillon R, Brandi ML, Casanueva FF, di Filippo L, Donini LM, Ebeling PR, Fuleihan GE, Fassio A, Frara S, Jones G, Marcocci C, Martineau AR, Minisola S, Napoli N, Procopio M, Rizzoli R, Schafer AL, Sempos CT, Ulivieri FM, Virtanen JK

Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline.

The Journal of clinical endocrinology and metabolism

Demay MB, Pittas AG, Bikle DD, Diab DL, Kiely ME, Lazaretti-Castro M, Lips P, Mitchell DM, Murad MH, Powers S, Rao SD, Scragg R, Tayek JA, Valent AM, Walsh JME, McCartney CR

Vitamin D and Long Covid: Is there a role in prevention or treatment?

The Journal of clinical endocrinology and metabolism

Bikle DD

Validation of Biomechanical Computed Tomography for Fracture Risk Classification in Metastatic Hormone-sensitive Prostate Cancer.

European urology oncology

Lin JK, Hearn CM, Getzen E, Long Q, Lee DC, Keaveny TM, Jayadevappa R, Robinson KW, Wong YN, Maxwell KN, Narayan V, Haas NB, Takvorian SU, Bikle DD, Chiang JM, Khan AN, Rajapakse CS, Morgans AK, Parikh RB

Mediator 1 ablation induces enamel-to-hair lineage conversion in mice through enhancer dynamics.

Communications biology

Thaler R, Yoshizaki K, Nguyen T, Fukumoto S, Den Besten P, Bikle DD, Oda Y

Vitamin D receptor cross-talk with p63 signaling promotes epidermal cell fate.

The Journal of steroid biochemistry and molecular biology

Oda Y, Wong CT, Oh DH, Meyer MB, Pike JW, Bikle DD

Vitamin D and malabsorptive gastrointestinal conditions: A bidirectional relationship?

Reviews in endocrine & metabolic disorders

Giustina A, di Filippo L, Allora A, Bikle DD, Cavestro GM, Feldman D, Latella G, Minisola S, Napoli N, Trasciatti S, Uygur M, Bilezikian JP

Highlights from the 24th workshop on vitamin D in Austin, September 2022.

The Journal of steroid biochemistry and molecular biology

Meyer MB, Bernal-Mizrachi C, Bikle DD, Biyani M, Campbell MJ, Chaudhari SN, Christakos S, Ingles SA, Knuth MM, Lee SM, Lisse TS, Liu ES, Piec I, Plum LA, Rao SD, Reynolds CJ, Thacher TD, White JH, Cantorna MT

Prevalence of osteoporosis in older male veterans receiving hip-containing computed tomography scans: opportunistic use of biomechanical computed tomography analysis (BCT).

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Teng PF, Chiang JM, Schafer AL, Sukerkar PA, Keaveny TM, Bikle D

Skin and bone crosstalk during aging.

Nature aging

Mauro T, Bikle D

Role of vitamin D and calcium signaling in epidermal wound healing.

Journal of endocrinological investigation

Bikle DD

Vitamin D Regulation of Immune Function.

Current osteoporosis reports

Bikle DD

Vitamin D regulation of immune function during covid-19.

Reviews in endocrine & metabolic disorders

Bikle DD

Association of Vitamin D Status and COVID-19-Related Hospitalization and Mortality.

Journal of general internal medicine

Seal KH, Bertenthal D, Carey E, Grunfeld C, Bikle DD, Lu CM

Hypercalcemia in non-Hodgkin's lymphoma due to cosecretion of PTHrP and 1,25-dihydroxyvitamin D.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Gonciulea AR, Wang Y, Bikle DD, Sellmeyer DE

Vitamin D regulation of and by long non coding RNAs.

Molecular and cellular endocrinology

Bikle DD

Decreased Calcium-Sensing Receptor Expression Controls Calcium Signaling and Cell-To-Cell Adhesion Defects in Aged Skin.

The Journal of investigative dermatology

Celli A, Tu CL, Lee E, Bikle DD, Mauro TM

Introduction: Special Issue on Vitamin D Dedicated to the Memory of Anthony W Norman.

JBMR plus

Bouillon R, Haussler M, Bikle D, Christakos S, Welsh J

Ablation of Ephrin B2 in Col2 Expressing Cells Delays Fracture Repair.

Endocrinology

Wang Y, Ling L, Tian F, Won Kim SH, Ho S, Bikle DD

Transcriptional Regulation of Dental Epithelial Cell Fate.

International journal of molecular sciences

Yoshizaki K, Fukumoto S, Bikle DD, Oda Y

MECHANISMS IN ENDOCRINOLOGY: Vitamin D and COVID-19.

European journal of endocrinology

Bilezikian JP, Bikle D, Hewison M, Lazaretti-Castro M, Formenti AM, Gupta A, Madhavan MV, Nair N, Babalyan V, Hutchings N, Napoli N, Accili D, Binkley N, Landry DW, Giustina A

p120-catenin suppresses proliferation and tumor growth of oral squamous cell carcinoma via inhibiting nuclear phospholipase C-?1 signaling.

Journal of cellular physiology

Li L, Ji S, Shrestha C, Jiang Y, Liao L, Xu F, Liu Z, Bikle DD, Xie Z

The Vitamin D Receptor as Tumor Suppressor in Skin.

Advances in experimental medicine and biology

Bikle DD

Vitamin D Metabolism Revised: Fall of Dogmas.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Bouillon R, Bikle D

Myosin 1a Regulates Osteoblast Differentiation Independent of Intestinal Calcium Transport.

Journal of the Endocrine Society

Munson S, Wang Y, Chang W, Bikle DD

Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions.

Endocrine reviews

Bouillon R, Marcocci C, Carmeliet G, Bikle D, White JH, Dawson-Hughes B, Lips P, Munns CF, Lazaretti-Castro M, Giustina A, Bilezikian J

New developments in our understanding of vitamin metabolism, action and treatment.

Metabolism: clinical and experimental

Christakos S, Li S, De La Cruz J, Bikle DD

The Fracture Callus Is Formed by Progenitors of Different Skeletal Origins in a Site-Specific Manner.

JBMR plus

Wang Y, Chen L, Kang M, Ling L, Tian F, Won-Kim SH, Ho S, Bikle DD

Determination of Free 25(OH)D Concentrations and Their Relationships to Total 25(OH)D in Multiple Clinical Populations.

The Journal of clinical endocrinology and metabolism

Schwartz JB, Gallagher JC, Jorde R, Berg V, Walsh J, Eastell R, Evans AL, Bowles S, Naylor KE, Jones KS, Schoenmakers I, Holick M, Orwoll E, Nielson C, Kaufmann M, Jones G, Bouillon R, Lai J, Verotta D, Bikle D

Vitamin D assays and the definition of hypovitaminosis D: results from the First International Conference on Controversies in Vitamin D.

British journal of clinical pharmacology

Sempos CT, Heijboer AC, Bikle DD, Bollerslev J, Bouillon R, Brannon PM, DeLuca HF, Jones G, Munns CF, Bilezikian JP, Giustina A, Binkley N

Vitamin D and bone and beyond.

Bone reports

Bikle DD, Bouillon R

p120-catenin is required for regulating epidermal proliferation, differentiation, and barrier function.

Journal of cellular physiology

Xie Z, Tang Y, Man MQ, Shrestha C, Bikle DD

Vitamin D Assays.

Frontiers of hormone research

Bikle DD

Current Controversies: Are Free Vitamin Metabolite Levels a More Accurate Assessment of Vitamin D Status than Total Levels?

Endocrinology and metabolism clinics of North America

Bikle DD, Malmstroem S, Schwartz J

IGF-1 signaling mediated cell-specific skeletal mechano-transduction.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Tian F, Wang Y, Bikle DD

Vitamin D Prevents Sunburn: Tips for the Summer?

The Journal of investigative dermatology

Bikle DD

Vitamin D: Mechanisms of Action and Clinical Applications.

Endocrinology and metabolism clinics of North America

Gallagher JC, Bikle DD

Mediator 1 contributes to enamel mineralization as a coactivator for Notch1 signaling and stimulates transcription of the alkaline phosphatase gene.

The Journal of biological chemistry

Yoshizaki K, Hu L, Nguyen T, Sakai K, Ishikawa M, Takahashi I, Fukumoto S, DenBesten PK, Bikle DD, Oda Y, Yamada Y

Current Assays to Determine Free 25-Hydroxyvitamin D in Serum.

Journal of AOAC International

Malmstroem S, Rejnmark L, Imboden JB, Shoback DM, Bikle DD

VITAMIN D BINDING PROTEIN AND 25-HYDROXYVITAMIN D LEVELS: EMERGING CLINICAL APPLICATIONS.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

Jassil NK, Sharma A, Bikle D, Wang X

Vitamin D metabolites in captivity? Should we measure free or total 25(OH)D to assess vitamin D status?

The Journal of steroid biochemistry and molecular biology

Bikle D, Bouillon R, Thadhani R, Schoenmakers I

p120-Catenin Is Required for Dietary Calcium Suppression of Oral Carcinogenesis in Mice.

Journal of cellular physiology

Xie Z, Yuan Y, Jiang Y, Shrestha C, Chen Y, Liao L, Ji S, Deng X, Liao E, Bikle DD

Osteogenic Differentiation of Periosteal Cells During Fracture Healing.

Journal of cellular physiology

Wang T, Zhang X, Bikle DD

Disruption of Vitamin D and Calcium Signaling in Keratinocytes Predisposes to Skin Cancer.

Frontiers in physiology

Bikle DD, Jiang Y, Nguyen T, Oda Y, Tu CL

Extraskeletal actions of vitamin D.

Annals of the New York Academy of Sciences

Bikle DD

Phosphoprotein Phosphatase 1 Is Required for Extracellular Calcium-Induced Keratinocyte Differentiation.

BioMed research international

Shrestha C, Tang Y, Fan H, Li L, Zeng Q, Pennypacker SD, Bikle DD, Xie Z

The Transient Role for Calcium and Vitamin�D during the Developmental Hair�Follicle Cycle.

The Journal of investigative dermatology

Mady LJ, Ajibade DV, Hsaio C, Teichert A, Fong C, Wang Y, Christakos S, Bikle DD

Regulation of Ligand and Shear Stress-induced Insulin-like Growth Factor 1 (IGF1) Signaling by the Integrin Pathway.

The Journal of biological chemistry

Tahimic CG, Long RK, Kubota T, Sun MY, Elalieh H, Fong C, Menendez AT, Wang Y, Vilardaga JP, Bikle DD

Synthesis and evaluation of vitamin D receptor-mediated activities of cholesterol and vitamin D metabolites.

European journal of medicinal chemistry

Teske KA, Bogart JW, Sanchez LM, Yu OB, Preston JV, Cook JM, Silvaggi NR, Bikle DD, Arnold LA

Antitumor Activity of 3-Indolylmethanamines 31B and PS121912.

Anticancer research

Guthrie ML, Sidhu PS, Hill EK, Horan TC, Nandhikonda P, Teske KA, Yuan NY, Sidorko M, Rodali R, Cook JM, Han L, Silvaggi NR, Bikle DD, Moore RG, Singh RK, Arnold LA

Role of IGF-I signaling in muscle bone interactions.

Bone

Bikle DD, Tahimic C, Chang W, Wang Y, Philippou A, Barton ER

Osteoblast-Specific Loss of IGF1R Signaling Results in Impaired Endochondral Bone Formation During Fracture Healing.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Wang T, Wang Y, Menendez A, Fong C, Babey M, Tahimic CG, Cheng Z, Li A, Chang W, Bikle DD

Vitamin D and calcium regulation of epidermal wound healing.

The Journal of steroid biochemistry and molecular biology

Oda Y, Tu CL, Menendez A, Nguyen T, Bikle DD

A Case of Hypercalcemia and Overexpression of CYP27B1 in Skeletal Muscle Lesions in a Patient with HIV Infection After Cosmetic Injections with Polymethylmethacrylate (PMMA) for Wasting.

Calcified tissue international

Hindi SM, Wang Y, Jones KD, Nussbaum JC, Chang Y, Masharani U, Bikle D, Shoback DM, Hsiao EC

IGF-I Signaling in Osterix-Expressing Cells Regulates Secondary Ossification Center Formation, Growth Plate Maturation, and Metaphyseal Formation During Postnatal Bone Development.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Wang Y, Menendez A, Fong C, ElAlieh HZ, Kubota T, Long R, Bikle DD

Maternal Hypercalcemia Due to Failure of 1,25-Dihydroxyvitamin-D3 Catabolism in a Patient With CYP24A1 Mutations.

The Journal of clinical endocrinology and metabolism

Shah AD, Hsiao EC, O'Donnell B, Salmeen K, Nussbaum R, Krebs M, Baumgartner-Parzer S, Kaufmann M, Jones G, Bikle DD, Wang Y, Mathew AS, Shoback D, Block-Kurbisch I

Gender-Specific Differences in the Skeletal Response to Continuous PTH in Mice Lacking the IGF1 Receptor in Mature Osteoblasts.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Babey M, Wang Y, Kubota T, Fong C, Menendez A, ElAlieh HZ, Bikle DD

UVB induces epidermal 11�-hydroxysteroid dehydrogenase type 1 activity in vivo.

Experimental dermatology

Tiganescu A, Hupe M, Jiang YJ, Celli A, Uchida Y, Mauro TM, Bikle DD, Elias PM, Holleran WM

Total 25(OH) vitamin D, free 25(OH) vitamin D and markers of bone turnover in cirrhotics with and without synthetic dysfunction.

Liver international : official journal of the International Association for the Study of the Liver

Lai JC, Bikle DD, Lizaola B, Hayssen H, Terrault NA, Schwartz JB

Highlights from the 17th workshop on vitamin D, Chicago, IL, June 17-21, 2014.

The Journal of steroid biochemistry and molecular biology

Welsh J, Bikle DD, Lips P

Vitamin D receptor, a tumor suppressor in skin.

Canadian journal of physiology and pharmacology

Bikle DD

Novel mechanisms for the vitamin D receptor (VDR) in the skin and in skin cancer.

The Journal of steroid biochemistry and molecular biology

Bikle DD, Oda Y, Tu CL, Jiang Y

Anticancer activity of VDR-coregulator inhibitor PS121912.

Cancer chemotherapy and pharmacology

Sidhu PS, Teske K, Feleke B, Yuan NY, Guthrie ML, Fernstrum GB, Vyas ND, Han L, Preston J, Bogart JW, Silvaggi NR, Cook JM, Singh RK, Bikle DD, Arnold LA

Ephrin B2/EphB4 mediates the actions of IGF-I signaling in regulating endochondral bone formation.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Wang Y, Menendez A, Fong C, ElAlieh HZ, Chang W, Bikle DD

Ablation of coactivator Med1 switches the cell fate of dental epithelia to that generating hair.

PloS one

Yoshizaki K, Hu L, Nguyen T, Sakai K, He B, Fong C, Yamada Y, Bikle DD, Oda Y

Calcium, Orai1, and epidermal proliferation.

The Journal of investigative dermatology

Bikle DD, Mauro TM

Highlights from the 16th Vitamin D Workshop, San Francisco, CA, June 11-14, 2013.

The Journal of steroid biochemistry and molecular biology

Bikle D

Vitamin D-binding protein and vitamin D in blacks and whites.

The New England journal of medicine

Hollis BW, Bikle DD

Development of novel Vitamin D Receptor-Coactivator Inhibitors.

ACS medicinal chemistry letters

Sidhu PS, Nassif N, McCallum MM, Teske K, Feleke B, Yuan NY, Nandhikonda P, Cook JM, Singh RK, Bikle DD, Arnold LA

A comparison of measured and calculated free 25(OH) vitamin D levels in clinical populations.

The Journal of clinical endocrinology and metabolism

Schwartz JB, Lai J, Lizaola B, Kane L, Markova S, Weyland P, Terrault NA, Stotland N, Bikle D

IDENTIFICATION OF VDR ANTAGONISTS AMONG NUCLEAR RECEPTOR LIGANDS USING VIRTUAL SCREENING.

Nuclear receptor research

Teske K, Nandhikonda P, Bogart JW, Feleke B, Sidhu P, Yuan N, Preston J, Goy R, Han L, Silvaggi NR, Singh RK, Bikle DD, Cook JM, Arnold LA

The vitamin D receptor: a tumor suppressor in skin.

Advances in experimental medicine and biology

Bikle DD

LncRNA profiling reveals new mechanism for VDR protection against skin cancer formation.

The Journal of steroid biochemistry and molecular biology

Jiang YJ, Bikle DD

Reprint of: policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich, et al.

Frontiers in neuroendocrinology

Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, S?der O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS

Variability in free 25(OH) vitamin D levels in clinical populations.

The Journal of steroid biochemistry and molecular biology

Schwartz JB, Lai J, Lizaola B, Kane L, Weyland P, Terrault NA, Stotland N, Bikle D

Reciprocal role of vitamin D receptor on �-catenin regulated keratinocyte proliferation and differentiation.

The Journal of steroid biochemistry and molecular biology

Hu L, Bikle DD, Oda Y

Insulin-like growth factor-1 receptor in mature osteoblasts is required for periosteal bone formation induced by reloading.

Acta astronautica

Kubota T, Elalieh HZ, Saless N, Fong C, Wang Y, Babey M, Cheng Z, Bikle DD

Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al.

European journal of endocrinology

Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, S?der O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS

Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al.

Endocrinology

Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, S?der O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS

Vitamin D3 effects on lipids differ in statin and non-statin-treated humans: superiority of free 25-OH D levels in detecting relationships.

The Journal of clinical endocrinology and metabolism

Kane L, Moore K, L?tjohann D, Bikle D, Schwartz JB

Fifteenth vitamin D workshop.

The Journal of steroid biochemistry and molecular biology

Norman AW, Bikle D, Bouillon R

Peroxisome proliferation-activated receptor d agonist GW0742 interacts weakly with multiple nuclear receptors, including the vitamin D receptor.

Biochemistry

Nandhikonda P, Yasgar A, Baranowski AM, Sidhu PS, McCallum MM, Pawlak AJ, Teske K, Feleke B, Yuan NY, Kevin C, Bikle DD, Ayers SD, Webb P, Rai G, Simeonov A, Jadhav A, Maloney D, Arnold LA

Vitamin D: beyond bone.

Annals of the New York Academy of Sciences

Christakos S, Hewison M, Gardner DG, Wagner CL, Sergeev IN, Rutten E, Pittas AG, Boland R, Ferrucci L, Bikle DD

Sex and age modify biochemical and skeletal manifestations of chronic hyperparathyroidism by altering target organ responses to Ca2+ and parathyroid hormone in mice.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Cheng Z, Liang N, Chen TH, Li A, Santa Maria C, You M, Ho H, Song F, Bikle D, Tu C, Shoback D, Chang W

Role of the calcium-sensing receptor in calcium regulation of epidermal differentiation and function.

Best practice & research. Clinical endocrinology & metabolism

Tu CL, Bikle DD

Anabolic effects of IGF-1 signaling on the skeleton.

Frontiers in endocrinology

Tahimic CG, Wang Y, Bikle DD

Ceramides stimulate caspase-14 expression in human keratinocytes.

Experimental dermatology

Jiang YJ, Kim P, Uchida Y, Elias PM, Bikle DD, Grunfeld C, Feingold KR

Protective actions of vitamin D in UVB induced skin cancer.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

Bikle DD

Vitamin D in cutaneous carcinogenesis: part I.

Journal of the American Academy of Dermatology

Tang JY, Fu T, Lau C, Oh DH, Bikle DD, Asgari MM

Vitamin D in cutaneous carcinogenesis: part II.

Journal of the American Academy of Dermatology

Tang JY, Fu T, Lau C, Oh DH, Bikle DD, Asgari MM

Simulated spaceflight produces a rapid and sustained loss of osteoprogenitors and an acute but transitory rise of osteoclast precursors in two genetic strains of mice.

American journal of physiology. Endocrinology and metabolism

Shahnazari M, Kurimoto P, Boudignon BM, Orwoll BE, Bikle DD, Halloran BP

Protective role of vitamin D signaling in skin cancer formation.

The Journal of steroid biochemistry and molecular biology

Bikle DD, Elalieh H, Welsh J, Oh D, Cleaver J, Teichert A

1a,25(OH)2-dihydroxyvitamin D3/VDR protects the skin from UVB-induced tumor formation by interacting with the �-catenin pathway.

The Journal of steroid biochemistry and molecular biology

Jiang YJ, Teichert AE, Fong F, Oda Y, Bikle DD

Calcium regulation of keratinocyte differentiation.

Expert review of endocrinology & metabolism

Bikle DD, Xie Z, Tu CL

Vitamin D and bone.

Current osteoporosis reports

Bikle DD

Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function.

The Journal of investigative dermatology

Tu CL, Crumrine DA, Man MQ, Chang W, Elalieh H, You M, Elias PM, Bikle DD

PTH/PTHrP and vitamin D control antimicrobial peptide expression and susceptibility to bacterial skin infection.

Science translational medicine

Muehleisen B, Bikle DD, Aguilera C, Burton DW, Sen GL, Deftos LJ, Gallo RL

The nonskeletal effects of vitamin D: an Endocrine Society scientific statement.

Endocrine reviews

Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, Manson JE, Murad MH, Kovacs CS

Discovery of the first irreversible small molecule inhibitors of the interaction between the vitamin D receptor and coactivators.

Journal of medicinal chemistry

Nandhikonda P, Lynt WZ, McCallum MM, Ara T, Baranowski AM, Yuan NY, Pearson D, Bikle DD, Guy RK, Arnold LA

Vitamin D receptor mediates DNA repair and is UV inducible in intact epidermis but not in cultured keratinocytes.

The Journal of investigative dermatology

Demetriou SK, Ona-Vu K, Teichert AE, Cleaver JE, Bikle DD, Oh DH

Vitamin D and the skin: Physiology and pathophysiology.

Reviews in endocrine & metabolic disorders

Bikle DD

SERCA2-controlled Ca�+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease.

The Journal of investigative dermatology

Celli A, Mackenzie DS, Zhai Y, Tu CL, Bikle DD, Holleran WM, Uchida Y, Mauro TM

Coactivator MED1 ablation in keratinocytes results in hair-cycling defects and epidermal alterations.

The Journal of investigative dermatology

Oda Y, Hu L, Bul V, Elalieh H, Reddy JK, Bikle DD

Osteoblast extracellular Ca2+ -sensing receptor regulates bone development, mineralization, and turnover.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Dvorak-Ewell MM, Chen TH, Liang N, Garvey C, Liu B, Tu C, Chang W, Bikle DD, Shoback DM

Skeletal unloading-induced insulin-like growth factor 1 (IGF-1) nonresponsiveness is not shared by platelet-derived growth factor: the selective role of integrins in IGF-1 signaling.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Long RK, Nishida S, Kubota T, Wang Y, Sakata T, Elalieh HZ, Halloran BP, Bikle DD

Negative cross-talk between calcium-sensing receptor and �-catenin signaling systems in colonic epithelium.

The Journal of biological chemistry

Rey O, Chang W, Bikle D, Rozengurt N, Young SH, Rozengurt E

Overexpression of hedgehog signaling is associated with epidermal tumor formation in vitamin D receptor-null mice.

The Journal of investigative dermatology

Teichert AE, Elalieh H, Elias PM, Welsh J, Bikle DD

IGF-1R signaling in chondrocytes modulates growth plate development by interacting with the PTHrP/Ihh pathway.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Wang Y, Cheng Z, Elalieh HZ, Nakamura E, Nguyen MT, Mackem S, Clemens TL, Bikle DD, Chang W

Vitamin D metabolism and function in the skin.

Molecular and cellular endocrinology

Bikle DD

Vitamin D3 inhibits hedgehog signaling and proliferation in murine Basal cell carcinomas.

Cancer prevention research (Philadelphia, Pa.)

Tang JY, Xiao TZ, Oda Y, Chang KS, Shpall E, Wu A, So PL, Hebert J, Bikle D, Epstein EH

Vitamin D regulation of immune function.

Vitamins and hormones

Bikle DD

Vitamin D: an ancient hormone.

Experimental dermatology

Bikle DD

Endoplasmic reticulum Ca2+ depletion activates XBP1 and controls terminal differentiation in keratinocytes and epidermis.

The British journal of dermatology

Celli A, Mackenzie DS, Crumrine DS, Tu CL, Hupe M, Bikle DD, Elias PM, Mauro TM

Lineage-specific effects of 1,25-dihydroxyvitamin D(3) on the development of effector CD4 T cells.

The Journal of biological chemistry

Palmer MT, Lee YK, Maynard CL, Oliver JR, Bikle DD, Jetten AM, Weaver CT

Differential regulation of epidermal function by VDR coactivators.

The Journal of steroid biochemistry and molecular biology

Bikle DD, Teichert A, Arnold LA, Uchida Y, Elias PM, Oda Y

Vitamin D and the skin.

Journal of bone and mineral metabolism

Bikle DD

Association of prediagnostic serum vitamin D levels with the development of basal cell carcinoma.

The Journal of investigative dermatology

Asgari MM, Tang J, Warton ME, Chren MM, Quesenberry CP, Bikle D, Horst RL, Orentreich N, Vogelman JH, Friedman GD

Hypercalcemia and overexpression of CYP27B1 in a patient with nephrogenic systemic fibrosis: clinical vignette and literature review.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Pao VY, Chang S, Shoback DM, Bikle DD

Quantification of the vitamin D receptor-coregulator interaction.

Biochemistry

Teichert A, Arnold LA, Otieno S, Oda Y, Augustinaite I, Geistlinger TR, Kriwacki RW, Guy RK, Bikle DD

Phosphatidylinositol-4-phosphate 5-kinase 1alpha mediates extracellular calcium-induced keratinocyte differentiation.

Molecular biology of the cell

Xie Z, Chang SM, Pennypacker SD, Liao EY, Bikle DD

Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formation.

The Journal of investigative dermatology

Oda Y, Uchida Y, Moradian S, Crumrine D, Elias PM, Bikle DD

Nonclassic actions of vitamin D.

The Journal of clinical endocrinology and metabolism

Bikle D

Vitamin D receptor, UVR, and skin cancer: a potential protective mechanism.

The Journal of investigative dermatology

Bikle DD

Vitamin D and the immune system: role in protection against bacterial infection.

Current opinion in nephrology and hypertension

Bikle DD

Growth hormone/insulin-like growth factor-1/PTH axis in bone.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Bikle DD

Integrins, insulin like growth factors, and the skeletal response to load.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Bikle DD

Vitamin D insufficiency/deficiency in gastrointestinal disorders.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Bikle DD

Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3.

The Journal of investigative dermatology

Schauber J, Oda Y, Büchau AS, Yun QC, Steinmeyer A, Zügel U, Bikle DD, Gallo RL

IGF-I receptor is required for the anabolic actions of parathyroid hormone on bone.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Wang Y, Nishida S, Boudignon BM, Burghardt A, Elalieh HZ, Hamilton MM, Majumdar S, Halloran BP, Clemens TL, Bikle DD

What is new in vitamin D: 2006-2007.

Current opinion in rheumatology

Bikle DD

Constitutive activity of the osteoblast Ca2+-sensing receptor promotes loss of cancellous bone.

Endocrinology

Dvorak MM, Chen TH, Orwoll B, Garvey C, Chang W, Bikle DD, Shoback DM

Insulin-like growth factor I stimulates recovery of bone lost after a period of skeletal unloading.

Journal of applied physiology (Bethesda, Md. : 1985)

Boudignon BM, Bikle DD, Kurimoto P, Elalieh H, Nishida S, Wang Y, Burghardt A, Majumdar S, Orwoll BE, Rosen C, Halloran BP

Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism.

The Journal of clinical investigation

Schauber J, Dorschner RA, Coda AB, Büchau AS, Liu PT, Kiken D, Helfrich YR, Kang S, Elalieh HZ, Steinmeyer A, Zügel U, Bikle DD, Modlin RL, Gallo RL

Differential role of two VDR coactivators, DRIP205 and SRC-3, in keratinocyte proliferation and differentiation.

The Journal of steroid biochemistry and molecular biology

Oda Y, Ishikawa MH, Hawker NP, Yun QC, Bikle DD

Sequential regulation of keratinocyte differentiation by 1,25(OH)2D3, VDR, and its coregulators.

The Journal of steroid biochemistry and molecular biology

Bikle D, Teichert A, Hawker N, Xie Z, Oda Y

Regulation of human epidermal keratinocyte differentiation by the vitamin D receptor and its coactivators DRIP205, SRC2, and SRC3.

The Journal of investigative dermatology

Hawker NP, Pennypacker SD, Chang SM, Bikle DD

Role of IGF-I signaling in regulating osteoclastogenesis.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Wang Y, Nishida S, Elalieh HZ, Long RK, Halloran BP, Bikle DD

Insulin-like growth factor-I is essential for embryonic bone development.

Endocrinology

Wang Y, Nishida S, Sakata T, Elalieh HZ, Chang W, Halloran BP, Doty SB, Bikle DD

Development and progression of alopecia in the vitamin D receptor null mouse.

Journal of cellular physiology

Bikle DD, Elalieh H, Chang S, Xie Z, Sundberg JP

Gender differences in the response of CD-1 mouse bone to parathyroid hormone: potential role of IGF-I.

The Journal of endocrinology

Wang Y, Sakata T, Elalieh HZ, Munson SJ, Burghardt A, Majumdar S, Halloran BP, Bikle DD

Vitamin D and skin cancer: a problem in gene regulation.

The Journal of steroid biochemistry and molecular biology

Bikle DD, Oda Y, Xie Z

Phospholipase cgamma1 is required for activation of store-operated channels in human keratinocytes.

The Journal of investigative dermatology

Tu CL, Chang W, Bikle DD

Vitamin D and skin cancer.

The Journal of nutrition

Bikle DD

The effect of LXR activators on AP-1 proteins in keratinocytes.

The Journal of investigative dermatology

Schmuth M, Elias PM, Hanley K, Lau P, Moser A, Willson TM, Bikle DD, Feingold KR

Vitamin D regulated keratinocyte differentiation.

Journal of cellular biochemistry

Bikle DD

Calcium and 1,25(OH)2D: interacting drivers of epidermal differentiation.

The Journal of steroid biochemistry and molecular biology

Bikle DD, Oda Y, Xie Z

Mice lacking 25OHD 1alpha-hydroxylase demonstrate decreased epidermal differentiation and barrier function.

The Journal of steroid biochemistry and molecular biology

Bikle DD, Chang S, Crumrine D, Elalieh H, Man MQ, Dardenne O, Xie Z, Arnaud RS, Feingold K, Elias PM

Two distinct coactivators, DRIP/mediator and SRC/p160, are differentially involved in VDR transactivation during keratinocyte differentiation.

The Journal of steroid biochemistry and molecular biology

Oda Y, Sihlbom C, Chalkley RJ, Huang L, Rachez C, Chang CP, Burlingame AL, Freedman LP, Bikle DD

25 Hydroxyvitamin D 1 alpha-hydroxylase is required for optimal epidermal differentiation and permeability barrier homeostasis.

The Journal of investigative dermatology

Bikle DD, Chang S, Crumrine D, Elalieh H, Man MQ, Choi EH, Dardenne O, Xie Z, Arnaud RS, Feingold K, Elias PM

The role of the calcium-sensing receptor in epidermal differentiation.

Cell calcium

Tu CL, Oda Y, Komuves L, Bikle DD

Skeletal unloading induces resistance to insulin-like growth factor-I (IGF-I) by inhibiting activation of the IGF-I signaling pathways.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Sakata T, Wang Y, Halloran BP, Elalieh HZ, Cao J, Bikle DD

PTH differentially regulates expression of RANKL and OPG.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Huang JC, Sakata T, Pfleger LL, Bencsik M, Halloran BP, Bikle DD, Nissenson RA

Human keratinocyte ATP2C1 localizes to the Golgi and controls Golgi Ca2+ stores.

The Journal of investigative dermatology

Behne MJ, Tu CL, Aronchik I, Epstein E, Bench G, Bikle DD, Pozzan T, Mauro TM

bFGF administration lowers the phosphate threshold for mineralization in bone marrow stromal cells.

Calcified tissue international

Nauman EA, Sakata T, Keaveny TM, Halloran BP, Bikle DD

Two distinct coactivators, DRIP/mediator and SRC/p160, are differentially involved in vitamin D receptor transactivation during keratinocyte differentiation.

Molecular endocrinology (Baltimore, Md.)

Oda Y, Sihlbom C, Chalkley RJ, Huang L, Rachez C, Chang CP, Burlingame AL, Freedman LP, Bikle DD

Skeletal unloading induces resistance to insulin-like growth factor I on bone formation.

Bone

Sakata T, Halloran BP, Elalieh HZ, Munson SJ, Rudner L, Venton L, Ginzinger D, Rosen CJ, Bikle DD

The impact of skeletal unloading on bone formation.

Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology

Bikle DD, Sakata T, Halloran BP

Vitamin D regulated keratinocyte differentiation: role of coactivators.

Journal of cellular biochemistry

Bikle DD, Tu CL, Xie Z, Oda Y

Squamous cell carcinomas fail to respond to the prodifferentiating actions of 1,25(OH)2D: why?

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer

Bikle DD, Xie Z, Ng D, Tu CL, Oda Y

Mechanical and chemical characteristics of mineral produced by basic fibroblast growth factor-treated bone marrow stromal cells in vitro.

Tissue engineering

Nauman EA, Ebenstein DM, Hughes KF, Pruitt L, Halloran BP, Bikle DD, Keaveny TM

The vitamin D response element of the involucrin gene mediates its regulation by 1,25-dihydroxyvitamin D3.

The Journal of investigative dermatology

Bikle DD, Ng D, Oda Y, Hanley K, Feingold K, Xie Z

Insulin-like growth factor I is required for the anabolic actions of parathyroid hormone on mouse bone.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Bikle DD, Sakata T, Leary C, Elalieh H, Ginzinger D, Rosen CJ, Beamer W, Majumdar S, Halloran BP

Epidermal expression of the full-length extracellular calcium-sensing receptor is required for normal keratinocyte differentiation.

Journal of cellular physiology

Komuves L, Oda Y, Tu CL, Chang WH, Ho-Pao CL, Mauro T, Bikle DD

The mechanism of 1,25-dihydroxyvitamin D(3) autoregulation in keratinocytes.

The Journal of biological chemistry

Xie Z, Munson SJ, Huang N, Portale AA, Miller WL, Bikle DD

Lack of the vitamin D receptor is associated with reduced epidermal differentiation and hair follicle growth.

The Journal of investigative dermatology

Xie Z, Komuves L, Yu QC, Elalieh H, Ng DC, Leary C, Chang S, Crumrine D, Yoshizawa T, Kato S, Bikle DD

The skeletal structure of insulin-like growth factor I-deficient mice.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Bikle D, Majumdar S, Laib A, Powell-Braxton L, Rosen C, Beamer W, Nauman E, Leary C, Halloran B

Calcium- and vitamin D-regulated keratinocyte differentiation.

Molecular and cellular endocrinology

Bikle DD, Ng D, Tu CL, Oda Y, Xie Z

Osteoblasts respond to pulsatile fluid flow with short-term increases in PGE(2) but no change in mineralization.

Journal of applied physiology (Bethesda, Md. : 1985)

Nauman EA, Satcher RL, Keaveny TM, Halloran BP, Bikle DD

Cholesterol sulfate stimulates involucrin transcription in keratinocytes by increasing Fra-1, Fra-2, and Jun D.

Journal of lipid research

Hanley K, Wood L, Ng DC, He SS, Lau P, Moser A, Elias PM, Bikle DD, Williams ML, Feingold KR

Selective inhibition of vitamin D hydroxylases in human keratinocytes.

Steroids

Schuster I, Egger H, Bikle D, Herzig G, Reddy GS, Stuetz A, Stuetz P, Vorisek G

Stimulation of PPARalpha promotes epidermal keratinocyte differentiation in vivo.

The Journal of investigative dermatology

Kömüves LG, Hanley K, Lefebvre AM, Man MQ, Ng DC, Bikle DD, Williams ML, Elias PM, Auwerx J, Feingold KR

Requirement of an AP-1 site in the calcium response region of the involucrin promoter.

The Journal of biological chemistry

Ng DC, Shafaee S, Lee D, Bikle DD

Farnesol stimulates differentiation in epidermal keratinocytes via PPARalpha.

The Journal of biological chemistry

Hanley K, Kömüves LG, Ng DC, Schoonjans K, He SS, Lau P, Bikle DD, Williams ML, Elias PM, Auwerx J, Feingold KR

Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription.

The Journal of investigative dermatology

Hanley K, Ng DC, He SS, Lau P, Min K, Elias PM, Bikle DD, Mangelsdorf DJ, Williams ML, Feingold KR

The calcium sensing receptor and its alternatively spliced form in murine epidermal differentiation.

The Journal of biological chemistry

Oda Y, Tu CL, Chang W, Crumrine D, Kömüves L, Mauro T, Elias PM, Bikle DD

Differences in calcium metabolism between black and white men and women.

Mineral and electrolyte metabolism

Bikle DD, Ettinger B, Sidney S, Tekawa IS, Tolan K

1,25 dihydroxyvitamin D3 enhances the calcium response of keratinocytes.

Journal of cellular physiology

Ratnam AV, Bikle DD, Cho JK

Bone and hormonal changes induced by skeletal unloading in the mature male rat.

The American journal of physiology

Dehority W, Halloran BP, Bikle DD, Curren T, Kostenuik PJ, Wronski TJ, Shen Y, Rabkin B, Bouraoui A, Morey-Holton E

Skeletal unloading causes resistance of osteoprogenitor cells to parathyroid hormone and to insulin-like growth factor-I.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Kostenuik PJ, Harris J, Halloran BP, Turner RT, Morey-Holton ER, Bikle DD

The response of bone to unloading.

Journal of bone and mineral metabolism

Bikle DD, Halloran BP

The calcium sensing receptor and its alternatively spliced form in keratinocyte differentiation.

The Journal of biological chemistry

Oda Y, Tu CL, Pillai S, Bikle DD

Keratinocyte differentiation is stimulated by activators of the nuclear hormone receptor PPARalpha.

The Journal of investigative dermatology

Hanley K, Jiang Y, He SS, Friedman M, Elias PM, Bikle DD, Williams ML, Feingold KR

Cloning of human 25-hydroxyvitamin D-1 alpha-hydroxylase and mutations causing vitamin D-dependent rickets type 1.

Molecular endocrinology (Baltimore, Md.)

Fu GK, Lin D, Zhang MY, Bikle DD, Shackleton CH, Miller WL, Portale AA

Skeletal unloading inhibits the in vitro proliferation and differentiation of rat osteoprogenitor cells.

The American journal of physiology

Kostenuik PJ, Halloran BP, Morey-Holton ER, Bikle DD

Biochemical markers in the assessment of bone disease.

The American journal of medicine

Bikle DD

Regional responsiveness of the tibia to intermittent administration of parathyroid hormone as affected by skeletal unloading.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Halloran BP, Bikle DD, Harris J, Tanner S, Curren T, Morey-Holton E

Spaceflight and the skeleton: lessons for the earthbound.

Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology

Bikle DD, Halloran BP, Morey-Holton E

Racial differences in bone density between young adult black and white subjects persist after adjustment for anthropometric, lifestyle, and biochemical differences.

The Journal of clinical endocrinology and metabolism

Ettinger B, Sidney S, Cummings SR, Libanati C, Bikle DD, Tekawa IS, Tolan K, Steiger P

Space flight and the skeleton: lessons for the earthbound.

The Endocrinologist

Bikle DD, Halloran BP, Morey-Holton E

1,25(OH)2D3-modulated calcium induced keratinocyte differentiation.

The journal of investigative dermatology. Symposium proceedings

Bikle DD

Changes in calcium responsiveness and handling during keratinocyte differentiation. Potential role of the calcium receptor.

The Journal of clinical investigation

Bikle DD, Ratnam A, Mauro T, Harris J, Pillai S

Regulation of involucrin gene expression by calcium in normal human keratinocytes.

Frontiers in bioscience : a journal and virtual library

Ng DC, Su MJ, Kim R, Bikle DD

22-Oxa calcitriol is a less potent regulator of keratinocyte proliferation and differentiation due to decreased cellular uptake and enhanced catabolism.

The Journal of investigative dermatology

Bikle DD, Abe-Hashimoto J, Su MJ, Felt S, Gibson DF, Pillai S

Skeletal unloading induces selective resistance to the anabolic actions of growth hormone on bone.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Halloran BP, Bikle DD, Harris J, Autry CP, Currier PA, Tanner S, Patterson-Buckendahl P, Morey-Holton E

The molecular response of bone to growth hormone during skeletal unloading: regional differences.

Endocrinology

Bikle DD, Harris J, Halloran BP, Currier PA, Tanner S, Morey-Holton E

Serum levels of free 1,25-dihydroxyvitamin D in vitamin D toxicity.

Annals of internal medicine

Pettifor JM, Bikle DD, Cavaleros M, Zachen D, Kamdar MC, Ross FP

Altered skeletal pattern of gene expression in response to spaceflight and hindlimb elevation.

The American journal of physiology

Bikle DD, Harris J, Halloran BP, Morey-Holton E

Alendronate increases skeletal mass of growing rats during unloading by inhibiting resorption of calcified cartilage.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Bikle DD, Morey-Holton ER, Doty SB, Currier PA, Tanner SJ, Halloran BP

Skeletal unloading induces resistance to insulin-like growth factor I.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Bikle DD, Harris J, Halloran BP, Morey-Holton ER

Expression of the genes for insulin-like growth factors and their receptors in bone during skeletal growth.

The American journal of physiology

Bikle DD, Harris J, Halloran BP, Roberts CT, Leroith D, Morey-Holton E

Impact of skeletal unloading on bone formation: role of systemic and local factors.

Acta astronautica

Bikle DD, Halloran BP, Morey-Holton E

1,25-Dihydroxyvitamin D3 potentiates the keratinocyte response to calcium.

The Journal of biological chemistry

Su MJ, Bikle DD, Mancianti ML, Pillai S

Production of 1,25 dihydroxyvitamin D3 by perfused pig skin.

The Journal of investigative dermatology

Bikle DD, Halloran BP, Riviere JE

Alcohol-induced bone disease: relationship to age and parathyroid hormone levels.

Alcoholism, clinical and experimental research

Bikle DD, Stesin A, Halloran B, Steinbach L, Recker R

Skeletal unloading decreases production of 1,25-dihydroxyvitamin D.

The American journal of physiology

Halloran BP, Bikle DD, Harris J, Foskett HC, Morey-Holton E

Elevated 1,25-dihydroxyvitamin D levels in patients with chronic obstructive pulmonary disease treated with prednisone.

The Journal of clinical endocrinology and metabolism

Bikle DD, Halloran B, Fong L, Steinbach L, Shellito J

Vitamin D, calcium, and epidermal differentiation.

Endocrine reviews

Bikle DD, Pillai S

Zipper protein, a newly described tropomyosin-like protein of the intestinal brush border.

The Journal of biological chemistry

Bikle DD, Munson S, Morrison N, Eisman J

Alcohol-induced bone disease.

World review of nutrition and dietetics

Bikle DD

Localization and quantitation of calcium pools and calcium binding sites in cultured human keratinocytes.

Journal of cellular physiology

Pillai S, Menon GK, Bikle DD, Elias PM

Metabolic acidosis reverses the increase in serum 1,25(OH)2D in phosphorus-restricted normal men.

The American journal of physiology

Portale AA, Halloran BP, Harris ST, Bikle DD, Morris RC

Effects of dietary protein deficiency on mineral metabolism and bone mineral density.

The American journal of clinical nutrition

Orwoll E, Ware M, Stribrska L, Bikle D, Sanchez T, Andon M, Li H

Progestin antagonism of estrogen stimulated 1,25-dihydroxyvitamin D levels.

The Journal of clinical endocrinology and metabolism

Bikle DD, Halloran BP, Harris ST, Portale AA

Limited tissue distribution of the intestinal brush border myosin I protein.

Gastroenterology

Bikle DD, Munson S, Mancianti ML

Uncoupling of the calcium-sensing mechanism and differentiation in squamous carcinoma cell lines.

Experimental cell research

Pillai S, Bikle DD, Mancianti ML, Hincenbergs M

Epidermal vitamin D metabolism, function, and regulation.

Advances in lipid research

Pillai S, Bikle DD

Different responses of trabecular and cortical bone to 1,25(OH)2D3 infusion.

The American journal of physiology

Bikle DD, Halloran BP, McGalliard-Cone C, Morey-Holton E

Serum vitamin D metabolites are not responsible for low turnover osteoporosis in chronic liver disease.

The Journal of clinical endocrinology and metabolism

Diamond T, Stiel D, Mason R, Lissner D, Bikle D, Wilson S, Posen S

Effects of simulated weightlessness on rat osteocalcin and bone calcium.

The American journal of physiology

Patterson-Buckendahl P, Globus RK, Bikle DD, Cann CE, Morey-Holton E

Bone response to normal weight bearing after a period of skeletal unloading.

The American journal of physiology

Sessions ND, Halloran BP, Bikle DD, Wronski TJ, Cone CM, Morey-Holton E

Transpleural gradient of 1,25-dihydroxyvitamin D in tuberculous pleuritis.

The Journal of clinical investigation

Barnes PF, Modlin RL, Bikle DD, Adams JS

Binding and biological effects of tumor necrosis factor alpha on cultured human neonatal foreskin keratinocytes.

The Journal of clinical investigation

Pillai S, Bikle DD, Eessalu TE, Aggarwal BB, Elias PM

Isotopic labeling affects 1,25-dihydroxyvitamin D metabolism.

Biochemistry

Halloran BP, Bikle DD, Castro ME, Gee E

Calmodulin binding to the intestinal brush-border membrane: comparison to other calcium-binding proteins.

Biochimica et biophysica acta

Bikle D, Munson S, Christakos S, Kumar R, Buckendahl P

Glucocorticoids and inhibition of bone formation induced by skeletal unloading.

The American journal of physiology

Halloran BP, Bikle DD, Cone CM, Morey-Holton E

Serum dihydrotachysterol levels and biological action in normal man.

The Journal of clinical endocrinology and metabolism

Taylor A, Bikle DD, Norman ME

Effects of alcohol abuse on bone.

Comprehensive therapy

Bikle DD

Vitamin D and epidermal differentiation: evidence for a role of endogenously produced vitamin D metabolites in keratinocyte differentiation.

Skin pharmacology : the official journal of the Skin Pharmacology Society

Pillai S, Bikle DD, Elias PM

Vitamin D metabolite production and function in keratinocytes.

Annals of the New York Academy of Sciences

Bikle DD, Pillai S

The effect of vitamin D status on cutaneous sterologenesis in vivo and in vitro.

Biochimica et biophysica acta

Feingold KR, Williams ML, Pillai S, Menon GK, Halloran BP, Bikle DD, Elias PM

Effect of dietary acid and calcium on 25-hydroxyvitamin D metabolism by chick kidney.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Cunningham J, Bikle DD, Avioli LV

The effects of simulated weightlessness on bone maturation.

Endocrinology

Bikle DD, Halloran BP, Cone CM, Globus RK, Morey-Holton E

Chronic administration of 1,25-dihydroxyvitamin D3: increased bone but impaired mineralization.

Endocrinology

Wronski TJ, Halloran BP, Bikle DD, Globus RK, Morey-Holton ER

Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein.

The Journal of clinical endocrinology and metabolism

Bikle DD, Gee E, Halloran B, Kowalski MA, Ryzen E, Haddad JG

Effect of ethanol on intestinal calcium transport in chicks.

Gastroenterology

Bikle DD, Gee EA, Munson SJ

Chronic 1,25-dihydroxyvitamin D3 administration in the rat reduces the serum concentration of 25-hydroxyvitamin D by increasing metabolic clearance rate.

The Journal of clinical investigation

Halloran BP, Bikle DD, Levens MJ, Castro ME, Globus RK, Holton E

Free 25-hydroxyvitamin D levels are normal in subjects with liver disease and reduced total 25-hydroxyvitamin D levels.

The Journal of clinical investigation

Bikle DD, Halloran BP, Gee E, Ryzen E, Haddad JG

1,25-Dihydroxyvitamin D3 production by human keratinocytes. Kinetics and regulation.

The Journal of clinical investigation

Bikle DD, Nemanic MK, Gee E, Elias P

Neonatal human foreskin keratinocytes produce 1,25-dihydroxyvitamin D3.

Biochemistry

Bikle DD, Nemanic MK, Whitney JO, Elias PW

Skeletal response to dietary calcium in a rat model simulating weightlessness.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Globus RK, Bikle DD, Halloran B, Morey-Holton E

The role of 1,25-dihydroxyvitamin D in the inhibition of bone formation induced by skeletal unloading.

Endocrinology

Halloran BP, Bikle DD, Wronski TJ, Globus RK, Levens MJ, Morey-Holton E

The temporal response of bone to unloading.

Endocrinology

Globus RK, Bikle DD, Morey-Holton E

Bone loss during simulated weightlessness: is it glucocorticoid mediated?

The Physiologist

Bikle DD, Halloran BP, Cone CM, Morey-Holton E

Effect of simulated weightlessness and chronic 1,25-dihydroxyvitamin D administration on bone metabolism.

The Physiologist

Halloran BP, Bikle DD, Wronski TJ, Globus RK, Levens MJ, Morey-Holton E

Serum protein binding of 1,25-dihydroxyvitamin D: a reevaluation by direct measurement of free metabolite levels.

The Journal of clinical endocrinology and metabolism

Bikle DD, Siiteri PK, Ryzen E, Haddad JG

Bone disease in alcohol abuse.

Annals of internal medicine

Bikle DD, Genant HK, Cann C, Recker RR, Halloran BP, Strewler GJ

Effects of simulated weightlessness on bone mineral metabolism.

Endocrinology

Globus RK, Bikle DD, Morey-Holton E

Acute, but not chronic, metabolic acidosis disturbs 25-hydroxyvitamin D3 metabolism.

Kidney international

Cunningham J, Bikle DD, Avioli LV

Simulating certain aspects of hypogravity: effects on bone maturation in the non-weight bearing skeleton.

Aviation, space, and environmental medicine

Simmons DJ, Grazman B, Russell JE, Walker WV, Bikle DD, Morey ER

Calcium absorption and vitamin D metabolism.

Clinics in gastroenterology

Bikle DD

Calcium potentiates the cyclic nucleotide and phosphaturic response to parathyroid hormone infusion.

The Journal of clinical endocrinology and metabolism

Bikle DD, Herman RH

Pharmacokinetics and pharmacodynamics of 1,25-dihydroxyvitamin D3 in the chick.

Endocrinology

Bikle DD, Peck CC, Holford NH, Zolock DT, Morrissey RL

The vitamin D endocrine system.

Advances in internal medicine

Bikle DD

Action of vitamin D on intestinal calcium transport.

Annals of the New York Academy of Sciences

Bikle DD, Zolock DT, Morrissey RL

The intestinal response to vitamin D.

Reviews of physiology, biochemistry and pharmacology

Bikle DD, Morrissey RL, Zolock DT, Rasmussen H

Calcium accumulation by chick intestinal mitochondria. Regulation by vitamin D-3 and 1,25-dihydroxyvitamin D-3.

Biochimica et biophysica acta

Bikle DD, Askew EW, Zolock DT, Morrissey RL, Herman RH

Effects of 1 alpha-hydroxy vitamin D3 on the rachitic chick intestine: a comparison to the effects of 1,25-dihydroxyvitamin D3.

Calcified tissue international

Bikle DD, Empson RN, Morrissey RL, Zolock DT, Bucci TJ, Herman RH, Pechet MM

The mechanism of action of vitamin D in the intestine.

The American journal of clinical nutrition

Bikle DD, Morrissey RL, Zolock DT

Stimulation of chick gut alkaline phosphatase activity by actinomycin D and 1,25-dihydroxyvitamin D3: evidence for independent mechanisms.

The Journal of laboratory and clinical medicine

Bikle DD, Morrissey RL, Zolock DT, Herman RH

Work-induced muscle hypertrophy in vitamin D-deficient rats.

The American journal of clinical nutrition

Bikle DD, Hagler L, Lollini LO, Hull SF, Herman RH

Immunoperoxidase localization of vitamin D dependent calcium binding protein.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

Morrissey RL, Zolock DT, Bucci TJ, Bikle DD

A biochemical model for the ionic control of 25-hydroxyvitamin D3 1alpha-hydroxylase.

The Journal of biological chemistry

Bikle DD, Rasmussen H

Independence of 1,25-dihydroxyvitamin D3-mediated calcium transport from de novo RNA and protein synthesis.

The Journal of biological chemistry

Bikle DD, Zolock DT, Morrissey RL, Herman RH

The effect of 1,25-dihydroxyvitamin D-3 on the distribution of alkaline phosphatase activity along the chick intestinal villus.

Biochimica et biophysica acta

Bikle DD, Empson RN, Herman RH, Morrissey RL, Zolock DR

The ionic control of 1,25-dihydroxyvitamin D3 production in isolated chick renal tubules.

The Journal of clinical investigation

Bikle DD, Rasmussen H

Hormonal control of the renal conversion of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol.

The Journal of clinical investigation

Rasmussen H, Wong M, Bikle D, Goodman DB